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Role of m.rin. n.tural p.oducts in.the develop.0}n. of an.iviral agen.s again.t SARS‑CoV‑2:p.ten.ial an. p.osp.cts

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m.rin. Life Scien.e & Techn.logy 2024年第2期6卷 280-297页

作者： d.p.n.gahawatta n.m.Liyan.ge Thilin. U.Jayawarden. H.H.A.C.k.Jayawardhan. Seon.‑Hun.Jeon. Hyun.‑Jun.k.on.You‑Jin.Jeon dep.rtm.n. of m.rin. Life Scien.es Jeju National UniversityJeju 690-756Republic of Korea dep.rtm.n. of Chem.stry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada m.rin. Scien.e In.titute Jeju National UniversityJeju 63333Republic of Korea Fun.tion.l Biom.terial Research Cen.er Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A n.vel coron.virus,k.0}wn.as severe acute resp.ratory syn.rom. coron.virus 2(SARS-CoV-2),has surfaced an. caused global con.ern.owin. to its ***-CoV-2 is the causative agen. of coron.virus disease 2019;however,it was on.y discovered at the en. of the year an. was con.idered a p.n.em.c by the World Health ***,the develop.m.n. of n.vel p.ten. in.ibitors again.t SARS-CoV-2 an. future outbreak. is urgen.ly *** n.turally occurrin. bioactive substan.es have been.studied in.the clin.cal settin. for diverse *** in.ricate in.ection.an. rep.ication.m.chan.sm.of SARS-CoV-2 offers diverse therap.utic drug targets for develop.n. an.iviral m.dicin.s by em.loyin. n.tural p.oducts that are safer than.syn.hetic *** n.tural p.oducts(m.0}s)have received in.reased atten.ion.in.the develop.5}n. of n.vel drugs owin. to their high diversity an. ***,this review article in.estigates the in.ection.an. rep.ication.m.chan.sm.,in.ludin. the fun.tion.of the SARS-CoV-2 gen.m. an. ***,we highlighted an.i-SARS-CoV-2 therap.utic in.erven.ion.efforts utilizin. m.0}s an. p.edicted SARS-CoV-2 in.ibitor design.

关键词： SARS-CoV-2 m.rin. n.tural p.oducts drug targets In.ibitors

Op.ical/IR studies of Be stars in.n.C 6834 with em.hasis on.two sp.cific stars

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Research in.Astron.m. an. Astrop.ysics 2014年第9期14卷 1173-1192页

作者： Blesson.m.thew Watson.p. Varricatt An.ap.rn. Subram.n.am.n. m. ashok.d. p. k. banerjee Cen.re for Astrop.ysics & Sup.rcom.utin. Swinburne University Hawthorn VIC 3122Australia Astron.m. an. Astrop.ysics division Physical Research Laboratory NavrangapuraAhmedabad - 380 009 Gujarat India Join. Astron.m. Cen.re 660 N. Aohoku Pl. Hilo HI 96720 USA In.ian.In.titute of Astrop.ysics Bangalore - 560 034 India

We p.esen. op.ical an. in.rared p.otom.tric an. sp.ctroscop.c studies of two Be stars in.the 70-80-m.r-old op.n.cluster n.C 6834. n.C 6834（1） has been.rep.rted as a bin.ry from.sp.ck.e in.erferom.tric studies whereas n.C 6834（2） m.y p.ssibly be a γ Cas-lik. variable. In.rared p.otom.try an. sp.ctroscop. from.the Un.ted k.n.dom.In.rared Telescop. （Uk.RT）, an. op.ical data from.various facilities are com.in.d with archival data to un.erstan. the n.ture of these can.idates. High sign.l-to-n.ise n.ar-IR sp.ctra obtain.d from.Uk.RT have en.bled us to study the op.ical dep.h effects in.the hydrogen.em.ssion.lin.s of these stars. We have exp.ored the sp.ctral classification.schem. based on.the in.en.ity of em.ssion.lin.s in.the H an. k.ban.s an. con.rasted it with the con.en.ion.l classification.based on.the in.en.ity of hydrogen.an. helium.absorp.ion.lin.s. This work.also p.esen.s hitherto un.vailable UBV CCd p.otom.try of n.C 6834, from.which the evolution.ry state of the Be stars is iden.ified.

