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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 236-244页

作者： Hital Shah Tejal gandhi Gujarat Technological University AhmedabadGujarat 382424India Department of Pharmacology Anand Pharmacy CollegeAnandGujarat 388001India

Objective:To investigate the cardioprotective potential of betulin in isoproterenol(ISO)-induced myocardial injury in ***:Wistar rats were divided into five groups(n=10):normal,ISO,nebivolol 5 mg/kg,and betulin(20&40 mg/kg).nebivolol and betulin were administered orally for 29 ***(85 mg/kg)was administered subcutaneously on day 27 and day 28 to induce myocardial *** day 29,blood was collected for determination of cardiac markers,and hemodynamic parameters were *** levels of oxidative stress markers and the gene expressions of apoptotic markers and inflammatory mediators were ***,2,3,5-triphenyltetrazolium chloride staining and histopathological analysis were also ***:Betulin reduced the size of myocardial infarction,decreased elevated levels of cardiac enzymes,and maintained hemodynamic *** also inhibited ISO-induced upregulation of Bax,caspase-3,nF-κB,and IL-6,enhanced endogenous antioxidant enzymes,and reduced lipid ***,pretreatment with betulin alleviated myocardial ischemic damage,as reflected by reduced myonecrosis,edema,and inflammatory ***:Betulin exhibits strong cardioprotective activity against ISO-induced myocardial injury by anti-inflammatory,anti-apoptotic,and antioxidant activities.

关键词： nF-κB Isoproterenol Betulin Myocardial injury Oxidative stress Inflammation Apoptosis

南非农村地区HIV阳性儿童的广泛耐药结核病情况

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国际结核病与肺部疾病杂志 2011年第4期6卷 162-168页

作者： T.A.Thomas S.V.Shenoi S.K.Heysell F.J.Eksteen V.B.Sunkari n.r.gandhi G.Friedland n.S.Shah 王冬梅 Tugela Ferry Care and research Collaboration Tugela Ferry KwaZulu-Natal South Africa Department of Medicine Yale University School of Medicine New Haven Connecticut Division of Infectious Disease and International Health University of Virginia Charlottesville Virginia AIDS Program Section of Infectious Diseases Yale University School of Medicine New Haven Connecticut USA Tugela Ferry Care and research Collaboration Tugela Ferry KwaZulu-Natal South AfricaChurch of Scotland Hospital and Philanjalo Care Centre Tugela FerryKwaZulu-Natal Department of Paediatrics King George V Hospital Durban South Africa Department of Medicine Albert Einstein College of Medicine Bronx New York New York USA

背景:全球均有对广泛耐药结核病的文献报道,但对儿童广泛耐药结核病的文献报道非常罕见。目的:报告南非农村地区广泛耐药结核病患儿的特征。设计:在南非共和国图盖拉渡口地区,对2006年1月—2007年12月间登记的经痰培养确诊为广泛耐药结... 详细信息

背景:全球均有对广泛耐药结核病的文献报道,但对儿童广泛耐药结核病的文献报道非常罕见。目的:报告南非农村地区广泛耐药结核病患儿的特征。设计:在南非共和国图盖拉渡口地区,对2006年1月—2007年12月间登记的经痰培养确诊为广泛耐药结核病的患儿进行了回顾性评估。从患儿病案中获得其人口统计学、临床和微生物学信息。结果:4例6～8岁的儿童为广泛耐药结核病患者。其中2例患儿先前有结核病史。4例患儿均为感染了人类免疫缺陷病毒的孤儿,其中3例在诊断患有广泛耐药结核病之前已接受了高效抗逆转录病毒治疗。在接受标准化抗广泛耐药结核病和高效抗逆转录病毒治疗后,所有患儿的临床表现、影像学均改善,痰培养阴转。其中2例患儿较好地耐受了抗广泛耐药结核病和高效抗逆转录病毒同时治疗。另外2例出现了环丝氨酸相关的神经精神系统不良反应。4例患儿的存活时间均超过24个月,广泛耐药结核病均得到治愈。在诊断为广泛耐药结核病之前,这些患儿在儿科病房的平均住院时间为8个月(5～17个月),包括3个月的住院重叠期。结论:广泛耐药结核病依靠微生物学来确诊,合并艾滋病的广泛耐药结核病患者也能被成功诊断。尽管需要对同时接受两种治疗的潜在交叉毒性开展更多的研究,但本研究显示患儿同时接受抗广泛耐药结核病和高效抗逆转录病毒治疗是可行且有效的。

关键词：广泛耐药结核病耐药结核病结核病儿科艾滋病/结核病双重感染

An in vitro Anti-urolithiasis Activity of a Herbal Formulation:Spinacia oleracea *** Coriandrum sativum L.

