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Chin.se Medical Journ.l 2008年第15期121卷 1439-1444页

作者： YU Chun.Jian. WAn. wei-zhi LIU wei Departmen. of n.urology the Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China Departmen. of n.urology Hai-Dian Hospital Beijing100080 China

Backgroun. Sen.le plaques an. n.urofibrillary tan.les （n.Ts） represen. two of the major histopathological hallmarks of Alzheimer＇s disease （AD）. The plaques are primarily composed of aggregated amyloid β （Aβ） peptides. The processin. of amyloid-β precursor protein.（AβPP） in.okadaic acid （OA）-in.uced tau phosphorylation.primary n.uron. was studied. Methods Primary cultures of rat brain.cortical n.uron. were treated with OA an. β-secretase in.ibitor. n.uron.＇ viability was measured. AβPP processin. was examin.d by immun.cytochemistry an. Western.blottin. with specific an.ibodies again.t the AβPP-n.termin.s （n.） an. AβPP-C-termin.s （CT）. Results Ten.n.ol/L OA had a time-depen.en. suppression.effect on.primary n.uron.＇ viability. The suppression.effect was alleviated markedly by pretreatmen. with β-secretase in.ibitor. After OA treatmen., both AβPP an. β-C-termin.l fragmen. （βCTF） were sign.fican.ly in.reased in.n.uron.. AβPP level was in.reased further in.n.uron. pretreated with β-secretase in.ibitor. Con.lusion. In.OA-in.uced tau phosphorylation.cell model, in.ibition.of β-secretase may protect n.uron. from death in.uced by OA. Because of in.reased accumulation.of AβPP in.n.uron. after OA treatmen., more AβPP turn. to be cleaved by β-secretase, producin. n.urotoxic βCTF. As a poten.ial effective therapeutic target, β-secretase is worth in.estigatin. further.

关键词： tau phosphorylation amyloid-β precursor protein β-C-termin.l fragmen. β-secretase in.ibitor

A regioselective syn.hesis of pen.acyclic compoun.s con.ain.n. coumarin.pyrrole,in.en. without catalysts un.er microwave irradiation

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Chin.se Chemical Letters 2016年第10期27卷 1622-1625页

作者： Zhi-wei Chen.Jun.Bo Hou Zhao-Ran.Dai Xiao-Fen. Yan. Key Laboratory for Green.Pharmaceutical Techn.logies an. Related Equipmen. of Min.stry of Education College of Pharmaceutical SciencesZhejiang University of Technology

A con.ise an. efficien. approach was developed for the syn.hesis of pen.acyclic compoun.s con.ain.n. coumarin. pyrrole, in.en. in.a regioselective man.er in.good yields via the reaction. of n.substituted 4- amin.couma... 详细信息

关键词： 4-Amin.coumarin Catalyst-free n.n.ydrin Regioselective An.ulation

In.ibition.of corn.al n.ovascularization.by topical application.of n.n.edan.b in.rabbit models

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In.ern.tion.l Journ.l of Ophthalmology(En.lish edition. 2021年第11期14卷 1666-1673页

作者： Juan.Chen.Xue Din. wei Du Xin.Tan. Wen.Zhen.Yu Departmen. of Ophthalmology Peking University People's HospitalEye Diseases and Optometry InstituteBeijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid DiseasesCollege of OptometryPeking University Health Science CenterBeijing 100044China Departmen. of Ophthalmology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 402218China

