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瑞典的区域科学与区域政策

开发研究 1995年第1期 39-41页

作者：安德.,ae 魏后凯中国社会科学院工业经济研究所

瑞典的区域科学与区域政策［瑞典］Ａ·Ｅ·安德森魏后凯译李仁贵校瑞典古典区域经济理论在３０年代，瑞典区域经济学就处于国际领先地位。瑞典经济学家－－主要是伯尔蒂尔·奥林（１９３３）和托德·帕兰德（１９３５）－－在两个方面... 详细信息

瑞典的区域科学与区域政策［瑞典］Ａ·Ｅ·安德森魏后凯译李仁贵校瑞典古典区域经济理论在３０年代，瑞典区域经济学就处于国际领先地位。瑞典经济学家－－主要是伯尔蒂尔·奥林（１９３３）和托德·帕兰德（１９３５）－－在两个方面奠定了区域科学和未来区域政策的基础...

关键词：瑞典区域科学区域政策区域经济

Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma

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International Journal of Oral Science 2022年第1期14卷 113-122页

作者： neeti Swarup Kyoung-Ok Hong Kunal Chawla Su-Jung Choi Ji-ae Shin Kyu-Young Oh Hye-Jung Yoon Jae-Il Lee Sung-Dae Cho Seong-Doo Hong Department of Oral Pathology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoulRepublic of Korea Department of Computer Science School of Interactive ComputingGeorgia Institute of TechnologyAtlantaGAUSA

Poly Adenylate Binding Protein Interacting protein 1(PAIP1) plays a critical role in translation initiation and is associated with the several cancer types. However, its function and clinical significance have not yet been described in oral squamous cell carcinoma(OSCC) and its associated features like lymph node metastasis(LnM). Here, we used the data available from Gene Expression Omnibus(GEO), The Cancer Genome Atlas(TCGA), and Clinical Proteomic Tumor Analysis Consortium(CPTAC) to analyze PAIP1 expression in oral cancer. The publicly available data suggests that PAIP1 mRnA and protein levels were increased in OSCC. The high PAIP1 expression was more evident in samples with advanced stage, LnM, and worse pattern of invasion. Moreover, the in vitro experiments revealed that PAIP1 knockdown attenuated colony forming, the aggressiveness of OSCC cell lines, decreasing MMP9 activity and SRC phosphorylation. Importantly, we found a correlation between PAIP1 and pSRC through the analysis of the IHC scores and CPTAC data in patient samples. Our findings suggest that PAIP1 could be an independent prognostic factor in OSCC with LnM and a suitable therapeutic target to improve OSCC patient outcomes.

关键词： squamous invasion metastasis

Clinicopathological features and prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgery

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 594-601页

作者： Seung Duk Lee Sang-Jae Park Sung-Sik Han Seong Hoon Kim Young-Kyu Kim Soon-ae Lee Young Hwan Ko Eun Kyung Hong Center for Liver Cancer Research Institute and Hospital National Cancer Center Goyang-si Gyeonggi-do Republic of Korea

BACKGROUnD： Combined hepatocellular carcinoma and cholangiocarcinoma （cHCC-CC） is a rare subtype of primary liver cancer consisting of both hepatocellular carcinoma （HCC） and cholangiocarcinoma （CC）. Because of the rarity of this tumor, its feature is poorly understood. The present study aimed to evaluate the clinicopathological features and long-term prognosis of patients with cHCC-CC after surgery and to compare with those of the patients with stage-matched HCC and CC. METHODS： The dinicopathological features of the patients who underwent surgery for cHCC-CC at our center during the period of 2001-2010 were retrospectively analyzed and compared with those of stage-matched HCC and CC patients. Cancer staging was performed according to the AJCC Cancer Staging Manual （6th ed.）. Overall survival and disease-free survival were compared among the groups and prognostic factors of cHCC-CC were evaluated. RESULTS： Significant differences were observed in clinico- pathological features among 42 patients with cHCC-CC, 90 patients with HCC and 45 patients with CC. Similar to HCC patients, cHCC-CC patients had frequent hepatitis B virus antigen positivity, microscopic vessel invasion, cirrhosis and high level of serum alpha-fetoprotein. Similar to CC patients, cHCC-CC patients showed increased bile duct invasion and decreased capsule. The 1-, 3-, and 5-year overall survival and disease- free survival of patients with cHCC-CC were not significantly different from those with stage-matched patients with CC;but significantly poorer than those with HCC. In subanalysis of patients with stage Ⅱ, the overall survival in patients with cHCC-CC or CC was significantly poorer than that in patients with HCC. We did not find the difference in patients with other stages. Univariate analysis of overall and disease-free survival of patients with cHCC-CC showed that the vascular invasion and intrahepatic metastasis were the significant predictive factors. COnCLUSIOn： Patients with cHCC-CC showe

关键词： hepatocellular carcinoma cholangiocarcinoma stage prognosis

Brain Activity Associated with Memory and Cognitive Function During Jaw-Tapping Movement in Healthy Subjects Using Functional Magnetic Resonance Imaging*

