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肺动脉高压患者的对比增强心血管磁共振成像检查

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 53-54页

作者： BlythK.G. Groenning B.A. Martin T.n. A.J. Peacock 潘闽 Scottish Pulmonary Vascular Unit Western Infirmary Glasgow G11 6NT United Kingdom

Aims: To determine the presence and extent of delayed contrast enhancement(DCE) in patients with pulmonary hypertension(PHT) using contrast enhanced-cardiovascular magnetic resonance imaging(ce-CMR). Methods and results: Twenty-five patients with PHT underwent ce-CMR and right heart catheterization. Right ventricular(RV) and left ventricular(LV) volumes, ejection fraction, mass, and DCE mass were determined with ce-CMR. Mean pulmonary artery pressure(mean pap) averaged 43(12) mmHg and cardiac output 4.3(1.2) L/min. DCE was demonstrated in 23 out of 25 patien ts. DCE was confined to the RV insertion points(RVIPs) in seven patients and extended into the interventricular septum(IVS) in the remaining 16 patients. In these 16 patients, septal contrast enhancement was associated with IVS bowing. The extent of contrast enhancement correlated positively with RV end-diastolic volu me/ body surface area, RV mass, mean pap, and pulmonary vascular resistance and correlated inversely with RV ejection fraction. Conclusion: DCE was present with in the RVIPs and IVS of most patients with PHT studied. Extent of DCE correlated with RV function and pulmonary haemodynamics. DCE was associated with IVS bowin g and may provide a novel marker for occult septal abnormalities directly relati ng to the haemodynamic stress experienced by these patients.

关键词：对比增强肺动脉磁共振成像心血管患者

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重度鳞状上皮内瘤样病变:缩短治疗后监测

世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 10-11页

作者： Skinner E.n. Gehrig P.A. Van Le L. 朱国栋 Dr.Division of Gynecology Oncology Univ. of North Carolina Chapel Hill CB 7570 Women's Hospital Chapel Hill NC 27599 United States

OBJECTIVE: To evaluate whether the surveillance schedule for patients treated with loop excision for high-grade squamous intraepithelial lesions could be improved. METHODS: Women treated in our dysplasia clinic for high-grade squamous intraepithelial lesions by loop excision between January 1990 and December 1999 were identified. Demographic information, pathologic diagnosis, and follow-up visits were extracted from medical records. Follow-up data included all papanicolaou (pap) tests and/or cervical biopsies performed in our clinic after the initial procedure. RESULTS: Women (n = 705) were treated for biopsy-proven high-grade dysplasia. Of those treated, 526 (74%) had at least 1 follow-up pap test performed in our clinics within 2 years of their original procedure. During the 2 years of posttreatment surveillance, 70 (13.3%) women demonstrated recurrent cervical intraepithelial neoplasia 2 or 3. Recurrence was highest during the first 6 months and between months 22 and 24 of surveillance. This rate was noted to be dramatically lower during months 7 to 21 of surveillance (P ncreasing age was independently associated with a 1.6-fold per decade (95%confidence interval 1.29, 1.9) increase in risk of recurrence. A negative margin status was independently associated with a 0.29-fold (95%confidence interval 0.17, 0.5) decrease in risk of recurrence. race was not shown to have an influence on risk of recurrence. COnCLUSIOn: A clinically and financially optimal surveillance schedule for women treated for high-grade dysplasia with loop excision would be to obtain pap tests every 6 months for 1 year and then return to annual screening. Lengthening the surveillance intervals could be beneficial to patients, while decreasing healthcare costs, without compromising the ability to detect and treat recurrent disease.

关键词：瘤样病变宫颈活检疾病门诊病变复发重度不典型增生病理诊断环切复发率复发风险病例记录

商陆营养器官解剖结构与非贮藏蛋白质组织化学定位

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农业生物技术学报 2009年第4期17卷 739-740页

作者：王桂芹努尔巴衣·阿布都沙勒克安徽科技学院生物系新疆大学资源与环境科学学院

美洲商陆(Phytolacca americana L.)是一种多年生草本植物。美洲商陆抗病毒蛋白(pap)是从这种植物不同器官分离提纯的一种碱性核糖体失活蛋白,该蛋白具有一种潜在的能阻碍病毒传播的因子,对多种动、植物病毒具有广谱抗性。

关键词：商陆蛋白质解剖结构组织化学定位

宫颈癌光学技术筛查研究中参与者的募集和动员

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 44-45页

作者： Shuhatovich O.M Sharman M.P Mirabal Y.n K. Basen-Engquist 柳蕴 Department of Behavioral Sciences UT M.D. Anderson Cancer Center 1515 Holcombe Blvd. Houston TX 77030 United States

In order to improve recruitment for cervical cancer screening trials, it is necessary to analyze the effectiveness of recruitment strategies used in current trials. A trial to test optical spectroscopy for the diagnosis of cervical neoplasia recruited 1000 women from the community; the trial evaluated the emerging technology against pap smears and colposcopically directed biopsies for cervical dysplasia. We have examined women’s reasons for participating as well as the effectiveness and efficiency for each recruitment strategy. Reasons for participation were identified and compared between trials. The recruitment method that resulted in the most contacts was newspaper reportorial coverage and advertising, followed by family and friends, then television news coverage. The most cost-effective method for finding eligible women who attend the research appointment is word of mouth from a family member or friend. Recommendations are given for maximizing the efficiency of recruitment for cervical cancer screening trials.

