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Cancer statistics and trends in China:the potential of natural product application

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Chinese Journal of Natural Medicines 2024年第8期22卷 673-675页

作者： LI Ting HUANG muyang LU Jinjian State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China MoE Frontiers Science Center for Precision Oncology University of MacaoMacao SAR 999078China Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoMacao SAR 999078China

Cancer presents a significant global challenge,impacting individuals,communities,and healthcare systems worldwide[1,2].Fundamentally,cancer involves the uncontrolled growth and proliferation of cells,driven by genetic and epigenetic alterations orchestrated by a complex array of molecular entities,including oncogenes,tumor suppressor genes,and various regulatory factors[3-5].This intricate interplay complicates early detection,often resulting in a significant mortality *** for nearly 30%of premature deaths globally,cancer is a major barrier to increasing human life expectancy[6,7].The urgent need for continued research,innovation,and collaborative efforts highlights the importance of combating this relentless disease.

关键词： Cancer incidence Mortality Increasing trends Natural products

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物流业资源配置效率与经济高质量发展

物流科技 2023年第6期46卷 92-95页

作者：杨沐阳武汉科技大学法学与经济学院湖北武汉430065

物流业是推动经济高质量发展的重要因素之一。文章在测算2011—2020年31个省/区经济高质量发展水平的基础上,从理论和实证角度分析物流业资源配置效率对经济高质量发展的影响。结果表明:第一,物流业资源配置效率能显著提升经济高质量发... 详细信息

物流业是推动经济高质量发展的重要因素之一。文章在测算2011—2020年31个省/区经济高质量发展水平的基础上,从理论和实证角度分析物流业资源配置效率对经济高质量发展的影响。结果表明:第一,物流业资源配置效率能显著提升经济高质量发展水平。第二,物流业资源配置效率对经济高质量发展的影响表现出非线性变化,当物流业资源配置效率低于16.2903时,更有利于发挥对经济高质量发展的促进作用。

关键词：物流业资源配置经济高质量发展系统GMM 门槛模型

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环己酮选择性构建功能芳烃的研究进展

有机化学 2022年第1期42卷 129-146页

作者：王硕文姜平宇李镕杨沐阳邓国军湘潭大学化学学院湖南湘潭411105

环己酮是一类廉价易得的重要的有机化工原料,含有极性的活泼羰基,可与亲核试剂进行亲核加成并进一步转化.此外,因羰基的活化作用,其邻位的亚甲基也具有较好的反应活性.因而,环己酮可以作为廉价的C2源参与成环及芳构化反应构筑芳香功能分... 详细信息

环己酮是一类廉价易得的重要的有机化工原料,含有极性的活泼羰基,可与亲核试剂进行亲核加成并进一步转化.此外,因羰基的活化作用,其邻位的亚甲基也具有较好的反应活性.因而,环己酮可以作为廉价的C2源参与成环及芳构化反应构筑芳香功能分子.将从环己酮参与的选择性构建单取代芳烃、多取代芳烃以及杂环芳烃三个方面进行阐述,重点综述近几年环己酮与醛、酮、胺、硫酚等亲核试剂经缩合、脱氢芳构化选择性构建功能芳烃的研究进展,并对未来进一步开发新型温和绿色的合成方法实现环己酮选择性构建功能芳烃进行了展望.

关键词：环己酮亲核加成脱氢芳构化缩合功能芳烃

Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESKAPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： Min Wang Huangsheng Pu yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin Peng Yin Chunhui Zhang Wing-Leung Wong muyang Wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESKAPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

Prevention and Nursing of Adverse Reactions of Novel Coronavirus Inactivated Vaccine (Vero Cells)

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Journal of Clinical and Nursing Research 2024年第5期8卷 100-107页

作者： Jingyu He muyang Bian Jianan Du Liping Wang Department of Disease Control Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004China

