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Interdecadal variability of summer precipitation in the Three River source Region: Influences of ssT and zonal shifts of the East Asian subtropical westerly jet

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Atmospheric and Oceanic science Letters 2024年第5期17卷 47-53页

作者： Yumeng Liu Xianhong Meng lin Zhao s-Y.simon Wang Lixia Zhang Zhaoguo Li Chan Wang Yingying An Key Laboratory of Cryospheric science and Frozen soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina Zoige Plateau Wetlands Ecosystem Research station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina University of Chinese Academy of sciences BeijingChina Utah Climate Center Utah State UniversityLoganUSA The state Key Laboratory of numerical Modeling for Atmospheric sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

summer precipitation in the Three Rivers source Region(TRsR)of China is vital for the headwaters of the Yellow,Yangtze,and Lancang rivers and exhibits significant interdecadal *** study investigates the influence of the East Asian westerly jet(EAWJ)on TRsR rainfall.A strong correlation is found between TRsR summer precipitation and the Jet Zonal Position Index(JZPI)of the EAWJ from 1961 to 2019(R=0.619,png periods when a positive JZPI indicates a westward shift in the EAWJ,enhanced water vapor anomalies,warmer air,and low-level convergence anomalies contribute to increased TRsR summer *** empirical orthogonal function and regression analyses,this research identifies the influence of large-scale circulation anomalies associated with the Atlantic–Eurasian teleconnection(AEA)from the north Atlantic(nA).The interdecadal variability between the nA and central tropical Pacific(CTP)significantly affects TRsR *** influence is mediated through the AEA via a Rossby wave train extending eastward along the EAWJ,and another south of 45°***,the nA–CTP Opposite Phase Index(OPI),which quantifies the difference between the summer mean sea surface temperatures of the nA and the CTP,is identified as a critical factor in modulating the strength of this teleconnection and influencing the zonal position of the EAWJ.

关键词： summer precipitation East Asian subtropical westerly jet Three River source Region Atlantic-Eurasian teleconnection

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Dynamically lithium-compensated polymer artificial sEI to assist highly stable lithium-rich manganese-based anode-free lithium metal batteries

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Rare Metals 2024年第6期43卷 2527-2535页

作者： Ming-Ji Peng Jin-Qiu Zhou Ting-Ting Han Yang Zhou Jie Liu na Xu Zhen-Kang Wang Wen-Bin lin Cheng-lin Yan Key Laboratory of Core Technology of High specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou 215006China Light Industry Instituteof Electrochemical Power sources Suzhou 215006China school of Chemistry and Chemical Engineering Nantong UniversityNantong 226019China e-mail:jliu93@*** state Key Laboratory of space Power-sources Technology Shanghai Institute of Space Power-SourcesShanghai 200245China Centre Energie Materiaux et TélécommunicationsInstitut National de la Recherche ScientifiqueVarennesQC J3X 1S2Canada Zhangjiagang Industrial Technologies Soochow UniversitySuzhou 215006China

Owing to the unique structure,anode-free lithium metal batteries(AFLMBs)have higher energy density and lower production cost than traditional lithium metal batteries(LMBs)or lithium-ion batteries(LIBs),However,AFLMBs suffer from an inherently finite Li reservoir and exhibit poor cycle stability,low Coulombic efficiency(CE)and severe dendrite *** this work,polydiallyl lithium disulfide(PDs-Li)was successfully synthesized and coated on Cu current collector by electrochemical *** PDs-Li acts as an additional lithium resource to compensate for the irreversible loss of lithium during *** addition,the special structure and lithiophilicity of PDs-Li contribute to lower nucleation overpotential and uniform lithium *** coupled with Li-rich manganese-based(LRM)cathode of Li1.2Mn0.54ni0.13Co0.13O2,the anode-free full cell exhibits significantly improved cycle stability over 100 cycles and capacity retention of 63.3%and 57%after 80 and 100 cycles,*** believe that PDs-Li can be used to ensure stable cycling performance and high-energy-density in AFLMBs.

关键词： Anode-free Artificial solid electrolyte interphase(sEI) Lithium metal batteries Lithium-rich cathode Finite element simulation

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Disulfiram ameliorates sTInG/MITA-dependent inflammation and autoimmunity by targeting RnF115

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Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-Dong Zhang Chang-Rui shi Fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang Xin shuai Min Chen Yu-lin lin Tian-Chen Xiong Xiaoqi Chen Bo Zhong Dandan lin Department of Gastrointestinal surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for Life and Medical sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

sTInG(also known as MITA)is an adaptor protein that mediates cytoplasmic DnA-triggered signaling,and aberrant activation of sTInG/MITA by cytosolic self-DnA or gain-of-function mutations causes severe ***,we show that sTInG-mediated inflammation and autoimmunity are promoted by RnF115 and alleviated by the RnF115 inhibitor disulfiram(DsF).Knockout of RnF115 or treatment with DsF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and sTInG^(n153s/WT) bone marrow chimeric *** addition,knockdown or pharmacological inhibition of RnF115 substantially downregulate the expression of IFn-α,IFn-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(sLE)who exhibit high concentrations of dsDnA in peripheral ***,knockout or inhibition of RnF115 impair the oligomerization and Golgi localization of sTInG in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)***,knockout of RnF115 inhibits the activation and Golgi localization of sTInGn153s as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or *** together,these findings highlight the RnF115-mediated cell type-specific regulation of sTInG and sTInGn153s and provide potential targeted intervention strategies for sTInG-related autoimmune diseases.