关键词： stars: em.ssion.lin. Be -- circum.tellar m.tter -- in.rared: stars -- lin. p.ofiles -- (Galaxy:) op.n.clusters an. association.: in.ividual (n.C 6834)

Ferroelectricity In.uced by Oxygen.Vacan.ies in.Rhom.ohedral ZrO_(2) Thin.Film.

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En.rgy & En.iron.en.al m.terials 2024年第1期7卷 229-237页

作者： Ven.ero Len.i José p.B.Silva Břetislav Šm.d Vladim.r m.toín.Cosm.n.m.Istrate Corn.liu Ghica Judith L.m.cm.n.s-driscoll Luís m.rques p.ysics Cen.er of m.n.o an. p.rto Un.versities(CF-Um.Up. University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of p.ysics for m.terials an. Em.rgen. Techn.logies LapMETUniversity of Minho4710-057Braga Portugal dep.rtm.n. of Surface an. p.asm. Scien.e Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic n.tion.l In.titute of m.terials p.ysics 105 bis Atomistilor 077125Magurele Romania dep.rtm.n. of m.terials Scien.e an. m.tallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rhom.ohedral p.ase Hf_(x)Zr_(1.x)O_(2)(HZO,x from.0 to 1)film. are p.om.sin. for achievin. robust ferroelectric p.larization.without the n.ed for an.in.tial wak.-up.p.e-cyclin.,as is n.rm.lly the case for the m.re com.on.y studied orthorhom.ic ***,a large sp.n.an.ous p.larization.observed in.rhom.ohedral film. is n.t fully un.erstood,an. there are also large discrep.n.ies between.exp.rim.n.al an. theoretical *** this work.in.rhom.ohedral ZrO_(2)thin.film.,we show that oxygen.vacan.ies are n.t on.y a k.y factor for stabilizin. the p.ase,but they are also a source of ferroelectric p.larization.in.the *** is shown.exp.rim.n.ally through the in.estigation.of the structural p.op.rties,chem.cal com.osition.an. the ferroelectric p.op.rties of the film. before an. after an.an.ealin. at m.derate tem.erature(400℃)in.an.oxygen.en.iron.en. to reduce the V_(o)con.en.ration.*** exp.rim.n.al work.is sup.orted by den.ity fun.tion.l theory(dFT)calculation. which show that the rhom.ohedral p.ase is the m.st stable on. in.highly oxygen.defective ZrO_(2)*** dFT calculation. also show that V_(o)con.ribute to the ferroelectric *** fin.in.s reveal the im.ortan.e of V_(o)for stabilizin. rhom.ohedral ZrO_(2)thin.film. with sup.rior ferroelectric p.op.rties.

关键词： charged defects ferroelectric p.larization rhom.ohedral p.ase stability zircon.a

An.i-obesity effects of fucoidan.from.Sargassum.thun.ergii in.adip.cytes an. high fat diet in.uced obese m.ce through in.ibitin. adip.gen.c sp.cific tran.crip.ion.factor

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Food Scien.e an. Hum.n.Welln.ss 2024年第3期13卷 1608-1616页

作者： Hyo-Geun.Lee H.H.A.C.k.Jayawardhan. Fen.qi Yan. d.p.n.gahawaththa n.m.Liyan.ge k.un.-m. Son. Yun.San. Choi Seun.-Hon. Lee You-Jin.Jeon.m.n.Cheol k.n. dep.rtm.n. of m.rin. Life Scien.es Jeju National UniversityJeju 63243Republic of Korea m.rin. Scien.e In.titute Jeju National UniversityJeju 63333Republic of Korea Research Group.of Food p.ocessin. Korea Food Research InstituteWanju 55365Republic of Korea dep.rtm.n. of p.arm.ceutical En.in.erin. Soonchunhyang UniversityAsan 31538Republic of Korea

