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Prognosis of hepatocellular carcinoma expressing cytokeratin 19:Comparison with other liver cancers

World Journal of Gastroenterology 2012年第34期18卷 4751-4757页

作者： Jung Il Lee Jin-Woo Lee joon Mee kim Ja Kyung kim Hyun Jung Chung Young Soo kim Department of Internal Medicine School of MedicineInha UniversityIncheon 400-711South Korea Department of Pathology School of MedicineInha UniversityIncheon 400-711South Korea Department of Internal Medicine Yonsei University College of MedicineGangnam Severance HospitalSeoul 135-720South Korea

AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers. METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (HCC), liver specimens of 70 patients with HCC were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19 - HCC and CK19 + HCC). CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5% of tumor cells with moderate or strong intensity. Patients with other primary liver cancers, such as com- bined HCC and cholangiocarcinoma (cHCC-CC), intrahe- patic cholangiocarcinoma (ICC) who received curative liver resection, were also included in the study. Clinical characteristics of CK19-HCC and CK19 + HCC patients, including survival outcome after curative liver resection, were compared with that of cHCC-CC and ICC patients. RESULTS: The overall survival (OS) rate of CK19 - HCC(n = 49) after the curative surgical treatment was 90.7%, and 80.4% at 1 and 5 years after the resection. OS rate of CK19 + HCC (n = 21) was 74.3%, 28.9% and OS rate of cHCC-CC (n = 22) was 66.7%, 32.2% at 1 and 5 years after the surgery. For ICC (n = 19), 1 and 5-year-OS rate was 50.2% and 14.3% after the cura-tive resection. The OS rates of CK19 + HCC and cHCC-CC were significantly lower than that of CK19-HCC, but higher than the OS rate of ICC (P = 0.000). There was no statistically significant difference in OS rate between CK19 + HCC and cHCC-CC. The disease free survival (DFS) rate of CK19-HCC was 72.0% and 54.5% at 1 and 3 years after the surgical treatment. DFS rate of CK19 + HCC was 53.3%, 34.3% and DFS rate of cHCC- CC was 51.5%, 39.2% at 1 and 3 years after the resection. For ICC, 1 and 3-year-DFS rate was 28.0% and 14.0% after the curative resection. DFS rate of CK19-HCC was significantly higher than that of ICC (P = 0.017), but marginally higher than DFS rate of either CK19 + HCC or cHCC-CC (P = 0.097, P = 0.089, respec-tively).

关键词： Cytokeratin 19 Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Liver cancers Hepa-tectomy

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Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice

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World Journal of Gastroenterology 2015年第28期21卷 8580-8587页

作者： Seong-joon Koh Ji Won kim Byeong Gwan kim Kook Lae Lee Joo Sung kim Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

AIM:To investigate the effects of restraint stress on chronic colitis in interleukin(IL)-10 deficient(IL-10^(-/-))***:The first experiment compared the effect of restraint stress on the development of intestinal inflammation in wild-type and IL-10^(-/-) *** wildtype and IL-10^(-/-) mice were physically restrained in a well-ventilated,50 cm3 conical polypropylene tube for2 h per day for three consecutive *** second experiment was performed to assess the effect of restraint stress on exacerbation of colitis induced by piroxicam in IL-10^(-/-) *** IL-10^(-/-) mice were exposed to restraint stress for 2 h per day for 3consecutive days,and then treated with piroxicam for4 d at a dose of 200 ppm administered in the rodent ***:In the first experiment,none of the wildtype mice with or without restraint stress showed clinical and histopathological abnormality in the ***,IL-10^(-/-) mice exposed to restraint stress exhibited histologically significant intestinal inflammation as compared to those without restraint *** the second experiment,restraint stress significantly reduced body weight and increased the severity of intestinal inflammation assessed by histopathologic grading in IL-10^(-/-) *** IL12p40 mRNA expression was strongly increased in mice exposed to restraint ***:This novel animal model could be useful in future study of psychological stress in the pathogenesis of inflammatory bowel disease.

