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Changes in human pluripotent stem cell gene expression after genotoxic stress exposures

World Journal of Stem Cells 2014年第5期6卷 598-605页

作者： mykyta v sokolov Ronald D Neumann Nuclear Medicine Division Department of Radiology and Imaging SciencesClinical CenterNational Institutes of HealthBethesdaMD 20892United States

Human pluripotent stem cells(h PSCs) represent heterogeneous populations, including induced pluripotent stem cells(i PSCs), endogenous plastic somatic cells, and embryonic stem cells(ESCs). Human ESCs are derived from the inner cell mass of the blastocyst, and they are characterized by the abilities to self-renew indefinitely, and to give rise to all cell types of embryonic lineage(pluripotency) under the guidance of the appropriate chemical, mechanical and environmental cues. The combination of these critical features is unique to h ESCs, and set them apart from other human cells. The expectations are high to utilize h ESCs for treating injuries and degenerative diseases; for modeling of complex illnesses and development; for screening and testing of pharmacological products; and for examining toxicity, mutagenicity, teratogenicity, and potential carcinogenic effects of a variety of environmental factors, including ionizing radiation(IR). Exposures to genotoxic stresses, such as background IR, are unavoidable; moreover, IR is widely used in diagnostic and therapeutic procedures in medicine on a routine basis. One of the key outcomes of cell exposures to IR is the change in gene expression, which may underlie the ultimate h ESCs fate after such a stress. However, gaps in our knowledge about basic biology of h ESCs impose a serious limitation to fully realize the potential of h ESCs in practice. The purpose of this review is to examine the available evidence of alterations in gene expression in human pluripotent stem cells after genotoxic stress, and to discuss strategies for future research in this important area.

关键词： Human pluripotent stem cells Gene expression alterations Genotoxic stress Ionizing radiation

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A metabolic signalling role for arginine in liver cancer

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Life Metabolism 2024年第1期3卷 1-3页

作者： David sokolov Lucas B.Sullivan Human Biology Division Fred Hutchinson Cancer CenterSeattleWA 98109United States

In addition to their canonical roles in biosynthetic pathways,metabolites can be active participants in oncogenic signal-ling,but our understanding of these signalling mechanisms is *** a recent article published in Cell,Mossmann et *** a novel signalling role for accumulated arginine in hepato-cellular carcinoma(HCC)mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39(RBM39).

关键词： incomplete cancer

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A metabolic signalling role for arginine in liver cancer

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Life Metabolism 2024年第01期 8-10页

作者： David sokolov Lucas B.Sullivan Human Biology Division Fred Hutchinson Cancer Center

In addition to their canonical roles in biosynthetic pathways, metabolites can be active participants in oncogenic signalling, but our understanding of these signalling mechanisms is incomplete. In a recent article published in Cell, Mossmann et al. find a novel signalling role for accumulated arginine in hepatocellular carcinoma(HCC) mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39(RBM39).It is now appreciated that cancer cells enact specific metabolic changes to accommodate increased proliferation, create permissive tumour microenvironments, and adapt to physiological stressors, among other functions. When considering the roles of different metabolites in cancer, an informative distinction can be made between so-called metabolic roles, in which molecules contribute biomass or energy towards tumour growth, and signalling roles, where molecules modify cellular physiology by interfacing with diverse nutrient-sensing pathways.

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Biological protection of plants in agricultular landscape—state of the art, problems and ways of their decision

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 398-400页

作者： sokolov M S Kolombet L v Research Center for Toxicology and Hygienic Regulation of Biopreparations State Research Center for Applied Microbiology 142279 Obolensk Moscow Region Russia 142253 Serpukhov Moscow reg. Russia

Biological protection of plants: definition and objectives. Technologically, biological protection of plants (hereinafter bioprotection) is a high agricultural technology involving agricultural landscape approach and basee on an ecological imperative, namely “use living beings against living beings”. In a wide sense, present-day bioprotection is a fundamental and applied field of knowledge providing harmless suppression of harmful agents during cultivation and storage of agricultural crops by use natural and (or) artificially constructed organisms (including genetically modified ones having pesticidal properties) and products of their live cycle. The overall objective of bioprotection consists in producing harmless, profitable and high-quality vegetative raw material, food, fodder. At the same time, bioprotection agrotechnologies are important environment forming and environment maintaining factors, steady and positively influencing the health of both rural ethnos, and agrosphere as a whole. Realization of integrated bioprotection approaches should provide minimum destruction of beneficial and non-target organisms, excluding the succession of harmful species and appearance of species resistant to biocontrol agents. 2. Theoretical foundation of bioprotection. The following postulates and imperatives of biosphere science, agrarian and social ecology make the scientific basis of bioprotection: “The Nature knows the how and why of things better”; Steady, balanced development of agrosphere (proceeding from a presumption of life support) is based on biocentrism and biosystem relations, or consortism of its consorbents; Control of the agrosphere by human beings could be effective only in case of primary realization of biocenotic regulation; Biocenotic regulation, dynamics of the number and species diversity of agrosphere is realized through trophically similar cenoconsorcia and tritrophic systems, that provides maintenance and preservation of trophically proved critica

