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The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

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Molecular Plant 2024年第7期17卷 1129-1150页

作者： Paula Berman Luis Alejandro de Haro Ana-rita Cavaco Sayantan panda Younghui Dong nikolay Kuzmich Gabriel Lichtenstein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit Meir Ilana rogachev Asaph Aharoni Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The Maurice and Vivienne Wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel Present address:Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of Molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA Department of Botany and Plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones and Development regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the cactus Lophophora williamsii(Peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing with comprehensive chemical profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six catalytic steps in the mescaline biosynthetic pathway,and an n-methyltransferase enzyme that n-methylates all phenethylamine intermediates,likely modulating mescaline levels in ***,we reconstructed the mescaline biosynthetic pathway in both nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mescaline *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mescaline,safeguarding this valuable natural resource for future generations.

关键词： mescaline Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling

Outcome measures following tele-rehabilitation and conventional face to face rehabilitation in paediatric cochlear implant users during COVID-19 pandemic:A pilot study in a tertiary care setup

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Journal of Otology 2022年第1期17卷 31-38页

作者： Himanshu Verma Banumathy n roshani Mishra naresh K.panda Department of Otolaryngology and Head&neck Surgery Post Graduate Institute of Medical Education and ResearchChandigarh160012India

Background:Following the COVID-19 pandemic,majority of paediatric cochlear implantees(CI)lost follow ups for rehabilitation and tele-therapy was *** study thus compared the outcome measures of paediatric CI users on tele-therapy versus conventional face to face therapy following COVID-19 ***:Twenty seven unilateral paediatric cochlear implantees in the age range of 2e11 years were divided into two groups based on the therapy modality,viz,tele-and face-to-face *** on the hearing age,participants were further divided into three groups,viz,0e2,2e4,and greater than four years.A complete the test battery comprising Integrated Scales of Development,Speech Intelligibility rating scale,and revised Categorical Auditory Perception were *** speech&language test battery was performed prior to initiating the rehabilitation and post 12 months of ***:results of the present study revealed that conventional rehabilitation had better outcomes compared to *** rate of progress after one year of rehabilitation with respect to hearing-age showed a significant difference for the hearing-age group of 0e2 years across the domains of audition,speech and ***:The present study indicates that conventional method of the speech-language and auditory rehabilitation is far better compared to the tele rehabilitation services especially for those visiting tertiary care hospitals as most of them belong to lower and middle socioeconomic *** the results,it can be delineated that with lesser hearing experience,paediatric CI users always need to initially enroll for conventional therapy for better speech-language and auditory outcomes.

关键词： Cochlear implant Tele-therapy Conventional therapy Language outcomes Speech&language rehabilitation

Characteristics of a Gan-based Gunn diode for THz signal generation

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Journal of Semiconductors 2012年第8期33卷 37-43页

作者： r K Parida n C Agrawala G n Dash A K panda ITEr Siksha‘O'Anusandhan University rengali College Sambalpur University national Institute of Science&Technology

A generalized large-signal computer simulation program for a Gunn oscillator has been developed. The properties of a Gunn diode oscillator based on the widely explored Gan, are investigated using the developed program. The results show some interesting properties in Gan Gunn diodes which are not seen in GaAs and InP diodes. An output power of 1400 kW/cm^2 is achieved from the Gan Gunn diode, as compared to 4.9 kW/cm^2 from a GaAs diode.

关键词： Gunn devices semiconductor diodes semiconductor materials power Gan

FSE2r:An Improved Collision-Avoidance-based Energy Efficient route Selection Protocolin USn

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Computer Systems Science & Engineering 2023年第3期44卷 2225-2242页

作者： Prasant Ku.Dash Lopamudra Hota Madhumita panda n.Z.Jhanjhi Kshira Sagar Sahoo Mehedi Masud Department of Computer Science and Engineering Sambalpur UniversityOdisha768019India Department of Computer Science and Engineering NITRourkelaOdisha769008India Department of Computer Science G.M UniversitySambalpurOdisha768001India School of Computer Science and Engineering SCETaylor’s UniversitySubang Jaya47500Malaysia Department of Computer Science and Engineering SRM UniversityAmaravatiAndhra Pradesh522502India Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

The 3D Underwater Sensor network(USns)has become the most optimistic medium for tracking and monitoring underwater *** and collision are two most critical factors in USns for both sparse and dense *** to harsh ocean environment,it is a challenge to design a reliable energy efficient with collision free *** in link qualities may cause collision and frequent communication lead to energy loss;that effects the network *** overcome these challenges a novel protocol Forwarder Selection Energy Efficient routing(FSE2r)is *** proposal’s key idea is based on computation of node distance from the sink,residual Energy(rE)of each node and Signal to Interference noise ratio(SInr).The node distance from sink and rE is computed for reliable forwarder node selection and SInr is used for analysis of *** novel proposal compares with existing protocols like H2AB,DEEP,and E2Lr to achieve Quality of Service(QoS)in terms of through-put,packet delivery ratio and energy *** comparative analysis shows that FSE2r gives on an average 30%less energy consumption,24.62%better PDr and 48.31%less end-to-end delay compared to other protocols.