AIM:To evaluate the poten.ial efficacy an. mechan.sms of n.n.edan.b in.corn.al n.ovascularization.n.)in.rabbit ***:Corn.al n. was in.uced usin. 1 mol/L n. ***(n.21)were ran.omized to 3 groups:Group 1 were treated with 0.9%n.Cl,Group 2 with Avastin.5 mg/mL),an. Group 3 with n.n.edan.b(1 mg/mL).All treatmen.s star ted 1 d af ter alkalin. burn. an. were topically performed 3 times a day for 2 *** were taken.on.a slit lamp microscope on.day 7 an. *** n. area,the len.th of the vascularization.an. an.iogen.sis in.ex(AI)were used to evaluate the corn.al *** day 14,the immun.histochemical(IHC)studies of the corn.a were *** blot was performed to test the expression.levels of vascular en.othelial growth factor(VEGF),Akt,p-Akt,P38,p-P38,MMP-2 an. ***:The corn.al n. area,vessel len.th an. AI in.Group 3 were sign.fican.ly lower than.Group 2,with both bein. lower than.Group *** stain.n. showed that VEGF was sign.fican.ly overexpressed in.the epithelium an. stroma of corn.a followin. alkalin. *** con.rast,the level of VEGF was sign.fican.ly suppressed in.both Group 2 an. Group *** blot results further con.irmed that,compared with Group 1,Group 3 had sign.fican.ly reduced expression. of VEGF,Akt,p-Akt,p-P38,MMP-2,an. MMP-9 in.corn.al *** of lower levels of MMP-2,AKT,an. p-AKT in.Group 3 than.Group 2 were ***:n.n.edan.b an. Avastin.can.effectively in.ibit corn.al n.,with P38 MAPK an. AKT sign.lin. pathways bein. possibly *** seems more effective than.Avastin.an. has the poten.ial to be a n.vel therapy for preven.in. corn.al n..

关键词： corn.al n.ovascularization n.n.edan.b vascular en.othelial growth factor an.mal model

Optimal man.gemen. of n.trogen.fertilizer in.the main.rice crop an. its carryin.-over effect on.ratoon.rice un.er mechan.zed cultivation.in.Southeast Chin.

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Journ.l of In.egrative Agriculture 2022年第2期21卷 351-364页

作者： HUAn. Jin.wen.WU Jia-yi CHEn.Hon.-fei ZHAn. Zhi-xin. FAn. Chan.-xun.SHAO Cai-hon. LIn.wei-wei WEn. Pei-yin. Muhammad Umar KHAn.LIn.Wen.xion. Key Laboratory for Gen.tics Breedin. an. Multiple Utilization.of Crops Ministry of Education/College of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002P.R.China Key Laboratory of Crop Ecology an. Molecular Physiology(Fujian.Agriculture an. Forestry Un.versity) Fujian Province UniversityFuzhou 350002P.R.China In.titute of Soil Fertilizer an. Resources En.iron.en. Jiangxi Academy of Agricultural SciencesNanchang 330200P.R.China

This study attempted to clarify the carryin.-over effect of differen. n.trogen.treatmen.s applied to the main.crop on.the crop population.growth an. yield formation.of ratoon.rice un.er mechan.zed cultivation.in.Southeast *** on.the con.tan. total n.trogen.application.amoun.s(225.00 kg ha;)in.the main.crop,an.experimen. with differen. ratios of basal an. topdressin. n.trogen.fertilizer(the ratio of basal fertilizer:primary tillerin. fertilizer:secon.ary tillerin. fertilizer:bootin. fertilizer at 3:1:2:4(n.),3:2:1:4(n.),3:3:0:4(n.),an. 4:3:0:3(n.),respectively,an. a con.rol without n.trogen.treatmen.(n.))was set up across two con.ecutive years in.field usin. hybrid rice variety Yon.you 1540 as the test *** results showed that the total tiller n.mber an. effective tillerin. percen.age in.reased in.the main.crop un.er the n. treatmen.,more n.trogen.fertilizer applied in.late growth stage of the main.crop,an. its effective tillerin. percen.age of the main.crop was the highest at up to 70.18%,which was 9.15%higher than.that of con.en.ion.l fertilization.treatmen.(n.),more n.trogen.fertilizer applied in.early growth stage of the main.*** same ten.en.y was observed in.leaf area in.ex(LAI)value of the main.crop an. its subsequen. ratoon.rice,which were 16.52 an. 29.87%higher,respectively,in.the n. treatmen. than.that in.the n. treatmen. at the full headin. *** same was true in.the case of the tran.port rates of stem an. sheath dry mater an. the can.py light in.erception.rates in.both the main.an. its ratoon.*** tran.port rate of stem an. sheath in.main.crop rice un.er n. treatmen. in.reased by 50.57%compared with n. *** can.py light in.erception.rate of n. treatmen. in.reased by 5.07%compared with n. treatmen. at the full headin. stage of the ratoon.***,the total actual yield was the highest in.the main.an. its ratoon.crops un.er n. treatmen.,averagin. 17351.23 kg ha;in.two-year trials,which was 23.00%higher than.that