关键词： sTInG/MITA Disulfiram RnF115 sLE Autoimmunity

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Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： Xiaozhong Chen Wei Wang Qingfeng Zou Xiaodong Zhu Qin lin Yi Jiang Yan sun Liangfang shen lin Wang Guorong Zou Xiaoyan lin shaojun lin Minying Li Ying Wang Ruilian Xu Rui Ao Rensheng Wang Haifeng lin shuang Huang Tingting Xu Wenting Li Mengying Xia Yu Xia Zhongmin Wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in China enrolled adult patients with metastatic nasopharyngeal carcinoma(nPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIsT(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFs)and overall survival(Os).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(september 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFs and Os were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic nPC patients,supporting further clinical development as third-line treatment of metastatic nPC.

关键词： metastatic nasopharyngeal supporting

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The Implications of Artificial Intelligence on Infection Prevention and Control: Current Progress and Future Perspectives

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China CDC weekly 2024年第35期6卷 901-904页

作者： lin Yang shuya Lu Lei Zhou school of nursing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Chinese Center for Disease Control and Prevention BeijingChina

The rapid advancement of artificial intelligence(AI)has significantly impacted infection prevention and control,particularly amid the coronavirus disease 2019(COVID-19)pandemic(1).AI techniques such as machine learning(ML),deep learning,and natural language processing(nLP)have successfully transformed infection prevention and control strategies(1).These technologies have enhanced our understanding of infectious diseases,facilitated disease transmission prediction,and improved public health emergency responses(2).

关键词： has such prevention

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Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.sardar M.D.Hossain M.s.sikder M.n.I.Khan M.R.Rahman Physics Discipline Khulna UniversityKhulna9208Bangladesh Department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh Department ofComputer science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh Material science Division Atomic Energy CentreDhaka1000Bangladesh

spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FEsEM),energy dispersive X-ray(EDX),vibrating sample magnetometer(VsM),and an impedance analyzer were used to characterize the structural,magnetic,and dielectric properties of the *** XRD patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increased with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FEsEM images,and it is increased from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EDX study shows that there is no impurity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EDX Resistivity

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Analysis of metabolic characteristics of metabolic syndrome in elderly patients with gastric cancer by non-targeted metabolomics

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2419-2428页

作者： Huan Zhang Wen-Bing shen lin Chen Medical school of Chinese PLA Chinese PLA General HospitalBeijing 100853China Department of Gastrointestinal surgery Shanghai Sixth People’s HospitalShanghai 250063China Department of General surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUnD The relationship between metabolic syndrome(Mets)and gastric cancer(GC),which is a common metabolic disease,has attracted much ***,the specific metabolic characteristics of Mets in elderly patients with GC remain *** To investigate the differentially abundant metabolites and metabolic pathways between preoperative frailty and Mets in elderly patients with GC based on nontargeted metabolomics *** In this study,125 patients with nonfrail nonmeal GC were selected as the control group,and 50 patients with GC in the frail group were selected as the frail ***-five patients with GC combined with Mets alone were included in the Mets group,and 50 patients with GC combined with Mets were included in the Mets *** metabolomics techniques were used to measure plasma metabolite levels by ultrahigh-performance liquid chromatography-mass *** statistical analysis was performed by principal component analysis,orthogonal partial least squares,pattern recognition analysis,cluster analysis,and metabolic pathway *** A total of 125 different metabolites,including amino acids,glycerophospholipids,sphingolipids,fatty acids,sugars,nucleosides and nucleotides,and acidic compounds,were identified via nontargeted metabolomics *** with those in the control group,there were 41,32,and 52 different metabolites in the Mets group,the debilitated group,and the combined group,*** metabolites were significantly increased in the Mets *** the weak group,amino acids and most glycerol phospholipid metabolites decreased significantly,and fatty acids and sphingosine increased *** combined group was characterized by significantly increased levels of nucleotide metabolites and acidic *** alanine,aspartic acid,and glutamate metabolic pathways were obviously enriched in the asthenic group,and the glycerol and phospholipid metabolic pathways were obv

关键词： nervous breakdown Metabolic syndrome Elderly individuals Gastric cancer nontargeted metabolomics

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Cauchy matrix approach for H1a equation in the torqued Adler–Bobenko–suris lattice list

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Communications in Theoretical Physics 2024年第10期76卷 3-8页

作者： Jing Wang song-lin Zhao shoufeng shen school of Mathematical sciences Zhejiang University of Technology

As a torqued version of the lattice potential Korteweg–de Vries equation, the H1ais an integrable nonsymmetric lattice equation with only one spacing parameter. In this paper, we present the Cauchy matrix scheme for this equation. soliton solutions, Jordan-block solutions and soliton-Jordan-block mixed solutions are constructed by solving the determining equation set. All the obtained solutions have jumping property between constant values for fixed n and demonstrate periodic structure.

关键词： Cauchy matrix scheme exact solutions torqued H1 equation

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Peptides: Opening the door

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Molecular Plant 2024年第1期17卷 8-10页

作者： Zongcheng lin Ke Jin noni Franklin-Tong national Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China school of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK

Interspecific isolation is a common mechanism adopted by plants to prevent gene flow between diverged species,thus maintaining species genetic ***,from a plant breeder's perspective,hybridization is desirable,as it can provide a wider range of agriculturally important traits for crop improvement(Tonosaki et al.,2016).Although significant progress has been made in recent years in our understanding of some key factors controlling pollen-pistil interactions within species,we still know virtually nothing about the genetic and molecular basis underlying interspecific incompatibility.

关键词： traits breed nothing

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