Objective:To discuss and analyze the causes of adverse reactions caused by the inactivated novel coronavirus vaccine(Vero cells),and to propose methods of prevention and ***:A questionnaire was used to randomly select 229 adults who were vaccinated with the inactivated novel coronavirus vaccine(Vero cells)at Xi’an People’s Hospital(Xi’an Fourth Hospital).The adverse reactions were statistically ***:Among the 229 adults vaccinated with the inactivated novel coronavirus vaccine(Vero cells),30 experienced vaccination *** main reaction was local induration at the inoculation site,and dizziness was the primary systemic ***:To reduce the incidence of adverse reactions to the inactivated novel coronavirus vaccine(Vero cells),it is necessary to effectively evaluate the health status of adults before vaccination,select the correct vaccination site,and strictly implement the rules of 3-inspections,7-checks,and *** the operation process and providing thorough health education after vaccination can effectively reduce the occurrence of adverse reactions.

关键词： Novel coronavirus inactivated vaccine(Vero cells) Vaccination Adverse reactions nursing

A comparative study on the spectral characteristics of nanosecond pulsed discharges in atmospheric He and a He+2.3%H_(2)O mixture

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Plasma Science and Technology 2024年第6期26卷 22-30页

作者：陈传杰彭东宇刘博通张婷琳钱沐杨周锋王如刚 School of Information Engineering Yancheng Institute of TechnologyYancheng 224051People’s Republic of China School of Physics and Materials Science Nanchang UniversityNanchang 330031People’s Republic of China

Nanosecond pulsed discharges at atmospheric pressure in a pin-to-pin electrode configuration are well reproducible in time and space, which is beneficial to the fundamentals and applications of low-temperature plasmas. In this experiment, the discharges in helium(He) and He with 2.3%water vapor(H_(2)O) are driven by a series of 10 ns overvoltage pulses(~13 k V). Special attention is paid to the spectral characteristics obtained in the center of discharges by time-resolved optical emission spectroscopy. It is found that in helium, the emission of atomic and molecular helium during the afterglow is more intense than that in the active discharge, while in the He+2.3%H_(2)O mixture, helium emission is only observed during the discharge pulse and the molecular helium emission disappears. In addition, the emissions of OH(A-X) and Hα present similar behavior that increases sharply during the falling edge of the voltage pulse as the electrons cool down rapidly. The gas temperature is set to remain low at 540 K by fitting the OH(A-X) band. A comparative study on the emission of radiative species(He, He_(2), OH and H)is performed between these two discharge cases to derive their main production mechanisms. In both cases, the dominant primary ion is He^(+) at the onset of discharges, but their He^(+) charge transfer processes are quite different. Based on these experimental data and a qualitative discussion on the discharge kinetics, with regard to the present discharge conditions, it is shown that the electron-assisted three-body recombination processes appear to be the significant sources of radiative OH and H species in high-density plasmas.

关键词： nanosecond repetitively pulsed discharge helium and water vapor optical emission spectroscopy atmospheric pressure micro-discharge kinetics

骨内局部给药在全膝关节置换术中的应用研究进展

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中华骨科杂志 2024年第5期44卷 322-328页

作者：余沐洋杨兴东徐溢明朱威翁习生冯宾中国医学科学院北京协和医学院北京100005 中国医学科学院北京协和医学院北京协和医院骨科北京100730

骨内局部给药(intraosseous regional administration,IORA)是将骨内输液与止血带技术相结合,利用止血带限制药物在靶肢体的分布,以实现局部组织浓度较全身给药更高的给药方式。近年来,IORA技术在全膝关节置换术(total knee arthroplast... 详细信息

