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IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling

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Cellular & Molecular Immunology 2023年第6期20卷 651-665页

作者： Holly Bachus Erin McLaughlin Crystal Lewis Amber M.Papillion Etty n.Benveniste Dave Durell Hill Alexander F.rosenberg AndréBallesteros-Tato Beatriz León Department of Medicine Division of Clinical Immunology and RheumatologyUniversity of Alabama at BirminghamBirminghamALUSA Department of Microbiology University of Alabama at BirminghamBirminghamALUSA Department of Cell Developmental and Integrative BiologyUniversity of Alabama at BirminghamBirminghamALUSA informatics Institute University of Alabama at BirminghamBirminghamALUSA Alexion Pharmaceuticals Inc.New HavenCTUSA

Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the development of Th2-driven diseases remains unknown. Using a model of house dust mite (HDM)-induced Th2 cell differentiation and allergic airway inflammation, we showed that IL-6 signaling in allergen-specific T cells was required to prevent Th2 cell differentiation and the subsequent IgE response and allergic inflammation. Th2 cell lineage commitment required strong sustained IL-2 signaling. We found that IL-6 turned off IL-2 signaling during early T-cell activation and thus inhibited Th2 priming. Mechanistically, IL-6-driven inhibition of IL-2 signaling in responding T cells was mediated by upregulation of Suppressor Of Cytokine Signaling 3 (SOCS3). This mechanism could be mimicked by pharmacological Janus Kinase-1 (JAK1) inhibition. Collectively, our results identify an unrecognized mechanism that prevents the development of unwanted Th2 cell responses and associated diseases and outline potential preventive interventions.

关键词： Th2 cell polarization IL-6 IL-2 SOCS3 JAK1 inhibitor

Atlas of Clinical neurology 3rd ed. 2012

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Visible fluorescence of biological fluids as a renal failure marker:new integrative approach

2009年

作者： Roger n. rosenberg

来源：畅想之星图书光盘版（南... 评论

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Journal of Innovative Optical Health Sciences 2015年第4期8卷 69-84页

作者： Artur I.Kuznetsov Aleksander Frorip Jekaterina Kozlova Vitali nagirnyi Mai Ots-rosenberg Ivo Romet Alar Sünter Tartu Science Park AS Ldiamon Riia str.18551014 TartuEstonia Institute of Physics Tartu University Ravila str.14^(c)Tartu 50411Estonia Department of Internal Medicine Tartu University Puusepa str.8Tartu 51014Estonia Biomedicum Tartu University Ravila str.1950411 TartuEstonia

Solid phases of visible fuorescence substance(VFS)of biological fuids(blood,urine,hemodia-lysate)which was proposed earlier as a morbidity and mortality marker by renal failure and diabetes were investigated in-depth by the methods of electron and confocal microscopy,optical spectroscopy and matrix assisted laser desorption-ionization(MALDI)mass *** is shown that dry VFS exists predominantly in the form of carbon-oxygen-nitrogen(n≈8.7 wt.%)nanoparticles(nPs)(5≤d≤100nm).For the first time the existence of the threshold energy E_(g)≈2.15eV for excitation of VFS was observed experimentally and confirmed by semi empirical calculations of the bathochromic shift.A good accordance with the earlier autonomous theo-retical calculations was ***,the long wavelength limit(575 nm)of the spectral range where the VFS can be used as a fluorescent marker was reliably determined.A pilot MALDI comparative study of graphene oxide(GO)and urine VFS was carried *** kinds of nitrogen-free particles(412≤M≤456 Da)were observed in each substance and possible computer models of those have been *** is established that along with nitrogen-containing advanced glycation end products(AGEs)also nitrogen-fee carbon-oxygen-lhydrogen particles(probably toxic)with the composition and structure related to GO can exist in *** types of particles should be taken into account in search for the reasons of high mortality among end stage renal disease patients.

关键词： Auto-fuorescence of biological fuids AGE glycosides end stage renal diseases MALDI of human metabolites fluorescence of graphene oxide

Surgical Treatment of Calcaneal Comminuted Intrarticular Fractures: Long-Term Follow-Up

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Open Journal of Clinical Diagnostics 2014年第3期4卷 117-122页

作者： M. Haddad Z. Horesh M. Soudry n. rosenberg Laboratory of Musculoskeletal Research Orthopedic Department Rambam-Health Care Campus Haifa Israel

There is a controversy whether the comminuted calcaneal fractures should benefit more from conservative or from surgical treatment. Aiming to contribute to this unsolved clinical question we reviewed the long-term outcome (up to 96 months) of in 44 patients (mean age 35 years) with 47 calcaneal fractures who were treated surgically. In these patients open reduction and internal fixation were performed using a calcaneal reconstruction plate. The functional outcome was measured according to the Rowe Score and the level of pain by Visual Analog Scale. The objective outcome was estimated by the current radiographs. The clinical results were good to excellent in 69% of patients. Poor outcome observed in one patient who developed Complex Regional Pain Syndrome in his foot. The radiographic evaluation showed satisfactory reconstruction (according to the Boehler angle measurements) in 35 of operated calcanei. These results indicate on the satisfactory outcome of surgical treatment in the majority of the patients who were diagnosed with comminuted fracture of calcaneus.