关键词：植物生物保护农业景观农业气候设施园艺

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Enhanced four-wave mixing process near the excitonic resonances of bulk MoS_2

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Photonics Research 2019年第3期7卷 251-259页

作者： BRIAN A.KO ALEXEI v.sokolov MARLAN O.SCULLY ZHENRONG ZHANG HO WAI HOWARD LEE Department of Physics Baylor University The Institute for Quantum Science and Engineering Texas A&M University College Station Princeton University Princeton

Two-dimensional materials are generating great interest due to their unique electrical and optical *** particular, transition metal dichalcogenides such as molybdenum disulfide(MoS_2) are attractive materials due to the existence of a direct band gap in the monolayer limit that can be used to enhance nonlinear optical phenomena, such as Raman spectroscopy. Here, we have investigated four-wave mixing processes in bulk MoS_2 using a multiplex coherent anti-Stokes Raman spectroscopy setup. The observed four-wave mixing signal has a resonance at approximately 680 nm, corresponding to the energy of the A excitonic transition of MoS_2. This resonance can be attributed to the increased third-order nonlinear susceptibility at wavelengths near the excitonic transition. This phenomenon could open the path to using MoS_2 as a substrate for enhancing four-wave mixing processes such as coherent anti-Stokes Raman spectroscopy.

关键词： Two-dimensional materials excitonic resonances MoS2

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vanadium-doped TiO_(2)-B/anatase mesoporous nanotubes with improved rate and cycle performance for rechargeable lithium and sodium batteries

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Journal of Materials Science & Technology 2020年第19期54卷 181-189页

作者： D.P.Opra S.v.Gnedenkov A.A.sokolov A.B.Podgorbunsky A.Yu.Ustinov v.Yu.Mayorov v.G.Kuryavyi S.L.Sinebryukhova Institute of Chemistry FEB RAS 159Pr.100-letiya Vladivostok1Vladivostok 690022Russia Far Eastern Federal University 8St.Sukhanov1Vladivostok 690950Russia

TiO_(2)-B/anatase nanotubes doped by vanadium have been synthesized through a facile one-step hydrothermal *** material shows a mesoporous structure with a specific surface area of 179.1 m^(2)g^(-1).XPS data presume the presence of v^(3+),v^(4+),v^(5+),and Ti^(3+) in doped TiO2-B/*** found by XRD and EIS investigations,the vanadium expands bronze titania crystal structure and enhances the conductivity of material by three orders of *** tested for lithium storage,the v-modified titania nanotubes show a specific capacity of 133 mA h g^(-1) after 100 charge/discharge cycles at the current density of 3000 mA g^(-1) with a Coulombic efficiency of around 98.9%,resulting in its good *** material still possesses a reversible capacity of 114 mA h g^(-1) at a very high current load of 6000 mA g^(-1),demonstrating superior rate characteristics for secondary lithium ***,v-doped Ti O2-B/anatase mesoporous nanotubes show promise performance as anode material for sodium-ion batteries,delivering about 119 mA h g^(-1) and 101 m A h g^(-1) at the current loads of 10 and 1500 m A g^(-1),respectively.

关键词： Lithium-ion battery Sodium-ion battery Anode TiO_(2)-B Anatase Doping Nanotubes Mesoporosity

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Preparation on the basis of Trichoderma asperellum in the system of biological protection of wheat from Fusarium ear scab

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 394-395页

作者： Kolombet L v sokolov M S Chuprina v P Schisler D A Samuels G J State Research Center for Applied Microbiology Obolensk Moscow Region RussiaResearch Center of Toxicology and Hygienic Regulation of Biological Products Serpukhov RussiaAll-Russia Research Institute of Biological Plant Disease Control Krasnodar Russia USDA-ARS NCAUR Peoria Illinois USA USDA-ARS Systematic Botany and Mycology Lab. Beltsville USA

During the last century, as the area of wheat grown under advanced grain husbandry has increased worldwide, so too has the importance of Fusarium ear scab (FES) (synonym, Fusarium head blight) caused by several species of the fungus Fusarium. Yield losses due to FES can total 20%-40% and more depending on climatic conditions. During the last twenty years epidemics of FES in cereals have become chronic all over the world, including the United States and Russia. The most destructive of these were observed in 1982, 1986, 1990-1996 in USA and in the south of Russia in 1982, 1984, 1988, 1992. The harmful effect of FES is manifested not only in reduced grain yields, but also in the contamination of grains and grain products with mycotoxins, such as deoxynivalenol (DON) and its derivatives (3-alfa acetyl-DON, 15-alfa acetyl-DON), T-2 toxin and zearalenone. Standard means to control FES (cultural control methodologies, chemical pesticides, and FES resistant varieties) have little effect or are not practical and rarely reduce the accumulation of mycotoxins in grain. We have developed a new technique to reduce FES using biological preparations. The technique utilizes wheat seed pretreatment with a biofungicide “Mycol” in combination with spraying wheat plants during flowering with a yeast preparation. Technology for production of Mycol on the basis of Trichoderma asperellum strain GJS 03-35 (systematics by Samuels) has been developed. This strain shows hyperparasitic activity against a wide spectrum of plant pathogens, including Fusarium graminearum, a causative agent of FES in wheat. Experiments conducted in the United States demonstrated that spraying wheat plants during flowering with the patented yeast Cryptococcus nodaensis OH 182.9 (NRRL Y-30216) reliably reduces FES development. Tests of the Mycol preparation and the yeast OH 182.9 (EOD) have been performed on the spring wheat “Ivolga” in greenhouse conditions (the Moscow region) and on the winter wheat “Kupava” in fie

