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n.uroprotective effects of G9a in.ibition.through modul.tion.of peroxisome-prol.ferator activator receptor gamma-depen.en. pathways by miR-128

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n.ural.Regen.ration.Research 2024年第11期19卷 2532-2542页

作者： Ain. Bel.ver-San.his Pedro AAvil.-l.pez Iva Tic David Val.e-García Marta Ribal.a-Vil.l.a l.is l.brador Deb Ran.an.Ban.rjee An. Guerrero Gemma Casadesus Coral.e Poul.rd Mercè Pal.às Christian.Grin.n.Ferré Departmen. of Pharmacol.gy an. Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Departmen. of Biochemistry an. Mol.cul.r Gen.tics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA In.titute of Biotechn.l.gy National Autonomous University of MexicoCuernavacaMexico Departmen. of Pharmacol.gy an. Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Departmen. of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Can.er Research Can.er l.on Universitéde LyonLyonFrance In.erm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance Cn.S UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Cen.ro de In.estigación.en.Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain n.uroimmun.l.gy Departmen. National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregul.tion.of G9a,a histon.-l.sin. n.methyl.ran.ferase,has been.observed in.Al.heimer’s disease an. has been.correl.ted with in.reased l.vel. of chron.c in.l.mmation.an. oxidative ***,microRn.s are in.ol.ed in.man. biol.gical.processes an. diseases pl.yin. a key rol. in.pathogen.sis,especial.y in.mul.ifactorial.diseases such as Al.heimer’s ***,our aim has been.to provide partial.in.ights in.o the in.ercon.ection.between.G9a,microRn.s,oxidative stress,an. *** better un.erstan. the biol.gy of G9a,we compared the gl.bal.microRn. expression.between.sen.scen.e-accel.rated mouse-pron. 8(SAMP8)con.rol.mice an. SAMP8 treated with G9a in.ibitor *** foun. a down.egul.tion.of miR-128 after a G9a in.ibition.treatmen.,which in.erestin.l. bin.s to the 3′un.ran.l.ted region.3′-UTR)of peroxisome-prol.ferator activator receptor γ(PPARG)***,Pparg gen. expression.l.vel. were higher in.the SAMP8 group treated with G9a in.ibitor than.in.the SAMP8 con.rol.*** al.o observed modul.tion.of oxidative stress respon.es might be main.y driven.Pparg after G9a *** con.irm these an.ioxidan. effects,we treated primary n.uron.cel. cul.ures with hydrogen.peroxide as an.oxidative *** this settin.,treatmen. with G9a in.ibitor in.reases both cel. survival.an. an.ioxidan. ***,up-regul.tion.of PPARγby G9a in.ibitor coul. al.o in.rease the expression.of gen.s in.ol.ed in.Dn. damage respon.es an. *** addition.we al.o described that the PPARγ/AMPK axis partial.y expl.in. the regul.tion.of autophagy markers ***,PPARγ/GADD45αpoten.ial.y con.ributes to en.an.in. syn.ptic pl.sticity an. n.urogen.sis after G9a ***,we propose that pharmacol.gical.in.ibition.of G9a l.ads to a n.uroprotective effect that coul. be due,at l.ast in.part,by the modul.tion.of PPARγ-depen.en. pathways by miR-128.

关键词： agin. cogn.tive decl.n. epigen.tics G9a in.ibition microRn.s miR-128 peroxisome-prol.ferator activator receptorγ(PPARγ) PPARG SAMP8

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Metastatic pan.reatic an. l.n. can.er patien. in.compl.te remission.fol.owin. immun.therapy: A case report an. review of l.terature

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Worl. Journ.l.of Gastroin.estin.l.On.ol.gy 2024年第5期16卷 2233-2240页

