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Nutritional evaluation,fatty acid analysis and anticancer properties investigation of seeds from kan-zaw,a potential diet oil and medicinal plant

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Oil Crop Science 2021年第3期6卷 122-127页

作者： moe moe Lwin Ye Jin Xianpeng Yang Hao Shen Chao Qi Yizhong Wang Phyo Phyo Zin Oo Za Khai Tuang Shiyou Lü Wannian Yang Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan430079PR China Department of Botany Kyaing Tong UniversityEastern Shan StateMyanmar College of Life Sciences Shandong Normal UniversityJinan250014PR China School of Life Sciences Hubei UniversityWuhan434200PR China

Payenapara lleloneura Kurz.(Kan-zaw),an endemic medicinal plant only found in Tanintharyi Region of mya.mar,is widely used in the treatment of various cancer and different *** the present research,the seeds were phytochemical investigated for their nutritional potential for their use as functional foods or novel diet oil *** evaluation showed that the seeds are rich in fats and carbohydrates(soluble sugars and starch).Fatty acid analyses showed that the seeds accumulate very richα-eleostearic acid(α-ESA,18:3^(Δ9 cis,11-trans),13 trans),an important conjugated fatty acid,up to more than 70% of total fatty *** seed oil derived from the Kan-zaw tree contains approximately 3.25% β-eleostearic acid(18:3^(Δ9 trans,11 trans,13 trans)),an unusual conjugated fatty acid that imparts a potent anticancer application and industrially important drying qualities to Kan-zaw *** properties of the Kan-zaw seeds were examined;petroleum ether(60–90℃)extract of seed oils were also investigated for the saponification value,iodine value and estimation of acid ***,the present study investigated cytotoxic potential of ethanol,methanol,acetone,chloroform Kan-zaw seed extracts and commercial Kan-zaw oil against human cervical cancer cell line(HeLa).The Kan-zaw extracts and oil have shown significant anticancer activity on HeLa cells.

关键词： Payenapara lleloneura Kurz. Kan-zaw seeds Nutritional evaluation Fatty acid analysis Physicochemical properties Anticancer activity

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井巷多断面岩层热传递方式与深井热环境动态分析

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东北大学学报（自然科学版） 2015年第3期36卷 423-427页

作者：鹿浩罗周全 MOMAYEZ moe 中南大学资源与安全工程学院湖南长沙410083 Department of Mining and Geological Engineering The University of Arizona

确定井巷风流热量来源及关键地点温度变化、热增量与损失量,并以之为依据有针对性地开展深井气候调节是通风工程需要解决的关键问题之一.通过改进传统的傅里叶导热模型,建立了基于通风井巷实际断面形状的三维热传导模型,针对不同井巷断... 详细信息

确定井巷风流热量来源及关键地点温度变化、热增量与损失量,并以之为依据有针对性地开展深井气候调节是通风工程需要解决的关键问题之一.通过改进传统的傅里叶导热模型,建立了基于通风井巷实际断面形状的三维热传导模型,针对不同井巷断面形状确定了反映流速与流量状态的动量相关的计算边界条件,并结合时间参数揭示了岩层内部导热以及井巷岩壁与气流间的热交换规律,建立了湿壁面与气流间的热湿传导方程.在此基础上,构建起国内某大型深井金属矿山井下通风系统,获得了关键地点的温度、湿度、热量等参数的走势和变化特点,为矿山开展深井气候调节与控制奠定了基础.

关键词：深井热环境岩层热多热源动态分析

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Interfacial forces between silica surfaces measured by atomic force microscopy

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Journal of Environmental Sciences 2009年第1期21卷 30-34页

作者： DUAN JinmingKey Laboratory of Northwest Water Resource,Environment and Ecology,moe,Xi’an University of Architecture and Technology,Xi’an 710055,China Key Laboratory of Northwest Water Resource Environment and Ecology MOE Xi'an University of Architecture and Technology Xi'an 710055 China