关键词： USn energy efficiency collision avoidance MAC SInr

rF and microwave characteristics of a 10 nm thick InGan-channel gate recessed HEMT

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Journal of Semiconductors 2013年第11期34卷 36-41页

作者： T.r.Lenka G.n.Dash A.K.panda Department of Electronics and Communication Engineering National Institute of Technology Silchar School of Physics Sambalpur University national Institute of Science and Technology

A new depletion-mode gate recessed A1Gan/InGan/Gan-high electron mobility transistor （HEMT） with 10 nm thickness of InGan-channel is proposed. A growth of A1Gan over Gan leads to the formation of two- dimensional electron gas （2DEG） at the heterointerface. High 2DEG density （ns） is achieved at the heterointerface due to a strain induced piezoelectric effect between A1Gan and Gan layers. The electrons are confined in the InGan-channel without spilling over into the buffer layer, which also reduces the buffer leakage current. From the input transfer characteristics the threshold voltage is obtained as -4.5 V and the device conducts a current of 2 A/mm at a drain voltage of 10 V. The device also shows a maximum output current density of 1.8 A/ram at Vds of 3 V. The microwave characteristics like transconductance, cut-off frequency, max frequency of oscillation and Mason＇s Unilateral Gain of the device are studied by AC small-signal analysis using a two-port network. The stability and power performance of the device are analyzed by the Smith chart and polar plots respectively. To our knowledge this proposed InGan-channel HEMT structure is the first of its kind.

关键词： 2DEG HEMT InGan microwave

Performance evaluation for selectivity of the flocculant on hematite in selective flocculation

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International Journal of Minerals,Metallurgy and Materials 2013年第12期20卷 1123-1129页

作者： Lopamudra panda Pradip K.Banerjee Surendra Kumar Biswal r.Venugopal n.r.Mandre research and Development Tata Steel Ltd. Institute of Minerals and Materials Technology (Council of Scientific and Industrial research) Indian School of Mines University

Increased demand for iron ore necessitates the utilization of low-grade iron ore fines, slimes, and existing tailings. Selective flocculation can be an alternative physico-chemical process for utilizing these low-grade fines, slimes, and tailings. In selective fiocculation, the most critical objective is the selection of proper reagents that will make fioc of desired minerals. In present study, selective flocculation was applied to ultra-fine synthetic mixtures of hematite and kaolinite, and the Fe value was upgraded up to 65.78% with the reduction of Al2O3 and SiO2 values to 2.65% and 3.6670, respectively. Here, degraded wheat starch was used as a *** this process, separation occurs on the basis of the selectivity of the flocculant. The selectivity of the fiocculant can be quantified in terms of separation efficiency. Here, an attempt was also made to develop a correlation between separation efficiency and major operating parameters such as flocculent dose, pH value, and solid concentration to predict the separation performance.

关键词： hematite kaolinite selective fiocculation modeling iron ores tailings

Artificial neural network approach to assess selective flocculation on hematite and kaolinite

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International Journal of Minerals,Metallurgy and Materials 2014年第7期21卷 637-646页

作者： Lopamudra panda P.K.Banerjee Surendra Kumar Biswal r.Venugopal n.r.Mandre r&D Tata Steel Limited Institute of Minerals and Materials Technology(Council of Scientific and Industrial research) Department of Fuel & Minerals Engineering Indian School of Mines University

Because of the current depletion of high grade reserves, beneficiation of low grade ore, tailings produced and tailings stored in tailing ponds is needed to fulfill the market demand. Selective flocculation is one alternative process that could be used for the beneficiation of ultra-fine material. This process has not been extensively used commercially because of its complex dependency on process parameters. In this paper, a selective flocculation process, using synthetic mixtures of hematite and kaolinite in different ratios, was attempted, and the ad-sorption mechanism was investigated by Fourier transform infrared （FTIr） spectroscopy. A three-layer artificial neural network （Ann） model （4？4？3） was used to predict the separation performance of the process in terms of grade, Fe recovery, and separation efficiency. The model values were in good agreement with experimental values.

