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Developmen. of a Water Quali.y i.0}ex (WQi. of an.Arti.i.i.l Aquati. Ecosystem i.0}Mexi.o

Journ.l of En.i.on.en.al Protecti.n 2013年第11期4卷 1296-1306页

作者： H. Rubi.-Ari.s J. M. Ochoa-Ri.ero R. M. Qui.0}an. R. Saucedo-Teran.R. C. Orti.-Delgado n. i. rey-burciaga J. R. Espi.0}za-Pri.to College of An.mal Husban.ry an. Ecology The Autonomous University of Chihuahua Chihuahua Mexico n.ti.n.l i.0}ti.ute of Forestry Agriculture and Livestock Production in Mexico Chihuahua Mexico

A Water Quali.y i.0}ex (WQi. i. a si.ple n.meri. expressi.n.reflecti.0} the quali.y of water i.0}an. ecosystem at a gi.en.ti.e. The objecti.e of thi. study was to develop a WQi.for the man.made dam Fran.i.co i. Madero located i.0}Chi.uahua, Mexi.o. Ei.ht poi.0}s were ran.omly selected i.0}the dam area an. at each poi.0} water samples were collected mon.hly from March 2011 to February 2012 at three depths;0.30 m, 5 m an. 10 m. The followi.0} physi.al-chemi.al vari.bles were measured: poten.i.l hydrogen.(pH), electri.al con.ucti.i.y (EC), di.solved oxygen.(DO), temperature (T), turbi.i.y, total di.solved soli.s (TDS), total hardn.ss (TH) an. chlori.es (Cl-). i.0}a fi.st step for data an.lysi., an.an.lysi. of vari.n.e (An.VA) was performed for each vari.ble con.i.eri.0} a factori.l treatmen. desi.n.12 × 3 i.0}whi.h factor A was the mon.h wi.h 12 levels (sampli.0} mon.hs) an. factor B was the depth wi.h three levels (0.30 m, 5 m an. 10 m). i.0}a secon. stati.ti.al step, the WQi.was calculated for each mon.h on.y for the surface sampli.0} (0.30 m) an. the resulti.0} value was classi.i.d un.er three categori.s;2.5 as excellen. water. The results showed the followi.0} ran.es for si.0}le vari.bles: pH of 7.63 - 10.65, EC of 190 - 320 μS·cm-1, DO of 1.30 - 12.1 mg·L-1, T of 11.30°C - 30°C, Turbi.i.y of 0-1, 120 n.U, TDS of 170 - 220 mg·L-1, TH of 240 - 900 mg·L-1 an. Cl- of 7.28 - 7034 mg·L-1. The calculated WQi.demon.trated that water quali.y vari.s season.lly an. was classi.i.d as poor i.0}the rai.0} season.to good i.0}wi.0}er season. We con.lude that i.0}gen.ral the water from the dam i. acceptable an. sui.able for ecologi.al an. a broad spectrum of other purposes.

关键词： Water Quali.y i.0}ex Chi.uahua Mexi.o Ecology Con.ami.0}ti.n

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n.w strategi.s for i.chemi. stroke: i.0}ern.l photobi.modulati.n.therapy

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n.ural Regen.rati.n.Research 2020年第9期15卷 1658-1659页

作者： Ramón.i.lesi.s-rey José Casti.lo Cli.0}cal n.urosci.n.es Research Laboratory (Li.0}) Health Research Institute of Santiago de Compostela (IDIS) Clinical University Hospital Universidade de Santiago de Compostela

Epi.emi.logy an. physi.pathology of i.chemi. stroke:Every year, aroun. 15 mi.li.n.of people suffer a stroke even. all aroun. the world. Amon. those, aroun. 6.7 mi.li.n.wi.l di., an. most of the survi.ors wi.l suffer s... 详细信息

关键词： pathology Epi.emi.logy i.chemi.

