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A multi-platform an.lysis of human.gin.ival crevicular fluid reveals ferroptosis as a relevan. regulated cell death mechan.sm durin. the clin.cal progression.of periodon.itis

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In.ern.tion.l Journ.l of Oral Scien.e 2024年第2期16卷 265-279页

作者： Alfredo Torres m.An.élica michea Ákos Végvári marion.Arce Valen.in. Pérez marcela Alcota Alicia morales Rolan.o Vern.l mauricio Budin. Roman.A.Zubarev Fermín.E.Gon.ález Laboratory of Experimen.al Immun.logy&Can.er Faculty of DentistryUniversity of ChileSantiagoChile Departmen. of Con.ervative Den.istry Faculty of DentistryUniversity of ChileSantiagoChile Division.of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodon.al Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular an. molecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in.the pathogen.sis of n.merous chron.c-in.lammatory diseases,yet its association.with progressive periodon.itis remain. *** in.estigate the in.olvemen. an. sign.fican.e of ferroptosis in.periodon.itis progression.we assessed sixteen.periodon.itis-diagn.sed *** progression.was clin.cally mon.tored over twelve weeks via weekly clin.cal evaluation. an. gin.ival crevicular fluid(GCF)collection.was performed for further *** metrics,proteomic data,in.silico methods,an. bioin.ormatics tools were combin.d to iden.ify protein.profiles lin.ed to periodon.itis progression.an. to explore their poten.ial con.ection.with *** western.blot an.lyses validated key ***,a sin.le-cell Rn. sequen.in.(scRn.-seq)dataset(GSE164241)for gin.ival tissues was an.lyzed to elucidate cellular dyn.mics durin. periodon.itis *** progression.was iden.ified as occurrin. at a faster rate than.tradition.lly *** samples from progressin. an. n.n.progressin. periodon.al sites showed quan.itative an. qualitatively distin.t proteomic *** addition.specific biological processes an. molecular fun.tion. durin. progressive periodon.itis were revealed an. a set of hub protein.,in.ludin. Sn.A,CA1,HBB,SLC4A1,an. An.1 was stron.ly associated with the clin.cal progression.status of ***,we foun. specific protein.-drivers or suppressors-associated with ferroptosis(Sn.A,FTH1,HSPB1,CD44,an. GCLC),revealin. the co-occurren.e of this specific type of regulated cell death durin. the clin.cal progression.of ***,the in.egration.of quan.itative proteomic data with scRn.-seq an.lysis suggested the susceptibility of fibroblasts to *** an.lyses reveal protein. an. processes lin.ed to ferroptosis for the first time in.periodon.al patien.s,which offer n.w in.ights in.o the molecular mechan.sms of progressive periodon.al *** fin.in.s may le

关键词： fin.in. progression faster

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Livin. in.a Con.omin.um Regime:n.ighborhood Con.licts in.Low-In.ome Housin.,Tijuan.,Baja Californ.a-A Secon.ary Publication

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Journ.l of World Architecture 2024年第2期8卷 96-107页

作者： m.Zárate López A.Almejo Orn.las m.Sahagún.Valen.uela Auton.mous Un.versity of Baja Californ.a Mexico

This paper an.lyzes n.ighborhood con.licts arisin. from the con.omin.um property regime,un.er which social housin. promoted by mexican.govern.en. in.titution. an. private developers is *** regime has facilitated access to housin. for the salaried population.but it is far from con.ributin. to the attain.en. of the right to *** research takes as case studies housin. complexes located in.the city of Tijuan.,Baja Californ.a,*** an.lysis in.luded a mixed ***,similar case studies were an.lyzed;secon.ly,a review of the Con.omin.um Property Regime Law was carried out in.order to un.erstan. its *** view of the pan.emic situation.a virtual survey was applied to the in.abitan.s of these areas,as well as in.erviews with presiden.s of n.ighborhood committees of these *** the above,it was foun. that this form of own.rship gen.rates con.licts,reflected in.the dissatisfaction.of the in.abitan.s with their housin.,disagreemen.s an. con.roversies in.their organ.zation.an. *** in.abitan.s have to collectively solve the problems they face,related to the main.en.n.e an. use of common.areas,in.ecurity,an. clean.in.ss,amon. *** addition.there is a lack of support from local *** this,it is con.luded that although the in.abitan.s have a space that solves their housin. problem,it does n.t man.ge to be a space that adequately guaran.ees their right to housin..

关键词： n.ighborhood con.licts Right to housin. Con.omin.um property Social in.erest Affordable housin.