作者： Joaquin. Martín.z-Gal.n.Cristin. Jimén.z-l.n. Isabel.Rodriguez El.sabeth Maza Carl.s García-Col.ado An.on.o Rodríguez-Fern.n.ez Javier l.is l.pez-Hidal.o Octavio Caba Departmen. of Medical.On.ol.gy Virgen de las Nieves University HospitalGranada 18014Spain In.tituto de In.estigación.Biosan.taria Ibs.GranadaGranada 18012Spain In.titute of Biopathol.gy an. Regen.rative Medicin.(IBIMER) University of GranadaGranada 18016Spain Pharmacogen.tics Un.t Virgen de las Nieves University HospitalGranada 18014Spain Departmen. of Medicin. n.cl.ar Virgen de las Nieves University HospitalGranada 18014Spain Departmen. of An.tomía Patol.gica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUn. Metastatic pan.reatic ductal.aden.carcin.ma(PDAC)is a l.thal.mal.gn.n.y with dispiritin. survival.*** is a promisin. approach to man. can.er types,but achieves poor outcomes in.advan.ed PDAC due to its immun.suppressive tumor *** describe a case of metastatic PDAC effectivel. treated with *** SUMMARY We report the case of a 67-year-ol. woman.with un.esectabl. l.cal.y advan.ed PDAC,treated with gemcitabin. pl.s n.b-pacl.taxel.fol.owed by radiotherapy pl.s *** n.n. mon.hs,pan.reatic tumor progression.was observed at the l.vel.of the hepatic hil.m with the appearan.e of a n.w pul.on.ry n.dul. suggestive of a secon. primary,con.irmed by l.ft l.n. *** immun.therapy was then.in.tiated with pembrol.zumab,an.immun. checkpoin. in.ibitor targetin. programmed cel. death protein.1 that covers the two tumor *** patien. showed a compl.te metabol.c respon.e that was main.ain.d throughout the *** patien. con.in.es to be disease-free at 5.6 years sin.e the start of *** These resul.s suggest that the admin.stration.of pembrol.zumab after chemoradiotherapy has a ben.ficial.effect in.patien.s with metastatic *** our kn.wl.dge,this is the first reported case of a patien. with metastatic PDAC an. metastatic l.n. can.er showin. such a l.n.-l.stin. compl.te respon.e after pembrol.zumab treatmen. without curative *** studies are required to determin. biomarkers that iden.ify PDAC patien.s most l.kel. to ben.fit from this immun.therapy.

关键词： Pan.reatic ductal.aden.carcin.ma l.n. can.er Immun.therapy Pembrol.zumab Programmed cel. death protein.1 Case report

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Mid-term survival.of the Optimys short stem: A prospective case series of 500 patien.s

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Worl. Journ.l.of Orthopedics 2024年第3期15卷 257-265页

作者： Bryan.Haman. Sheryl.de Waard Sjoerd Kaarsemaker Esther R C Jan.sen.In.er n.Sierevel. Gin. M M J Kerkhoffs Dan.ël.Haverkamp Departmen. of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands Departmen. of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Esther R C Jan.sen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands Cen.re for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Departmen. of Orthopaedic Surgery an. Sports Medicin. Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Departmen. of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BACKGROUn. In.recen. years,there has been.an.in.rease in.the n.mber of total.hip arthropl.sty procedures in.the youn.er patien. *** active group has higher expectation. of their prosthesis in.comparison.to the ol.er popul.tion.an. there is a greater physical.deman. for the *** femoral.stems were in.troduced to retain.proximal.bon. stock an. join. biomechan.cs an. became more common.to impl.n. in.this specific ***,the l.n.-term survival.an. fun.tion.l.outcomes of various short stems are stil. bein. in.estigated in.differen. *** To determin. the 5-year survival.of the Optimys hip *** This was a prospective mul.icen.er cohort study of 500 patien.s con.ucted in.two hospital. in.the *** patien.s received the Optimys short stem(Mathys l.d,Bettl.ch,Switzerl.n.).The primary outcome measure was survival.of the hip stem,with revision.as the *** secon.ary outcome measuremen.s in.l.ded patien.-reported outcome measures(PROMs).Kapl.n.Meier an.l.sis was used to cal.ul.te the 5-year survival.***-min.s-l.g tran.formation.was performed to cal.ul.te the 95%con.iden.e in.erval.95%CI).Mixed model.an.l.ses were performed to assess the course of the PROMs durin. the 1st 2 years after *** were model.d separatel. for the 1st an. 2n. years to cal.ul.te the yearl. chan.e in.PROMs durin. both fol.ow-up periods with accompan.in. 95%*** The mean.age of the total.500 patien.s was 62.3 years(stan.ard deviation.10.6)an. 202 were mal.(40%).At a median.fol.ow-up of 5.5 years(in.erquartil. ran.e:4.5-6.7),7 patien.s were deceased an. 6 revision. were registered,for in.ection.n.3),subsiden.e(n.2)an. mal.osition.n.1).This resul.ed in.an.overal. 5-year survival.of 98.8%(95%CI:97.3-99.5).If in.ection.was l.ft out as reason.for revision.a stem survival.of 99.4%(95%CI:98.1-99.8)was *** question.aires were compl.ted by 471 patien.s(94%),317 patien.s(63%)compl.ted the 1-year fol.ow-up question.a

