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Characterization of CD8＋CD57＋ T cells in patients wit acute myocardial infarction

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Cellular & Molecular Immunology 2015年第4期12卷 466-473页

作者： Hee Tae Yu Jong-Chan Youn Jino Lee Seunghyun Park Ho-Seok Chi Jungsul Lee Chulhee Choi Sungha Park Donghoon Choi Jong-Won Ha Eui-cheol shin Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and Engineering KAIST Daejeon Republic of Korea Cardiology Division Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Republic of Korea Department of Bio and Brain Engineering KAIST Daejeon Republic of Korea ' ' The first two authors contributed equally to this article

Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction （MI）. We studied the immunological characteristics and clinical impact of CD8＋CD57＋ T cells in acute MI patients. The frequency of CD57＋ cells among CD8＋ T cells was examined in peripheral blood sampled the morning after acute MI events. Interestingly, the frequency of CD57＋ cells in the CD8＋ T-cell population correlated with cardiovascular mortality 6 months after acute MI. The immunological characteristics of CD8＋CD57＋ T cells were elucidated by surface immunophenotyping, intracellular cytokine staining and flow cytometry. Immunophenotyping revealed that the CD8＋CD57＋ T cells were activated, senescent T cells with pro-inflammatory and tissue homing properties. Because a high frequency of CD8＋CD57＋ T cells is associated with short-term cardiovascular mortality in acute MI patients, this specific subset of CD8＋ T cells might contribute to acute coronary events via their pro-inflammatory and high cytotoxic capacities. Identification of a pathogenic CD8＋ T-cell subset expressing CD57 may offer opportunities for the evaluation and management of acute MI.

关键词： acute myocardial infarction CD8+CD57+ T cells immunosenescence

RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering

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Regenerative Biomaterials 2017年第3期4卷 159-166页

作者： Yong cheol shin Jeonghyo Kim Sung Eun Kim Su-Jin Song SuckWon Hong Jin-Woo Oh Jaebeom Lee Jong-Chul Park Suong-Hyu Hyon Dong-Wook Han Department of Cogno-Mechatronics Engineering Department of Optics and Mechatronics Engineering Department of Nanoenergy Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Korea Cellbiocontrol Laboratory Department of Medical EngineeringYonsei University College of MedicineSeoul 03722Korea and 5Center for Fiber and Textile Science Kyoto Institute of TechnologyMatsugasakiKyoto 606-8585Japan

In recent years,much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular *** our study,RGD peptide and graphene oxide(GO)co-functionalized poly(lactide-co-glycolide,PLGA)(RGD-GO-PLGA)nanofiber mats were fabricated via electrospinning,and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue *** electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of randomoriented electrospun nanofibers with average diameter of *** successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic ***,the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and *** was found that the mats were thermally stable under the cell culture ***,the initial attachment and proliferation of primarily cultured vascular smoothmuscle cells(VSMCs)on the RGD-GO-PLGA nanofibermats were *** was revealed that the RGD-GO-PLGA nanofibermats can effectively promote the growth of *** conclusion,our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smooth muscle.

关键词： RGD peptide graphene oxide poly(lactic-co-glycolic acid) biofunctional scaffold vascular smooth muscle cell

Disease progression in chronic hepatitis C patients with normal alanine aminotransferase levels

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World Journal of Gastroenterology 2013年第14期19卷 2256-2261页

作者： Dong Hyun Sinn Geum-Youn Gwak Jae-uk shin Moon Seok Choi Joon Hyeok Lee Kwang cheol Koh Seung Woon Paik Byung Chul Yoo Department of Internal Medicine Sanggye Paik HospitalInje University School of Medicine Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate whether the disease progression of chronic hepatitis C patients with normal alanine aminotransferase(ALT) levels differs by ALT ***:A total of 232 chronic hepatitis C patients with normal ALT( 26 IU/L(highnormal),respectively(P = 0.043),and it was 1.4% and 4.8% for female patients with baseline ALT levels ≤ 22 IU/L(low-normal) and > 23 IU/L(high-normal),respectively(P = 0.023).ALT levels fluctuated during the follow-up *** the follow-up,more patients with "high-normal" ALT levels at baseline experienced ALT elevation(> 41 IU/L) than did patients with "lownormal" ALT levels at baseline(47.7% vs 27.9%,P = 0.002).The 5 year cumulative incidence of disease progression was significantly lower in patients with persistently "low-normal" ALT levels than "high-normal" ALT levels or those who exhibited an ALT elevation > 41 U/L during the follow-up period(0%,8.3% and 34.3%,P < 0.001).CONCLUSION:A "high normal" ALT level in chronic hepatitis C patients was associated with disease progression,suggesting that the currently accepted normal threshold of serum ALT should be lowered.