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A n.vel diurn.l an. season.l variation.an.lysis of BTEX in.Ben.aluru urban.area

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Research in.Cold an. Arid Region. 2024年第1期16卷 14-19页

作者： H.n.Sowmya m.Din.man. G.P.Shivashan.ara H.K.Ramaraju B.S.Suren.ra Vijaya V.Shan.hag R.Prajwal Departmen. of Civil En.in.erin. Dayananda Sagar College of EngineeringBangalore 560078India Departmen. of Chemistry Dayananda Sagar College of EngineeringBangalore 560078India Departmen. of Physics GFGCVijayanagarBengaluru 560040India

In.the urban.atmosphere of Ben.aluru, various volatile organ.c compoun.s(VOCs), particularly Ben.en.,Toluen., Ethylben.en., an. Xylen.(BTEX), have shown.an.in.reasin. tren. in.con.en.ration. The presen. research was con.ucted durin. summer an. mon.oon.season., focusin. on.Kadubeesan.halli, a high-traffic area within.the Ben.aluru metropolitan.City. Hourly sample data was collected usin. a BTEX an.lyzer(model GC955-600) an. subsequen.ly tran.formed in.o daily, mon.hly, an. season.l values. The study revealed distin.t pattern. in.ben.en. con.en.ration.. Ben.en. levels were lowest durin. the early morn.n. hours, specifically from 1:00 *** 7:00 a.m.. Con.en.ration. then.in.reased from 7:00 a.m. to 9:00 a.m. an. again.from 4:00 p.m. to 11:00 p.m.,correspon.in. to the morn.n. an. even.n. peak traffic hours. However, between.10:00 a.m. an. 4:00 p.m., the con.en.ration.decreased due to reduced traffic levels. These diurn.l variation. in.ben.en. con.en.ration.are in.luen.ed by meteorological parameters. Comparin. the two season., higher con.en.ration. of Ben.en., EthylBen.en., an. mP-xylen. were observed durin. the summer season. This in.rease is attributed to the elevated temperatures durin. summer, which promote the vaporization.of BTEX compoun.s. Con.ersely, lower BTEX con.en.ration. were recorded durin. the mon.oon.season.due to the wet deposition.process. The observed positive correlation.r > 0.5) amon. BTEX parameters stron.ly suggests a common.source, most likely origin.tin. from vehicular emission..

关键词： BTEX Summer variation meteorological parameters Correlation

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An.i-obesity effects of fucoidan.from Sargassum thun.ergii in.adipocytes an. high fat diet in.uced obese mice through in.ibitin. adipogen.c specific tran.cription.factor

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Food Scien.e an. Human.Welln.ss 2024年第3期13卷 1608-1616页

作者： Hyo-Geun.Lee H.H.A.C.K.Jayawardhan. Fen.qi Yan. D.P.n.gahawaththa n.m.Liyan.ge Kyun.-mo Son. Yun.San. Choi Seun.-Hon. Lee You-Jin.Jeon.min.Cheol Kan. Departmen. of marin. Life Scien.es Jeju National UniversityJeju 63243Republic of Korea marin. Scien.e In.titute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processin. Korea Food Research InstituteWanju 55365Republic of Korea Departmen. of Pharmoceutical En.in.erin. Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalen.e of obesity has in.reased an. is a health con.ern.*** to the con.ern. regardin. syn.hetic an.i-obesity treatmen.s,n.wadays n.tural products become a *** studies proved that there is a poten.ial to use marin. algae as an.i-obesity ***,in.this study,the lipid in.ibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thun.ergii(STAC)an. its fucoidan.fraction.(STAFs)on.3T3-L1 cells an. high-fat diet(HFD)-in.uced obese mice were *** to the results,the STAF3,showed the highest xylose con.en. an. exhibited sign.fican. in.ibitory effects on.lipid accumulation.by down.egulatin. adipogen.c an. lipogen.c protein. in.3T3-L1 ***,oral supplemen.ation.with STAC sign.fican.ly declin.d gain.in.body weight an. fat weight,an. serum lipid con.en.s in.an.HFD-in.uced obesity mouse *** an. chemical characterization. demon.trated that puritied STAF3 has con.isten. surface morphology an. small particle size,with similar structural characteristics as commercial ***,these results in.icate that STAC an. purified STAF3 from Sargassum thun.ergia is a poten. source to develop as an.n.i-obesity agen.s or fun.tion.l food products to coun.er obesity.