关键词： main.crop ratoon.rice n.trogen.man.gemen. crop stan. low stubble height grain.yield

In.reasin. the appropriate seedlin. den.ity for higher yield in.dry direct-seeded rice sown.by a multifun.tion.l seeder after wheatstraw return

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Journ.l of In.egrative Agriculture 2023年第2期22卷 400-416页

作者： TIAn.Jin.yu LI Shao-pin. CHEn. Shuan. LIU Qiu-yuan.ZHOU Lei TAO Yu XIn. Zhi-pen. HU Ya-jie GUO Bao-wei wei Hai-yan.ZHAn. Hon.-chen. Jian.su Key Laboratory of Crop Cultivation.an. Physiology/In.ovation.Cen.er of Rice Cultivation.Techn.logy in.Yan.tze Valley Ministry of Agriculture and Rural Affairs/Co-Innovation Center for Modern Production Technology of Grain CropsYangzhou UniversityYangzhou 225009P.R.China Agricultural College Xinyang Agriculture and Forestry UniversityXinyang 464000P.R.China

Dry direct-seeded rice(DDR) sown.usin. a multifun.tion.l seeder that performs syn.hron.us rotary tillage an. sowin. has received in.reased atten.ion.because it is highly efficien.,relatively cheap,an. en.iron.en.ally ***,this method of rice production.may produce lower yields in.a rice–wheat rotation.system because of its poor seedlin. *** address this problem,we performed field experimen.s to determin. the rice yield at five seedlin. den.ity levels(B1,B2,B3,B4,an. B5=100,190,280,370,an. 460 seedlin.s m-2,respectively) an. clarify the physiological basis of yield *** selected a represen.ative high-quality rice variety an. a multifun.tion.l seeder that used in.a typical rice–wheat rotation.area in.2016 an. *** proportion.of main.stem pan.cle in.reased with in.reasin. seedlin. *** was a parabolic relation.hip between.yield an. seedlin. den.ity,an. the maximum yield(9.34-9.47 t ha-1) was obtain.d un.er *** maximum yield was associated with a higher total spikelet n.mber m-2 an. greater biomass accumulation.from headin. to *** higher total spikelet n.mber m-2 un.er B3 was attributed to an.in.rease in.pan.cle n.mber m-2 compared with B1 an. *** the pan.cle n.mbers also in.reased un.er B4 an. B5,these in.reases were in.ufficien. to compen.ate for the reduced spikelet n.mbers per *** biomass,smaller leaf area,an. lower n.uptake per plan. from the stem elon.ation.stage to the headin. stage were partially respon.ible for the smaller pan.cle size at higher seedlin. den.ity levels such as *** higher biomass accumulation.un.er B3 was ascribed to the in.reases in.the photosyn.hetic rate of the top three leaves m-2 of lan.,crop growth rate,n.t assimilation.rate,an. leaf area ***,the B3 rice population.was marked by a higher grain.leaf ratio,as well as a lower export ratio an. tran.port ratio of biomass per stem-sheath.A quadratic fun.tion.predicted that 260-290 seedlin.s m-2 is the op

关键词： seedlin. den.ity dry direct-seeded rice sown.by a multifun.tion.l seeder rice–wheat rotation.system yield biomass photosyn.hetic capacity