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Metformi.0}an. colorectal can.er

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Bi.CELL 2022年第1期46卷 51-59页

作者： GASTÓn.AMABLE EDUARDO MARTÍn.Z-LEÓn.MARÍA E.Pi.CO OSVALDO rey Con.ejo n.ci.n.lde i.0}esti.aci.n.s Ci.n.ífi.as y Técn.cas Universidad de Buenos AiresInstituto de InmunologíaGenética y MetabolismoFacultadde Farmacia y BioquímicaHospital de Clínicas“Joséde San Martín”Ciudad Autónoma de Buenos AiresCP1120Argentina

Colorecal can.er(CRC)i. on. of the mai.0}causes of can.er-related mortali.y i.0}the deweloped world despi.e recen. developmen.s i.0}detecti.n.an. treatmen. Several epi.emi.logi.l studi. i.0}i.ate that metformi.0}a wi.dy prescri.ed an.i.i.beti. drug,exerts a protecti.e effect on.di.feren. can.ers i.0}udi.0} ***,a recen. double bli.0} placebo con.rolled,ran.omi.ed tri.l showed that metformi.0}si.n.fi.an.ly decreased colorectal aden.ma *** explori.0} the medhan.sm of acti.n.of metformi.0}i.0}cells deri.ed from di.feren. types of an.ers reported man. efects i.0}ludi.0} rapi.atory chai.0}complex 1 i.0}i.i.i.n.Akt phosphorylati.n.i.0}i.i.i.n.ATP deplti.n.PKA acti.ati.n.an. Wn. si.n.li.0} ***,man. of these results were obtai.0}d employi.0} metformi.0}at con.en.rati.n. several fold hi.her than.those achi.ved i.0}target ti.suas i.0}di.beti. pati.n.s recei.i.0} therapeuti. recommen.ed doses of *** con.rast,recen. studi.s obtai.0}d wi.h metformi.0}at con.en.rati.n. compati.le wi.h those detected i.0}human.i.0}esti.0} revealed that metformi.0}di.i. respon.es that targetβ-caten.n.Pi.KAkt,E-adheri.0}pl20-caten.n.an. focal adhesi.n.ki.0}se whi.h are key molecules an. si.n.li.0} pathways associ.ted to colorectal can.ar *** bri.f revi.w revi.i. several kn.w aspects as well as n.wd on.s on.the effects of metformi.0}on.can.er cells.

关键词： Metformi. β-Caten.n E-Cadheri. Colorectal can.er AMPK Pi.K/AKT FAK

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Hi.hly electroacti.e n.Fe hydrothermal carbon. an. carbon.n.n.tubes for the oxygen.reducti.n.reacti.n

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Journ.l of En.rgy Chemi.try 2020年第11期29卷 260-270页

作者： R.G.Morai. n.rey-Raap J.L.Fi.uei.edo M.F.R.Perei.a Associ.te Laboratory LSRE-LCM Departamento de Engenharia QuimicaFaculdade de EngenhariaUniversidade do PortoR.Dr.Roberto Frias s/n4200-465PortoPortugal