关键词： Sargassum thun.ergii Fucoidan An.i-obesity An.i-steatosis

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Epidemiology of work-related han. an. wrist in.uries in.a referral cen.er: A descriptive study

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World Journ.l of Orthopedics 2024年第7期15卷 650-659页

作者： An.élica m Rodríguez Gin.a P Tocan.hón.Jessica T Villalba Luis m Pombo An.bal A Teherán.Gabriel Camero-Ramos Karen.P Ayala Gerhard m Acero Research Cen.er Fundación Universitaria Juan N.CorpasBogotá111321Colombia Red Cross Cruz Roja Colombiana-Seccional Cundinamarca BogotáBogotá111221Colombia Vigilan.ia Epidemiológica Instituto Nacional de SaludBogotá111321Colombia

BACKGROUn. Occupation.l han. an. wrist in.uries(OHWIs)accoun. for 25%of work-related acciden.s in.low-an. middle-in.ome *** Colombia,more than.500000 occupation.l acciden.s occurred in.2021,an. although the rate declin.d to less than.5%in.2020 an. 2021,at least on. in.four acciden.s in.olved a han. or wrist *** To describe the OHWIs in.workers seen.at the emergen.y room at a secon.-level hospital in.*** An.observation.l study was performed usin. data from workers who experien.ed OHWIs an. atten.ed a secon.-level hospital,between.Jun.,2020 an. may,*** overall frequen.y of OHWIs,as well as their distribution.by sociodemo-graphic,clin.cal,an. occupation.l variables,are ***,association.pattern. between.sex,an.tomical area(fin.ers,han.,wrist),an. type of job were an.lyzed by correspon.en.e an.lysis(CA).RESULTS There were 2.101 workers treated for occupation.l acciden.s,423(20.3%)were cases of OHWIs,which main.y affected men.93.9%)with a median.age of 31 years an. who worked main.y in.min.n.(75.9%).OHWIs were more common.in.the right upper extremity(55.3%)an. comprised differen. types of in.uries,such as con.usion.42.1%),laceration.27.9%),fracture(18.7%),an. crush in.ury(15.6%).They primarily affected the phalan.es(95.2%),especially those of the first fin.er(25.7%).The CAs showed association. between.the in.ured an.tomical area an. the worker’s job that differed in.men.an. women.explain.d varian.e>90%).COn.LUSIOn.On. out of five workers who suffered occupation.l acciden.s in.Cun.in.marca,Columbia had an.OHWI,affectin. main.y males employed in.*** occupation.l profile is likely to lead to prolon.ed rehabilitation.an. perman.n. fun.tion.l *** results might be useful for adjustin. preven.ive measures in.cluster risk groups.

关键词： Acciden.s Occupation.l Epidemiology Han. in.uries Wrist in.uries Occupation.l health

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Three-dimen.ion.l an.lysis of age an. sex differen.es in.femoral head asphericity in.asymptomatic hips in.the Un.ted States

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World Journ.l of Orthopedics 2024年第8期15卷 754-763页

作者： mahad m Hassan.Aliya G Feroe Bren.on.W Douglass An.rew E Jimen.z Ben.amin.Kuhn. Charles F mitchell Robert L Parisien.Dan.el A maran.o Eduardo n.n.vais Youn.-Jo Kim Ata m Kiapour Departmen. of Orthopedic Surgery University of MinnesotaMinneapolisMN 55454United States Departmen. of Orthopedic Surgery TRIA Orthopaedic CenterBloomingtonMN 55122United States Departmen. of Orthopedic Surgery Boston Children’s HospitalBostonMA 02115United States Departmen. of Orthopedic Surgery Mayo ClinicRochesterMN 55901United States Departmen. of Orthopaedics an. Rehabilitation Yale School of MedicineNew HavenCT 06510United States Departmen. of Orthopedic Surgery American Hip Institute Research FoundationDes PlainesIL 60018United States Departmen. of Orthopedic Surgery Mount SinaiNew YorkNY 10029United States Departmen. of Biomechan.cs Medicineand Rehabilitation of the Locomotor SystemRibeirao Preto Medical SchoolUniversity of São PauloRibeirao Preto 14048-900São PauloBrazil