关键词： Total.hip arthropl.sty Femoral.stem Short stem Optimys Survival 5-year survival Revision PROMs

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Aerosol.jet prin.in. of surface acoustic wave microfl.idic devices

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Microsystems & n.n.en.in.erin. 2024年第1期10卷 231-242页

作者： Joseph Rich Brian.Col. Ten. l. Bran.on.l. Han.u Fu Brittan. n.Smith Jian.in. Xia Shujie Yan. Ruoyu Zhon. James l.Doherty Kan.i Kan.ko Hiroaki Suzuki Zhen.ua Tian.Aaron.D.Fran.l.n.Ton. Jun.Huan. Departmen. of Biomedical.En.in.erin. Duke UniversityDurhamNC 27708USA Departmen. of El.ctrical.an. Computer En.in.erin. Duke UniversityDurhamNC 27708USA Departmen. of Mechan.cal.En.in.erin. Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas l.rd Departmen. of Mechan.cal.En.in.erin. an. Material. Scien.e Duke UniversityDurhamNC 27708USA Deptartmen. of Precision.Mechan.cs Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Departmen. of Chemistry Duke UniversityDurhamNC 27708USA

The addition.of surface acoustic wave(SAW)techn.l.gies to microfl.idics has greatl. advan.ed l.b-on.a-chip appl.cation. due to their un.que an. powerful.attributes,in.l.din. high-precision.man.pul.tion.versatil.ty,in.egrabil.ty,biocompatibil.ty,con.actl.ss n.ture,an. rapid ***,the devel.pmen. of SAW microfl.idic devices is l.mited by compl.x an. time-con.umin. micro/n.n.fabrication.techn.ques an. access to cl.an.oom facil.ties for mul.istep photol.thography an. vacuum-based *** simpl.fy the fabrication.of SAW microfl.idic devices with customizabl. dimen.ion. an. fun.tion.,we util.zed the additive man.facturin. techn.que of aerosol.jet *** successful.y fabricated customized SAW microfl.idic devices of varyin. material.,in.l.din. sil.er n.n.wires,graphen.,an. pol.(3,4-ethyl.n.dioxythiophen.)pol.styren. sul.on.te(PEDOT:PSS).To characterize an. compare the acoustic actuation.performan.e of these aerosol.jet prin.ed SAW microfl.idic devices with their cl.an.oom-fabricated coun.erparts,the wave displ.cemen.s an. reson.n. frequen.ies of the differen. fabricated devices were directl. measured through scan.in. l.ser Doppl.r ***,to exhibit the capabil.ty of the aerosol.jet prin.ed devices for l.b-on.a-chip appl.cation.,we successful.y con.ucted acoustic streamin. an. particl. con.en.ration.***,we demon.trated a n.vel.sol.tion.based,direct-write,sin.l.-step,cl.an.oom-free additive man.facturin. techn.que to rapidl. devel.p SAW microfl.idic devices that shows viabil.ty for appl.cation. in.the fiel.s of biol.gy,chemistry,en.in.erin.,an. medicin..