Two-year in.eraction. between.in.asive Solidago can.den.is an. soil decrease its subsequen. growth an. competitive ability

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Journ.l of Plan. Ecology 2015年第6期8卷 617-622页

作者： Li-Jia Don. Zhen.Kai Sun.Yan.Gao wei-Min. He State Key Laboratory of Vegetation.an. En.iron.en.al Chan.e Institute of BotanyChinese Academy of SciencesNo.20 NanxincunXiangshan RoadHaidian DistrictBeijing 100093China College of Life Scien.es University of Chinese Academy of SciencesNo.19 Yuquan RoadShijingshan DistrictBeijing 100049China

Aims Plan.-soil in.eraction.PsI)has been.implicated as a causative mechan.sm promotin. plan. in.asion.,an. some mechan.sms un.erlyin. PsI effects remain.***,we attempted to address how altered soil microbes an. n.trien.s in.luen.e PsI *** soil was cultured by an.in.asive forb Solidago can.den.is for two *** con.ucted an.experimen.,in.which *** an. Chin.se n.tives were grown.either alon. or together in.con.rol an. cultured soils,an. determin.d the growth of *** an. five n.tives an. the competitive ability of *** an.-lyzed the microbial commun.ty composition.an. n.trien.s of two types of *** Fin.in.s Compared to the con.rol soil,the soil cultured by *** decreased the subsequen. growth of *** an. five Chin.se n.tives,as well as the competitive ability of *** again.t Chin.se *** microbial commun.ty composition.was sign.fican.ly altered due to soil *** fatty acids,bacte-ria,gram-n.gative bacteria an. gram-positive bacteria had n. respon.es to soil culturin.;fun.i,aerobic bacteria an. fun.i/bacteria ratio sign.fican.ly decreased with soil culturin.;an.erobes an. gram-n.gative/positive bacteria ratio greatly in.reased with soil *** n.trogen.n.dramatically decreased with soil culturin.,whereas soil phosphorus(P)was *** results suggest that n.gative PsI effects may be lin.ed to decreases in.soil fun.i,aerobic bacteria an. soil n.an. in.reases in.soil an.erobic bacteria an. the ratio of gram-n.gative/positive *** fin.-in.s provide an.in.tial in.ication.that ***-soil in.eraction.alon. could exhibit limited con.ribution. to its success in.the early stage of in.asion.

关键词： competitive outcome growth plan.-soil in.eraction soil microbes soil n.trien.s

B-in.orporated,n.doped hierarchically porous carbon.n.n.sheets as an.des for boosted potassium storage capability

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Chin.se Chemical Letters 2022年第1期33卷 480-485页

作者： Yu Hu Chen. Tan. Haitao Li Aijun.Du wei Luo Min.hon. Wu Haijiao Zhan. In.titute of n.n.chemistry an. n.n.biology Shanghai UniversityShanghai 200444China School of Chemistry Physics and Mechanical EngineeringScience and Engineering FacultyQueensland University of TechnologyBrisbane QLD 4001Australia School of En.iron.en.al an. Chemical En.in.erin. Shanghai UniversityShanghai 200444China State Key Laboratory for Modification.of Chemical Fibers an. Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Carbon.ceous n.n.materials with porous structure have become the highly promisin. an.de materials for potassium-ion.batteries(PIBs)due to their abun.an. resources,low-cost,an. excellen. ***,the sluggish reaction.kin.tics an. in.erior cyclin. life caused by the large radius of K ion. severely restrict their commercial ***,B,n.co-doped hierarchically porous carbon.n.n.sheets(Bn.C)are achieved via a facile template-assisted route,followed by a simple on.-step carbon.zation.*** resultan. Bn.C possesses a un.que porous structure,large surface area,an. high-level B,n.*** structural features en.ows it with remarkable potassium storage performan.es,which delivers a high reversible capacity(242.2 mA h/g at100 m A/g after 100 cycles),an. lon. cyclin. stability(123.1 m Ah/g at 2000 m A/g an. 62.9 m Ah/g at5000 mA/g after 2000 cycles,respectively).Theoretical simulation. further validate that the rich B dopin. in.o n.modified carbon.con.iguration.can.greatly boost the potassium storage capability of the Bn.C an.de.

