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低剂量儿童冠状动脉CT检查有效辐射剂量与影像质量的评估

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国际医学放射学杂志 2016年第5期 581-581页

作者： B.H.Geryes R.Calmon D.Khraiche n.boddaert *** F.Raimondi 李玲 Service de Radiologie pédiatrique Hpital Universitaire Necker Enfants Malades

摘要目的评估儿童冠状动脉CT(c CT)不同扫描方案对辐射剂量以及成像质量的影响。方法纳入2012年1月—2014年6月采用64层CT行c CT的140例儿童。扫描中均采用以下2个参数:自适应统计迭代重建技术(ASIR);对采集参数进行优化。根据有关剂量... 详细信息

摘要目的评估儿童冠状动脉CT(c CT)不同扫描方案对辐射剂量以及成像质量的影响。方法纳入2012年1月—2014年6月采用64层CT行c CT的140例儿童。扫描中均采用以下2个参数:自适应统计迭代重建技术(ASIR);对采集参数进行优化。根据有关剂量长度积(DLP)计算有效剂量

关键词：影像质量辐射剂量冠状动脉儿童 CT

Studying gaze abnormalities in autism: Which type of stimulus to use?

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Open Journal of Psychiatry 2013年第2期3卷 32-38页

作者： Ana Saitovitch Anne Bargiacchi nadia Chabane Anne Phillipe Francis Brunelle nathalie boddaert Yves Samson Monica Zilbovicius Child Psychiatry Service Robert Debre Hospital Paris France Stroke Unity Pitié-Salpêtrière Hospital Paris VI Pierre et Marie Curie University Paris France U1000 Brain Imaging in Psychiatry INSERM-CEA Pediatric Radiology Service Necker Enfants Malades Hospital Paris V René Descartes University Paris France U781 Génétique Service Necker Enfants Malades Hospital Paris V René Descartes University Paris France

Background: Eye-tracking has been used to investigate social perception in autism spectrum disorder (ASD) with variable results. This heterogeneity may be due to the types of stimuli used. In this study, we investigated whether the use of moving vs static stimuli or human actors vs cartoons characters would be more sensitive in detecting gaze abnormalities and discriminating children with ASD from typically developing children. Methods: We studied 18 children with ASD (mean age = 12.9 ± 2.9) and 21 typically developing controls (mean age = 11.3 ± 2.5). Gazes were tracked using Tobii-T120 eye-tracker. Four different types of stimuli were presented: movie with human actors, cartoon movie, picture with human actors and cartoon picture. To identify the type of stimuli that best discriminate the ASD group from the control group, a two-way AnOVA was performed using ecological dimension [human-actors/cartoon] and presentation form [movie/picture] as factors. Results: Children with ASD presented significantly less fixations to eyes and faces in the movie with human actors and in the picture with human actors. Children with ASD also presented significantly more fixations to non-social backgrounds in the movie with human actors and in the cartoon movie. A significant ecological effect was observed for the reduction in fixations to the eyes [human-actors > cartoon]. A significant presentation form effect was observed for the increased fixations to the non-social background [movie > picture]. Conclusions: The direct comparison of gaze behavior across four different types of stimuli demonstrates that gaze abnormalities in ASD depend on the type of stimuli that is used. Our results suggest that general gaze abnormalities in children with ASD are better detected when using dynamic stimuli, and finer details of these abnormalities, especially looking less to the eyes, are better detected in a more ecologically relevant situation presenting human characters.

关键词： Autism Eye-Tracking Social Perception

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孤独症严重程度与颞叶功能异常

世界核心医学期刊文摘(神经病学分册) 2006年第1期 10-11页

作者： Meresse I.G. Zilbovicius M. boddaert n. 郭俊 CEA Service Hospitalier Frédéric Joliot 4 place du General Leclerc 91406 Orsay France Dr.

Two independent studies have described bilateral temporal hypoperfusion in autistic children. Temporal regions are implicated in social perception, language, and “theory-of-mind,”abilities that are impaired in autism. We investigated a putative relationship between cerebral blood flow (rCBF) measured at rest and clinical profile of 45 autistic children (Autism Diagnostic Interview-Revised ADI-R scores). A whole-brain covariance analysis was performed. Significant negative correlation was observed between rCBF and ADI-R score in the left superior temporal gyrus. The more severe the autistic syndrome, the more rCBF is low in this region, suggesting that left superior temporal hypoperfusion is related to autistic behavior severity.

关键词：孤独症严重程度情感性精神病颞叶大脑皮质

组蛋白H3 K27M和BRAF V600E共突变的儿童中线Ⅰ级节细胞胶质瘤

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临床与实验病理学杂志 2017年第5期33卷 538-538页

作者： Pagès M Beccaria K boddaert n 蔡珊珊王行富福建医科大学附属第一医院病理科福州350005

节细胞胶质瘤是一种Ⅰ级肿瘤，其特点为MAPK通路突变，包括BRAFV600E突变。最近，伴H3K27M突变的弥漫中线胶质瘤作为一种Ⅳ级的新类型被WHO（2016）新分类收录。

关键词：节细胞胶质瘤突变 BRAF 中线组蛋白儿童 MAPK通路

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