Colloidal particle stability and some other interfacial phenomena are governed by interfacial force interactions. The two well known forces are van der Waals force and electrostatic force, as documented by the classical Derjaguin, Landau, Verwey, and Overbeek （DLVO） theory. Moreover, advances in modern instrumentation and colloid science suggested that some short-ranged forces or structure forces are important for relevant colloidal systems. The interfacial and/or molecular forces can be measured as a resultant force as function of separation distance by atomic force microscopy （AFM） colloid probe. This article presents a discussion on AFM colloid probe measurement of silica particle and silica wafer surfaces in solutions with some technical notifications in measurement and data convolution mechanisms. The measured forces are then analyzed and discussed based on the ＇constant charge＇ and ＇constant potential＇ models of DLVO theory. The difference between the prediction of DLVO theory and the measured results indicates that there is a strong short-range structure force between the two hydrophilic surfaces, even at extremely low ionic concentration, such as Milli-Q water purity solution.

关键词： colloid probe DLVO theory solvation forces interfacial interactions

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Inositol 1,4,5-trisphosphate 3-kinases:functions and regulations

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Cell Research 2005年第2期15卷 83-91页

作者： Hui Jun XIA*, Guang YANGKey Laboratory of moe for Plant Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072,China Key Laboratory of moe for Plant Developmental Biology College of Life Sciences Wuhan University Wuhan China

Inositol 1,4,5-trisphosphate 3-kinase (IP3 3-kinase/IP3K) plays an important role in signal transduction in animal cellsby phosphorylating inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5-tetrakisphosphate (IP4). Both IP3 and IP4 arecritical second messengers which regulate calcium (Ca2+) homeostasis. Mammalian IP3Ks are involved in many biologicalprocesses, including brain development, memory, learning and so on. It is widely reported that Ca2+ is a canonicalsecond messenger in higher plants. Therefore, plant IP3K should also play a crucial role in plant development. Recently,we reported the identification of plant IP3K gene (AtIpk2β/AtIP3K) from Arabidopsis thaliana and its ***, we summarize the molecular cloning, biochemical properties and biological functions of IP3Ks from animal, yeastand plant. This review also discusses potential functions of IP3Ks in signaling crosstalk, inositol phosphate metabolism,gene transcriptional control and so on.

关键词： inositol 1 4 5-trisphosphate 3-kinase (IP3 3-kinase/IP3K) inositol polyphosphate kinase (Ipk) inositol phos-phate multikinase (Ipmk) calcium (Ca2+) signal transduction

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Superhard nano-multilayers and nanocomposite coatings

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Progress in Natural Science:Materials International 2005年第2期15卷 2-12页

作者： BAI Xiaoming, ZHENG Weitao* and AN Tao(Department of Material Science and Key Laboratory of Automobile of moe, Jilin University, Changchun 130012, China) Lab. of Automobile of moe Dept. of Mat. Sci. Jilin Univ. Changchun 130012 China

This paper reviews the recent development of nano-multilayers and nanocomposite coatings. The hardening mechanisms and design of hard coating are discussed in details. Recent research on Ti/TiN and nitride/nitride multilayer, Ti-Si-N and Ti-Al-Si-N nanocomposite coatings is described, and the perspectives of the related research are proposed.

关键词： nano-structured materials multilayer nanocomposite hardness

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Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2329-2344页

作者： Junhui Hu Ping Tan moe Ishihara Nicholas ABayley Shiruyeh Schokrpur Jeremy GReynoso Yangjun Zhang Raymond JLim Camelia Dumitras Lu Yang Steven MDubinett Parmjit SJat Jacques Van Snick Jiaoti Huang Arnold IChin Robert MPrins Thomas GGraeber Hua Xu Lily Wu Department of Molecular and Medical Pharmacology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA90095USA Department of Urology West China HospitalChengduChina Department of Hematology and Oncology University of California San DiegoSan DiegoCA92103USA Department of Neurosurgery David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA90095USA Department of Biological Repositories Department of UrologyZhongnan Hospital of Wuhan UniversityWuhanChina Department of Medicine David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA90095USA Jonsson Comprehensive Cancer Center David Geffen School of Medicine at UCLAUniversity of California Los AngelesLos AngelesCA90095USA MRC Prion Unit at UCL Institute of Prion Diseases33 Cleveland StreetLondonW1W 7FFUK Ludwig Institute for Cancer Research Ltd BrusselsBelgium Department of Pathology Duke UniversityDurhamNCUSA Department of Urology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA90095USA Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center WuhanChina