关键词： Alanine aminotransferase Upper limits of normal Disease progression Hepatitis C virus Hepatocellular carcinoma

An Evaluation of the Machinability of Nitinol SMA Using Combined Process of EP and MR Polishing

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Journal of Iron and Steel Research(International) 2012年第S2期19卷 629-632页

作者： HA Seok-Jae shin Bong-cheol CHO Myeong-Woo LEE Eun-Sang CHOI Seung-Bok Department of Mechanical Engineering Inha University Samsung Electro-Mechanics

Nitinol,a shape memory alloy(SMA),is manufactured from titanium and *** is employed in various fields for use in devices such as micro sensors,ultra-precision devices and satellite *** is highly recommended as a material in medical stents for insertion into the body because it has excellent organic ***,because they are intended to be inserted into the human body,products such as medical stents require a high-quality *** nitinol has more of the characteristics of titanium than of nickel,one of its drawbacks is that heat generated in nitinol during machining is not discharged smoothly,leading to areas of inner stress which occur when traditional machining methods are *** overcome this difficulty,various non-traditional machining methods,including non-contact machining,have been investigated for use with *** study is focused on the application of an effective fabrication method that combines electrolytic polishing(EP)and MR polishing to improve the surface integrity of nitinol through a series of *** roughness variations of the polished nitinol were investigated by changing the imposed polishing conditions of EP and MR polishing,***,the variations in the surface roughness were observed with polished previously performed via the EP process.

关键词： electrolytic polishing(EP) magnetorheological(MR)fluids Ni-Ti alloy shape memory alloy(SMA) surface roughness

Extremely low-frequency magnetic field exposure level for Koreans by occupational code

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Emerging Contaminants 2018年第1期4卷 40-46页

作者： Joon Sig Jung Mailan Arachchige Don Rajitha Kawshalya In Keun Shim Jung Min Ryu Myung Hee Kwon Duck shin Park Seung cheol Hong National Indoor Environment&Noise Research Division National Institute of Environmental Research42 Hwankyeong-RoSeo-KuIncheonSouth Korea Dept.of Emergency and Disaster Management Inje University197 Inje-roGimhae-siGyungnamSouth Korea Transportation Environment Research Team Korea Railroad Research Institute176 Cheoldobagmulgwan-RoUiwang-siGyeonggi-doSouth Korea Dept.of Occupational Health&Safety Engineering Inje University197 Inje-roGimhae-siGyungnamSouth Korea

This study attempted to identify the level of exposure of 350 subjects to the extremely low-frequency magnetic field(ELF-MF).The occupational group showed significantly high levels of ELF-MF in every exposure indicator during work and transportation(p<0.05).About 11%and 6%of the members of the occupational group were exposed to over 2mG and 4 mG,respectively,of ELF-MF during"all"*** 24-h ELF-MF exposure levels of the subjects in both groups were *** the occupational group,for every activity,the percentile for less than 2mG corresponded to 100%of C-4(agriculture),95%of C-1(professional),97%of C-2(engineer,office/sales),81%of C-3(services),85%of C-5(technician,labor management),and 50%of C-6(electrician).In the non-occupational group,the percentile for less than 2mG corresponded to 92%of students,83%of homemakers,81%of the elderly,and 88%of the *** percentile for over 4mG was 5%for students,homemakers,and the elderly and 13%of the *** and the unemployed had the highest ELF-MF levels in both groups,*** were exposed to ELF-MF mostly at work,while the unemployed subjects were most affected by the activities classified under sleep and transportation.

关键词： ELF-MF EMF Exposure assessment Occupational code Occupational exposure

Differentiation of hepatocellular carcinoma from its variousmimickers in liver magnetic resonance imaging:What arethe tips when using hepatocyte-specific agents?

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World Journal of Gastroenterology 2016年第1期22卷 284-299页

作者： Yang shin Park Chang Hee Lee Jeong Woo Kim Sora shin cheol Min Park Department of Radiology Korea University Guro HospitalKorea University College of MedicineSeoul 152-703South Korea Korea University College of Medicine Anam-dong 5-gaSeongbuk-GuSeoul 136-701South Korea

Hepatocellular carcinoma is the most common primary hepatic malignant *** widespread use of liver imaging,various cirrhosis-related nodules are frequently detected in patients with chronic liver disease,while diverse hypervascular hepatic lesions are incidentally detected but undiagnosed on dynamic computed tomography and magnetic resonance imaging(MRI).However,use of hepatocyte-specific MR contrast agents with combined perfusion and hepatocyte-selective properties have improved diagnostic performance in detection and characterization of focal liver ***,the enhancement patterns observed during dynamic phases using hepatocyte-specific agents may be different from those observed during MRI using conventional extracellular fluid agents,leading to confusion in ***,we discuss useful tips for the differentiation of hepatocellular carcinoma from similar lesions in patients with and without chronic liver disease using liver MRI with hepatocyte-specific agents.