关键词：曲霉素木霉素镰刀霉穗痂病小麦生物防治

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Preparation on the basis of Trichoderma asperellum in the system of biological protection of wheat from Fusarium ear scab

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浙江大学学报(农业与生命科学版) 2004年第4期 44-45页

作者： Kolombet L v,sokolov M S,Chuprina v P,Schisler D A,Samuels G J State Research Center for Applied Microbiology Obolensk Moscow Region Russia Research Center of Toxicology and Hygienic Regulation of Biological Products Serpukhov Russia All-Russia Research Institute of Biological Plant Disease Control Krasnodar Russia USDA-ARS NCAUR Peoria Illinois USA USDA-ARS Systematic Botany and Mycology Lab. Beltsville USA

关键词： Fusarium ear scab (FES) Fusarium head blight mycotoxins deoxynivalenol (DON) biofungicide “Mycol” Trichoderma asperellum strain GJS 03-35 yeast Cryptococcus nodaensis OH 182.9 (NRRL. Y-30216) biocontrol

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Slc7a5 regulation of neural development

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Neural Regeneration Research 2021年第10期16卷 1994-1995页

作者： Aidan M.sokolov David M.Feliciano Department of Biological Sciences Clemson UniversityClemsonSCUSA

Membrane transport proteins are appreciated for their ability to transport molecules across biological membranes and have received a renewed focus for their role in nervous system *** such group of transporters are members of the solute carrier(SLC)*** transporters shuttle various molecules,including neurotransmitters,fatty acids,amino acids,and inorganic *** such,they play an integral role in supplying cells with essential *** example is that amino acids are transported by SLC family ***7a5 is a SLC family member that transports essential amino acids important for neuronal development,as well as other biological molecules including thyroid hormones T3,T4,and ***7a5 forms a heterodimer with Slc3a2 that facilitates the subcellular distribution of *** acids including leucine,glutamine,and arginine support cell growth by activating the protein kinase,mammalian target of rapamycin complex 1(mTORC1)(Liu et al.,2020).Consistent with this notion is that Slc7a5 transport of amino acids regulates mTORC1 activity in numerous cell types(Nicklin et al.,2009).A recent manuscript expands upon these findings to demonstrate that Slc7a5 plays a previously unrecognized and critical role in the regulation of mTORC1 activity and neuron development(sokolov et al.,2020).

关键词： inorganic solute notion

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Characterization and Electrochemical Properties of Nanostructured Zr-Doped Anatase TiO_2 Tubes Synthesized by Sol–Gel Template Route

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Journal of Materials Science & Technology 2017年第6期33卷 527-534页

作者： Denis P.Opra Sergey v.Gnedenkov Sergey L.Sinebryukhov Elena I.voit Alexander A.sokolov Evgeny B.Modin Anatoly B.Podgorbunsky Yury v.Sushkov veniamin v.Zheleznov Institute of Chemistry Far Eastern Branch of Russian Academy of Sciences Far Eastern Federal University National Research Centre "Kurchatov Institute"

A series of nanostructured Zr-doped anatase TiO_2 tubes with the Zr/Ti molar ratio of 0.01, 0.02, 0.03, and0.09 were prepared by a sol–gel technology on a carbon fiber template. The electrochemical performance of Zr-doped anatase TiO_2 as anodes for rechargeable lithium batteries was investigated and compared with undoped titania. Tests represented that after 35-fold charge/discharge cycling at C/10 the reversible capacity of Zr-doped titania（Zr/Ti = 0.03） reaches 135 m A h g^（-1）, while the capacity of undoped titania（Zr/Ti = 0） yielded only 50 m A h g^（-1）. Based on the results of the physicochemical investigation, three reasons of improving electrochemical performance of Zr-doped titania were suggested. According to the scanning electron microscopy and transmission electron microscopy, Zr^（4＋） doping induces a decrease in nanoparticle size, which facilitates the Li＋diffusion. The Raman investigations show the more open structure of Zr-doped TiO_2 as compared to undoped titania due to changing of the unit cell parameters, that significantly affects on the reversibility of the insertion/extraction process. The electrochemical impedance spectroscopy results indicate that substitution of Zr^（4＋） for Ti^（4＋） into anatase TiO_2 has favorable effects on the conductivity.

关键词： Li-ion batteries Anatase titania Nanostructured materials Sol–gel template process Doping Electrochemical performance

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