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Chinese Journal of Integrative Medicine 2013年第6期19卷 409-417页

作者： Seung-Yeon Cho ae-Sook Shin Byung-Jo na Geon-Ho Jahng Seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Department of Cardiovascular and neurological Diseases College of Korean MedicineKyung Hee UniversitySeoulKorea Department of Internal Medicine Kang-Nam Korean HospitalKyung Hee UniversitySeoulKorea Department of Radiology Kyung Hee University Hospital at GangdongSchool of MedicineKyuna Hee UniversitySeoulKorea

Objective： TO determine whether jaw-tapping movement, a classically described as an indication of personal well-being and mental health, stimulates the memory and the cognitive regions of the brain and is associated with improved brain performance. Methods： Twelve healthy right-handed female subjects completed the study. Each patient performed a jaw-tapping task and an n-back task during functional magnetic resonance imaging （fMRI）. The subjects were trained to carry out the jaw-tapping movement at home twice a day for 4 weeks. The fMRI was repeated when they returned. Results： During the first and second jaw-tapping session, both sides of precentral gyrus and the right middle frontal gyrus （BA 6） were activated. And during the second session of the jaw-tapping task, parts of frontal lobe and temporal lobe related to memory function were more activated. In addition, the total percent task accuracy in n-beck task significantly increased after 4 weeks of jaw- tapping movement. After jaw-tapping training for 4 weeks, brain areas related to memory showed significantly increased blood oxygen level dependent signals. Conclusion： Jaw-tapping movement might be a useful exercise for stimulating the memory and cognitive regions of the brain.

关键词： Jaw-tapping movement functional magnetic resonance imaging memory cognitive function dementia

Anger as a Predictor of Active Public Protest： Extended Application of the Situational Theory of Publics to a Health Crisis

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Journalism and Mass Communication 2013年第3期3卷 199-211页

作者： Jin-ae Kang Seon-Kyoung An Kyung Yoon Kwak East Carolina University Greenville USA Media Research Labs (LLC) Dallas USA Sogang University Seoul Korea

This study applies the situational theory of publics （STP） to a health crisis by exploring the effect of anger on public behavior. The results of a survey administered on the case of the candlelight rallies on the U.S. beef imports in South Korea in 2008 demonstrated that involvement, problem recognition, and constraint recognition predicted communication behaviors as well as various issue-related online and offline behaviors. In addition, anger was found to be a significant driving force for publics to perform the behaviors. The segmented publics showed significantly different levels of anger, information processing and seeking, online behaviors, and participation in the candlelight rallies

关键词： crisis communication situational theory of publics emotion online behaviors food safety Korea

Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer

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World Journal of Gastroenterology 2015年第2期21卷 571-577页

作者： Eun Hyo Jin Dong Ho Lee Sung-ae Jung Ki-nam Shim Ji Yeon Seo nayoung Kim Cheol Min Shin Hyuk Yoon Hyun Chae Jung Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 110-744South Korea Department of Internal Medicine Seoul National University Bundang HospitalGyeonggi-do 463-707South Korea Department of Internal Medicine Ewha Womans University College of MedicineSeoul 158-710South Korea

AIM: To analyze predictive factors for lymph node metastasis in early gastric ***: We analyzed 1104 patients with early gastric cancer(EGC) who underwent a gastrectomy with lymph-node dissection from May 2003 through July 2011. The clinicopathologic factors and molecular markers were assessed as predictors for lymph node metastasis. Molecular markers such as microsatellite instability, human mut L homolog 1, p53, epidermal growth factor receptor(EGFR) and human epidermal growth factor receptor 2(HER2) were included. The χ2 test and logistic regression analysis were used to determine clinicopathologic ***: Lymph node metastasis was observed in 104(9.4%) of 1104 patients. Among 104 cases of lymph node positive patients, 24 patients(3.8%) were mucosal cancers and 80 patients(16.7%) were submucosal. According to histologic evaluation, the number of lymph node metastasis found was 4(1.7%) for well differentiated tubular adenocarcinoma, 45(11.3%) for moderately differentiated tubular adenocarcinoma, 36(14.8%) for poorly differentiated tubular adenocarcinoma, and 19(8.4%) for signet ring cell carcinoma. Of 690 EGC cases, 77 cases(11.2%) showed EGFR overexpression. HER2 overexpression was present in 110 cases(27.1%) of 406 EGC patients. With multivariate analysis, female gender(OR = 2.281, P = 0.009), presence of lymphovascular invasion(OR = 10.950, P nd EGFR overexpression(OR = 2.185, P = 0.044) were independent risk factors for lymph node ***: Female gender, tumor size, lymphovascular invasion and EGFR overexpression were predictive risk factors for lymph node metastasis in EGC.