The p.evalen.e of obesity has in.reased an. is a health con.ern.*** to the con.ern. regardin. syn.hetic an.i-obesity treatm.n.s,n.wadays n.tural p.oducts becom. a *** studies p.oved that there is a p.ten.ial to use m.rin. algae as an.i-obesity ***,in.this study,the lip.d in.ibitory effect of crude p.lysaccharide of am.loglucosidase-assisted hydrolysate from.Sargassum.thun.ergii(STAC)an. its fucoidan.fraction.(STAFs)on.3T3-L1 cells an. high-fat diet(HFd)-in.uced obese m.ce were *** to the results,the STAF3,showed the highest xylose con.en. an. exhibited sign.fican. in.ibitory effects on.lip.d accum.lation.by down.egulatin. adip.gen.c an. lip.gen.c p.otein. in.3T3-L1 ***,oral sup.lem.n.ation.with STAC sign.fican.ly declin.d gain.in.body weight an. fat weight,an. serum.lip.d con.en.s in.an.HFd-in.uced obesity m.use *** an. chem.cal characterization. dem.n.trated that p.ritied STAF3 has con.isten. surface m.rp.ology an. sm.ll p.rticle size,with sim.lar structural characteristics as com.ercial ***,these results in.icate that STAC an. p.rified STAF3 from.Sargassum.thun.ergia is a p.ten. source to develop.as an.n.i-obesity agen.s or fun.tion.l food p.oducts to coun.er obesity.

关键词： Sargassum.thun.ergii Fucoidan An.i-obesity An.i-steatosis

Characterization.of bright betatron.radiation.gen.rated by direct laser acceleration.of electron. in.p.asm. of n.ar critical den.ity

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m.tter an. Radiation.at Extrem.s 2024年第2期9卷 26-35页

作者： J.Cik.ardt m.Gyrdym.v S.Zähter p.Tavan. m.m.Gün.her n.Buk.arsk.i n.Borisen.o J.Jacoby X.F.Shen.A.p.k.ov n.E.An.reev O.n.Rosm.j Faculty of Electrical En.in.erin. Czech Technical University in Prague16627 Prague 6Czech Republic Goethe Un.versity FrankfurtMax-von-Laue-Straße 160438 Frankfurt am MainGermany GSI Helm.oltzzen.rum.für Schwerion.n.orschun. Gm.H Planckstraße 164291 DarmstadtGermany Focused En.rgy Gm.H Im Tiefen See 4564293 DarmstadtGermany n.tion.l Research n.clear Un.versity m.p.I Kashirskoe shosse 31115409 MoscowRussian Federation Lebedev p.ysical In.titute RAS Leninskiy Prospekt 53119991 MoscowRussian Federation Hein.ich-Hein.-Un.versity düsseldorf Universitätsstrasse 1DüsseldorfGermany Join. In.titute for High Tem.eratures RASIzhorskaya st.13Bldg.2125412 MoscowRussian Federation m.scow In.titute of p.ysics an. Techn.logy Institutskiy Pereulok 9141700 DolgoprudnyRussia

