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numerical investigation of spallation neutrons generated from petawatt-scale laser-driven proton beams

Matter and Radiation at Extremes 2022年第2期7卷 8-17页

作者： B.Martinez S.n.Chen S.Bolaños n.blanchot G.Boutoux W.Cayzac C.Courtois X.Davoine A.Duval V.Horny I.Lantuejoul L.Le Deroff P.E.Masson-Laborde G.Sary B.Vauzour R.Smets L.Gremillet J.Fuchs LULI-CnRS CEAUPMC Univ Paris 06:Sorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance CEA DAMDIFF-91297 ArpajonFrance Horia Hulubei national Institute of Physics and nuclear Engineering Bucharest-MagureleRomania CEA DAMCESTAF-33114 Le BarpFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChâtelFrance LPP Sorbonne UniversitéCNRSEcole PolytechniqueF-91128 Palaiseau CedexFrance

Laser-driven neutron sources could offer a promising alternative to those based on conventional accelerator technologies in delivering compact beams of high brightness and short *** examine this through particle-in-cell and Monte Carlo simulations that model,respectively,the laser acceleration of protons from thin-foil targets and their subsequent conversion into neutrons in secondary lead *** parameters relevant to the 0.5 PW LMJ-PETAL and 0.6–6 PW Apollon systems are *** to its high intensity,the 20-fs-duration 0.6 PW Apollon laser is expected to accelerate protons up to above 100MeV,thereby unlocking efficient neutron generation via spallation *** a result,despite a 30-fold lower pulse energy than the LMJ-PETAL laser,the 0.6 PW Apollon laser should perform comparably well both in terms of neutron yield and ***,we predict that very compact neutron pulses,of∼10 ps duration and∼100μm spot size,can be released provided the lead convertor target is thin enough(∼100μm).These sources are characterized by extreme fluxes,of the order of 10^(23) n cm^(−2) s^(−1),and even ten times higher when using the 6 PW Apollon *** values surpass those currently achievable at large-scale accelerator-based neutron sources(∼10^(16) n cm^(−2) s^(−1)),or reported from previous laser experiments using low-Z converters(∼10^(18) n cm^(−2) s^(−1)).By showing that such laser systems can produce neutron pulses significantly brighter than existing sources,our findings open a path toward attractive novel applications,such as flash neutron radiography and laboratory studies of heavy-ion nucleosynthesis.

关键词： thereby attractive extreme

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Experimental measurements of gamma-photon production and estimation of electron/positron production on the PETAL laser facility

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Matter and Radiation at Extremes 2024年第5期9卷 32-47页

作者： F.Brun L.Ribotte G.Boutoux X.Davoine P.E.Masson-Laborde Y.Sentoku n.Iwata n.blanchot D.Batani I.Lantuéjoul L.Lecherbourg B.Rosse C.Rousseaux B.Vauzour D.Raffestin E.D’Humières X.Ribeyre Centre Lasers Intenses et Applications UMR 5107Universitéde Bordeaux-CNRS-CEA33405 TalenceFrance CEA DAMCESTAF-33116 Le BarpFrance CEA DAMDIFF-91297 ArpajonFrance CEA LMCEUniversitéParis-Saclay91680 Bruyères-le-ChâtelFrance Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan

This article reports the first measurements of high-energy photons produced with the high-intensity PETawatt Aquitaine Laser(PETAL)*** experiments were performed during the commissioning of the *** laser had an energy of about 400 J,an intensity of 8×10^(18)W cm^(−2),and a pulse duration of 660 fs(FWHM).It was shot at a 2 mm-thick solid tungsten *** high-energy photons were produced mainly from the bremsstrahlung process for relativistic electrons accelerated inside a plasma generated on the front side of the *** paper reports measurements of electrons,protons and *** electrons up to35 MeV with a few-MeV temperature were recorded by a spectrometer,called SESAME(SpectreÉlectronS Angulaire MoyenneÉnergie).K-and L-shells were clearly detected by a photon spectrometer called SPECTIX(Spectromètre PetalàCristal en TransmIssion pour le rayonnnement X).High-energy photons were diagnosed by CRACC-X(Cassette de RAdiographie Centre Chambre-rayonnement X),a bremsstrahlung *** cannon analysis is strongly dependent on the hypothesis adopted for the spectral *** shapes can exhibit similar reproductions of the experimental *** eliminate dependence on the shape hypothesis and to facilitate analysis of the data,simulations of the interaction were *** model the mechanisms involved,a simulation chain including hydrodynamic,particle-in-cell,and Monte Carlo simulations was *** simulations model the preplasma generated at the front of the target by the PETAL laser prepulse,the acceleration of electrons inside the plasma,the generation of MeV-range photons from these electrons,and the response of the detector impacted by the energetic photon *** this work enabled reproduction of the experimental *** high-energy photons produced have a large emission angle and an exponential distribution *** addition to the analysis of the photon spectra,positron production was also ***,if high

关键词： process positron hypothesis

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Enhanced ion acceleration using the high-energy petawatt PETAL laser

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Matter and Radiation at Extremes 2021年第5期6卷 62-79页

作者： D.Raffestin L.Lecherbourg I.Lantúejoul B.Vauzour P.E.Masson-Laborde X.Davoine n.blanchot J.L.Dubois X.Vaisseau E.d’Humières L.Gremillet A.Duval Ch.Reverdin B.Rosse G.Boutoux J.E.Ducret Ch.Rousseaux V.Tikhonchuk D.Batani CEA DAMCESTAF-33116 Le BarpFrance Centre Laser Intenses et Applications Universit´e de Bordeaux-CNRS-CEAUMR 510733405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Universit´e Paris-Saclay CEALMCE91680 Bruy`eres-le-ChˆatelFrance CEA DRFIRFUGANILF-14000 CaenFrance ELI-Beamlines Research Centre 25241 DolníBrezanyCzech Republic

The high-energy petawatt PETAL laser system was commissioned at CEA’s Laser M´egajoule facility during the 2017–2018 *** paper reports in detail on the first experimental results obtained at PETAL on energetic particle and photon generation from solid foil targets,with special emphasis on proton *** a moderately relativistic(ntensity,proton energies as high as 51 MeV have been measured significantly above those expected from preliminary numerical simulations using idealized interaction *** hydrodynamic and kinetic simulations,taking into account the actual laser parameters,show the importance of the energetic electron production in the extended low-density preplasma created by the laser *** hot-electron generation occurs through two main pathways:(i)stimulated backscattering of the incoming laser light,triggering stochastic electron heating in the resulting counterpropagating laser beams;(ii)laser filamentation,leading to local intensifications of the laser field and plasma channeling,both of which tend to boost the electron ***,owing to the large(∼100μm)waist and picosecond duration of the PETAL beam,the hot electrons can sustain a high electrostatic field at the target rear side for an extended period,thus enabling efficient target normal sheath acceleration of the rear-side *** particle distributions predicted by our numerical simulations are consistent with the measurements.

关键词： acceleration high energy

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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