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 76-84页

作者： Sumathy raj Monica Shree Gnana Soundara rajan Suganthi ramasamy rimal Isaac rajamony Suthies Goldy ramathilaga Ariyamuthu Monisha Sudhagar Sakthivel gandhi Prakash Shoba Manikandan Gurusamy School of Biotechnology Dr.G.R.Damodaran College of ScienceCoimbatoreTamil NaduIndia Department of Biotechnology Dr.N.G.P Arts and Science CollegeCoimbatoreTamil NaduIndia Department of nanotechnology Noorul Islam Centre for Higher EducationKumaracoilThuckalayKanyakumari DistrictTamil NaduIndia PG and research Department of Biochemistry Kongunadu Arts and Science CollegeCoimbatoreTamil NaduIndia Department of Biological and Chemical Engineering Mekelle UniversityMekelleEthipoia Department of Zoology Holy Cross College(Autonomous)NagercoilTamilnaduIndia Department of Pharmaceutical Sciences Tshwane University of TechnologyArcadia CampusPretoriaSouth Africa

Background:Hard mineral and acid salt deposits that clump together in concentrated urine are known as kidney stones.A complicated chain of physicochemical events,including hyper saturation,nucleation,growth,aggrega-tion,and retention in the urinary tract,leads to urolithiasis,the third most prevalent urinary tract *** traditional medications and therapies are less successful in treating urolithiasis and frequently cause ***:The present study is focused on evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from Spinacia oleracea *** Coriandrum sativum ***:To evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from *** and *** seeds against oxalate crystals by employing an in vitro inhibition,aggregation,and nucleation assay,employing a spectrophotometer followed by microscopic observation,and further monitored by egg semiperme-able membrane model,using cystone as a standard ***:In the present work,the alkaloids,glycosides,flavonoids,glycosides,phenols,saponins,steroids,tannins,terpenoids,and triterpenoids were found in the extracts of *** and *** in vitro assays in the present study clearly indicated that all the mixture extracts readily prevented crystal nucleation,growth and *** aqueous extract of the mixture inhibited significant inhibitory potential against the crystallization ***:It can be said that the phyto-constituents enriched homemade preparation possibly will be used as a medication for the management of kidney stones by dissolving the oxalate stone in the kidney.

关键词： Urolithiasis Polyherbal Egg membrane Spinacia oleracea Coriandrum sativum

Investigation of 58ni(n, p)58Co reaction cross-section with covariance analysis

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Chinese Physics C 2024年第2期48卷 78-90页

作者： Akash Hingu S.Mukherjee Siddharth Parashari Arora Sangeeta A.gandhi Mahima Upadhyay Mahesh Choudhary Sumit Bamal namrata Singh G.Mishra Sukanya De Saurav Sood Sajin Prasad G.Saxena Ajay Kumar r.G.Thomas B.K.Agrawal K.Katovsky A.Kumar Department of Physics Faculty of ScienceThe M.S.University of BarodaVadodara 390002India Faculty of Electrical Engineering and Communication Brno University of TechnologyBrnoCzech Republic Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.32Zagreb 10000Croatia Department of Physics University Institute of SciencesChandigarh UniversityGharuanMohali 140413PunjabIndia Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei national Institute for Physics and nuclear Engineering Măgurele 077125Romania nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Physics(H&S) Government Women Engineering CollegeAjmer 305002India Saha Institute of nuclear Physics Kolkata 700064India Homi Bhabha national Institute Anushakti NagarMumbai 400094India

The excitation function of the 58ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray *** in the energy range of 1.7 to 2.7 MeV were generated using the 7Li(p,n)*** neutron flux was measured using the standard 115In(n,n’)115mIn monitor *** results of the neutron spectrum averaged cross-section of 58ni(n,p)58Co reactions were compared with existing cross-section data available in the EXFOr data library as well as with various evaluated data libraries such as EnDF/B-VIII.0,JEFF-3.3,JEnDL-4.0,and *** calculations were performed using the nuclear reaction code *** nuclear level density(nLD)models were tested,and their results were compared with the present *** nLDs were also obtained through the spectral distribution method(SDM).The cross-section results,along with the absolute errors,were obtained by investigating the uncertainty propagation and using the covariance *** forγ-ray true coincidence summing,low-energy background neutrons,andγ-ray self attenuation were *** experimental cross-section obtained in the present study is consistent with previously published experimental data,evaluated libraries,and theoretical calculations carried out using the TALYS code.