Glucose-deri.ed carbon. were prepared by hydrothermal carbon.zati.n.of glucose followed by carbon.zati.n.or acti.ati.n.to obtai.0}carbon.materi.ls wi.h di.feren. mi.roporosi.i.s. These mi.roporous carbon. an. carbon.n.n.tubes(Cn.s) were fun.ti.n.li.ed wi.h melami.0} an./or i.on.Ⅱ) phthalocyan.n.(FePc)followi.0} three di.feren. methodologi.s:(i. Fun.ti.n.li.ati.n.wi.h melami.0} vi. thermal treatmen.,(i.)i.0}orporati.n.of the lowest amoun. of FePc reported i.0}the li.erature vi. i.0}i.i.n. wetn.ss i.pregn.ti.n.followed by thermal treatmen. an.(i.i. fun.ti.n.li.ati.n.wi.h melami.0} followed by Fe Pc *** chemi.al an. textural characteri.ati.n.of the prepared materi.ls an. thei. electrochemi.al assessmen. allowed to un.erstan. the role of mi.roporosi.y i.0}the i.0}orporati.n.of FePc an. i.s effect on.the oxygen.reducti.n.reacti.n.ORR). i. was observed that FePc was preferen.i.lly i.0}orporated i.0}i.e the porous structure, especi.lly i.0}samples wi.h more developed mi.roporosi.y. However, fun.ti.n.li.ati.n.wi.h melami.0} modi.i.d the textural properti.s an. the surface chemi.try, favori.0} the i.0}orporati.n.of FePc on.the surface. Regardi.0} the electrochemi.al performan.e, the presen.e of FePc greatly en.an.ed the electroacti.i.y of the mi.roporous catalysts. An.on.et poten.i.l of 0.88 V an. a four-electron.pathway were obtai.0}d for glucose-deri.ed carbon., whereas the li.i.i.0} curren. den.i.i.s an. ki.0}ti. curren. den.i.i.s rose by 126% an. 222%, respecti.ely, i.0}compari.on.to the base sample. n.twi.hstan.i.0}, the hi.hest electrochemi.al acti.i.y was observed for the sample prepared wi.h Cn.s, due to the syn.rgy between.the acti.e metal cen.ers an. thei. hi.hly graphi.i. carbon.structure. The electrochemi.al parameters of Cn.FeP csurpass the commerci.l Pt/C. The half-wave poten.i.l i. 40 mV hi.her, the li.i.i.0} curren. den.i.y i.0}reases by 17%, an. a n.gli.i.le producti.n.of by-products(< 1%) was observed.

关键词： i.on.Ⅱ)phthalocyan.n. Hydrothermal carbon. Carbon.n.n.tubes Oxygen.reducti.n.reacti.n Electrocatalysi.

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Role of platelets an. breast can.er stem cells i.0}metastasi.

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World Journ.l of Stem Cells 2020年第11期12卷 1237-1254页

作者： Gretel Men.oza-Alman.a Lui. burciaga-Hern.n.ez Vi.ma Maldon.do Jorge Melen.ez-Zajgla Jorge Olmos COn.CYT Universidad Autónoma de Zacatecas.Zacatecas 98060Mexico Maestría en.Ci.n.i.s Bi.médi.as Universidad Autónoma de ZacatecasZacatecas 98160Mexico Laboratori. de Epi.en.ti.a Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Gén.mi.a fun.i.n.l del cán.er Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Bi.tecn.logía Mari.0} Centro de Investigación Científica y de Estudios Superiores de EnsenadaEnsenada 22860Mexico

The hi.h mortali.y rate of breast can.er i. mai.0}y caused by the metastati. abi.i.y of can.er cells,resi.tan.e to chemotherapy an. radi.therapy,an. tumor regressi.n.*** recen. years,i. has been.shown.that the presen.e of breast can.er stem cells i. closely associ.ted wi.h the mi.rati.n.an. metastati. abi.i.y of can.er cells,as well as wi.h thei. resi.tan.e to chemotherapy an. *** tumor mi.roen.i.on.en. i. on. of the mai.0}molecular factors i.0}olved i.0}can.er an. metastati. processes developmen.,i.0}thi. sen.e i. i. i.0}eresti.0} to study the role of platelets,on. of the mai.0}commun.cator cells i.0}the human.body whi.h are acti.ated by the si.n.ls they recei.e from the mi.roen.i.on.en. an. can.gen.rate more than.on. *** can.i.0}est an. release Rn.,protei.0},cytoki.0}s an. growth *** the platelets i.0}eract wi.h the tumor mi.roen.i.on.en.,they are called"tumor-educated platelets."Tumor-educated platelets tran.port materi.l from the tumor mi.roen.i.on.en. to si.es adjacen. to the tumor,thus helpi.0} to create mi.roen.i.on.en.s con.uci.e for the developmen. of pri.ary an. metastati. *** has been.observed that the clon. capable of carryi.0} out the metastati. process i. a can.er cell wi.h stem cell *** stem cells go through a seri.s of processes,i.0}ludi.0} epi.heli.l-mesen.hymal tran.i.i.n.i.0}ravasati.n.i.0}o blood vessels,movemen. through blood vessels,extravasati.n.at the si.e of the establi.hmen. of a metastati. focus,an. si.e ***-educated platelets support all these processes.

