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Antibacterial, cytotoxicity and wound healing assessments of amine-functionalised zeolite Y

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Particuology 2019年第4期17卷 116-123页

作者： Muhammad Hariz Asraf Nik Ahmad Nizam Nik Malek Khairunadwa Jemon Nor Suriani Sani mustapha Salisu Muhammad Department of Biosciences Faculty of Science Universiti Teknologi Malaysia 81310 Skudai Johor Malaysia Centre for Sustainable Nanomaterials (CSNano) Ibnu Sina Institute for Scientific and Industrial Research (IS1-ISIR) Universiti Teknologi Malaysia 81310 UTMJohor Malaysia Office of Deputy Vice Chancellor (Research and Innovation) Universiti Teknologi Malaysia 81310 UTM Skudai Johor Malaysia

The antibacterial activities,cytotoxicity,and wound healing of amine(3-aminopropyltriethoxysilane (APTES))-functionalised zeolite Y against normal human fibroblast cells were *** characterisation of unmodified and amine-functionalised zeolites Y (Z,ZA 0.04,ZA 0.4,and ZA 0.6) by Fourier transform infrared spectroscopy,X-ray powder diffraction,and energy dispersive X-ray analysis proved that the APTES molecules were grafted onto the zeolite Y surface without distorting its framework *** amine-functionalised zeolite Y samples possessed antibacterial activities against several ATCC bacteria that were correlated with the increased amount of APTES on the zeolite Y ***,when a higher concentration of APTES was grafted on the zeolite Y,higher cytotoxicity was observed against the fibroblast *** the ZA 0.6 sample (zeolite Y functionalised with 0.6 M of APTES) had higher antibacterial activity,it was cytotoxic to the ***,the selection of an antibacterial agent for human treatment purposes must also consider its cytotoxicity effect against human cells to ensure it is biocompatible.

关键词： Zeolite Y Amine functionalised zeolite Functionalisation Antibacterial agent Cytotoxicity

Factors influencing IOP changes in postmenopausal women

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Family Medicine and Community Health 2018年第3期6卷 97-103页

作者： Chin P.Siuw Suresh Vasudevan Mushawiathi mustapha Ophthalmology Department Sultanah Aminah HospitalJohor BahruJohorMalaysia Ophthalmology Department Pusat Perubatan UniversityKebangsaanJalan Yaacob LatifBandar Tun RazakWilayah Persekutuan Kuala LumpurMalaysia

Objective:Intraocular pressure(IOP)is essential in maintaining normal function of the *** IOP is associated with *** physiological factors,including age and hormones,can cause variation in *** study was designed to investigate IOP changes in postmenopausal women and the associated factors,which included sex hormones and body mass index(BMI).Methods:This was a cross-sectional ***-eight women were recruited:49 premenopausal women and 49 postmenopausal *** between the two groups were *** influence of estradiol,progesterone,testosterone,and BMI on IOP was analyzed by a multivariate method.P<0.05 was considered ***:The age of the premenopausal group was 47.14±3.93 years and that of the postmenopausal group was 52.10±3.04 *** other factors in both groups,which included BMI,blood pressure,and central cornea thickness,were not significantly *** mean IOP in the postmenopausal group was significantly higher than the mean IOP in the premenopausal group(15.26±2.96 mm Hg vs.14.07±2.65 mm Hg,P=0.04).BMI had a weak positive correlation with IOP in premenopausal women(r=0.31,P=0.03).Estradiol was less likely to influence IOP changes in the postmenopausal group as compared with the premenopausal group(B=−0.021,P=0.002).IOP was not significantly related to progesterone and testosterone ***:Menopausal status has a significant effect on IOP,with a significant increase in IOP seen in postmenopausal women as shown by our *** was shown to be a protective factor in reducing IOP among postmenopausal *** understanding of the influence of postmenopausal status and sex hormones on IOP,glaucoma management may be improved and the target group for disease screening may be more specific.

关键词： Intraocular pressure postmenopausal hormones body mass index

Versatile synthesis of cadalene and iso-cadalene from himachalene mixtures:Evidence and application of unprecedented rearrangements

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Chinese Chemical Letters 2020年第7期31卷 1851-1854页

作者： mustapha Ait El Had Abdelouahd Oukhrib Mohamed Zaki Martine Urrutigoity Ahmed Benharref Remi Chauvin Laboratoire de Chimie Biomoleculaire Substances Naturelies et Reactivite(URAC 16)Faculte des Sciences SemlaliaUniversite Cadi AyyadB.P.2390MarrakechMorocco CNRS LCC(Laboratoire de Chimie de Coordination)BP 4409931077Toulouse Cedex 4France INP-ENSIACET 4 allee Emile Monso31030Toulouse CedexFrance Universite de Toulouse UPSICT-FR 259931062Toulouse Cedex 9France

From a mixture of α-,β-and y-himachalenes extracted from waste wood of Atlas cedar(Cedrus atlantica),cadalene(1,6-dimethyl-4-isopropylnaphthalene)and iso-cadalene(1,6-dimethyl-3-isopropylnaphthalene)were produced in two steps with up to 71%±5%yield through the ar-himachalene intermediate using I2 and/or AlCl3 as *** selectivity is shown to sharply depend on the operating conditions:while I2/AlCl3 in dichloromethane promotes the formation of cadalene,the formation of iso-cadalene is favored in the presence of AlCl3 in *** bicyclic aromatic compounds were thus obtained through unique rearrangements involving sequential C—C bond cleavage/fo rmation and hydride transfer *** the absence of AlCl3 or I2,dihydrocurcumene was also found to be formed with up to 70%selectivity.A tentative mechanism is proposed and discussed.

