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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

Heavy metal pollution assessment in marine sediments in the Northwest coast of Sabah,Malaysia

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China Geology 2023年第4期6卷 580-593页

作者： Sin-Yi Ling Asis Junaidi Abdullah Mohd-Harun musta Baba Faculty of Science and Natural Resources Universiti Malaysia SabahKota KinabaluSabah 88400Malaysia Small Island Research Center Universiti Malaysia SabahKota KinabaluSabah 88400Malaysia

Heavy metal contents along the Northwest coast of Sabah were determined to interpret the pollution level in the marine sediment. The metal abundance is regulated by the physico-chemical properties such as the average sediment pH(7.82, 9.00 and 8.99), organic matter(0.62%, 1.60%, and 2.27%), moisture content(25.00%, 29.70%, and 15.00%) and sandy texture in Kota Belud, Kudat and Mantanani Island,respectively. The major elements show Ca>Fe>Mg>Al>Mn for all study sites, while the heavy metals show Ni>Cr>Zn>Cu>Co>Pb, Cr>Ni>Zn>Cu>Pb>Co and Zn>Pb>Cr>Ni, for Kota Belud, Kudat and Mantanani Island, respectively. The pollution degree of heavy metals was evaluated by using the Sediment Quality Assessment(SQA). The SQA parameters indicated none to moderate pollution in Kota Belud that shows Class 0, Class 1 and Class 2 pollution. The parameters also indicated none to low pollution in Kudat and Mantanani Island that show only Class 0 pollution. The enrichment factor(EF) suggested minor to moderately severe metal enrichment by anthropogenic sources in Kota Belud, whereas only minor enrichment in Kudat and Mantanani Island. The modified pollution degree(MCD<1.5) and pollution load index(0 PLI<1) indicating only low pollution level in the marine sediments for all study sites. The objectives of this study are:(1) to determine the physico-chemical parameters of sediments,(2) interpret the heavy metal contents and(3) evaluate the sediment quality.

关键词： Physico-chemical properties Sediment quality Major elements Heavy metal pollution Ni-Cr-Zn-Cu-Co-Pb pollution Marine sediment Coastline

振源胶囊结合比索洛尔对冠心病心绞痛患者心肌重构和心功能改善效果的研究

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中国医学创新 2025年第1期22卷 39-43页

作者：承卡常州市中医医院GCP办公室江苏常州213003

目的:研究振源胶囊结合比索洛尔对冠心病心绞痛患者的心肌重构和心功能的改善效果。方法:选择2021年8月—2023年9月于常州市中医医院治疗的84例冠心病心绞痛患者,随机分为对照组和研究组,各42例。对照组给予比索洛尔治疗,研究组在对照... 详细信息

目的:研究振源胶囊结合比索洛尔对冠心病心绞痛患者的心肌重构和心功能的改善效果。方法:选择2021年8月—2023年9月于常州市中医医院治疗的84例冠心病心绞痛患者,随机分为对照组和研究组,各42例。对照组给予比索洛尔治疗,研究组在对照组基础上加用振源胶囊治疗。比较两组临床疗效、心绞痛症状及治疗前后心肌重构指标、血管内皮功能参数。结果:研究组心绞痛总有效率、心电图总有效率均高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组心绞痛持续时间均短于治疗前,发作次数均少于治疗前,且研究组心绞痛持续时间短于对照组,发作次数少于对照组,差异均有统计学意义(P<0.05)。治疗后,两组左心室质量(LVM)、左心室质量指数(LVMI)、内皮素-1(ET-1)水平均低于治疗前,一氧化氮(NO)水平均高于治疗前,且研究组LVMI、LVM、ET-1水平均低于对照组,NO水平高于对照组,差异均有统计学意义(P<0.05)。结论:振源胶囊结合比索洛尔可以明显改善冠心病心绞痛患者的心肌重构和心功能,治疗效果良好。

关键词：振源胶囊比索洛尔冠心病心绞痛心肌重构心功能

Kenaf cellulose-based poly(amidoxime) ligand for adsorption of rare earth ions

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Rare Metals 2019年第3期38卷 259-269页

作者： Md Lutfor Rahman Mohd Sani Sarjadi Sazmal Effendi Arshad Mashitah M. Yusoff Shaheen M. Sarkar Baba musta Faculty of Science and Natural Resources Universiti Malaysia Sabah Faculty of Industrial Sciences and Technology University Malaysia Pahang

A well-known adsorbent, poly(amidoxime)ligand, was prepared from polyacrylonitrile(PAN) grafted kenaf cellulose, and subsequent characterization was performed by Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscope(FESEM) and inductively coupled plasma mass spectrometry(ICP-MS).The adsorption capacities of the prepared ligand for rare earth metals are found to be excellent, with adsorptions of la^(3+), Ce^(3+), Pr^(3+), Gd^(3+) and Nd^(3+) experimentally determined to be 262, 255, 244, 241 and 233 mg·g^(-1), respectively, at pH 6. The experimental values of the adsorption of rare earth metals are well matched with the pseudosecond-order rate equation. The reusability of the adsorbent is examined for seven cycles of sorption/desorption,demonstrating that the proposed adsorbent could be reused for over seven cycles without any significant loss in the original removal capability of the ligand.