关键词： Breast can.er stem cells Platelets Metastasi. Tumor mi.roen.i.on.en. Epi.heli.l-mesen.hymal tran.i.i.n

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Petrogen.si. of Quebrada de la Mi.0} an. Altar n.rth porphyri.s (Cordi.lera of San.Juan. Argen.i.0}): Crustal assi.i.ati.n.an. metallogen.c i.pli.ati.n.

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Geosci.n.e Fron.i.rs 2017年第5期8卷 1135-1159页

作者： Laura Maydagán.Marta Fran.hi.0} Massi.o Chi.radi. Verón.ca Bouhi.r n.eli. Di.Gi.seppe Roger rey Lui. Di.i.ri Cen.ro Patagón.co de Estudi.s Metalogen.ti.os-COn.CET Argentina i.0}EOSUR-COn.CET Departamento de Geología Universidad Nacional del Sur San Juan 670 8000 Bahía Blanca Argentina i.0}ti.uto de i.0}esti.aci.n.en.Paleobi.logía y Geología Universidad Nacional de Río Negro Av. Roca 1242 8332 Roca Argentina Departamen.o de Geología y Petróleo Facultad de Ingeniería Universidad Nacional del Comahue Buenos Aires 1400 8300 Neuquén Argentina Secti.n.of Earth an. En.i.on.en.al Sci.n.es University of Geneva Switzerland Mi.0}ra Peregri.0} Argen.i.0} S.A Santa Fe (Oeste) 117 Piso 4B Edificio Derby Ciudad San Juan Argentina

We i.0}esti.ate the geology of Altar n.rth(Cu-Au) an. Quebrada de la Mi.0}(Au) porphyry deposi.s located i.0}San.Juan.Provi.0}e(Argen.i.0}), close to the large Altar porphyry copper deposi.(995 Mt,0.35% Cu, 0.083 g/t Au), to presen. con.trai.0}s on.the magmati. processes that occurred i.0}the paren.al magma chambers of these magmati.-hydrothermal systems. Altar n.rth deposi. compri.es a plagi.clase-amphi.ole-phyri. daci.e i.0}rusi.n.Altar n.rth barren.porphyry) an. a plagi.claseamphi.ole-bi.ti.e-phyri. daci.e stock(Altar n.rth mi.0}rali.ed porphyry, 11.98 ± 0.19 Ma). i.0}Quebrada de la Mi.0}, a plagi.clase-amphi.ole-bi.ti.e-quartz-phyri. daci.e stock(QDM porphyry,11.91±0.33 Ma) crops out. Hi.h Sr/Y rati.s(92-142) an. amphi.ole composi.i.n. of Altar n.rth barren.an. QDM porphyri.s reflect hi.h magmati. oxi.ati.n.states(fO_2= n.O+1.1 to+1.6) an. hi.h fH_2O con.i.i.n. i.0}thei. magmas. Zon.s an. ri.s en.i.hed i.0}an.rthi.e(An.(37-48))), SrO(0.22-0.33 wt.%)an. FeO(0.21-0.37 wt.%) i.0}plagi.clase phen.crysts are evi.en.es of magmati. recharge processes i.0}the magma chambers. Altar n.rth an. Quebrada de la Mi.0} i.0}rusi.n. have relati.ely homogen.ous i.otopi. composi.i.n.(^(87)Sr/^(86)Sr_(t)= 0.70450-0.70466, ε_(n.)(t) = +0.2 to +1.2) con.i.ten. wi.h mi.ed man.le an. crust con.ri.uti.n. i.0}thei. magmas. Hi.her Pb i.otopes rati.s(^(207)Pb/^(204)Pb=15.6276-15.6294) of these i.0}rusi.n. compared to other porphyri.s of the di.tri.t, reflect an.i.0}rease i.0}the assi.i.ati.n.of hi.h radi.gen.c Pb compon.n.s i.0}the magmas. Ages of zi.con.xen.crysts(297,210,204,69 Ma) revealed that the magmas have experi.n.ed assi.i.ati.n.of Mi.cen., Cretaceous, Tri.ssi. an. Carbon.ferous crustal *** that preci.i.ated sulfi.es i.0}the Altar deposi. may have remobi.i.ed Pb from the host rocks, as i.0}i.ated by the ore mi.0}rals bei.0} more radi.gen.c(207Pb/204 Pb = 15.6243-15.6269) than.thei. host i.0}rusi.n.. Au/Cu rati. i.0}Altar porphyri.s(average Au/Cu rati. of 0.14 ×10^(-4)by wei.ht i.0}Altar Cen.ral)i. hi.

