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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian.s.inal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Combustion.s.nthesis and lumin.s.ence characteristic of rare earth activated LiCaBO_3

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Journal of Rare Earths 2012年第10期30卷 1005-1008页

作者： n.s. Bajaj s.K. Omanwar Department of Physics SGB Amravati University Amravati-444602 (M.S.)

Lithium calcium borate （LiCaBO3） polycrystalline thermolumin.s.ence （TL） phosphor doped with rare earth （Tb3＋ and Dy3＋） elemen.s.was synthesized by novel solution combustion.s.nthesis. The reaction produced very stable crystalline LiCaBO3：D（D=Tb3＋ and Dy3＋） phosphors. These rare earth doped phosphors material showed maximum TL sensitivity with favorable glow curve shape. TL glow curve of X-ray irradiated that LiCaBO3：Tb3＋ and LiCaBO3：Dy3＋ samples showed two major well-separated glow peaks. The TL sensitivity of these phosphors to X-ray radiation was comparable with that of TLD-100（Harshaw）. Photolumin.s.ence spectra of LiCaBO3：Tb3＋ and LiCaBO3：Dy3＋ showed the characteristic Tb3＋ and Dy3＋ peaks respectively. TL response to X-ray radiation dose was linear up to 25 Gy.

关键词： lumin.s.ence LiCaBO3 combustion.s.nthesis rare earths kinetics

Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig Ali n.Ali Arshad Majid sheffield Institute for Translational neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(Vns)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been.s.gnificant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive Vns paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatmen.s.of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,sTOP-AUsT,and TRAIGE did not show improvemen.s.in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Olfactory receptors in neural regeneration in the central nervous system

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neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan.s.rrano-Marín Rafael Rivas-santisteban Jaume Lillo Molecular neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical Research in neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagn.s.ics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechan.s.s underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compoun.s.and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compoun.s.that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： aden.s.ne receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endin.s.and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kin.s. B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal coun.s.to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kin.s.s A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endin.s.in developmental *** dynamic changes that occur simultaneously in.s.veral nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechan.s.s of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release aden.s.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kin.s.s tropomyosin-related kin.s. receptorB

stability and survival Rates of a Hydrophilic Versus a Conventional sandblast,acid-etched Implant surface

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Stability and Survival Rates of a Hydrophilic Versus a Conve...

作者： HUTHAYFA n.s. ALMAssRI 重庆医科大学

学位级别：硕士

Background: Modifying the implant surface by enhancing the wettability(hydrophilicity)improves osseointegration,thus reducing the healing *** this study,the authors aimed to evaluate the stability and survival rates of implan.s.with a hydrophilic surface compared to those with a sandblasted and acid-etched *** of studies reviewed: The included studied(randomized controlled trials RCTs)were identified by searching the PubMed,scienceDirect,and Cochrane library databases without date of publication *** assessment was performed using the Cochrane Collaboration.s.*** the primary outcome,confidence intervals were set at 95%;weighted means across the studies were calculated using a fixed-effects model or using risk ratios and their 95% confidence intervals for the secondary ***: The authors included 5 RCTs(246 dental implan.s.in the systematic review which compared a hydrophilic with conventional sandblast and acid-etched implant *** implant stability(primary outcome)was measured at baseline and 3,6,and 8 weeks,and the implant survival rates were measured as a secondary ***,compared with the control groups,no clinically significant differences in implant stability or survival rates were identified for the hydrophilic surface ***: results didn't show any clinically significant effect of a hydrophilic surface on improving implant stability or survival ***,these findin.s.must be analyzed carefully due to the limitations of this review,such as the small sample size and some differences among the included studies.

关键词： Dental implants hydrophilic surface sandblasted and acid-etched surface implant stability meta-analysis

Regulator of G protein.s.gnaling 6 mediates exercise-induced recovery of hippocampal neurogen.s.s,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.spicer Jianqi Yang Daniel Fu Alison n.DeVore Marisol Lauffer nilufer s.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogen.s.s is reduced in patien.s.with Alzheimer’s *** stimulates adult hippocampal neurogen.s.s in roden.s.and improves memory and slows cognitive decline in patien.s.with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogen.s.s and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein.s.gnaling 6(RGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogen.s.s in ***,we generated novel RGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of RGs6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogen.s.s and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairmen.s.to that of control *** cognitive rescue was abolished by RGs6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogen.s.s was reduced in.s.dentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogen.s.s reduced by RGs6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patien.s.with Alzheimer’s disease with significant loss of these RGs6-expressing ***,RGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogen.s.s in APP_(sWE) mice,identifying RGs6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogen.s.s Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein.s.gnaling 6(RGs6)

Two-Phase Flow Modeling in a single Closed Loop Pulsating Heat Pipes

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Journal of Donghua University(English Edition) 2007年第4期24卷 439-444页

作者：杨洪海 sameer Khandekar sanka V. V.s. n.s. Manyam Manfred Groll College of Environmental science and Engineering Donghua University Institute of nuclear Technology and Energy system University of Stuttgart70569 StuttgartGermany

Mathematical modeling of pulsating heat pipes through ‘first’ principles is a contemporary problem which remains quite elusive. simplifications and assumptions made in all the modeling approaches developed so far render them unsuitable for engineering design. In this paper, a more realistic modeling scheme is presented which provides considerable try for thought toward the next progressive step. At high enough heat flux level, closed loop pulsating heat pipes experience a bulk internal unidirectional fluid circulation. Under such a condition, conventional two-phase flow modeling in capillary tubes may be applied. This has been attempted for single-loop PHPs. A homogeneous model and a separated two-fluid flow model based on.s.multaneous conservation of mass, momentum and energy, have been developed for an equivalent ‘open flow’ system. The model allows prediction of two-phase flow parameters in each sub-section of the device thereby providing important insights into its operation. The concept of ‘void fraction constraint’ in pulsating heat pipe operation is introduced and its relevance to future modeling attempts is outlined.

关键词： Closed loop pulsating heat pipe flow modeling parametric influences