关键词：巴氏涂片阴道镜报纸报道电视新闻新兴技术家庭成员朋友之间新生物

Research on rat models of hypobaric hypoxia-induced pulmonary hypertension

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Research on rat models of hypobaric hypoxia-induced pulmonar...

青藏铁路运营十周年学术研讨会

作者： T.-T.MA Y WAnG X.-L.ZHOU H.JIAnG R.GUO L.-n.JIA H.CHAnG Y GAO X.-Y.YAO Z.-M.GAO L.PAn Department of Geriatric Medicine Beijing Shijitan HospitalCapital Medical University Department of Hypoxia Laboratory Beijing Shijitan HospitalCapital Medical University Department of Pathology Beijing Shijitan HospitalCapital Medical University Health Science Center of Peking University

OBJECTIVE:rat models of hypobaric hypoxia-induced pulmonary hypertension are commonly used in studies of chronic mountain sickness,while there are few researches specially focusing on these rats *** study aims to exploring possible pathogenesis of hypobaric hypoxia-induced pulmonary hypertension by experimenting on hypobaric hypoxiainduced PH rat models at different *** AnD METHODS:32 healthy male SD rats were randomly divided into six groups of different degree and time period of hypobaric *** mean pulmonary arterial pressure（m pap）,right ventricular pressure（RVSP）,the right ventricle（RV）,left ventricular（LV）,ventricular septal（S）,the right ventricular hypertrophy index（RVHI）[calculated under the formula of RV/（LV + S）],hematoxylin-eosin staining,elastic fibers staining,the ratio of the thickness of vascular wall to its outer diameter（MT%）,the ratio of the cross-sectional area of the middle vascular wall to the total vascular cross-sectional area（MA%）;the a-SMA,and the Ki6 expressions were detected to evaluated the pulmonary ***:There were significant differences of the mpap,RVSP and RVHI value between the hypobaric hypoxia groups and the control group（p ＜ 0.05）.The mpap,RVSP,RVHI,MT%,MA%,α-SMA,and Ki6 of rats in model groups at an altitude of 3KM were higher than those of the control group,which raised gradually with the number of weeks *** mpap,RVSP,RV/（LV + S） value,MT%,MA%,a-SMA,and Ki67 of the 5KM-4W group were significantly higher than those of the control group（p ＜ 0.05）.COnCLUSIOnS:rat models with pulmonary hypertension at different altitudes have been successfully established by automatic adjusting hypobaric hypoxia *** to a low oxygen environment at a simulate-altitude of 3km for 8 weeks have caused the pathological remodeling of pulmonary vascular walls and pulmonary hypertension,and further led to a series of pathological changes,including right ventricular ***

关键词： Hypobaric hypoxia Pulmonary hypertension Animal models

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FROG数据加密算法的一种改进方案

通信技术 2003年第8期36卷 87-88,98页

作者：张有志郭宁山东大学信息学院济南250061 北京邮电大学经济管理学院北京100876

FROG算法是一种对称式数据加密算法,它具有诸多优点,但是速度比较慢。分析了其速度慢的原因,提出了一种改进方案,使得在保持原算法可靠性的基础上,运行速度有了显著提高。

关键词：数据加密网络安全保密通信 FROG算法

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癌症筛查之未来

上海预防医学 2017年第3期29卷 245-247页

作者： Cheryll C.Thomas Thomas B.Richards Marcus Plescia Faye L.Wong rachel Ballard Theodore R.Levin Bruce n.Calonge Otis W.Brawley John Iskander 徐海燕(翻译) 陆仁敏(审校) 蔡颖(审校) Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health PromotionCDC national Cancer Institute The Permanente Medical Group Inc.and Kaiser Permanente Medical CenterWalnut Creek and AntiochCalifornia The Colorado Trust American Cancer Society Office of the Associate Director for Science CDC 不详

1引言癌症已成为美国的第二大致死病因,52%的人死于肺癌、支气管癌、女性乳腺癌、宫颈癌、结直肠癌、口腔及咽喉癌、前列腺癌和皮肤癌（黑色素瘤）。19世纪30年代,包括宫颈癌在内的子宫癌,位居美国女性癌症死亡第一位。50年代,随着巴氏... 详细信息