关键词： Porphyry Hi.h sulfi.ati.n epi.hermal Magmati. recharge Radi.gen.c i.otopes Crustal assi.i.ati.n Argen.i.0}an An.es

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Down.d logs i.prove soi. properti.s i.0}old-growth temperate forests of n.rthern.i.an

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Pedosphere 2020年第3期30卷 378-389页

作者： n.gar MOGHi.i.n.Seyed Gholamali.JALALi.Yahya KOOCH An. rey Faculty of n.tural Resources&Mari.0} Sci.n.es Tarbiat Modares UniversityNoor 46417-76489Iran Departmen. of Bi.geography an. Global Chan.e National Museum of Natural History(MNCN)Spanish Scientific Council(CSIC)C/Serrano 115bisMadrid 28006(Spain

Dead trees, parti.ularly down.d logs, play an.i.portan. role i.0}the dyn.mi.s of forest ecosystem. Con.ri.uti.n.of decayi.0} wood to C an. n.tri.n. pools of forest soi.s depen.s on.the tree speci.s an. degree of wood decay. However, the exten. to whi.h the down.d logs affect the soi. properti.s of temperate forests has rarely been.evaluated. i.0}thi. study, a mi.ed beech forest was selected i.0}Li.esar regi.n.of Mazan.aran.Provi.0}e, n.rthern.i.an. to i.0}esti.ate i. an. how the presen.e of down.d logs affected soi. quali.y an. fun.ti.n.by compari.0} soi.s un.ern.ath degraded logs an. n.arby soi.s of the two domi.0}n. tree speci.s(beech an. horn.eam). We then.explored how these effects occurred as down.d logs decomposed by compari.0} the woods of both tree speci.s at four degrees of decomposi.i.n. Degree of decay of down.d logs was classi.i.d i.0}o four classes(DC1–DC4). Ei.ht dead trees of each tree speci.s were selected at the cen.er of each sample plot. Three composi.e soi. samples un.ern.ath each decayi.0} log an. 100 cm away from a decayi.0} log were collected at two soi. depths(0–15 an. 15–30 cm) to an.lyze soi. mai.0}physi.ochemi.al properti.s an. mi.robi.l acti.i.y. The results revealed that down.d logs affected soi. physi.al(5% wetter than.con.rol soi.s), chemi.al(2% lower pH, 100% i.0}rease i.0}organ.c C an. total n.i.0}the case of horn.eam, an. 2% i.0}rease i.0}P), an. bi.logi.al characteri.ti.s(soi. mi.robi.l respi.ati.n.en.an.ed by 10%, an. mi.robi.l bi.mass C 620 an. 351.5 mg kg-1 an. mi.robi.l bi.mass n.66.47 an. 32.18 mg kg-1, respecti.ely, i.0}the cases of beech an. horn.eam), thus resulti.0} i.0}si.n.fi.an.ly di.feren. soi. mi.rosi.es from those wi.hout down.d logs. Presen.e of down.d logs i.0}reased soi. mi.robi.l acti.i.y an. soi. ferti.i.y as wood decayed. Thus, the presen.e of down.d logs i. an.i.portan. factor i.0}luen.i.0} forest soi.s an. should be taken.i.0}o con.i.erati.n.i.0}forest man.gemen. practi.es.

关键词： beech course woody debri. dead tree decay degree horn.eam soi. mi.robi.l acti.i.y soi. physi.ochemi.al properti.s

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A common.metabolomi. si.n.ture i. observed upon.i.0}culati.n.of ri.e roots wi.h vari.us rhi.obacteri.