关键词： nuclear reactions (n,p)reaction cross-section measurement covariance analysis nuclear level density

Enhancement of solubility and mass transfer coefficient of salicylic acid through hydrotropy

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第5期10卷 739-745页

作者： S.THEnESHKUMAr D.GnAnAPrAKASH n.nAGEnDrA gandhi Department of Chemical Engineering St. Peter's Engineering CollegeChennai 600054 India Department of Chemical Engineering Alagappa College of Technology Anna UniversityChennai 600025 India

这研究在溶解度和水杨酸酸的集体转移系数上处理水疗院修辞的效果。溶解度和集体转移研究用水疗院修辞被执行，即，在 0 ∼3.0 mol/L 的集中和 303 ∼333 K 的系统温度的钠醋酸盐，钠水杨酸盐，柠檬性的酸，和脲。溶解度和水杨酸酸的集... 详细信息

这研究在溶解度和水杨酸酸的集体转移系数上处理水疗院修辞的效果。溶解度和集体转移研究用水疗院修辞被执行，即，在 0 ∼3.0 mol/L 的集中和 303 ∼333 K 的系统温度的钠醋酸盐，钠水杨酸盐，柠檬性的酸，和脲。溶解度和水杨酸酸的集体转移系数与系统温度随水疗院修辞集中并且也的增加增加，这被发现。在这个工作使用的所有水疗院修辞在溶解度和集体转移系数显示出改进到不同的度。最大的改进因素价值为在这研究使用的所有水疗院修辞被决定。最高的价值为溶解度研究是 28.08， 10.42 为质量转移研究。水疗院修辞的表演以 Setschenow 常数被测量(K s ) 。观察的最高的价值是 0.696。

关键词：传质系数水杨酸钠溶解度尿素浓度增强因子堪萨斯州最高值醋酸钠

recent progress in emerging BiPO_(4)-based photocatalysts:Synthesis,properties,modification strategies,and photocatalytic applications

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Journal of Materials Science & Technology 2022年第13期108卷 208-225页

作者： rohit Kumar Pankaj raizada Aftab Aslam Parwaz Khan Van-Huy nguyen Quyet Van Le Suresh Ghotekar rangabhashiyam Selvasembian Vimal gandhi Archana Singh Pardeep Singh School of Advanced Chemical Sciences Shoolini UniversitySolan(Himachal Pradesh)-173212India Center of Excellence for Advanced Materials research King Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia Chemistry Department Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia Faculty of Biotechnology Binh Duong UniversityThu Dau MotVietnam. Department of Materials Science and Engineering Korea University145Anam-ro Seongbuk-guSeoul 02841South Korea Department of Chemistry Smt.Devkiba Mohansinhji Chauhan College of Commerce and ScienceSilvassa 396230University of MumbaiDadra and Nagar Haveli(UT)India Department of Chemistry S.N.ArtsD.J.M.Commerce and B.N.S.Science CollegeSangamner 422605Savitribai Phule Pune UniversityMaharashtraIndia Department of Biotechnology School of Chemical and BiotechnologySASTRA Deemed UniversityThanjavur-613401TamilnaduIndia Department of Chemical Engineering Faculty of TechnologyDharmsinh Desai UniversityNadiad-387001GujaratIndia Advanced Materials and Processes research Institute Hoshangabad RoadBhopal 462026India

In this perspective,we have highlighted the current literature and explained the synthesis,structure,morphology,modification strategies,and photocatalytic applications of emerging BiPO_(4)-based *** BiPO_(4)is a large bandgap photocatalyst,it uses UV light for the excitation of electrons,and also,the recombination of charge carriers is an issue in BiPO_(4).Various novel modification strategies of BiPO_(4)photocatalysts *** modifications,heterojunction formation,phase-junctions,surface plasmon resonance,Schottky junction have been successfully proposed and *** modifications enhance the light absorption and inhibit the recombination of charge carriers BiPO_(4)***,future aspects for further research on BiPO_(4)-based photocatalysts are also *** expects that BiPO_(4)-based photocatalysts represent a promising strategy for developing practical photocatalysts for energy and environmental remediation applications.