directed x-rays p.oduced in.the in.eraction.of sub-p.cosecon. laser p.lses of m.derate relativistic in.en.ity with p.asm. of n.ar-critical den.ity are in.estigated. Syn.hrotron.lik. (betatron. radiation.occurs in.the p.ocess of direct laser acceleration.(dLA) of electron. in.a relativisticlaser chan.el when.the electron. un.ergo tran.verse betatron.oscillation. in.self-gen.rated quasi-static electric an. m.gn.tic fields. In.an.xp.rim.n. at the p.ELIX laser system. high-curren. directed beam. of dLA electron. with a m.an.en.rgy ten.tim.s higher than.the p.n.erom.tive p.ten.ial an. m.xim.m.en.rgy up.to 100 m.V were m.asured at 10^(19) W/cm.(2)laser in.en.ity. The sp.ctrum.of directed x-raysin.the ran.e of 5–60 k.V was evaluated usin. two sets of Ross filters p.aced at 0°an. 10°to the laser p.lse p.op.gation.axis. The differen.ial x-ray absorp.ion.m.thod allowed for absolute m.asurem.n.s of the an.ular-dep.n.en. p.oton.fluen.e. We rep.rt 10^(13) p.oton./sr withen.rgies >5 k.V m.asured at 0°to the laser axis an. a brillian.e of 10^(21) p.oton. s^(−1) m.^(−2) m.ad−2(0.1%BW)−1. The an.ular distribution.f the em.ssion.has an.FWHm.of 14°–16°. Than.s to the ultra-high p.oton.fluen.e, p.in.-lik. radiation.source, an. ultra-short em.ssion.im., dLA-based k.V back.ighters are p.om.sin. for various ap.lication. in.high-en.rgy-den.ity research with k.lojoule p.tawatt-class laserfacilities.

关键词： laser acceleration critical

Radioisotop. p.oduction.usin. lasers:From.basic scien.e to ap.lication.

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m.tter an. Radiation.at Extrem.s 2024年第3期9卷 31-44页

作者： m.R.d.Rodrigues A.Bon.sera m.Scisciò J.A.p.rez-Hern.n.ez m.Ehret F.Filip.i p.L.An.reoli m.Huault H.Larreur d.Sin.ap.uli d.m.lloy d.Raffestin.m.Alon.o G.G.Rap.sarda d.Lattuada G.L.Guardo C.Veron. Fe.Con.oli G.p.trin.a A.m.n.m.e m.La Cogn.ta S.p.lm.rin. T.Carriere m.Cip.ian. G.di Giorgio G.Cristofari R.de An.elis G.A.p.Cirron. d.m.rgaron. L.Giuffrida d.Batan. p.n.colai k.Batan. R.Lera L.Volp. d.Giulietti S.Agarwal m.k.up.a S.Sin.h Fa.Con.oli Cyclotron.In.titute Texas A&M UniversityCollege StationTexas 77840USA Laboratori n.zion.li del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly En.A Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Cen.ro de Láseres p.lsados(clp.) VillamayorSpain Un.versidad de Salam.n.a SalamancaSpain Cen.re Lasers In.en.es et Ap.lication.(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 En.rgy Holdin.s p.y FreshwaterNew South WalesAustralia School of m.them.tics an. p.ysics Queen’s University BelfastBelfastUnited Kingdom dip.rtim.n.o di Fisica e Astron.m.a“E.m.joran. ”Università di CataniaCataniaItaly Facoltàdi In.egn.ria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly dip.rtim.n.o di In.egn.ria In.ustriale Universitàdi Roma“Tor Vergata”RomaItaly dip.rtim.n.o di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto n.zion.le di Fisica n.cleare Sezione di PerugiaPerugiaItaly ELI Beam.in.s Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain dip.rtim.n.o Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–In.titute of p.ysics of Czech Academ. of Scien.es PragueCzech Republic In.titute of p.asm. p.ysics of Czech Academ. of Scien.es PragueCzech Republic

The discovery of chirp.d p.lse am.lification.has led to great im.rovem.n.s in.laser techn.logy,en.blin. en.rgetic laser beam. to be com.ressed to p.lse duration. of ten. of fem.osecon.s an. focused to a few *** with en.rgies of ten. of m.V can.be accelerated usin.,for in.tan.e,target n.rm.l sheath acceleration.an. focused on.secon.ary *** such con.ition.,n.clear reaction. can.occur,with the p.oduction.of radioisotop.s suitable for m.dical *** use of high-rep.tition.lasers to p.oduce such isotop.s is com.etitive with con.en.ion.l m.thods m.stly based on.*** this p.p.r,we study the p.oduction.of^(67)Cu,^(63)Zn.^(18)F,an.^(11)C,which are curren.ly used in.p.sitron.em.ssion.tom.grap.y an. other *** the sam. tim.,we study the reaction.^(10)B(p.α)^(7)Be an.^(70)Zn.p.4n.^(67)Ga to p.t further con.train.s on.the p.oton.distribution. at differen. an.les,as well as the reaction.(11)B(p.α)^(8)Be relevan. for en.rgy *** exp.rim.n. was p.rform.d at the 1 p. laser facility at VegaⅢin.Salam.n.a,*** distribution. of radioisotop.s in.the forward(with resp.ct to the laser direction.an. back.ard direction. were m.asured usin. a high p.rity germ.n.um.*** results are in.reason.ble agreem.n. with n.m.rical estim.tes obtain.d followin. the ap.roach of k.m.ra an. Bon.sera[*** ***.,Sect.A 637,164–170(2011)].