关键词： prin.in. wave fl.id

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l.gume Green.Man.re an. In.ercroppin. for High Biomass Sorghum Production

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Agricul.ural.Scien.es 2024年第6期15卷 605-621页

作者： Cl.rk B. n.el. Fran.is M. Rouquette Jr. Cristin. l. S. Morgan.Fran. M. Hon. Wil.iam l. Roon.y Geral. R. Smith Departmen. of Soil.an. Crop Scien.e Washington State University Pullman WA USA Texas A&M Agril.fe Research Overton TX USA Soil.Heal.h In.titute Morrisville NC USA Departmen. of Soil.an. Crop Scien.e Texas A&M University College Station TX USA

Before the adven. of cheap, syn.hetic fertil.zers, l.gumes were common.y used as green.man.re crops for their abil.ty to fix atmospheric n.trogen.(n.. A three-year study at Overton. TX examin.d l.gume in.egration.in.o high-biomass sorghum (Sorghum bicol.r l.) production.systems on.a l.l.ert l.amy fin. san. recen.l. cul.ivated after a fertil.zed bermudagrass [Cyn.don.dactyl.n.(l.) Pers.] pasture. In.this spl.t-spl.t pl.t design. ‘Dixie’ crimson.cl.ver (Trifol.um in.arn.tum l.) an. ‘Iron.an. Cl.y’ cowpea (Vign. un.uicul.ta l.) were in.egrated in.o a high-biomass sorghum production.system to eval.ate impacts on.n.con.en.ration. C con.en.ration. an. yiel. of high-biomass sorghum an. their impacts on.soil.total.n.an. soil.organ.c carbon.(SOC). Main.pl.ts were spl.t in.o crimson.cl.ver green.man.re (Cl.M) an. win.er fal.ow (FAl.) fol.owed by three sub-pl.ts spl.t in.o warm-season.crop rotation.: cowpea green.man.re (CPGM), cowpea-sorghum in.ercrop (CPSR), an. sorghum mon.crop (SORG). Three n.fertil.zer treatmen.s (0, 45, 90 kg n.ha−1) were ran.omized an. appl.ed as sub-sub pl.ts. The Cl.M in.reased (P sorghum biomass yiel. (16.5 t DM∙ha−1) 28% in.year three but had n. effect in.the first two years. The CPSR treatmen. reduced sorghum yiel. up to 62% compared to SORG;whereas CPGM in.reased sorghum yiel. 56% an. 18% the two years fol.owin. cowpea in.orporation. Rate of n.fertil.zer had n. effect on.sorghum biomass yiel.. Decrease in.SOC an. soil.n.over time in.icated min.ral.zation.of organ.c n.an. may expl.in.why n. n.fertil.zer respon.e was observed in.sorghum biomass yiel.. Cowpea showed stron. poten.ial.as a green.man.re crop but proved to be too competitive for successful.in.ercroppin. in.high-biomass sorghum production.systems.

关键词： High-Biomass Sorghum l.gumes Green.Man.re In.ercrop Cowpea Crimson.Cl.ver Soil.Organ.c Carbon Soil.n.trogen

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Measuremen. of yiel.s an. an.ul.r distribution. ofγ-quan.a from the in.eraction.of 14.1 MeV n.utron. with oxygen.phosphorus,an. sul.ur

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Chin.se Physics C 2024年第3期48卷 79-92页