关键词： Stress Colitis Interleukin-10 Inflammatorybowel disease Mouse model

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Improved formaldehyde gas sensing properties of well-controlled Au nanoparticle-decorated In2O3 nanofibers integrated on low power MEMS platform

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Journal of Materials Science & Technology 2020年第3期38卷 56-63页

作者： Dongha Im Donghyun kim Dasol Jeong Woon Ik Park myoungpyo Chun joon-Shik Park Hyunjung kim Hyunsung Jung Nano Materials&Nano Technology Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Department of Mineral Resources and Energy Engineering Chonbuk National UniversityJeonju 54896Republic of Korea Smart Sensor Research Center Korea Electronic Technology InstituteSeongnam 13509Republic of Korea

Approaches for the fabrication of a low power-operable formaldehyde(HCHO)gas sensor with high sensitivity and selectivity were performed by the utilization of an effective micro-structured platform with a micro-heater to reach high temperature with low heating power as well as by the integration of indium oxide(In2O3)nanofibers decorated with well-dispersed Au nanoparticles as a sensing *** In2O3 nanofibers with the large specific surface area were prepared by the electrospinning following by calcination *** nanoparticles with the well-controlled size as a catalyst were synthesized on the surface of In2O3 *** Au-decorated In2O3 nanofibers were reliably integrated as sensing materials on the bridge-type micro-platform including micro-heaters and *** micro-platform designed to maintain high temperature with low power consumption was fabricated by a microelectromechanical system(MEMS)*** micro-platform gas sensor consisting with Au-In2O3 nanofibers were fabricated effectively to detect HCHO gases with high sensitivity and *** HCHO gas sensing behaviors were schematically studied as a function of the gas concentration,the size of the adsorbed Au nanoparticles,the applied power to raise the temperature of a sensing part and the kind of target gases.

关键词： Gold nanoparticle In2O3 nanofiber Formaldehyde Gas sensor Low power Micro-platform

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Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-na?ve Korean patients infected with genotype C2

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World Journal of Gastroenterology 2017年第23期23卷 4222-4232页

作者： Ji-Eun kim So-Young Lee Hong kim Ki-Jeong kim Won-Hyeok Choe Bum-joon kim Department of Biomedical Sciences Microbiology and Immunologyand Liver Research InstituteSeoul National University College of Medicine Department of Microbiology School of MedicineJoong-Ang University Department of Internal Medicine Konkuk University School of Medicine

AIM To report naturally occurring mutations in the reverse transcriptase region(RT) of hepatitis B virus(HBV) polymerase from treatment na?ve Korean chronic patients infected with genotype *** Here, full-length HBV reverse transcriptase RT sequences were amplified and sequenced from 131 treatment na?ve Korean patients chronically infected with hepatitis B genotype C2. The patients had two distinct clinical statuses: 59 patients with chronic hepatitis(CH) and 72 patients with hepatocellular carcinoma(HCC). The deduced amino acids(AAs) at42 previously reported potential nucleos(t)ide analog resistance(NAr) mutation positions in the RT region were analyzed. RESULTS Potential NAr mutations involving 24 positions were found in 79 of the 131 patients(60.3%). Notably, AA substitutions at 2 positions(rt184 and rt204) involved in primary drug resistance and at 2 positions(rt80 and rt180) that functioned as secondary/compensatory mutations were detected in 10 patients(1 CH patient and 9 HCC patients) and 7 patients(1 CH and 6 HCC patients), respectively. The overall mutation frequencies in the HCC patients(3.17%, 96/3024 mutations) were significantly higher than the frequencies in the CH patients(2.09%, 52/2478 mutations)(P = 0.003). In addition, a total of 3 NAr positions, rt80, rt139 and rt204 were found to be significantly related to HCC from treatment na?ve Korean patients. CONCLUSION Our data showed that naturally occurring NAr mutations in South Korea might contribute to liver disease progression(particularly HCC generation) in chronic patients with genotype C2 infections.

关键词： Hepatitis B virus Polymerase Reverse transcriptase Potential nucleos(t)ide analog resistance Chronic hepatitis Hepatocellular carcinoma

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Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant

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World Journal of Gastroenterology 2015年第22期21卷 6872-6883页

作者： In-Kyung Lee Seoung-Ae Lee Hong kim You-Sub Won Bum-joon kim Department of Microbiology and Immunology Liver Research Institute Cancer Research Institute and SNUMRCCollege of Medicine Seoul National University

AIM: To investigate the mechanism of endoplasmic reticulum(ER) stress induction by an occult infection related hepatitis B virus S surface antigen(HBsAg)***: We used an HBsAg variant with lower secretion capacity, which was a KD variant from a Korean subject who was occultly infected with the genotype C. We compared the expression profiles of ER stress-related proteins between HuH-7 cells transfected with HBsAg plasmids of a wild-type and a KD variant using Western ***: Confocal microscopy indicated that the KD variant had higher levels of co-localization with ER than the wild-type HBsAg. The KD variant upregulated ER stress-related proteins and induced reactive oxygen species(ROS) compared to the wildtype via an increase in calcium. The KD variant also down-regulated anti-oxidant proteins(HO-1, catalase and SOD) compared to the wild-type, which indicates positive amplification loops of the ER-ROS axis. The KD variant also induced apoptotic cell death via the upregulation of caspase proteins(caspase 6, 9 and 12).Furthermore, the KD variant induced a higher level of nitric oxide than wild-type HBsAg via the up-regulation of the iNOS ***: Our data indicate that occult infection related HBsAg variants can lead to ER-derived oxidative stress and liver cell death in HuH-7 cells.