关键词： Receptor Epidermal growth factor Stomach neoplasms

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低温冷冻异体骨移植在髋关节翻修术中的应用

中国修复重建外科杂志 1994年第2期8卷 108-110页

作者：于进祥 Gross,ae 兰州市解放军第一医院骨科

髋关节因各种原因行人工关节置换术后，由于假体的磨损和松动常引起骨质腐蚀和溶解，导致严重的骨缺损。报道从１９７２年～１９９０年１月，应用大块冷冻异体骨移植的髋关节翻修术２１２例，获随访１年以上的１８７例（１９８个髋），... 详细信息

髋关节因各种原因行人工关节置换术后，由于假体的磨损和松动常引起骨质腐蚀和溶解，导致严重的骨缺损。报道从１９７２年～１９９０年１月，应用大块冷冻异体骨移植的髋关节翻修术２１２例，获随访１年以上的１８７例（１９８个髋），总有效率达８５％。讨论了髋关节翻修术中常见的骨缺损类型及异体骨移植方法，以及异体骨的切取和保存，移植亏的免疫反应和转归等。

关键词：异体骨移植修复术髋关节骨移植

Trends and risk factors of elderly-onset Crohn’s disease: A nationwide cohort study

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World Journal of Gastroenterology 2020年第4期26卷 404-415页

作者： Jung Min Moon Eun ae Kang Kyungdo Han Seung Wook Hong Hosim Soh Seona Park Jooyoung Lee Hyun Jung Lee Jong Pil Im Joo Sung Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of MedicineSeoul 03080South Korea Department of Biostatistics College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUnD The incidence of inflammatory bowel disease(IBD)is increasing in *** risk factors associated with IBD development have been *** To investigate trends and environmental risk factors of Crohn’s disease(CD)diagnosed in persons aged≥40 years in South *** Using the national Health Insurance Service database,a total of 14060821 persons aged>40 years who underwent national health screening in 2009 were followed up until December *** with newly diagnosed CD were enrolled and compared with non-CD *** was identified according to the International Classification of Diseases 10th revision and the rare/intractable disease registration program codes from the national Health Insurance Service *** mean follow-up periods was 7.39 ***,sex,diabetes,hypertension,smoking,alcohol consumption,regular exercise,body mass index,anemia,chronic kidney disease(CKD)and dyslipidemia were adjusted for in the multivariate analysis *** During the follow-up,1337(1.33/100000)patients developed *** in the middle-aged group(40-64 years)had a higher risk than women[adjusted hazard ratio(aHR)1.46,95%confidence interval(CI):1.29-1.66];however,this difference tended to disappear as the age of onset *** the middle-aged group,patients with a history of smoking[(aHR 1.46,95%CI:1.19-1.79)and anemia(aHR 1.85,95%CI:1.55-2.20)]had a significantly higher CD *** the elderly group(age,≥65 years),ex-smoking and anemia also increased the CD risk(aHR 1.68,95%CI:1.22-2.30)and 1.84(95%CI:1.47-2.30,respectively).Especially in the middle-aged group,those with CKD had a statistically elevated CD risk(aHR 1.37,95%CI:1.05-1.79).Alcohol consumption and higher body mass index showed negative association trend with CD incidence in both of the age groups.[Middle-aged:aHR 0.77(95%CI:0.66-0.89)and aHR 0.73(95% CI:0.63-0.84),respectively][Elderly-group:aHR 0.57(95% CI:0.42-0.78)and aHR 0.84(95%CI 0.67-1.04),respectively].For regular p

关键词： Crohn’s disease Aged Environmental Risk factors Epidemiology nationwide cohort

Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with diabetes mellitus

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Chinese Journal of Cancer Research 2014年第3期26卷 341-344页

作者： Young ae Kim Sol Lee Ji Woong Jung Yu Jin Kwon Gyeong Bok Lee Dong Gue Shin Sang Su Park Jin Yun Yong-Seog Jang Dong Hui Cho Department of Surgery Seoul Medical CenterSeoulKorea Department of Surgery Red Cross HospitalSeoulKorea

The side effects of tamoxifen are generally mild, including the effect on lipoprotein metabolism. However, there are few cases of severe tamoxifen induced hypertriglyceridemia. Hypertriglyceridemia is a marked risk factor for acute pancreatitis and approximately 2% to 5% of cases of acute pancreatitis are related to drugs. We report on tamoxifen-induced hypertriglyceridemia and acute pancreatitis in a 40 years old woman with type 2 diabetes mellitus occurred by dexamethasone. She was treated with insulin infusion and fenofibrate, and goserelin acetate was started instead of tamoxifen after discharge from the hospital. Also, probable pathogenic hypotheses about the correlation between tamoxifen and dexamethasone induced type 2 diabetes mellitus on severe acute pancreatitis are provided. Clinicians should take care of risks of severe acute pancreatitis on using tamoxifen, especially for patients with dexamethasone induced diabetes mellitus. These individuals should undergo pre-post tamoxifen lipid screening and careful history taking of drugs, including dexamethasone.

关键词： Tamoxifen acute pancreatitis hypertriglyceridemia type 2 diabetes mellitus dexamethasone