作者： D.n.Grozdan.v n.A.Fedorov S.B.Dabyl.va Yu.n.Kopatch I.n.Ruskov V.R.Skoy T.Yu.Tretyakova C.Hramco P.I.Kharl.mov G.V.Pampushik P.G.Fil.n.hik A.V.An.reev Join. In.titute for n.cl.ar Research(JIn.) DubnaRussia In.titute for n.cl.ar Research an. n.cl.ar En.rgy Bulgarian Academy of SciencesSofiaBulgaria Facul.y of Physics Lomonosov Moscow State UniversityMoscowRussia l.n.Gumil.ov Eurasian.n.tion.l.Un.versity AstanaKazakhstan Skobel.syn.In.titute of n.cl.ar Physics Moscow State UniversityMoscowRussia In.titute of Chemistry of Mol.ova ChisinauRepublic of Moldova Moscow In.titute of Physics an. Techn.l.gy MoscowRussia

A study of the in.l.stic scatterin. of n.utron. with an.en.rgy of 14.1 MeV on.the n.cl.i of oxygen.phosphorus,an. sul.ur was performed at the TAn.RA facil.ty at JIn.(Dubn.).The experimen. aimed to refin. existin. data an. obtain.n.w data on.the yiel.s an. an.ul.r distribution. ofγ-quan.a emitted by the studied n.cl.i due to n.utron.in.uced n.cl.ar reaction. usin. the tagged n.utron.*** types of detector systems were used to registerγ-***γ-ray yiel.s were measured usin. a high-purity german.um(HPGe)*** an.ul.r distribution. ofγ-rays were obtain.d usin. a system of 18 scin.il.ation.detectors based on.bismuth german.te Bi_(4)Ge_(3)O_(12)(BGO)l.cated aroun. the *** performed experimen.s measured the yiel.s of two tran.ition. for the reaction.of tagged n.utron. with 16O,n.n. tran.ition. for the reaction.with ^(31)P,an. n.n. tran.ition. for the reaction.with ^(32)S for the first *** an.ul.r an.sotropy of theγ-radiation.accompan.in. the in.l.stic scatterin. of n.utron. with an.en.rgy of 14.1 MeV on.^(31)P n.cl.i was al.o measured for the first time.

关键词： tagged n.utron.method yiel.s of gamma-quan.a high-resol.tion.gamma-spectrometry n.utron.n.cl.ar reaction. n.utron.scatterin.

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Hopf-fl.p bifurcation.of high dimen.ion.l.maps an. appl.cation.to vibro-impact systems

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Acta Mechan.ca Sin.ca 2005年第4期21卷 402-410页

作者： Jian.ua Xie Wan.cai Din. E.H. Dowel. l. n. Virgin Departmen. of Appl.ed Mechan.cs an. En.in.erin. Southwest Jiaotong University Chengdu 610031 China School.of Mechan.cal.En.in.erin. Lanzhou Jiaotong UniversityLanzhou 730070 China School.of En.in.erin..Duke Un.versity. Durham NC27708-0300USA

This paper addresses the probl.m of Hopf-fl.p bifurcation.of high dimen.ion.l.maps. Usin. the cen.er man.fol. theorem, we obtain.a three dimen.ion.l.reduced map through the projection.techn.que. The reduced map is further tran.formed in.o its n.rmal.form whose coefficien.s are determin.d by that of the origin.l.system. The dyn.mics of the map n.ar the Hopf-fl.p bifurcation.poin. is approximated by a so cal.ed “time-2τ^2 map” of a pl.n.r auton.mous differen.ial.equation. It is shown.that high dimen.ion.l.maps may resul. in.cycl.s of period two, tori T^1 （Hopf in.arian. circl.s）, tori 2T^1 an. tori 2T^2 depen.in. both on.how the critical.eigen.al.es pass the un.t circl. an. on.the sign. of reson.n. terms＇ coefficien.s. A two-degree-of-freedom vibro-impact system is given.as an.exampl. to show how the procedure of this paper works. It reveal. that through Hopf-fl.p bifurcation., periodic motion. may l.ad directl. to differen. types of motion. such as subharmon.c motion., quasi-periodic motion., motion. on.high dimen.ion.l.tori an. even.to chaotic motion. depen.in. both on.chan.e in.direction.of the parameter vector an. on.the n.n.in.ar terms of the first three orders.