骨内局部给药(intraosseous regional administration,IORA)是将骨内输液与止血带技术相结合,利用止血带限制药物在靶肢体的分布,以实现局部组织浓度较全身给药更高的给药方式。近年来,IORA技术在全膝关节置换术(total knee arthroplasty,TKA)中获得了广泛的关注和应用。目前在TKA中主要通过IORA技术给予预防性抗生素。研究证明在TKA术前通过IORA技术给药可以显著提高局部组织的药物浓度。此外,也有研究在TKA中使用IORA技术进行术前镇痛,获得了良好的术后早期镇痛效果。然而,目前尚不明确通过IORA技术给予抗生素是否可有效预防人工关节感染。同时,关于IORA技术是否会增加穿刺点意外、脂肪栓塞等并发症尚存争议。本文通过对TKA中使用IORA技术给药的相关研究进行综述,显示IORA技术在TKA中的应用不会增加并发症发生率,同时可以显著提高局部的药物浓度。在初次TKA中,IORA技术在术后感染预防、疼痛控制等方面可能较传统静脉全身给药方案具有优势。但是,在肥胖、糖尿病以及翻修TKA等感染高危人群中,通过IORA技术给予预防性抗生素的效果尚不明确。

关键词：骨内局部给药膝关节置换术有效性安全性

未预期减税的环保效应:来自增值税税率下调政策的证据

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中国农村经济 2024年第9期 42-62页

作者：潘妍张牧扬王辉南京农业大学金融学院上海财经大学中国公共财政研究院湖南大学经济与贸易学院

在大规模减税情境下,如何在防范财政风险的同时强化生态环境建设是新发展阶段完善地方治理体系、推动经济高质量发展的重要着力点。基于2015-2020年地级市层面的面板数据,本文从地方环保收支行为视角构建统一理论框架,深入剖析增值税税... 详细信息

在大规模减税情境下,如何在防范财政风险的同时强化生态环境建设是新发展阶段完善地方治理体系、推动经济高质量发展的重要着力点。基于2015-2020年地级市层面的面板数据,本文从地方环保收支行为视角构建统一理论框架,深入剖析增值税税率下调政策实施对地方环境治理的影响。增值税税率下调政策实施有效降低了地级市的细颗粒物浓度、二氧化硫浓度和一氧化碳浓度,带来意料之外的环保效应。机制分析表明,增值税税率下调政策实施导致地方政府选择通过强化生态环境执法来获得非税收入,缓解短期财政压力。这一政策的实施同时起到了规范地方生态环境执法的效果,有利于减轻环境污染。进一步分析表明,设置软经济增长目标约束与强环境保护目标约束的地方政府在面对减税政策冲击时更有可能通过强化生态环境执法来实现缓解财政压力和减轻环境污染的“双赢”结果。上述结论不仅为新发展阶段下中国环境质量改善现象提供了一个新解释,还对未来中国如何统筹协调减税政策和环保政策提供了借鉴。

关键词：增值税减税政策环保收支生态环境执法环境质量

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意识三态观视野下的香港地区教育改革

港澳研究 2024年第1期 85-92,96页

作者：张沐阳中央港澳工作办公室港澳研究所

随着香港地区开启由乱到治走向由治及兴的新阶段,教育等深层次问题愈加受到国家和社会各界的高度重视,亟待进行深入改革。意识三态观作为一种三维的综合教育观,包括了宏观、中观和微观三种视野,以意识形态、意识生态和意识心态,从国家... 详细信息

随着香港地区开启由乱到治走向由治及兴的新阶段,教育等深层次问题愈加受到国家和社会各界的高度重视,亟待进行深入改革。意识三态观作为一种三维的综合教育观,包括了宏观、中观和微观三种视野,以意识形态、意识生态和意识心态,从国家、社会(地方)和个体三个层面对教育进行综合性的分析。作为一项重要的教育人类学理论创新,意识三态观在教育理论整合上取得了一系列成果,对于教育实证研究和教育改革也发挥了重要作用。出于香港地区特殊历史背景和“一国两制”现实考量,加强香港地区教育国家认同的愿景必须兼顾社会和个体的局限。目前,关于香港地区教育改革的研究仍局限于具体的政策措施,缺乏整体性的理论思考。因此,将教育人类学研究范式意识三态观应用于有关香港地区教育改革的研究,将是综合性思考研究“一国两制”下香港地区教育改革的一项积极尝试。

关键词：意识三态观一国两制国家认同