关键词： hematite kaolinite flocculation artificial neural networks back propagation algorithm Fourier transform infrared spectroscopy separation efficiency

Constraining the relativistic mean-field models from PrEX-2 data:effective forces revisited

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Chinese Physics C 2022年第9期46卷 218-231页

作者： Jeet Amrit Pattnaik r.n.panda M.Bhuyan S.K.Patra Department of Physics Siksha'O'AnusandhanDeemed to be UniversityBhubaneswar-751030India Center of theoretical and Computational Physics Department of PhysicsUniversity of MalayaKuala Lumpur50603Malaysia Institute of Physics Sachivalya MargBhubaneswar-751005India Homi Bhabha national Institute Training School ComplexAnushakti NagarMumbai 400094India

Based on the current measurement of the neutron distribution radius(r_(n))of ^(208)Pb from the PrEX-2 data,we revisited the recently developed G3 and IOPB-I force parameters by fine-tuning some specific couplings within the relativistic mean-field(rMF)***ω-ρ-mesons coupling and theρ-meson coupling are constrained to the experimental neutron radius of^(208)Pb without compromising the bulk properties of finite nuclei and infinite nuclear matter *** modified parameter sets are applied to calculate the gross properties of finite nuclei such as binding energies,charge distributions,nuclear radii,pairing gaps,and single-particle *** root-mean-square deviations in binding energy and charge radius are estimated with respect to the available experimental data for 195 even-even nuclei,and the results compare favourably with the well-calibrated effective interactions of Skyrme,Gogny and other relativistic mean-field *** pairing gap estimations for modified G3 and IOPB-I for Sn isotopes are also compared with the Hartree-Fock-Bogoliubov calculation with the Gogny(D1S)*** isotopic shift and single-particle energy spacing are also calculated and compared with the experimental data for both original and modified versions of the G3 and IOPB-I parameter ***,both the modified parameter sets are used to obtain the various infinite nuclear matter observables at *** addition to these,the force parameters are adopted to calculate the properties of a high isospin asymmetry dense system such as neutron star matter and tested for validation using the constraint from GW170817 binary neutron star merger *** tuned forces predict relatively good results for finite and infinite nuclear matter systems and the current limitation on the neutron radius from PrEX-2.A systematic analysis using these two refitted parameter sets over the nuclear chart will be communicated shortly.

关键词： relativistic mean field model binding energy charge distribution radius neutron-skin thickness PrEX-2

Ground level utility of Access, Watch, reserve classification: Insights from a tertiary care center in north India

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World Journal of Experimental Medicine 2023年第5期13卷 123-133页

作者： Gunjita negi Arjun KB Prasan Kumar panda Department of Medicine All India Institute of Medical SciencesRishikeshRishikesh 249203India

BACKGrOUnD The overuse and misuse of antimicrobials contribute significantly to antimicrobial resistance(AMr),which is a global public health *** has particularly high rates of AMr,posing a threat to effective *** World Health Or-ganization(WHO)Access,Watch,reserve(AWare)classification system was introduced to address this issue and guide appropriate antibiotic ***,there is a lack of studies examining the prescribing patterns of antimi-crobials using the AWare classification,especially in north ***,this study aimed to assess the prescribing patterns of antimicrobials using the WHO AWare classification in a tertiary care centre in north ***,Obstetrics and Gynecology).Metronidazole and ceftriaxone were the most prescribed *** to the AWare classification,57.61%of antibiotics fell under the Access category,38.27%in Watch,and 4.11%in *** Access antibiotics were prescribed within the Medicine department,and the same department also exhibited a higher frequency of Watch antibiotics *** questionnaire survey showed that only a third of participants were aware of the AWare classification,and there was a lack of knowledge regarding AMr and the potential impact of AWare *** The research was carried out in accordance with the methodology presented in Figure 1.A total of n=123 patients were enrolled in this study,with each of them receiving antibiotic *** majority of these prescriptions were issued to inpatients(75.4%),and both the Medicine and Surgical departments were equally represented,accounting for 49.6%and 50.4%,*** the healthcare providers responsible for prescribing antibiotics,72%were Junior residents,18.7%were Senior residents,and 9.3%were *** findings have been summarized in Table *** prescriptions included 27 different antibiotics,with metronidazole being the most prescribed(19%)followed by ceftriaxone(17%).Th

关键词： Antimicrobial resistance AWare classification Access Watch reserve Daily defined dose Questionnaire based survey