关键词： Aromatic reactivity Cadalenes Dihydrocurcumene Himachalenes Rearrangements

On an Axiomatic about Functional Means

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Analysis in Theory and Applications 2018年第1期34卷 36-44页

作者： mustapha Raissouli Mohamed Chergui Abdellah Alla Department of Mathematics Science Faculty Taibah University AI Madinah AI Munawwarah P.O.Box 30097 Zip Code 41477 Saudi Arabia Department of Mathematics Science Faculty Moulay Ismail University Meknes Morocco Department of Mathematics LaREAMA Lab Centre Regional des Metiers de l'Education et de la Formation (CRMEF) Kenitra Morocco Department of Mathematics Mohammed V University Faculty of Sciences LAMA-ANLIMAD Rabat Morocco

In this paper, we introduce an axiomatic approach about functional means. This includes that of operator means already introduced in the literature.

关键词： Functional mean operator mean convex function.

Hepato-biliary profile of potential candidate liver progenitor cells from healthy rat liver

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World Journal of Gastroenterology 2012年第27期18卷 3511-3519页

作者： Cédric Maerckx Isabelle Scheers Tatiana Tondreau David Campard Omar Nyabi mustapha Najimi Etienne Sokal Laboratory of Pediatric Hepatology and Cell Therapy Université Catholique de Louvain1200 BrusselsBelgium

AIM:To evaluate the presence of progenitor cells in healthy adult rat liver displaying the equivalent advanced hepatogenic profile as that obtained in ***:Rat fibroblastic-like liver derived cells (rFLDC) were obtained from collagenase-isolated liver cell suspensions and characterized and their phenotype profile determined using flow cytometry,immunocytochemistry,reverse transcription polymerase chain reaction and functional ***:rFLDC exhibit fibroblastoid morphology,express mesenchymal (CD73,CD90,vimentin,-smooth muscle actin),hepatocyte (UGT1A1,CK8) and biliary (CK19) ***,these cells are able to store glycogen,and have glucose 6 phosphatase activity,but not UGT1A1 *** the hepatogenic differentiation protocol,rFLDC display an up-regulation of hepatocyte markers expression (albumin,tryptophan 2,3-dioxygenase,G6Pase) correlated to a down-regulation of the expression of the biliary marker ***:Advanced hepatic features observed in human liver progenitor cells could not be demonstrated in ***,we demonstrated the presence of an original rodent hepato-biliary cell type.

关键词：大鼠肝脏肝干细胞档案健康逆转录聚合酶链反应磷酸酶活性免疫细胞化学成纤维细胞

Time Management of Open Lower-Leg Fractures in Morocco

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Open Journal of Emergency Medicine 2014年第3期2卷 53-61页

作者： Adonis Magoumou Yassir El Andaloussi Simohamed Fahsi Othmane Hiba mustapha Fadili Mohamed Nechad Mohamed Ouarab Fatima Zahra Widad Samira Nani Samira Hassoune Abderrahmane maaroufi Department of Orthopedic Traumatology Wing 4 Chu Ibn Rochd Casablanca Morocco Laboratory of Epidemiology Faculty of Medicine and Pharmacy Casablanca Morocco

Background: It is recommended that the management of open lower-leg fractures should occur within six hours to avoid complications affecting both prognosis and functionality. This study aimed to evaluate the time taken for each step of management, identify causes of delay, and propose solutions to reduce the rate of complications. Patients and methods: This was a prospective study involving 153 patients treated from January 2011 to December 2012. Standardized data collection forms documented the times taken for each management step from the accident until surgical intervention. Results: For patients admitted directly to our institution, median time to surgical debridement from arrival was 5 hours. Median time for bone fixation was 24 hours. External fixation was used in 119 patients. There were several causes of delay;lack of financial resources was the most common. Certain causes of delay were significantly correlated with time to debridement. However, although 86.7% of patients who developed an infection had a time from injury to debridement greater than six hours, there was no statistically significant association between infection and delay beyond six hours (p = 0.403). Conclusion: By identifying causes of treatment delay, we hope to be able to avoid complications, and therefore reduce the socio- economic impact of these important surgical emergencies.