关键词： Hepatocellular carcinoma Gadoxetic acid Magnetic resonance imaging Liver cirrhosis

Malnutrition in patients with chronic kidney disease

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Open Journal of Internal Medicine 2012年第2期2卷 89-99页

作者： Sungjin Chung Eun Sil Koh Seok Joon shin cheol Whee Park Division of Nephrology Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Republic of Korea

Malnutrition is a major issue in patients with chronic kidney disease (CKD), adversely affecting morbidity, mortality, functional activity and patients’ quality of life. Our knowledge of the pathogenic mechanisms of malnutrition in patients with CKD, including endstage renal disease, has been improved. This has led to the development of clinical practice guidelines for nutritional care in CKD which provide a framework for the nutritional issues facing patients and physiccians. Extensive research in the field of nutrition in patients with CKD has resulted in the formation of general guidelines, although some uncertainties still exist on some of the best therapeutic or preventive options in uremic malnutrition. It is important to search actively for malnutrition since early diagnosis and treatment can improve the prognosis for CKD patients and reduce the monetary costs connected with treatment.

关键词： Chronic Kidney Disease End-Stage Renal Disease Inflammation Malnutrition

Identification and Biological Activities of the Phenolic Compounds in <i>Eisenia arborea</i>

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American Journal of Plant Sciences 2021年第2期12卷 259-265页

作者： Hyeon cheol shin Ignacio Beamonte Wayas Byoung Wook Choi Bong Ho Lee CEWIT Center for Systems Biology The State University of New York 119 Songdo Moonhwaro Yeonsu-gu Incheon Korea Baja Kelp Talasoterapia Ensenada Mexico Department of Chemical and Biological Engineering Hanbat National University 125 Dongseodaero Yuseong-gu Daejeon Korea

Four polyphenols were isolated and purified from a brown alga Eisenia arborea. These phlorotannin compounds showed strong radical scavenging and some enzyme inhibitory activities. All of the compounds showed strong antioxidative, acetylcholinesterase and butyrylcholinesterase inhibitory, and tyrosinase inhbibitory activities at 100 μg/mL. Dieckol and PFF inhibited butyrylcholinesterase, a new target for the treatment of Alzheimer’s disease, very strongly even at 10 μg/mL, more strongly than AChE. These two compounds also effectively inhibited tyrosinase. These results support the potential of developing natural antioxidants and antidementia agents from the brown alga.

关键词： Eisenia arborea Phenolic Compounds DPPH Radical Scavenger Enzyme Inhibition Isolation

Sex-based differences in histology,staging,and prognosis among 2983 gastric cancer surgery patients

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World Journal of Gastroenterology 2022年第9期28卷 933-947页

作者： Yonghoon Choi Nayoung Kim Ki Wook Kim Hyeong Ho Jo Jaehyung Park Hyuk Yoon cheol Min shin Young Soo Park Dong Ho Lee Hyeon Jeong Oh Hye Seung Lee Young Suk Park Sang-Hoon Ahn Yun-Suhk Suh Do Joong Park Hyung-Ho Kim Ji-Won Kim Jin Won Kim Keun-Wook Lee Won Chang Ji HoonPark Yoon Jin Lee Kyoung Ho Lee Young Hoon Kim Department ofInternal Medicine Seoul National University Bundang HospitalSeongnam 13620South Korea Nayoung Department of Internal Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University College of MedicineSeoul 03080South Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Surgery Seoul National University College of MedicineSeoul 03080South Korea Department of Radiology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Radiology Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer(GC).AIM To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for *** A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were *** clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were *** Among the 2983 patients, 2005(67.2%) and 978(32.8%) were males and females, *** average age of the female group(59.36 years) was significantly younger than that of the male group(61.66 years;P < 0.001).Cancer of the gastric body(P < 0.001) and diffuse-type histology(P < 0.001) were more common in females than in *** trend was more prominent in females younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male *** of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with *** overall survival rate was significantly higher in females(P < 0.001).However, this difference disappeared for GC-specific survival(P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer(stage Ⅲ or above) in females(P = 0.045).The risk factors for GC-related mortality were older age, upper location of GC, and diffuse-or mixed-type *** terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in *** Sex-based differences in GC were

关键词： Gastric cancer Histology Prognosis Sex difference Survival