关键词： Calcaneus Fracture Surgical Treatment

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疗愈景观概念及其在健康地理学中的研究进展

地理科学进展 2023年第3期42卷 602-616页

作者：周佩玲程杨 Mark W.rosenberg 哈尔滨工业大学(深圳)建筑学院城乡规划系广东深圳518055 哈尔滨工业大学(深圳)深圳市城市规划分析与决策仿真重点实验室广东深圳518055 北京师范大学地理科学学部北京100875 加拿大女王大学地理与规划学系加拿大金士顿K7L3N6

20世纪90年代起,从西方医学地理学中发展出一门新的分支学科——健康地理学。在这一新学科框架下,地理学研究的重心逐步从关注疾病与诊疗服务向关注广泛意义上的健康与福祉拓展,一大批关于地方与疗愈过程的研究在过去的30年间迅速兴起... 详细信息

20世纪90年代起,从西方医学地理学中发展出一门新的分支学科——健康地理学。在这一新学科框架下,地理学研究的重心逐步从关注疾病与诊疗服务向关注广泛意义上的健康与福祉拓展,一大批关于地方与疗愈过程的研究在过去的30年间迅速兴起并在地理学与社会科学领域产生了显著的影响力。而这些关于疗愈的研究拥有一个共同的理论基点,即***在1992年提出的“疗愈景观”这一概念,并在随后的发展中逐步发展出一套具有影响力的理论框架,成为当之无愧的健康地理学的重要理论贡献。疗愈景观相关研究在中国的地理学研究中鲜少提及。论文从本体论(即疗愈景观中的景观指什么)与认识论(即如何理解景观的疗愈性)两个方面对1990年代以来疗愈景观的理论发展过程和研究现状进行了回顾。疗愈景观概念借鉴了新文化地理学的结构主义和人本主义理论。后期受到地理学关系转向的影响,逐步发展成为健康地理学最具影响力的理论框架。关系视角下的疗愈景观研究受到非表征理论、行动者网络理论、移动转向等理论的深刻影响,逐步发展出了疗愈组合、赋能场所、疗愈移动、疗愈任务景观等分支理论。最后,文章总结了当前疗愈景观研究存在的一些问题,并对新时期疗愈景观框架下的中国健康地理学的发展提出了建议。

关键词：疗愈景观健康地理学关系转向赋能场所疗愈组合

社会经济及环境因子对不同收入群体自评健康的影响

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地理研究 2017年第7期36卷 1257-1270页

作者：顾丽娟 Mark rosenberg 曾菊新华中师范大学地理过程分析与模拟湖北省重点实验室武汉430079 女王大学地理与规划系加拿大金斯顿K7L3N6 湖北省发展和改革委员会华中师范大学武汉城市圈研究院武汉430079

对健康影响因素的干预是将"健康中国"战略落实到实处的重点,而深入探究健康的影响因子是实施有效干预的前提。结合中国当前工业化、环境退化及收入差距扩大化的背景,基于中国综合社会调查2013年数据,采用多层次Logistic回归分析模型,从... 详细信息

对健康影响因素的干预是将"健康中国"战略落实到实处的重点,而深入探究健康的影响因子是实施有效干预的前提。结合中国当前工业化、环境退化及收入差距扩大化的背景,基于中国综合社会调查2013年数据,采用多层次Logistic回归分析模型,从个体、社区及省级三个层次,深入解析社会经济及环境因子对较低、中等及较高收入群体自评健康状况的影响。结果表明:(1)个体与地方特征对自评健康有不同程度的影响。个体特征的解释力最强,省级因子解释力最弱。(2)社会经济因子对健康的作用在不同收入群体间差异很大。通常被认为是有益于健康的因子如收入、教育水平、政府服务等仅对中低等收入群体有显著作用。(3)环境因子与健康呈正相关性,且此相关性对较高收入群体最强。(4)环境污染可以抵消一部分社会经济发展的健康促进作用。(5)除了不平等的社会经济条件,环境不公正是导致健康不公平的另一重要原因。

关键词：健康社会经济发展污染环境不公正多层次Logistic回归分析收入群体