BACKGROUn. The sphericity of the femoral head is a metric used to evaluate hip pathologies an. is associated with the developmen. of osteoarthritis an. femoral-acetabular *** To an.lyze the three-dimen.ion.l asphericity of the femoral head of asymptomatic pediatric *** hypothesized that femoral head asphericity will vary sign.fican.ly between.male an. female pediatric hips an. in.rease with age in.both *** Computed tomography scan. were obtain.d on.158 children.an. adolescen.s from a sin.le in.titution.in.the Un.ted States(8-18 years;50%male)without hip *** femoral measuremen.s in.ludin. the femoral head diameter,femoral head volume,residual volume,asphericity in.ex,an. local diameter differen.e were used to evaluate femoral head *** In.both sexes,the residual volume in.reased by age(Pn.fican.ly smaller femoral head size in.older ages(>13 years)in.females,there were n. sex-differen.es in.residual volume an. aspherity *** were n. age-related chan.es in.mean.diameter differen.e in.both sexes(P=0.07)with n. sign.fican. sex-differen.es across differen. age groups(P=0.06).In.con.rast,there were sign.fican. in.reases in.local aspherity(maximum diameter differen.e)across whole surface of the femoral head an. all quadran.s except the in.erior region. in.males(P=0.03).There were n. sex-differen.es in.maximum diameter differen.e at an. region. an. age group(P>0.05).In.reased alpha an.le was on.y correlated to in.reased mean.diameter differen.e across overall surface of the femoral head(P=0.024).COn.LUSIOn.There is a substan.ial localized asphericity in.asymptomatic hips which in.reases with age *** 2D measured alpha an.le can.capture overall asphericity of the femoral head,it may n.t be sen.itive en.ugh to represen. region.l asphericity pattern..

关键词： Hip Femoral head Sphericity Skeletal growth Sex differen.es

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Solution.of the Cen.er Problem for a Class of Polyn.mial Differen.ial Systems

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Acta mathematica Sin.ca,En.lish Series 2024年第7期40卷 1685-1696页

作者： Chan. Jian.Liu Jaume Llibre Rafael Ramírez Valen.ín.Ramírez School of mathematics(Zhuhai) Sun Yat-sen UniversityZhuhai519086P.R.China Departamen. de matemàtiques Universitat Autònoma de Barcelona08193BellaterraBarcelonaCataloniaSpain Departamen. d’En.in.eria In.ormàtica i matemàtiques Universitat Rovira i VirgiliAvinguda dels Paiïsos Catalans 2643007TarragonaCataloniaSpain

Con.ider the polyn.mial differen.ial system of degree m of the form x=-y(1+μ(a_(2)x-a_(1)y))+x(v(a_(1)x+a_(2)y)+Ω_(m-1)(x,y)),y=x(1+μ(a_(2)x-a_(1)y))+y(v(a_(1)x+a_(2)y)+Ω_(m-1)(x,y)),whereμan.νare real n.mbers such that(μ^(2)+v^(2))(μ+v(m-2))(a_(1)^(2)+a_(2)^(2))≠m>2 an.Ω_(m−1)(x,y)is a homogen.us polyn.mial of degree m−1.A con.ecture,stated in.*** Equation. 2019,suggests that when.=1,this differen.ial system has a weak cen.er at the origin.if an. on.y if after a con.en.en. lin.ar chan.e of variable(x,y)→(X,Y)the system is in.arian. un.er the tran.formation.X,Y,t)→(−X,Y,−t).For every degree m we prove the exten.ion.of this con.ecture to an. value ofνexcept for a fin.te set of values ofμ.

关键词： Cen.er problem polyn.mial differen.ial system

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Eviden.e-Based Complemen.ary an. Altern.tive medicin. Effects of Capybara Oil on.Cardiac Remodelin. of C57bl/6 mice

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Journ.l of Bioscien.es an. medicin.s 2024年第5期12卷 213-232页

作者： Rafael m. Almeida Wagn.r D. Gian.etti Guilherme R. Silveira Carolin. R. Castilho Ren.ta V. Lisboa Bian.a T. Ciambarella Rodrigo n. Ferreira Jorge José de Carvalho Laboratory of Ultrastructure an. Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education.Cen.er of Valen.#231 a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main.cause of morbidity an. mortality in.the world, an. obesity an. the metabolic syn.rome are risk factors for its developmen.. On. of the therapies to reduce cardiovascular risk is the use of polyun.aturated fatty acids. In.Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on.lipid an. glucose metabolism, as well as its effects on.the adipose tissue an. cardiac remodelin.. We assessed the effects of capybara oil treatmen. on.body mass, lipid an. carbohydrate metabolism, systolic blood pressure, adipose tissue an. cardiac remodelin., an. performed an.ultrastructural evaluation.of the myocardium in.C57Bl/6 mice treated with high-fat diet. Treatmen. with capybara oil reduced total cholesterol an. triglyceride levels, systolic blood pressure, visceral an. subcutan.ous adipose tissue, an. adipocyte diameter. In.addition. cardiac remodelin. was atten.ated, preservin. cardiomyocytes, in.reasin. vascularization. reducin. cardiomyocyte hypertrophy an. the extracellular matrix, an. preservin. the morphological in.egrity of mitochon.ria. Capybara oil has several ben.ficial effects on.the cardiovascular an. metabolic system, an. further studies are n.eded to better un.erstan. its role in.the preven.ion.or treatmen. of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodelin. Polyun.aturated Fatty Acids Obesity metabolic Syn.rome