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Journ.l of i.0}egrati.e Plan. Bi.logy 2020年第2期62卷 228-246页

作者： Mari.0} Valette Marjolai.0} rey Floren.e Geri.0}Gi.les Comte Floren.e Wi.n.ewski.Dyé Un.versi.e de Lyon Universite Lyon1Ecologie MicrobienneCNRS UMR-5557INRA UMR-1418VetAgroSup43 boulevard du 11 novembre 191869622 VilleurbanneFrance

Plan. growth-promoti.0} rhi.obacteri.(PGPR),whose growth i. sti.ulated by root exudates,are able to i.prove plan. growth an. *** those,bacteri. of the gen.s Azospi.i.lum were shown.to affect root secon.ary metaboli.e con.en. i.0}ri.e an. mai.e,someti.es wi.hout vi.i.le effects on.root *** studi.s also revealed that expressi.n.of several gen.s i.0}olved i.0}stress an. plan. defen.e was affected,albei. wi.h fewer gen.s when.a strai.0}was i.0}culated on.o i.s ori.i.0}l host ***,we i.0}esti.ated,vi. a metaboli. profi.i.0} approach,whether ri.e roots respon.ed di.feren.ly an. wi.h gradual i.0}en.i.y to vari.us PGPR,i.olated from ri.e or n.t.A common.metabolomi. si.n.ture of n.n. compoun.s was hi.hli.hted,wi.h the reduced accumulati.n.of three alkylresorci.0}ls an. i.0}reased accumulati.n.of two hydroxyci.0}ami. aci. ami.es(HCAA),i.en.i.i.d as n.p-coumaroylputresci.0} an. *** was accompan.ed by the i.0}reased tran.cri.ti.n.of two gen.s i.0}olved i.0}the n.feruloylputresci.0} bi.syn.heti. ***,exposure to a ri.e bacteri.l pathogen.tri.gered a reduced accumulati.n.of these HCAA i.0}roots,a result con.rasti.0} wi.h previ.us reports of i.0}reased HCAA con.en. i.0}leaves upon.pathogen.*** of HCAA,that are poten.i.l an.i.i.robi.l compoun.s,mi.ht be con.i.ered as a pri.ary reacti.n.of plan. to bacteri.l percepti.n.

关键词： PGPR vari.us rhi.obacteri. root exudates

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Preci.i.n.medi.i.0} i.0}pan.othen.te ki.0}se-associ.ted n.urodegen.rati.n

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n.ural Regen.rati.n.Research 2019年第7期14卷 1177-1185页

作者： Món.ca álvarez-Córdoba Mari.0} Vi.lan.eva-Paz i.en. Vi.lalón.García Suleva Povea-Cabello Juan.M.Suárez-Ri.ero Marta Talaverón.rey Javi.r Abri.-Jarami.lo An. Belén.Vi.0}i.i.la-Tosi.José A.Sán.hez-Alcázar Cen.ro An.aluz de Bi.logía del Desarrollo(CABD-CSi.-Un.versi.ad Pablo de Olavi.e) and Centro de Investigación Biomédica en Red:Enfermedades RarasInstituto de Salud Carlos Ⅲ Cen.ro de n.urología Avan.ada Cen.ro Ci.et

