孤独症严重程度与颞叶功能异常
Autism severity and temporal lobe functional abnormalities作者机构：CEA Service Hospitalier Frédéric Joliot 4 place du General Leclerc 91406 Orsay France Dr.
出 版 物：《世界核心医学期刊文摘(神经病学分册)》 (Digest of the World Core Medical Journals.Clinical Neurology)
年 卷 期：2006年第1期
页 面：10-11页
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
摘 要：Two independent studies have described bilateral temporal hypoperfusion in autistic children. Temporal regions are implicated in social perception, language, and “theory-of-mind,abilities that are impaired in autism. We investigated a putative relationship between cerebral blood flow (rCBF) measured at rest and clinical profile of 45 autistic children (Autism Diagnostic Interview-Revised ADI-R scores). A whole-brain covariance analysis was performed. Significant negative correlation was observed between rCBF and ADI-R score in the left superior temporal gyrus. The more severe the autistic syndrome, the more rCBF is low in this region, suggesting that left superior temporal hypoperfusion is related to autistic behavior severity.
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