关键词： Endoplasmic reticulum oxidative stress Hepatitis B virus KD variant Colocalization Reactive oxidative species Apoptotic cell death

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Staging of liver fibrosis or cirrhosis: The role of hepatic venous pressure gradient measurement

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World Journal of Hepatology 2015年第3期7卷 607-615页

作者： Ki Tae Suk Dong joon kim Department of Internal Medicine Hallym University College of Medicine

Liver fibrosis is a common histological change of chronic liver injury and it is closely related with portalhypertension which is hemodynamic complication of chronic liver disease. Currently, liver fibrosis has been known as a reversible dynamic process in previous literatures. Although liver biopsy is a gold standard for assessing the stage of liver fibrosis, it may not completely represent the stage of liver fibrosis because of sampling error or semi-quantative measurement. Recent evidences suggested that histologic, clinical, hemodynamic, and biologic features are closely associated in patients with chronic liver disease. Hepatic venous pressure gradient(HVPG) measurement has been known as a modality to evaluate the portal pressure. The HVPG measurement has been used clinically for fibrosis diagnosis, risk stratification, preoperative screening for liver resection, monitoring the efficacy of medical treatments, and assessing the prognosis of liver fibrosis. Therefore, the HVPG measurement can be used to monitor areas the chronic liver disease but also other important areas of chronic liver disease.

关键词： Fibrosis Liver Venous pressure

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Detection of damage locations and damage steps in pile foundations using acoustic emissions with deep learning technology

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Frontiers of Structural and Civil Engineering 2021年第2期15卷 318-332页

作者： Alipujiang JIERULA Tae-Min OH Shuhong WANG joon-Hyun LEE Hyunwoo kim Jong-Won LEE School of Resource&Civil Engineering Northeastern UniversityShenyang110819China School of Mechanical Engineering Pusan National UniversityBusan46241Korea Department of Civil and Environmental Engineering Pusan National UniversityBusan46241Korea Korea Institute of Geoscience and Mineral Resource(KIGAM) Daejeon34132Korea

The aim of this study is to propose a new detection method for determining the damage locations in pile foundations based on deep learning using acoustic emission ***,the damage location is simulated using a back propagation neural network deep learning model with an acoustic emission data set acquired from pile hit *** particular,the damage location is identified using two parameters:the pile location(PL)and the distance from the pile cap(DS).This study investigates the influences of various acoustic emission parameters,numbers of sensors,sensor installation locations,and the time difference on the prediction accuracy of PL and *** addition,correlations between the damage location and acoustic emission parameters are ***,the damage step condition is determined using a classification model with an acoustic emission data set acquired from uniaxial compressive strength ***,a new damage detection and evaluation method for pile foundations is *** new method is capable of continuously detecting and evaluating the damage of pile foundations in service.

关键词： pile foundations damage location acoustic emission deep learning damage step

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Relation between preoperative hyperopia and surgical outcome in infantile esotropia

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1963-1967页

作者： Haeng Jin Lee Jeong-Ah kim Seong-joon kim Young Suk Yu Department of Ophthalmology Seoul National University College of Medicine Seoul Artificial Eye Center Seoul National University Hospital Clinical Research Institute

AIM: To evaluate the relation between preoperative hyperopia and surgical outcomes of infantile esotropia in patients younger than 24 months of ***: Medical records of patients who underwent bilateral medial rectus muscle recession for infantile esotropia between November 1, 2002 and December 1, 2011 were retrospectively reviewed. Patients were divided into two groups according to the degree of preoperative hyperopia. Group I had less than +3.0 diopter(D) of hyperopia and group II had between +3.0 and +5.0 D of hyperopia. Postoperative alignments were evaluated 1 wk, 3, 6 mo, and 1 y after surgery. Following the 1-year postoperative visit, patients were monitored yearly. Relationships between preoperative factors including hyperopia and postoperative outcomes were evaluated. RESULTS: Forty-six patients were included, with 33 patients in group I and 13 patients in group II. The preoperative mean refractive error was +0.88 D in group I and +3.45 D in group II. Surgical outcomes were not significantly different between groups at any postoperative time point examined. Cumulative probability of surgical success, prevalence of inferior oblique overaction, dissociated vertical deviation, and re-operation rate were not significantly different between ***: Preoperative moderate hyperopia(less than +5.0 D) did not affect the surgical outcome of infantile esotropia. Therefore, the surgical correction of esotropia should be considered when the angle of esodeviation is unchanged following hyperopia correction, even in children with moderate hyperopia.