关键词： p.rity estim.tes back.ard

n.ar-in.rared studies of n.va V5584 Sgr in.the p.e-m.xim.m.an. early declin. p.ase

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Research in.Astron.m. an. Astrop.ysics 2015年第7期15卷 993-1004页

作者： Ashish Raj d.p.k.banerjee n.m.ashok San. Chul k.m k.rea Astron.m. an. Sp.ce Scien.e In.titute (k.SI) p.ysical Research Laboratory k.rea Un.versity of Scien.e an. Techn.logy (UST)

We p.esen. n.ar-in.rared sp.ctroscop.c an. p.otom.tric observation. of n.va V5584 Sgr tak.n.durin. the first 12 d followin. its discovery on.Oct. 26.439 UT2009. The evolution.of the sp.ctra is shown.from.the in.tial p.Cygn. p.ase to an.em.ssion.lin. p.ase. The p.om.n.n. carbon.lin.s seen.in.the JHk.sp.ctra closely m.tch those observed in.an.Fe II class n.va outburst. The sp.ctra show first-overton. CO ban.s in.em.ssion.between.2.29-2.40 μm. By exam.n.n. WISE an. other p.blicly available data, we show that the n.va un.erwen. a p.on.un.ed dust form.tion.p.ase between.February- Ap.il 2010.

关键词： lin.: iden.ification.-- techn.ques: sp.ctroscop.c -- stars: in.ividual(V5584 Sgr) -- n.vae cataclysm.c variables

design.of a n.vel Exosk.leton.with p.ssive m.gn.tic Sp.in. Self-lock.n. an. Sp.n. Lateral Balan.in.

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Journ.l of Bion.c En.in.erin. 2024年第1期21卷 236-255页

作者： Jhon.F.Rodríguez-León.Betsy d.m.Chap.rro-Rico dan.ele Cafolla Fran.esco Lago Eduardo Castillo-Castañeda Giusep.e Carbon. Cen.ro de In.estigacion.en.Cien.ia Ap.icada y Tecn.logia Avan.ada Un.dad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico dep.rtm.n. of m.chan.cal Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly Faculty of Scien.e an. En.in.erin. Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This p.p.r p.op.ses a n.w up.er-lim. exosk.leton.to reduce work.r p.ysical *** p.op.sed design.is based on.a n.vel p.RRp.p.p.ism.tic;R-Revolute)k.n.m.tic chain.with 5 p.ssive degrees of Freedom.doF).Utilizin. a m.gn.tic sp.in.,the p.op.sed m.chan.sm.in.ludes a sp.cially design.d lock.n. m.chan.sm.that m.in.ain. an. desired task.*** p.op.sed exosk.leton.in.orp.rates a balan.in. m.chan.sm.to alleviate discom.ort an. sp.n.l torsion.l effects also help.n. in.lim. weight *** p.p.r rep.rts sp.cific m.dels an. sim.lation. to dem.n.trate the feasibility an. effectiven.ss of the p.op.sed *** exp.rim.n.al characterization.is p.rform.d to validate the p.rform.n.e of the m.chan.sm.in.term. of forces an. p.ysical strain.durin. a sp.cific ap.lication.con.istin. of ceilin.-surface drillin. *** obtain.d results p.elim.n.rily validate the en.in.erin. feasibility an. effectiven.ss of the p.op.sed exosk.leton.in.the in.en.ed op.ration.task.thereby requirin. the user to exert sign.fican.ly less force than.when.n.t wearin. it.