关键词： Maps Vibro-impact dyn.mics Hopf-fl.p bifurcation Torus Chaos

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Risk Factors Associated with Un.uccessful.Vagin.l.Birth after On. Cesarean.(VBAC-1) in.Puerto Rico

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Open.Journ.l.of Obstetrics an. Gyn.col.gy 2024年第6期14卷 888-902页

作者： Irazú Guin.n.Marjorie Suárez Fabiol. An.ul. l.is Mayol.Paul. Suárez l.san.ris Domin.cci n.thal.e Chan. Saribel.Torres An.on.o Rodríguez Raymon. l. Trembl.y Maricarmen.Col.n.Díaz Departmen. of Physiol.gy an. Pathol.gy San Juan Bautista School of Medicine Caguas USA

Backgroun.: Cesarean.section.(CS) has in.reased steadil. over the l.st decade, with an.estimated on.-third of women.del.verin. by cesarean.section.worl.wide. Objective: Our study aimed to in.estigate the demographic an. associated factors in.l.en.in. vagin.l.birth after on. cesarean.(VBAC-1) success focusin. on.variabl.s l.ke pre-pregn.n.y BMI, diabetes, hyperten.ion. education. an. smokin.. Study Design.an. Methods: In.this retrospective study, we an.l.zed 285 cases (81 un.uccessful.VBAC-1, 204 successful.VBAC-1) from San.Juan.City Hospital.(Puerto Rico) between.Jan.ary 1, 2019, an. December 31, 2020. We used odds ratios an. model.sel.ction.comparison.to assess the impact of variabl.s on.successful.VBAC-1, usin. a sign.fican.e threshol. of 95% CI. Model.sel.ction.assessed bin.mial.model.combin.tion. usin. a gen.ral.zed l.n.ar approach to iden.ify key risk factors. Resul.s: Un.uccessful.VBAC-1 (a repeat cesarean., was associated with diabetes (OR: 0.376, p = 0.086), hyperten.ion.(OR: 0.23, p = 0.006), an. un.versity-educated women.(OR: 1.372, p = 0.711). High school.educated women.had an.OR of 3.966 (p = 0.105), whil. overweight women.were 0.481 times more l.kel. to have un.uccessful.VBAC-1 (p = 0.041). Sign.fican. association. were n.t foun. with obesity (OR: 0.574, p = 0.122), un.erweight/n.rmal.(OR: 1.01, p = 0.810), or smokin. (OR: 1.227, p = 0.990). Con.l.sion. Resul.s reveal.d women.with higher education.l.vel., hyperten.ion. or diabetes are l.ss l.kel. to have a successful.VBAC-1. Un.erstan.in. the compl.x in.eraction. affectin. these outcomes is aimed at establ.shin. guidel.n.s for heal.hcare profession.l. to con.uct systematic risk/ben.fit assessmen.s. This study l.ys a foun.ation.for eviden.e-based practices an. pol.cies, offerin. in.tial.in.ights in.o VBAC-1 success factors in.Puerto Rico.

关键词： Diabetes Hyperten.ion Obesity Trial.of l.bor Vagin.l.Birth after Cesarean

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Improved An.l.tical.Methods for Determin.tion.of Residues of n.trapyrin.an. 6-Chl.ropicol.n.c Acid in.Differen. Crop Matrices by l.quid Chromatography-Tan.em Mass Spectrometry

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Journ.l.of Agricul.ural.Chemistry an. En.iron.en. 2024年第3期13卷 263-281页

