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Garlic Extract (Allium sativum) Enhances Spatial Working Memory in Wistar Rats: Involvement of Hippocampal Na+/K+ATPase and Ca2+ATPase Activities

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Journal of Behavioral and Brain Science 2017年第2期7卷 31-40页

作者： Abass Alao Safiriyu Ibrahim Semuyaba Figueredo Niurka Remón Temitope Akhigbe Etibor musa iyiola ajibola Department of Physiology Faculty of Biomedical SciencesKampala International UniversityIshakaUganda Department of Human Anatomy Faculty of Biomedical SciencesKampala International UniversityIshakaUganda Institute of Neuroscience National Yang-Ming UniversityTaiwan

Hippocampus plays a central role in the acquisition and recall of both episodic and spatial memory. Studies have shown that garlic has neuroprotective effects in various capacities and enhancement of different forms of memory. However, the effect of garlic spatial memory and direct effect of garlic extract on the activities of membrane bound enzymes Na+/K+ ATPase and Ca2+ ATPase in the hippocampus of rat still remain elusive. Therefore, we studied the effect of ethanolic extract of garlic on spatial working memory using object location memory OLM test and the hippocampal Na+/K+ ATPase and Ca2+ ATPase activities. Sixteen male wistar rats weighted 120 - 150 g were used and divided into two groups of eight rats each. The control and experimental groups were treated 1ml of normal saline and 500 mg/kg body weight of ethanolic extract of garlic respectively orally for three weeks. OLM test was carried out on the two groups. Animals were sacrificed and the brains were removed, and hippocampi were carefully excised and homogenate was obtained. Homogenate was analyzed for Na+/K+ ATPase and Ca2+ ATPase activities. There was significant increase in the exploration time in experimental group when compared with control group (p +/K+ ATPase and Ca2+ ATPase activities in experimental group when compared with control group (p +/K+ ATPase and Ca2+ ATPase. Our findings provide potential mechanism and therapeutic target for memory deficit neurological disorders.

关键词： Ca2+ ATPase Garlic Hippocampus Na+/K+ ATPase Spatial Working Memory

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Datura metelAdministration Distorts Medial Prefrontal Cortex Histology of Wistar Rats

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World Journal of Neuroscience 2015年第4期5卷 282-291页

作者： Temitope Akhigbe Etibor musa iyiola ajibola Mohammad Olanrewaju Buhari Abass Alao Safiriyu Oluwole Busayo Akinola Ezekiel A. Caxton-Martins Department of Human Anatomy Kampala International University Western Campus Ishaka Bushenyi Uganda Department of Physiology Kampala International University Western Campus Ishaka Bushenyi Uganda Department of Anatomy University of Ilorin Ilorin Nigeria

Datura metel is one of psychoactive substances of great ethno-pharmacological significance often abused because of its unrestricted availability, yet, little is known about its mechanisms of action. This work was therefore aimed at assessing the activity of ethanolic seed extract of D. metel on Nissl substances, astrocytes, axonal and neuronal integrity of the medial prefrontal cortex (mPFC) of Wistar rats. Eighteen Wistar rats averaging 175 g were used and randomly assigned to three groups: group A rats (n = 6) were administered extract of 100 mg/kg bw, group B rats (n = 6) received extract of 200 mg/kg bw, and group C-control (n = 6) took distilled water only for 14 days. The results revealed that D. metel is deleterious to the health of Wistar rats at a dose-dependent rate as observed in its actions on the medial prefrontal cortex at 100 mg/kg bw and 200 mg/kg bw. The histological study of the treated Wistar rats exhibited features of disoriented neuronal integrity such as, chromatolysis, reduced protein synthesis due to loss of Nissl substances and nuclei, neuronal loss as well as axonal injuries.