关键词： Assistive m.chan.sm Exosk.leton Lock.n. m.chan.sm Bion.c robot

Eviden.e for p.rticle acceleration.ap.roachin. p.V en.rgies in.the W51 com.lex

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Scien.e Bulletin 2024年第18期69卷 2833-2841页

作者： Cao, Zhen.Aharon.an. F. Axik.gu Bai, Y.X. Bao, Y.W. Bastieri, d. Bi, X.J. Bi, Y.J. Bian. W. Buk.vich, A.V. Cao, Q. Cao, W.Y. Cao, Zhe Chan., J. Chan., J.F. Chen. A.m. Chen. E.S. Chen. H.X. Chen. Lian. Chen. Lin.Chen. Lon. Chen. m.J. Chen. m.L. Chen. Q.H. Chen. S. Chen. S.H. Chen. S.Z. Chen. T.L. Chen. Y. Chen., n. Chen., Y.d. Cui, m.Y. Cui, S.W. Cui, X.H. Cui, Y.d. dai, B.Z. dai, H.L. dai, Z.G. dan.en.luobu don., X.Q. duan. k.k. Fan. J.H. Fan. Y.Z. Fan., J. Fan., J.H. Fan., k. Fen., C.F. Fen., H. Fen., L. Fen., S.H. Fen., X.T. Fen., Y. Fen., Y.L. Gabici, S. Gao, B. Gao, C.d. Gao, Q. Gao, W. Gao, W.k. Ge, m.m. Gen., L.S. Giacin.i, G. Gon., G.H. Gou, Q.B. Gu, m.H. Guo, F.L. Guo, X.L. Guo, Y.Q. Guo, Y.Y. Han. Y.A. Hasan. m. He, H.H. He, H.n. He, J.Y. He, Y. Hor, Y.k. Hou, B.W. Hou, C. Hou, X. Hu, H.B. Hu, Q. Hu, S.C. Huan., d.H. Huan., T.Q. Huan., W.J. Huan., X.T. Huan., X.Y. Huan., Y. Ji, X.L. Jia, H.Y. Jia, k. Jian., k. Jian., X.W. Jian., Z.J. Jin. m. k.n., m.m. k.rp.k.v, I. k.leshov, d. k.rin.v, k. Li, B.B. Li, C.m. Li, Chen. Li, Con. Li, d. Li, F. Li, H.B. Li, H.C. Li, Jian.Li, Jie Li, k. Li, S.d. Li, W.L. Li, X.R. Li, Xin.Li, Y.Z. Li, Zhe Li, Zhuo Lian., E.W. Lian., Y.F. Lin. S.J. Liu, B. Liu, C. Liu, d. Liu, d.B. Liu, H. Liu, H.d. Liu, J. Liu, J.L. Liu, m.Y. Liu, R.Y. Liu, S.m. Liu, W. Liu, Y. Liu, Y.n. Luo, Q. Luo, Y. Lv, H.k. m., B.Q. m., L.L. m., X.H. m.o, J.R. m.n. Z. m.tthum.iri, W. m., H.J. n.n. Y.C. n.ron.v, A. Ou, L.J. p.ttarak.jwan.ch, p. p.i, Z.Y. Qi, J.C. Qi, m.Y. Qiao, B.Q. Qin. J.J. Raza, A. Ruffolo, d. Sáiz, A. Saeed, m. Sem.k.z, d. Shao, L. Shchegolev, O. Shen., X.d. Shu, F.W. Son., H.C. Sten.in. Yu.V. Step.n.v, V. Su, Y. Sun. d.X. Sun. Q.n. Sun. X.n. Sun. Z.B. Tak.ta, J. Tam. p.H.T. k.y Laboratory of p.rticle Astrop.ysics & Exp.rim.n.al p.ysics division.& Com.utin. Cen.er Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Un.versity of Chin.se Academ. of Scien.es Beijing 100049 China TIAn.U Cosm.c Ray Research Cen.er Chengdu China dublin.In.titute for Advan.ed Studies 31 Fitzwilliam Place 2 Dublin Ireland m.x-p.an.k.In.titut for n.clear p.ysics P.O. Box 103980 Heidelberg 69029 Germany School of p.ysical Scien.e an. Techn.logy & School of In.orm.tion.Scien.e an. Techn.logy Southwest Jiaotong University Chengdu 610031 China School of Astron.m. an. Sp.ce Scien.e Nanjing University Nanjing 210023 China Cen.er for Astrop.ysics Guangzhou University Guangzhou 510006 China Tsun.-dao Lee In.titute & School of p.ysics an. Astron.m. Shanghai Jiao Tong University Shanghai 200240 China In.titute for n.clear Research of Russian.Academ. of Scien.es Moscow 117312 Russia Hebei n.rm.l Un.versity Shijiazhuang 050024 China Un.versity of Scien.e an. Techn.logy of Chin. Hefei 230026 China State k.y Laboratory of p.rticle detection.an. Electron.cs China k.y Laboratory of dark.m.tter an. Sp.ce Astron.m. & k.y Laboratory of Radio Astron.m. Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210023 China Research Cen.er for Astron.m.cal Com.utin. Zhejiang Laboratory Hangzhou 311121 China k.y Laboratory for Research in.Galaxies an. Cosm.logy Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China School of p.ysics an. Astron.m. Yunnan University Kunming 650091 China k.y Laboratory of Cosm.c Rays (Tibet Un.versity) Ministry of Education Lhasa 850000 China n.tion.l Astron.m.cal Observatories Chinese Academy of Sciences Beijing 100101 China School of p.ysics an. Astron.m. (Zhuhai) & School of p.ysics (Guan.zhou) & Sin.-Fren.h In.titute of n.clear En.in.erin. an. Techn.logy (Zhuhai) Sun Yat-sen University Zhuhai 519000 & Guangzhou 510275 Guangdong China In.titute of Fron.ier an.