关键词： Open Fracture Lower-Leg Fracture Chu Ibn Rochd Casablanca

Cervical Spondylodiscitis Revealed by Tracheostomy Infected: A Rare Case Report Management and Outcome

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Open Journal of Modern Neurosurgery 2023年第1期13卷 18-24页

作者： José Dimbimakoso Djimrabeye Alngar Moune Michèle Yolande mustapha Hamama Nizaireel Fatemi Rachid El Maaquil Faculty of Medicine and Pharmacy Université Mohamed V Rabat Morocco Department of Neurosurgery CHU ibnSina Rabat Morocco

Background: Spondylodiscitis is a spinal infection rare affecting primarily the intervertebral disk and the adjacent vertebral bodies. His diagnosis is difficult and often delayed or missed due to the rarity of the disease. Cervical spondylodiscitis has quite rare findings regarding the common location of spinal abscesses in the lumbar and thoracic regions. To obtain the best patient outcomes, these spinal infections require prompt diagnosis and appropriate treatment. Case description: A 44-year-old boy was admitted to the neurosurgery department of our hospital for heaviness in 4 limbs without gait disorders in context infected tracheostomy after staying in intensive care. MRI spine showed a spine deformity with lyse C4C5 epiduritis and spinal cord compressed. Antibiotics intravenous were started for 1 month the patient benefited from a corpectomy with an iliac graft and anterior cervical plate. The anatomopathological examination revealed an inflammation not specific. He was therefore put on antibiotics for 6 weeks. Three months later the neck pain and limb pain resolved after treatment and a complete return of lower extremity strength. Conclusion: Cervical spondylodiscitis has increased and become more aggressive. While radical surgical debridement, stable reconstruction together with antibiotic therapy remained a reliable approach to achieve complete healing of the inflammation, anterior alone surgery became more applicable.

关键词： Cervical Spondylodiscitis Spinal Tracheostomy Infection

Ultimate load analysis of pretensioned inverted T-beams with circular web openings

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Frontiers of Structural and Civil Engineering 2009年第3期3卷 262-271页

作者： Hock Tian CHENG Bashar SMOHAMMED Kamal Nasharuddin mustapha Faculty of Civil and Environmental Engineering Universiti Malaysia PahangMalaysia Department of Civil Engineering College of EngineeringUniversiti Tenaga NasionalMalaysia

The provision of transverse openings in floor beams to facilitate the passage of utility pipes and service ducts not only results in a more systematic layout of pipes and ducts,it also translates into substantial economic savings in the construction of a multi-storey *** this paper,ultimate load analysis of statically loaded simply supported pretensioned inverted T-beams with circular web openings is *** findings relevant to ultimate load analysis of pretensioned beams with circular web openings are *** attempt has been made to answer the frequently asked questions related to ultimate load analysis on multiple circular web *** has been shown that the analysis method for pretensioned beams with multiple large circular web openings can be further simplified without sacrificing rationality.

关键词： pretensioned inverted T-beam web opening

Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 80-87页

作者： Devaraj Ezhilarasan Jonathan Evraerts Brice Sid Pedro Buc Calderon Sivanesan Karthikeyan Etienne Sokal mustapha Najimi institut de recherche expérimentale et clinique (irec) laboratory of pediatric hepatology and cell therapyuniversité catholique de louvain 1200 Brussels Belgium louvain drug research institute toxicology and cancer biology research group pmnt unituniversité catholique de louvain 1200 Brussels Belgium facultad de ciencias de la salud universidad arturo prat Iquique Chil department of pharmacology and environmental toxicology food and hepatotoxicology laboratory dr. alm post graduate institute of basic medical sciences university of madrastaramani campus Chennai-600 l13 India

BACKGROUND： Proliferation of hepatic stellate cells （HSCs） plays a pivotal role in the progression of liver fibrosis conse- quent to chronic liver injury. Silibinin, a flavonoid compound, has been shown to possess anti-fibrogenic effects in animal models of liver fibrosis. This was attributed to an inhibition of cell proliferation of activated HSCs. The present study was to gain insight into the molecular pathways involved in silibinin anti-fibrogenic effect. METHODS： The study was conducted on LX-2 human stellate cells treated with three concentrations of silibinin （10, 50 and 100 μmol/L） for 24 and 96 hours. At the end of the treatment cell viability and proliferation were evaluated. Protein expression of p27, p21, p53, Akt and phosphorylated-Akt was evaluated by Western blotting analysis and Ki-67 protein expression was by immunocytochemistry. Sirtuin activity was evaluated by chemiluminescence based assay. RESULTS： Silibinin inhibits LX-2 cell proliferation in doseand time-dependent manner; we showed that silibinin upregulated the protein expressions of p27 and p53. Such regulation was correlated to an inhibition of both downstream Akt and phosphorylated-Akt protein signaling and Ki-67 protein expression. Sirtuin activity also was correlated to silibinin- inhibited proliferation of LX-2 cells. CONCLUSION： The anti-proliferative effect of silibinin on LX-2 human steUate cells is via the inhibition of the expres- sions of various cell cycle targets including p27, Akt and sir- tuin signaling.

关键词： silibinin hepatic stellate cells in vitro cell cycle arrest proliferation