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neurocircuit regeneration by extracellular matrix reprogramming

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neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian n.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison n.DeVore marisol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Dissolution mechanism and kinetics ofβ(mg_(17)Al_(12))phases in AZ91 magnesium alloy

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Journal of magnesium and Alloys 2024年第4期12卷 1581-1592页

作者： sultan Alomairy Department of Physics College of ScienceTaif UniversityTaif 21944Saudi Arabia

In this study,the phase transformations,crystallization kinetics and dissolution mechanism ofβphase(mg_(17)Al_(12))in magnesium alloy AZ91 were investigated by optical microscopy,X-ray diffraction,differential scanning calorimetry and differential *** results indicate that this AZ91 alloy undergoes a phase transformation during aging,a discontinuous precipitation of theβphase(mg_(17)Al_(12))at 150℃at the grain boundaries and another continuous at 350℃within the *** activation energy of the dissolution reaction of theβphase(mg_(17)Al_(12))under non-isothermal conditions is 116.781 kJ/mol,while it is 129.7383 kJ/mol under isothermal *** Avrami coefficient,n,relevant for the dissolution kinetics of theβphase(mg_(17)Al_(12))is 1.152 and 1.211 in the non-isothermal and isothermal conditions *** numerical coefficients m and Avrami n are 0.993 and 1.152.

关键词： AZ91 kinetics β(mg_(17)Al_(12)) Activation energy Discontinuous precipitation Continuous precipitation DSC

manufacturing Process Selection of “Green” Oil Palm natural Fiber Reinforced Polyurethane Composites Using Hybrid TEA Criteria Requirement and AHP method for Automotive Crash Box

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Journal of Renewable materials 2020年第6期8卷 647-660页

作者： n.S.B.Yusof S.m.Sapuan m.T.H.sultan m.Jawaid Laboratory of Biocomposite Technology Institute of Tropical Forestry and Forest Products(INTROP)Universiti Putra MalaysiaSelangorMalaysia Faculty of Information Sciences and Engineering management Science&University SelangorMalaysia Advanced Engineering materials and Composites Research Centre Department of mechanical and manufacturing Engineering Universiti Putra MalaysiaSelangorMalaysia Department of Aerospace Engineering Faculty of EngineeringUniversiti Putra MalaysiaSelangorMalaysia

In this study,the best manufacturing process will be selected to build an automotive crash box using green oil palm natural fibre-reinforced polyurethane composite *** paper introduces an approach consist of technical aspects(T),the economic point of view(E)and availability(A),and it’s also called as TEA *** approach was developed with the goal of assisting the design engineer in the selection of the best manufacturing process during the design phase at the criteria selection *** this study,the TEA requirement will integrate with the analytical hierarchy process(AHP)to assist decision makers or manufacturing engineers in determining the most appropriate manufacturing process to be employed in the manufacture of a composite automotive crash box(ACB)at the early stage of the product development *** is obvious that a major challenge in the manufacturing selection process is lack of information regarding manufacturing of ACB using natural fibre composite(nFC).There have been no previous studies that examined ranking manufacturability processes in terms of their ***,the TEA-AHP hybrid method was introduced to provide unprejudiced criteria-ranking selection prior to evaluation of pairwise *** the end of this study,the pulforming process was selected as the best manufacturing process for fabrication of the ACB structural component.

关键词： manufacturing process selection automotive crash box natural fibre composites TEA requirement

The Effect of Fibre Length on Flexural and Dynamic mechanical Properties of Pineapple Leaf Fibre Composites

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Journal of Renewable materials 2020年第7期8卷 833-843页

作者： A.A.mazlan m.T.H.sultan S.n.A.Safri n.Saba A.U.m.Shah m.Jawaid Department of Aerospace Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdangSelangor Darul Ehsan43400 UPMMalaysia Laboratory of Biocomposite Technology Institute of Tropical Forestry and Forest Products(INTROP)SerdangSelangor Darul Ehsan43400 UPMMalaysia Aerospace malaysia Innovation Centre(944751-A) Prime Minister’s DepartmentMIGHT Partnership HubJalan Impact63000 CyberjayaMalaysia

The present paper deals with the effect of loading different pineapple leaf fibre(PALF)length(short,mixed and long fibres)and their reinforcement for the fabrication of vinyl ester(VE)*** of PALF/VE composites was investigated through three-point bending flexural testing and viscoelastic(dynamic)mechanical properties through dynamic mechanical analysis(DmA).DmA results revealed that the long PALF/VE composites displayed better mechanical,damping factor and dynamic properties as compared to the short and mixed PALF/VE *** flexural strength and modulus of long PALF/VE composites were 113.5 mPa and 14.3 GPa,*** storage(E′)and loss(E″)moduli increased to 2000 mPa and 225 mPa respectively for PALF/VE *** result analysis indicated that increasing the length of the reinforcement fibre results in satisfactory mechanical performance and dynamic properties of composites.

关键词： Pineapple leaf fibre vinyl ester resin flexural strength dynamical mechanical properties damping factor

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medical Research Unit for neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Transmitter-Receiver Path Selection for Cell Range Extension Using multi-Hop D2D

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Computers, materials & Continua 2021年第8期68卷 2075-2093页

作者： Farah Akif Kiran sultan Aqdas n.malik Ijaz m.Qureshi Saba mahmood Department of Electrical Engineering International Islamic UniversityIslamabad44000Pakistan Department of CIT FASKing Abdulaziz UniversityJeddah21551Saudi Arabia Department of Electrical Engineering Air UniversityIslamabad44000Pakistan Department of Computer Science Bahria UniversityIslamabad44000Pakistan

Conventional approach of dealing with more users per coverage area in cellular networks implies densifying the amount of(Access Point)AP which will eventually result in a larger carbon *** this paper,we propose a base station off-loading and cell range extension(CRE)scheme based on multi-hop device-to-device(mHD2D)path selection between transmitter and receiver *** paper also provides derivations of upper and lower bounds for energy efficiency,capacity,and transmit *** proposed path selection scheme is inspired by the foraging behavior of honey *** present the algorithm as a modified variant of the artificial bee colony algorithm(mVABC).The proposed optimization problem is modeled as a minimization problem where we optimize the Energy Efficiency(EE).The proposed path selection mVABC is compared with the Genetic Algorithm(GA)and also with classical artificial bee colony(ABC)through simulations and statistical *** student’s t-test,p-value,and standard error of means(SEm)clearly show that mVABC based path selection out-performs the GA and classical ABC *** based approach is 66%more efficient when compared with classic ABC and about 62%efficient when compared with GA based scheme.

关键词： multi-hop ultra-dense D2D path-selection ABC GA