1引言癌症已成为美国的第二大致死病因,52%的人死于肺癌、支气管癌、女性乳腺癌、宫颈癌、结直肠癌、口腔及咽喉癌、前列腺癌和皮肤癌（黑色素瘤）。19世纪30年代,包括宫颈癌在内的子宫癌,位居美国女性癌症死亡第一位。50年代,随着巴氏涂片技术（pap test）的应用,可以在细胞水平检测宫颈的变化,宫颈癌死亡率显著降低,这是第一个癌症筛查检测技术。此后,已有多种影像学检查（例如乳腺癌钼靶X线、内窥镜检查和计算机体层扫描）和实验室检测方法（粪便隐血试验）用于癌症筛检。

关键词：筛查方法女性乳腺癌巴氏涂片癌死亡率结直肠癌致死病因钼靶黑色素瘤计算机体层扫描粪便隐血试验

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小剂量塞克硝唑治疗细菌性阴道病

世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 51-51页

作者： nú■nez J.T. Gómez G. 杨晓梅 Laboratory of Molecular Technology National Cancer Institute 915 Tollouse Ave Frederick MD 21701 United States

Objective: To determine whether bacterial vaginosis could be cured with a single 1- g oral dose of secnidazole. Material and methods: A total of 80 women were recruited at the outpatient gynecologic clinic of Manuel noriega Hospital, Maracaibo, Venezuela. Diagnosis and patient enrollment were based on the Amsel criteria. The participants were randomized to 2 groups. In group 1 (n = 44) participants received a single 1- g oral dose and in group 2 (n=32) participants received a single 2- g oral dose of secnidazole. Clinical cure was defined as the absence of the characteristic symptoms (a bad odor and a grossly abnormal discharge) and at least 2 of the following: vaginal pH less than 4.5, no fish odor on addition of KOH, and no Gardnerella vaginalis or clue cells on wet- mount examination. Cytologic cure was defined as an absence of G. vaginalis on a papanicolaou (pap) smear. Results: Clinical cure was experienced by 95.5% of the women who received the 1- g oral dose and by 97.4% of the women who received the 2- g oral dose of secnidazole. There was no significant difference between the groups in the clinical resolution of bacterial vaginosis. Following treatment, results were negative for G. vaginalis in 94.7% of the women. In group 1, 41 women (93.2% ), and in group 2, 31 women (96.9% ) had cytologic cure. The pap smear revealed G. vaginalis in 3 of the women in group 1 and 1 of the women in group 2 (P=0.47). Twenty- seven women (35.5% ) reported mild side effects. More women had adverse effects in group 1 (n=16) than in group 2 (n=11) but this difference was not statistically significant. Conclusion: This clinical study showed that a single 1- g oral dose of secnidazole is effective to cure bacterial vaginosis associated with G. vaginalis.

关键词：细菌性阴道病塞克硝唑阴道加德纳菌线索细胞阴道分泌物妇科门诊巴氏涂片特有症状难闻的气味马拉开波

肺动脉高压病人的局部和整体双心室功能:心脏MRI研究

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国际医学放射学杂志 2013年第2期 162-162页

作者： M.L. Shehata A.A. Harouni J. Skrok T.A. Basha D. Boyce n. Lechtzin 李宁 Department of radiology and radiological Sciences Johns Hopkins University School of Medicine 600 N Wolfe St Nelson Basement MRI 110Baltimore MD

目的探讨慢性肺动脉压力(pap)增高能否影响双心室局部功能,右心室(RV)整体功能正常的肺动脉高压(PAH)病人是否降低局部心肌功能。材料与方法经知情同意后,35例PAH病人接受右心导管及心脏MR成像检查并与13名健康对照者进行比较。PAH病人... 详细信息

目的探讨慢性肺动脉压力(pap)增高能否影响双心室局部功能,右心室(RV)整体功能正常的肺动脉高压(PAH)病人是否降低局部心肌功能。材料与方法经知情同意后,35例PAH病人接受右心导管及心脏MR成像检查并与13名健康对照者进行比较。PAH病人与对照组的双心室节段、截面和平均心室收缩期峰值纵向应变值(ELL),以及左心室(LV)周向和右心室(RV)切向压力都进行了比较,并分析各参数与整体功能和右心室导管指数的相关性。使用Spearman相关ρ和Bonferroni校正。采用多元线性回归分析来确定局部心肌功能的预测因素。结果 PAH病人右心室在心底、中部及心尖水平发生纵向收缩减低,在心室中部发生切向收缩减低。平均右室ELL与平均pap(r=0.62,Ppap是平均RVELL(β=0.19,P=0.005)的预测因素。而LV纵向及周向收缩减低均发生于心底部。左室前间壁ELL与平均pap增加(r=0.5,P=0.03)和隔偏心指数(r=0.5,P=0.01)呈正相关。右心室整体功能正常的PAH病人,心底及前中室间隔区及右心室中前室壁纵向收缩明显减低(均为Ppap和肺血管阻力指数(PVRI)]增加有关。心脏MR成像有助于鉴别右心室整体功能正常的PAH病人的右心室局部功能受损。

关键词：双心室 PAH 局部功能病人右心室心脏肺动脉