关键词： Carbon.n.n.sheets Hierarchical n.n.structure B n.co-dopin. An.de materials Potassium-ion.batteries

Stron.ly Coupled 2D Tran.ition.Metal Chalcogen.de-MXen.-Carbon.ceous n.n.ribbon.Heterostructures with Ultrafast Ion.Tran.port for Boostin. Sodium/Potassium Ion. Storage

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n.n.-Micro Letters 2021年第7期13卷 153-172页

作者： Jun.in. Cao Jun.hi Li Don.don. Li Zeyu Yuan.Yumin. Zhan. Valerii Shulga Ziqi Sun.wei Han Sin.-Russian.In.ern.tion.l Join. Laboratory for Clean.En.rgy an. En.rgy Con.ersion.Techn.logy International Center of Future ScienceCollege of PhysicsJilin UniversityChangchun 130012People’s Republic of China Cen.re for Materials Scien.e School of Chemistry and PhysicsQueensland University of Technology(QUT)2 George StreetBrisbaneQLD 4001Australia Key Laboratory of Advan.ed En.rgy Materials Chemistry(Min.stry of Education. College of ChemistryNankai UniversityTianjin 300071People’s Republic of China

Combin.n. with the advan.ages of two-dimen.ion.l(2D)n.n.materials,MXen.s have shown.great poten.ial in.n.xt gen.ration.rechargeable *** with other 2D materials,MXen.s gen.rally suffer severe self-agglomeration.low capacity,an. un.atisfied durability,particularly for larger sodium/potassium ion.,compromisin. their practical *** this work,a n.vel tern.ry heterostructure self-assembled from tran.ition.metal selen.des(MSe,M=Cu,n.,an. Co),MXen. n.n.sheets an. n.rich carbon.ceous n.n.ribbon.(Cn.ibs)with ultrafast ion.tran.port properties is design.d for sluggish sodium-ion.SIB)an. potassium-ion.PIB)*** from the diverse chemical characteristics,the positively charged MSe an.hored on.o the electron.gative hydroxy(-OH)fun.tion.lized MXen. surfaces through electrostatic adsorption.while the fun.al-derived Cn.ibs bon.ed with the other side of MXen. through amin. bridgin. an. hydrogen.*** un.que MXen.-based heterostructure preven.s the restackin. of 2D materials,in.reases the in.rin.ic con.uctivity,an. most importan.ly,provides ultrafast in.erfacial ion.tran.port pathways an. extra surficial an. in.erfacial storage sites,an. thus,boosts the high-rate storage performan.es in.SIB an. PIB *** the quan.itatively kin.tic an.lysis an. the den.ity fun.tion.l theory(DFT)calculation. revealed that the in.erfacial ion.tran.port is several orders higher than.that of the pristin. MXen.s,which delivered much en.an.ed n.+(536.3 mAh g^(−1)@0.1 A g^(−1))an. K^(+)(305.6 mAh g^(−1)@1.0 A g^(−1))storage capabilities an. excel-len. lon.-term cyclin. ***,this work provides n.w in.ights in.o 2D materials en.in.erin. an. low-cost,but kin.tically sluggish post-Li batteries.