关键词： infantile esotropia hyperopia medial rectus muscle recession

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Influence of glass-based dental ceramic type and thickness with identical shade on the light transmittance and the degree of conversion of resin cement

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International Journal of Oral Science 2018年第1期10卷 44-49页

作者： Soram Oh Su-Mi Shin Hyun-Jung kim Janghyun Paek Sung-joon kim Tai Hyun Yoon Sun-Young kim Department of Conservative Dentistry Graduate School Kyung Hee University Seoul Korea Department of Prosthodontics School of Dentistry Kyung Hee University Seoul Korea Department of Dentistry School of Medicine Jeju National University Jeju Korea Department of Physics Korea University Seoul Korea and SDepartment of Conservative Dentistry Dental Research Institute School of Dentistry Seoul National University Seoul Korea

The purpose of this study was to assess the influence of the types and thicknesses of glass ceramic plates on light transmittance and compare the degrees of conversion(DC) of resin cement under the ceramic materials. Three ceramic plates with thicknesses of 0.5, 1.0, 2.0, and 4.0 mm were fabricated from each of five commercial ceramic blocks in shade A2: high-translucency and low-translucency IPS Empress CAD(EmpHT and EmpLT); high-translucency and low-translucency IPS *** CAD(EmxHT and EmxLT); and Vita Mark Ⅱ(Vita). The translucency parameter was obtained using a colorimeter. The light transmittance rate was measured using a photodetector attached to an optical power meter. The DC of a resin cement(Variolink N) underneath the ceramic plates was examined by Fourier transform infrared spectroscopy. The translucency parameter, light transmittance rate, and DC showed significant differences by ceramic type and thickness(P 0.05). Both type and thickness of the glass ceramics significantly influenced the light transmittance and DC of the light-cured resin cement beneath the ceramic of the same shade.

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Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections,rt269L and rt269I

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World Journal of Gastroenterology 2023年第11期29卷 1721-1734页

作者： Kijeong kim Yu-Min Choi Dong Hyun kim Junghwa Jang Won Hyeok Choe Bum-joon kim Department of Microbiology College of MedicineChung-Ang UniversitySeoul 06974South Korea Department of Microbiology and Immunology College of MedicineSeoul National UniversitySeoul 03080South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Department of Biomedical Sciences College of MedicineSeoul National UniversitySeoul 03080South Korea Liver Research Institute College of MedicineSeoul National UniversitySeoul 03080South Korea Seoul National University Medical Research Center Seoul 03080South Korea

BACKGROUND The presence of two distinct hepatitis B virus(HBV)Pol RT polymorphisms,rt269L and rt269I,could contribute to the unique clinical or virological phenotype of HBV genotype ***,a simple and sensitive method capable of identifying both types in chronic hepatitis B(CHB)patients infected with genotype C2 should be *** To develop a novel simple and sensitive locked nucleic acid(LNA)-real timepolymerase chain reaction(RT-PCR)method capable of identifying two rt269 types in CHB genotype C2 *** We designed proper primer and probe sets for LNA-RT-PCR for the separation of rt269 *** synthesized DNAs of the wild type and variant forms,melting temperature analysis,detection sensitivity,and endpoint genotyping for LNA-RT-PCR were *** developed LNA-RT-PCR method was applied to a total of 94 CHB patients of genotype C2 for the identification of two rt269 polymorphisms,and these results were compared with those obtained by a direct sequencing *** The LNA-RT-PCR method could identify two rt269L and rt269I polymorphisms of three genotypes,two rt269L types[‘L1’(WT)and‘L2’]and one rt269I type(‘I’)in single(63 samples,72.4%)or mixed forms(24 samples,27.6%)in 87(92.6%sensitivity)of 94 samples from Korean CHB *** the results were compared with those obtained by the direct sequencing protocol,the LNA-RT-PCR method showed the same results in all but one of 87 positive detected samples(98.9%specificity).CONCLUSION The newly developed LNA-RT-PCR method could identify two rt269 polymorphisms,rt269L and rt269I,in CHB patients with genotype C2 *** method could be effectively used for the understanding of disease progression in genotype C2 endemic areas.

关键词： Hepatitis B virus Genotype C2 Polymerase rt269 Locked nucleic acid-real time-polymerase chain reaction Chronic hepatitis B

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