Inositol 1,4,5-trisphosphate 3-kinases:functions and regulations

作     者：Hui Jun XIA*, Guang YANGKey Laboratory of MOE for Plant Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072,China Hui Jun XIA*, Guang YANGKey Laboratory of MOE for Plant Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072,China

作者机构：Key Laboratory of MOE for Plant Developmental Biology College of Life Sciences Wuhan University Wuhan China 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2005年第15卷第2期

页      面：83-91页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：国家自然科学基金 国家重大科技专项 国家教育部留学回国人员科研启动基金 

主　　题：inositol 1 4 5-trisphosphate 3-kinase (IP3 3-kinase/IP3K) inositol polyphosphate kinase (Ipk) inositol phos-phate multikinase (Ipmk) calcium (Ca2+) signal transduction 

摘      要：Inositol 1,4,5-trisphosphate 3-kinase (IP3 3-kinase/IP3K) plays an important role in signal transduction in animal cellsby phosphorylating inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5-tetrakisphosphate (IP4). Both IP3 and IP4 arecritical second messengers which regulate calcium (Ca2+) homeostasis. Mammalian IP3Ks are involved in many biologicalprocesses, including brain development, memory, learning and so on. It is widely reported that Ca2+ is a canonicalsecond messenger in higher plants. Therefore, plant IP3K should also play a crucial role in plant development. Recently,we reported the identification of plant IP3K gene (AtIpk2β/AtIP3K) from Arabidopsis thaliana and its ***, we summarize the molecular cloning, biochemical properties and biological functions of IP3Ks from animal, yeastand plant. This review also discusses potential functions of IP3Ks in signaling crosstalk, inositol phosphate metabolism,gene transcriptional control and so on.