关键词： Photocatalysis Modification strategies Environmental remediation BiPO_(4)photocatalyst

Carbon Disulphide Induced Sensitivity Changes of rat Anococcygeus Muscle to noradrenaline(nA)

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Biomedical and Environmental Sciences 1993年第3期6卷 223-230页

作者： D.n.gandhi H.VEnKATAKrISHnA-BHATT Department Department of Neurobehavioural Toxicology National Institute of Occupational Health(ICMRMeghani NagarAhmedabad 380016Indiaof Neurobehavioural Toxicology National Institute of Occupational Health(ICMRMeghani NagarAhmedabad 380016India

The sensitivity of rat anococcygeus muscle to noradrenaline (nA) was reduced following carbon disulphide (CS2) pretreatment. Preparations incubated in excess Ca++ (4.2 mrnol-L-1) or Zero Ca++ (***-L-1) media showed decrease in sensitivity to nA. reserpinization failed to induce supersensitivity to nA in any Mg+ + concentration in the media. reserpinized tissue in Mg++ free media with EDTA showed increased sensitivity while decreased sensitivity and maximum response to nA in Mg+ + (1.2 mmol-L-1) and excess Mg+ + (3.6mmol-1 ') concentration of the medium. In the presence of EDTA, the inhibition observed with CS2 in excess Mg+ + (3.6m mol-L-1') medium was comparatively much less in both non-reserpinized and reserpinized preparations. In normal Ca++ and its deficient medium decrease in sensitivity to CS2 and the relevant maximum response to nA were observed. In excess Ca + +, the CS2 effect depressed corresponding to its maximal response to nA. Thus CS2 may be inhibiting responses to nA by interfering with Ca+ + utilization.

关键词： nA

Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet Gauhar Khi Yung Fong Mario Sofer Moisés rodríguez Socarrás Azimdjon n Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev nariman Gadzhiev Mohammed Taif Bendigeri Jeremy Yuen-Chun Teoh Marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQr).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,Pr 3 months,the overall rate ofincontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

Life Cycle Assessment of recycling High-Density Polyethylene Plastic Waste

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Journal of renewable Materials 2021年第8期9卷 1463-1483页

作者： neeti gandhi nicholas Farfaras nien-Hwa Linda Wang Wan-Ting Chen Department of Chemical Engineering Virginia Polytechnic and State InstituteBlacksburg24061USA Department of Plastics Engineering University of Massachusetts LowellLowell01854USA School of Chemical Engineering Purdue UniversityWest Lafayette47907USA

Increasing production and use of various novel plastics products,a low recycling rate,and lack of effective recycling/disposal methods have resulted in an exponential growth in plastic waste accumulation in landfills and in the *** better understand the effects of plastic waste,Life Cycle Analysis(LCA)was done to compare the effects of various production and disposal *** shows the specific effects of the cradle-to-grave or cradle-to-cradle scenarios for landfill,incineration,and mechanical *** analysis clearly indicates that increasing recycling of plastics can significantly save energy and eliminate harmful emissions of various carcinogens and GHGs into the *** recycling increases,the need for virgin-plastic production can be greatly ***,the results of this study may help improve current mechanical recycling processes as well as potential future recycling methods,such as chemical *** about the current recycling/disposal methods for plastics have brought increasing attention to the waste accumulation ***,with the current COVID-19 pandemic,plastic accumulation is expected to increase significantly in the near future.A better understanding of the quantitative effects of the various disposal methods can help guide policies and future research toward effective solutions of the plastic waste problem.

关键词： Life Cycle Analysis(LCA) mechanical recycling microplastic chemical recycling plastic policy

High-sensitivity simultaneous liquid chromatography-tandem mass spectrometry assay of ethinyl estradiol and levonorgestrel in human plasma

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Journal of Pharmaceutical Analysis 2015年第5期5卷 316-326页

作者： Abhishek gandhi Swati Guttikar Priti Trivedi Bioanalytical research Veeda Clinical Research Department of Pharmaceutical Chemistry K.B.Institute of Pharmaceutical Education and Research Department of Pharmaceutical Chemistry K.B. Institute of Pharmaceutical Education and Research

A sensitive and simultaneous liquid chromatography-tandem mass spectrometry method was developed and validated for quantification of ethinyl estradiol and levonorgestrel. The analytes were extracted with methyl-tert-butyl ether： n-hexane （50：50, v/v） solvent mixture, followed by dansyl derivatization. The chromatographic separation was performed on a Kinetex Cla （50 mm × 4.6 mm, 2.6 μm） column with a mobile phase of 0.1% （v/v） formic acid in water and acetonitrile in gradient composition. The mass transitions were monitored in electrospray positive ionization mode. The assay exhibited a linear range of 0.100-20.0 ng/mL for levonorgestrel and 4.00-500 pg/mL for ethinyl estradiol in human plasma. A run time of 9.0 min for each sample made it possible to analyze a throughput of more than 100 samples per day. The validated method has been successfully used to analyze human plasma samples for application in pharmacokinetic and bioequivalence studies.

关键词： Ethinyl estradiolLevonorgestrelLC-MS]MSHuman plasmaDerivatization