关键词： Adsorption Poly(amidoxime) Rare earths Separation Kenaf cellulose

Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations

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World Journal of Stem Cells 2023年第5期15卷 302-322页

作者： Żaneta kałuzińska-Kołat Damian Kołat katarzyna Kośla Elżbieta Płuciennik Andrzej K Bednarek Department of Experimental Surgery Medical University of LodzLodz 90-136LodzkiePoland Department of Molecular Carcinogenesis Medical University of LodzLodz 90-752LodzkiePoland Department of Functional Genomics Medical University of LodzLodz 90-752LodzkiePoland

Literature data on glioblastoma ongoingly underline the link between metabolism and cancer stemness,the latter is one responsible for potentiating the resistance to treatment,inter alia due to increased *** recent years,glioblastoma stemness research has bashfully introduced a key aspect of cytoskeletal rearrangements,whereas the impact of the cytoskeleton on invasiveness is well *** non-stem glioblastoma cells are less invasive than glioblastoma stem cells(GSCs),these cells also acquire stemness with greater ease if characterized as invasive cells and not tumor core *** suggests that glioblastoma stemness should be further investigated for any phenomena related to the cytoskeleton and metabolism,as they may provide new invasion-related ***,we proved that interplay between metabolism and cytoskeleton existed in *** searching for cytoskeleton-related processes in which the investigated genes might have been involved,not only did we stumble across the relation to metabolism but also reported genes that were found to be implicated in ***,dedicated research on these genes in GSCs seems justifiable and might reveal novel directions and/or biomarkers that could be utilized in the ***,we review the previously identified cytoskeleton/metabolism-related genes through the prism of glioblastoma stemness.

关键词： Glioblastoma Stemness Cytoskeleton Metabolism Biomarkers Therapy

Tribonacci Partition Formulas Modulo m

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Acta Mathematica Sinica,English Series 2010年第3期26卷 465-476页

作者： Ji■í Kla■ka Institute of Mathematics Brno University of Technology

Each Tribonacci sequence starting with an arbitrary triple of integers is periodic modulo m for any modulus m 〉 1. For a given m, the mapping between the set S of all m^3 triples of initial values and the set of their coresponding periods define a partition of the set S. In this paper we shall investigate some basic questions related to these partitions from the point of view of enumerative combinatorics.

关键词： Tribonacci sequence modular periodicity partition formulas

Two cases of imported malaria in Western Romania,2010-2011

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Asian Pacific Journal of Tropical Medicine 2012年第4期5卷 326-328页

作者： Raul Neghina Elena Doina Nicola Camelia Nita Virgil musta Emilia Nicoara Tudor Rares Olariu Victor Babes University of Medicine and Pharmacy 2nd Eftimie Murgu Square300041 TimisoaraRomania Municipal Hospital Timisoara Romania Victor Babes Infectious Diseases Hospital TimisoaraRomania Victor Babes University of Medicine and Pharmacy 2nd Eftimie Murgu Square 300041 TimisoaraRomania

Malaria is a major problem for European travelers to endemic *** Romania during 1980-2007 approximately 20 imported cases were detected *** aim of our short communication is to present 2 interesting cases of imported malaria detected in Western *** first patienl was a 20-year female who traveled to India and acquired an infection with Plasmodium vivax(***).The second patient,a 60-year female,contracted an infection with Plasmodium falciparum(***) during a trip to Ghana:the evolution of the disease was severe with many complications and the patient finally *** cases presented revealed the difficulties in establishing a correct diagnosis of malaria in a non-endemic country, consequences of an incomplete taken *** history should always represent a mandatory part of a well conducted *** the same time,we must underline the importance of a correct and complete prophylaxis prior to every departure to tropical countries.

关键词： Malaria Importation Prophylaxis Travel Romania

Computational design of structured chemical products

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1033-1049页

作者： Faheem Mushtaq Xiang Zhang ka Y.Fung ka M.Ng Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina

In chemical product design,the aim is to formulate a product with desired *** and internal product structure are two key drivers of product performance with direct impact on the mechanical,electrical,and thermal ***,there is a keen interest in elucidating the dependence of product performance on ingredients,structure,and the manufacturing process to form the *** of product structure,particularly microstructure,is an intrinsically complex problem that involves different phases of different physicochemical properties,mass fraction,morphology,size distribution,and ***,computational methods have emerged that assist systematic microstructure quantification and *** objective of this paper is to review these computational methods and to show how these methods as well as other developments in product design can work seamlessly in a proposed performance,ingredients,structure,and manufacturing process framework for the design of structured chemical *** begins with the desired target properties and key *** is followed by computation for microstructure and then selection of processing steps to realize this *** framework is illustrated with the design of nanodielectric and die attach adhesive products.

关键词： product design performance ingredients structure manufacturing process framework structured chemical products microstructure design

All-parameters Rayleigh wave inversion

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 517-534页

作者： Xiao-Hui Yang ka-Veng Yuen State Key laboratory of Internet of Things for Smart City and Department of Civil and Environmental Engineering University of MacaoMacao 999078China

Since S-wave velocity of the subsurface is an important parameter in near surface applications,many studies have been conducted for its *** the various methods that use surface waves or body waves,Rayleigh wave inversion is the most *** practice,the densities and P-wave velocities of different layers are usually assumed to be known to avoid ill-posed problems,as they have less influence on the dispersion ***,improper assignment of these two groups of parameters leads to inaccurate estimation of the S-wave velocity *** order to address this problem,the all-parameters Rayleigh wave inversion strategy is proposed in which the S-wave velocities,layer thicknesses,densities and P-wave velocities of different layers are included as the unknown parameters for ***,the transitional Markov Chain Monte Carlo(TMCMC)algorithm is applied for the implementation of all-parameters Rayleigh wave *** simulated example and two real-test applications are demonstrated to verify the capability of the proposed method in the estimation of the S-wave velocity profile,the densities and the P-wave ***,it is verified that the proposed method achieved more accurate S-wave velocity profile estimation than the traditional approach.

关键词： all-parameters Rayleigh wave inversion Bayesian S-wave velocity profile TMCMC algorithm uncertainty quantification