The γ-ray em.ssion.from.the W51 com.lex is widely ack.1}wledged to be attributed to the in.eraction.between.the cosm.c rays (CRs) accelerated by the shock.of sup.rn.va rem.0}n. (Sn.) W51C an. the den.e m.lecular clouds in.the adjacen. star-form.n. region. W51B. However, the m.xim.m.acceleration.cap.bility of W51C for CRs rem.in. elusive. Based on.observation. con.ucted with the Large High Altitude Air Shower Observatory (LHAASO), we rep.rt a sign.fican. detection.of γ rays em.n.tin. from.the W51 com.lex, with en.rgies from.2 to 200 TeV. The LHAASO m.asurem.n.s, for the first tim., exten. the γ-ray em.ssion.from.the W51 com.lex beyon. 100 TeV an. reveal a sign.fican. sp.ctrum.ben.in. at ten. of TeV. By com.in.n. the "π0-decay bum." featured data from.Ferm.-LAT, the broadban. γ-ray sp.ctrum.of the W51 region.can.be well-characterized by a sim.le p.-collision.m.del. The observed sp.ctral ben.in. feature suggests an.exp.n.n.ial cutoff at ∼400 TeV or a p.wer-law break.at ∼200 TeV in.the CR p.oton.sp.ctrum. m.st lik.ly p.ovidin. the first eviden.e of Sn.s servin. as CR accelerators ap.roachin. the p.V regim.. Addition.lly, two youn. star clusters within.W51B could also be theoretically viable to p.oduce the m.st en.rgetic γ rays observed by LHAASO. Our fin.in.s stron.ly sup.ort the p.esen.e of extrem. CR accelerators within.the W51 com.lex an. p.ovide n.w in.ights in.o the origin.of Galactic CRs. © 2024 Scien.e Chin. p.ess

关键词： Cosm.c rays