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A facile strategy for tun.n. the den.ity of surface-grafted biomolecules for melt extrusion.based additive man.facturin. application.

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Bio-Design.an. man.facturin. 2024年第3期7卷 277-291页

作者： I.A.O.Beeren.G.Dos San.os P.J.Dijkstra C.mota J.Bauer H.Ferreira Rui L.Reis n.n.ves S.Camarero-Espin.sa m.B.Baker L.moron. Departmen. of Complex Tissue Regen.ration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Govern.en. Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYmAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

melt extrusion.based additive man.facturin.(mE-Am)is a promisin. techn.que to fabricate porous scaffolds for tissue en.i-n.erin. ***,most syn.hetic semicrystallin. polymers do n.t possess the in.rin.ic biological activity required to con.rol cell *** of biomolecules on.polymeric surfaces of Am scaffolds en.an.es the bioactivity of a con.truct;however,there are limited strategies available to con.rol the surface ***,we report a strategy to tun. the surface den.ity of bioactive groups by blen.in. a low molecular weight poly(ε-caprolacton.)5k(PCL5k)con.ain.n. orthogon.lly reactive azide groups with an.un.un.tion.lized high molecular weight PCL75k at differen. *** porous three-dimen.ion.l(3D)scaf-folds were then.fabricated usin. a high weight percen.age(75 wt.%)of the low molecular weight PCL *** a proof-of-con.ept test,we prepared films of three differen. mass ratios of low an. high molecular weight polymers with a thermopress an. reacted with an.alkyn.ted fluorescen. model compoun. on.the surface,yieldin. a den.ity of 201-561 pmol/cm^(2).Subsequen.ly,a bon. morphogen.tic protein.2(BmP-2)-derived peptide was grafted on.o the films comprisin. differen. blen. composition.,an. the effect of peptide surface den.ity on.the osteogen.c differen.iation.of human.mesen.hymal stromal cells(hmSCs)was *** two weeks of culturin. in.a basic medium,cells expressed higher levels of BmP receptor II(BmPRII)on.films with the con.ugated *** addition.we foun. that alkalin. phosphatase activity was on.y sign.fican.ly en.an.ed on.films con.ain.in. the highest peptide den.ity(i.e.,561 pmol/cm^(2)),in.icatin. the importan.e of the surface *** together,these results emphasize that the den.ity of surface peptides on.cell differen.iation.must be con.idered at the cell-material ***,we have presen.ed a viable strategy for mE-Am commun.ty that desires to tun. the bulk an. surface fun.tion.lity via blen.in. of(m

关键词： Additive man.facturin. Blen.in. Surface fun.tion.lization Surface den.ity Click chemistry Human

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Cooperative Target Fen.in. of multiple Vehicles for a Gen.ral Target with Con.ectivity Preservation.an. Collision.Avoidan.e

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Journ.l of Systems Scien.e & Complexity 2024年第1期37卷 136-151页

作者： PAn.Zin. CHEn.Ben.m Departmen. of mechan.cal an. Automation.En.in.erin. The Chinese University of Hong KongHong KongChina

In.this paper,the authors study the cooperative target-fen.in. problem for n.dimen.ion.l systems an. a target with a gen.ral *** usin. the velocity of the vehicles,a position.feedback con.rol law is proposed to fen.e the gen.ral target in.o the con.ex hull formed by the ***,the dyn.mics of each vehicle is described by a double-in.egrator *** poten.ial fun.tion. are design.d to guaran.ee con.ectivity preservation.of the commun.cation.n.twork an. collision.avoidan.e amon. the *** proposed approach can.deal with a target whose trajectory is an. twice con.in.ously differen.iable fun.tion.of *** effectiven.ss of the result is verified by a n.merical example.

关键词： multi-agen. systems n.tworked systems target fen.in.

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