作者： Fabiol. G. Zun.-Fl.rian. Riza l. Reyes-Pun.n.bayan.Matt J. Hen.el Departmen. of En.iron.en.al.Toxicol.gy University of California Davis California USA

n.vel.an.l.tical.methods were devel.ped for the determin.tion.of n.trapyrin.an. 6-chl.ropicol.n.c acid (6-CPA) residues in.agricul.ural.products. n.trapyrin.was extracted with hexan.: tol.en. (1:1, v/v) an. 6-CPA with 0.1 n.sodium hydroxide (n.OH). For n.trapyrin. sampl.s were cl.an.d with sil.ca sol.d phase extraction.(SPE) an. for 6-CPA with C18 or carbon.SPE. An.l.sis was performed by l.quid chromatography-tan.em mass spectroscopy (l.-MS/MS) with extern.l.cal.bration.(0.010 to 0.0010 µg∙ml.1 for n.trapyrin.an. 0.0050 to 0.00025 µg∙ml.1 for 6-CPA). Recoveries for n.trapyrin.an. 6-CPA were 68% - 102% an. 66% - 90%, respectivel.. n.trapyrin.was detected in.cel.ry an. on.on.(−1) an. 6-CPA in.on.on. mustard green. an. l.ttuce (−1). l.wer l.vel.method val.dation.(l.MV) for n.trapyrin.an. 6-CPA was 0.020 µg∙g−1 an. 0.050 µg∙g−1, respectivel.. The methods presen.ed in.this study are robust an. were util.zed for the registration.of n.trapyrin.on.agricul.ural.commodities in.the Un.ted States.

关键词： Herbicide Agricul.ural.Products Extern.l.Cal.bration l.-MS/MS Registration

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Determin.tion.of the stan.ardized il.al.digestibl. cal.ium requiremen. of Ross broil.rs from hatch to day 14 post-hatch

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An.mal.n.trition 2024年第1期16卷 122-129页

作者： Carrie l.Wal. Raffael.a Aurel. Paul.n. Jen. DSM n.trition.l.Products Delves RoadHeanorDerbyshireDE757SGUnited Kingdom Research Cen.er for An.mal.n.trition.an. Heal.h DSM Nutritional ProductsVillage-Neuf68128France

An.experimen. was con.ucted to determin. the stan.ardized il.al.digestibl.(SID)cal.ium requiremen. of fast-growin. broil.rs from hatch to d 14 *** 308(n.360)mal. broil.rs were obtain.d on.day of hatch an. al.ocated to 1 of 5 treatmen.s in.battery *** were 6 birds per cage an. 12 pen. per *** treatmen.s were formul.ted to con.ain.0.60%,0.46%,0.32%or 0.18%SID *** fin.l.treatmen. was formul.ted usin. total.Ca to meet or exceed al. n.trien. requiremen.s,in.l.din. 0.90%total.Ca an. 0.49%n.n.phytate P(n.P),usin. the same *** treatmen. was the referen.e diet for comparison.an. val.dation.of the SID Ca *** an. feed were weighed at pl.cemen. an. on.d *** an. il.al.con.en.s were obtain.d on.d 14 an. excreta was col.ected per pen.an. pool.d on.d *** were an.l.zed usin. JMP Pro an. requiremen.s were estimated usin. 3differen. n.n.l.n.ar regression.*** the SID Ca con.en. in.the diet from 0.18%to 0.60%improved(quadratic,Pn.an. mortal.ty corrected feed con.ersion.ratio(mFCR).The estimated SID Ca requiremen. to optimize gain.or m FCR was between.0.39%an. 0.52%.Tibia ash percen. an. weight in.reased(quadratic,Pn.en. in.the diet in.reased an. the estimated SID Ca requiremen. was between.0.32%an. 0.58%.Phosphorus util.zation.was improved in.birds fed diets formul.ted usin. SID Ca compared with birds fed the referen.e *** con.l.sion.the SID Ca requiremen. of fast-growin. broil.rs from hatch to d 14 was estimated between.0.534%an. 0.398%when.quadratic,straight-broken.l.n.,or quadratic-broken.l.n. regression. were *** resul.s agree with previousl. publ.shed data eval.atin. the SID Ca requiremen. of fast-growth broil.rs from hatch to d 10.

关键词： Apparen. il.al.digestibil.ty Digestibl. cal.ium Requiremen.s Reten.ion Tibia ash

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