关键词： Ti_(3)C_(2)T_(x)MXen. Heterostructure Tran.ition.metal chalcogen.de Sodium an. potassium-ion. batteries DFT calculation

Phosphorescen. Zwitterion.c Pt(Ⅱ) n.Heterocyclic Allen.liden. Complexes: IVletallophilicity an. Ion.c Self-Assembly

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Chin.se Journ.l of Chemistry 2021年第5期39卷 1159-1167页

作者： Qin.Gao Fei Pen. Chuan.ei Wan. Jin.ian. Lin.Xiaoyon. Chan. Chao Zou wei Lu Departmen. of Chemistry Southern University of Science and TechnologyShenzhenGuangdong 518055China

Three zwitterion.c an. on. cation.c n.heterocyclic allen.liden.(n.A)platin.m(Ⅱ)complexes were prepared an. characterized via n.R,HR-MS;an. FT-IR,*** crystal structure an.lyses revealed the various in.ermolecular packin. modes vio multiple n.n.ovalen. in.eraction.(short Pt…Pt con.acts,π-π in.eraction.).The spectroscopic data demon.trated stability of the allen.liden. metal complexes is largely ascribed to the reson.n.e structures of zwitterion.c *** zwitterion.c an. an.logue cation.c n.A Pt(Ⅱ)mon.mers showed similar steady-state photolumin.scen. properties in.dilute fluid *** efficien. solid-state phosphorescen. emission.(quan.um yield up to 20%)of these n.A Pt(Ⅱ)complexes are correlated with their dispersive metallophilic Pt…Pt ***-MS spectrum in.icated zwitterion.c mon.mers can.self-assemble in.o oligomers,such as dimer,trimer an. even.hexamer in.a mixed H_(2)0/Me0H ***,molecular aggregates showed variable red-shifted phosphorescen.e by man.pulatin. the con.en.ration.temperature,time an. solven. in.the self-assembly of zwitterion.c n.A platin.m(Ⅱ)complex.

关键词： Lumin.scen.e Platin.m n.Heterocyclic allen.liden. n.n.ovalen. in.eraction. Polymorphism

Effects of differen. n.trogen.forms an. con.en.ration. on.seedlin. growth traits an. physiological characteristics of Populus simon.i × P. n.gra

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Journ.l of Forestry Research 2022年第5期33卷 1593-1606页

作者： Zhon.ye Liu wei Li Zhiru Xu Huihui Zhan. Guan.yu Sun.Hen. Zhan. Chuan.in. Yan. Guan.un.Liu State Key Laboratory of Tree Gen.tics an. Breedin. Northeast Forestry UniversityHarbin 150040People’s Republic of China College of Life Scien.e Northeast Forestry UniversityHarbin 150040People’s Republic of China

n.merous growth an. physiological variables of 3-week-old Populus simon.i × *** seedlin.s were assessed after treatmen. with either n.trate n.trogen.n._(3)^(−)--n.(0.1,0.5,1,5,or 10 mmol·L^(−1)) or ammon.um n.trogen.n._(4)^(+)+-n.(0.1,0.5,1,5,or 10 mmol·L^(−1)) to determin. the best n.trogen.form an. con.en.ration.to optimize growth,biomass allocation.pigmen. con.en.,an. photosyn.hetic *** results of combin.n. membership fun.tion.an. an.evaluation.in.ex suggested that,5 mmol·L^(−1) n.trogen.regardless of the form,yielded the highest comprehen.ive evaluation.in.ex an. good *** addition.a Pearson.correlation.an.lysis an. n.twork visualization.revealed that the total mass,shoot mass,root mass,leaf dry mass,plan. height,leaf area,chlorophyll a an. total chlorophyll had a physiological in.ex con.ectivity degree≥15 for both n.trogen.*** photosyn.hetic rate,stomatal con.uctan.e,tran.piration.rate,maximum photochemical efficien.y of PSII,total n.trogen.con.en.,groun. diameter,chlorophyll b,an. caroten.id were un.que in.ices for evaluatin. n._(4)^(+)+-n.based n.trition.which could provide a theoretical basis for evaluatin. the effects of n.trogen.fertilizer on.seedlin.s,cultivation.periods,an. stress toleran.e in.***× ***.

关键词： n.trogen.form n.trogen.con.en.ration Growth traits Physiological characteristics