Loss of function of the von Hippel-Lindau(VHL)tumor suppressor gene is a hallmark of clear cell renal cell carcinoma(ccRCC).The importance of heterogeneity in the loss of this tumor suppressor has been under *** study the impact of intratumoral VHL heterogeneity observed in human ccRCC,we engineered VHL gene deletion in four RCC models,including a new primary tumor cell line derived from an aggressive metastatic *** VHL gene-deleted(VHL-KO)cells underwent epithelial-to-mesenchymal transition(EMT)and exhibited increased motility but diminished proliferation and tumorigenicity compared to the parental VHL-expressing(VHL+)*** tumors with either VHL+or VHL-KO cells alone exhibit minimal metastatic *** tumors displayed rampant lung metastases,highlighting a novel cooperative metastatic *** poorly proliferative VHL-KO cells stimulated the proliferation,EMT,and motility of neighboring VHL+***(POSTN),a soluble protein overexpressed and secreted by VHL non-expressing(VHL−)cells,promoted metastasis by enhancing the motility of VHL-WT cells and facilitating tumor cell vascular *** deletion or antibody blockade of POSTN dramatically suppressed lung metastases in our preclinical *** work supports a new strategy to halt the progression of ccRCC by disrupting the critical metastatic crosstalk between heterogeneous cell populations within a tumor.

关键词： VHL metastasis motility

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混杂型高模量高韧性复合材料加强筋

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复合材料学报 2006年第2期23卷 93-98页

作者：崔益华 NORUZIAAN Bahman LEE Stephen CHANG moe 陶杰南京航空航天大学材料科学与技术学院南京210016 香港科技大学土木工程系香港科技大学先进工程材料实验所

针对现有复合材料加强筋存在的弹性模量低、断裂延伸率小、成本高等问题,以成本低廉的钢纤维作为主要增强材料,建立了一种新型混杂型复合材料加强筋的理论模型。分别制备了玻璃纤维复合材料加强筋和新型混杂型复合材料加强筋试样,测试... 详细信息

针对现有复合材料加强筋存在的弹性模量低、断裂延伸率小、成本高等问题,以成本低廉的钢纤维作为主要增强材料,建立了一种新型混杂型复合材料加强筋的理论模型。分别制备了玻璃纤维复合材料加强筋和新型混杂型复合材料加强筋试样,测试并分析了其单轴拉伸行为,并进行了加速腐蚀试验。结果表明:这种新型混杂型复合材料加强筋的弹性模量达142 GPa,与玻璃纤维复合材料加强筋相比,具有耐腐蚀、韧性好、成本低的特点。

关键词：混杂复合材料加强筋韧性模量

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Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing

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Journal of Environmental Sciences 2016年第11期28卷 113-124页

作者： Birget moe Hanyong Peng Xiufen Lu Baowei Chen Lydia W.L.Chen Stephan Gabos Xing-Fang Li X.Chris Le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and Pathology Faculty of Medicine and DentistryUniversity of Alberta Alberta Centre for Toxicology Department of Physiology and Pharmacology Faculty of Medicine University of Calgary moe Key Laboratory of Aquatic Product Safety School of Marine Sciences Sun Yat-Sen University Department of Chemistry Brock University Department of Chemistry and Chemical Biology McMaster University