关键词： D. metel Nissl Substance Prefrontal Cortex Chromatolysis

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Challenging management of congenital bilateral radial club hand: A case report

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Case Reports in Clinical Medicine 2014年第1期3卷 32-35页

作者： Abdulrahman Alhaji Mahmud Muhammad Kabir Abubakar musa Adamu Kabir Mohammed Inuwa Ismail Muslimat ajibola Alada Bashir Bello 1Department of Surgery Aminu Kano Teaching Hospital Kano Nigeria Department of Physiotherapy Faculty of Medicine Bayero Uni-versity Kano Nigeria Department of Surgery Aminu Kano Teaching Hospital Kano Nigeria Department of Surgery Aminu Kano Teaching Hospital Kano Nigeria Department of Surgery Faculty of Medicine Bayero University Kano Nigeria

Congenital radial club hand (CRCH) is a terminal deficiency characterized by the radial deviation of the hand, marked shortening of the forearm, and generalized underdevelopment of the extremity with an incidence rate of 1 per 100,000 live births. Both sexes are nearly or equally affected. Challenges that the disease poses to the patient are multifaceted, ranging from medical, social, cosmetic and functional issues which also are the multidimensional treatment modalities. We report a case of a 2-month-old baby with the severe case of bilateral CRCH. The patient had the centralization of the left ulna with Kwire stabilization. About 160d of correction was achieved. He did well and was discharged after two weeks at the orthopedic clinic for follow-up. Congenital radial club hand though uncommon may be amenable to surgery. Centralization is still the treatment of choice in severe cases and early intervention will offer a better outcome.

关键词： Congenital Radial Club Hand Centralization Early Intervention

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Care and Support Programmes for Orphans and Vulnerable Children: Achievements and Implications of HIV/AIDS Funded Project in Osun State, Nigeria

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World Journal of AIDS 2019年第4期9卷 195-213页

作者： Adebola A. Adejimi ajibola Olagunoye Adeyemi Amuda Olubukola Alawale Oluwatoyin Adeola-musa Abayomi Adenekan Akin Oyebade Mosur Bello Michael Olugbile Olusegun Adeoye Gabriel Olatunji Department of Community Medicine Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital Osogbo Osun State Nigeria Department of Community Medicine University of Ibadan Ibadan Nigeria Department of Epidemiology and Disease Control Osun State Ministry of Health Osogbo Osun State Nigeria Osun State Agency for the Control of AIDS Osogbo Nigeria HIV Programme Development Project (HPDP2) World Bank Abuja Nigeria

Orphans and Vulnerable Children (OVC) and their families face many challenges but there are opportunities to provide care and support programmes for them in their communities. This paper presents the achievements and implications of HIV Programme Development Project (HPDP) funded by World Bank on care and support services for OVC in Osun State, Nigeria. Eight Civil Society Organisations (CSOs) were engaged by Osun State Agency for the Control of AIDS (OSACA) as part of HPDP to provide care and support services for OVC between year 2013 and 2015. Using reporting tools, data collected by the CSOs were entered into District Health Information System 2 (DHIS2) platform and analysed using Microsoft Excel. In addition, Key Informant Interviews (KII) were conducted among the selected CSOs, OVC and the caregivers who were beneficiaries of HPDP in Osun State, Nigeria. A total of 12,353 OVC were reached and about half of them were female. There was an increase in the trends of number of OVC seen and the support services provided from the year 2013 to 2015. Of the 12,353 OVC that benefitted from this programme, 1905 (15.4%) received health care services, 5383 (43.6%) received nutritional services, 5317 (43.0%) received educational services and 9861 (79.8%) were provided with psychosocial support services. About 503 (4.1%) of the OVC received economic strengthening services while 270 (2.2%) of household heads were provided with economic support. However, 3 OVC were lost to follow-up, 14 OVC voluntarily withdrew from the project and 6 OVC died. The FGD and KII revealed that the project was very impactful in transforming the lives of the OVC. Programmes for children orphaned and made vulnerable by HIV/AIDS will contribute to the achievement of HIV/ AIDS prevention and control efforts. The HIV/AIDS free generation can be built by responding to the physical, social and mental needs of these children and their families in their communities. There is a need to scale-up this programme

关键词： HIV Orphans Vulnerable Children HPDP Care and Support Nigeria

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