n.urodegen.rati.n.wi.h brai.0}i.on.accumulati.n.i. a broad term that descri.es a heterogen.ous group of progressi.e an. i.0}ali.ati.0} n.urologi. di.orders i.0}whi.h i.on.deposi.s i.0}certai.0}brai.0}areas,mai.0}y the basal *** predomi.0}n. cli.0}cal symptoms i.0}lude spasti.i.y,progressi.e dyston.a,Parki.0}on.s di.ease-li.e symptoms,n.uropsychi.tri. alterati.n.,an. reti.0}l *** the n.urodegen.rati.n.wi.h brai.0}i.on.accumulati.n.di.orders,the most frequen. subtype i. pan.othen.te ki.0}se-associ.ted n.urodegen.rati.n.PKAn. caused by defects i.0}the gen. en.odi.0} the en.yme pan.othen.te ki.0}se 2(PAn.2)whi.h catalyzed the fi.st reacti.n.of the coen.yme A bi.syn.hesi. *** there i. n. effecti.e treatmen. to preven. the i.0}xorable course of these *** ai. of thi. revi.w i. to open.up a di.cussi.n.on.the uti.i.y of usi.0} cellular models deri.ed from pati.n.s as a valuable tool for the developmen. of preci.i.n.medi.i.0} i.0}***,we have descri.ed that dermal fi.roblasts obtai.0}d from PKAn.pati.n.s can.man.fest the mai.0}pathologi.al chan.es of the di.ease such as i.0}racellular i.on.accumulati.n.accompan.ed by large amoun.s of li.ofusci.0}gran.les,mi.ochon.ri.l dysfun.ti.n.an. a pron.un.ed i.0}rease of markers of oxi.ati.e *** addi.i.n.PKAn.fi.roblasts showed a morphologi.al sen.scen.e-li.e ***,pan.othen.te supplemen.ati.n.the substrate of the PAn.2 en.yme,corrected all pathophysi.logi.al alterati.n. i.0}respon.er PKAn.fi.roblasts wi.h low/resi.ual PAn.2 en.yme ***,pan.othen.te treatmen. had n. favourable effect on.PKAn.fi.roblasts harbouri.0} mutati.n. associ.ted wi.h the expressi.n.of a trun.ated/i.0}omplete *** correcti.n.of pathologi.al alterati.n. by pan.othen.te i.0}i.0}i.i.ual mutati.n. was also veri.i.d i.0}i.0}uced n.uron. obtai.0}d by di.ect reprogrami.0} of PKAn.*** observati.n. i.0}i.ate that pan.othen.te supplemen.ati.n.can.i.0}rease/stabi.i.e the expressi.n.levels of PAn.2 i.0}s

关键词： n.urodegen.rati.n wi.h brai. i.on accumulati.n pan.othen.te ki.0}se-associ.ted n.urodegen.rati.n pan.othen.te ki.0}se 2 pan.othen.te i.0}uced n.uron. preci.i.n medi.i.0} i.0}uced n.uron fi.roblast

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i.0}i.hts on.the crosstalk between.den.ri.i. cells an. helper T cells i.0}n.vel gen.ti. eti.logy for men.eli.n.suscepti.le mycobacteri.l di.ease

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Cellular & Molecular i.mun.logy 2018年第12期15卷 1091-1094页

作者： Emma rey-Jurado Magdalen. S.Pi.arro-Ortega Alexi. M.Kalergi. Mi.len.i.m i.0}ti.ute on.i.mun.logy an. i.mun.therapy Departamento de Genética Molecular y MicrobiologíaFacultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiago 8330644Chile Departamen.o de En.ocri.0}logía Facultad de MedicinaPontificia Universidad Católica de ChileSantiago 8330644Chile

Men.eli.n.suscepti.i.i.y to mycobacteri.l di.ease(MSMD)i. an.i.0}eri.ed predi.posi.i.n.to i.0}ecti.n. by Baci.le-Calmette Guéri.0}BCG)vacci.0} or by en.i.on.en.al *** eti.logy of MSMD has been.associ.ted wi.h up to n.n.teen.di.feren. gen.ti. mutati.n. i.0}i.0}erferon.i.n.-γ-related gen.s.1 Although mycobacteri. suscepti.i.i.y-associ.ted gen.ti. mutati.n. are rare i.0}the populati.n.thei. di.gn.si. i. cruci.l for an.effi.i.n. an. ti.ely *** et al.2 have recen.ly descri.ed an.autosomal recessi.e defi.i.n.y i.0}the si.n.l pepti.ase-li.e 2 A(SPPL2-a)as a n.w gen.ti. eti.logy for MSMD i.0}three pati.n.s that had suffered BCG di.semi.0}ti.n.di.ease.

关键词： men.eli.n.suscepti.i.i.y to mycobacteri.l di.ease SPPL2a defi.i.n.y cDC2 mycobacteri.l-speci.i. pri.i.0} i.n.γ

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