The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in various cell lines using different assays, making comparison difficult. We report real-time cell sensing of two human cell lines to examine the cytotoxicity of fourteen arsenic species： arsenite（As~Ⅲ）, monomethylarsonous acid（MMA~Ⅲ） originating from the oxide and iodide forms, dimethylarsinous acid（DMA~Ⅲ）, dimethylarsinic glutathione（DMAG~Ⅲ）, phenylarsine oxide（PAO~Ⅲ）, arsenate（AsV）, monomethylarsonic acid（MMA~Ⅴ）, dimethylarsinic acid（DMA~Ⅴ）,monomethyltrithioarsonate（MMTTA~Ⅴ）, dimethylmonothioarsinate（DMMTA~Ⅴ）,dimethyldithioarsinate（DMDTA~Ⅴ）, 3-nitro-4-hydroxyphenylarsonic acid（Roxarsone, Rox）,and 4-aminobenzenearsenic acid（p-arsanilic acid, p-ASA）. Cellular responses were measured in real time for 72 hr in human lung（A549） and bladder（T24） cells. IC50 values for the arsenicals were determined continuously over the exposure time, giving rise to IC50 histograms and unique cell response profiles. Arsenic accumulation and speciation were analyzed using inductively coupled plasma-mass spectrometry（ICP-MS）. On the basis of the 24-hr IC50 values, the relative cytotoxicity of the tested arsenicals was in the following decreasing order： PAO~Ⅲ？ MMA~Ⅲ≥ DMA~Ⅲ≥ DMAG~Ⅲ≈ DMMTA~Ⅴ≥ As~Ⅲ？ MMTTA~Ⅴ〉 AsV〉 DMDTA~Ⅴ〉DMA~Ⅴ〉 MMA~Ⅴ≥ Rox ≥ p-ASA. Stepwise shapes of cell response profiles for DMA~Ⅲ, DMAG~Ⅲ,and DMMTA~Ⅴcoincided with the conversion of these arsenicals to the less toxic pentavalent DMA~Ⅴ. Dynamic monitoring of real-time cellular responses to fourteen arsenicals provided useful information for comparison of their relative cytotoxicity.

关键词： Arsenic species Thio-arsenicals Methylarsenicals Phenylarsenicals Toxicity Real-time sensing

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Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases

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Acta Pharmacologica Sinica 2004年第8期 3-11页

作者： moe KYAW,Masanori YOSHIZUMI,Koichiro TSUCHIYA,Yuki IZAWA,Yasuhisa KANEMATSU,Toshiaki TAMAKI Department of Pharmacology Department of Pharmacology Department of Clinical Pharmacology Department of Pharmacology Department of Pharmacology Department of Pharmacology The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Pharmaceutical Sciences 3-18-15 Kuramoto Tokushima 770-8503 Japan The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine

Reactive oxygen species (ROS) have been known to play an important role in the pathogenesis of atherosclerosis and several other cardiovascular diseases. It is now apparent that ROS induce endothelial cell damage and vascular smooth muscle cell (VSMC) growth and cardiac remodeling, which are associated with hypertension, atherosclerosis, heart failure, and restenosis. Several lines of evidence have indicated that ROS and mitogen activated protein (MAP) kinases were involved in vascular remodeling under various pathological conditions. Recently, it was also reported that MAP kinases were sensitive to oxidative stress. MAP kinases play an important role in cell differentiation, growth, apoptosis, and the regulation of a variety of transcription factors and gene expressions. Bioflavonoids and polyphenolic compounds are believed to be beneficial for the prevention and treatment of atherosclerosis and cardiovascular diseases. One of the most widely distributed bioflavonoids, 3,3',4',5,7-penta hydroxyflavone (

关键词： reactive oxygen species mitogen-activated protein kinase antioxidant vascular smooth muscle cell atherosclerosis

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再生型木塑复合材料的研究

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南京航空航天大学学报 2005年第5期37卷 587-592页

作者：崔益华 Noruziaan Bahman Lee Stephen Chang moe 陶杰南京航空航天大学材料科学与技术学院南京210016 香港科技大学土木工程系香港科技大学先进工程材料实验所

为了充分利用城市固体废弃物中的各项资源,本项工作将固体废弃物中的高密度聚乙烯(H igh dens itypo lyethy lene,HDPE)回收后与废弃的木纤维进行复合,成功地制备出再生型木塑复合材料。研究了木纤维长度、含量以及相容剂对木塑复合材... 详细信息

为了充分利用城市固体废弃物中的各项资源,本项工作将固体废弃物中的高密度聚乙烯(H igh dens itypo lyethy lene,HDPE)回收后与废弃的木纤维进行复合,成功地制备出再生型木塑复合材料。研究了木纤维长度、含量以及相容剂对木塑复合材料热性能和力学性能的影响。通过扫描电子显微镜观察了复合材料的冲击断口形貌,分析了此类复合材料的断裂机制。结果表明:木纤维的加入使HDPE的结晶温度降低,结晶速度减慢;相容剂的加入大大改善了木纤维与基体树脂之间的界面结合。随着木纤维含量的增加,木塑复合材料的弯曲强度升高,冲击强度下降。

关键词：木塑复合材料再生材料高密度聚乙烯木纤维

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