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r.tionale and design of Tenecteplase r.per.usion Ther.py in Acute Ischaemic Cer.br.vascular.Events III (Tr.CE III): a r.ndomised, phase III, open- label, contr.lled tr.al

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Str.ke & Vascular.Neur.logy 2024年第1期9卷 82-89页

作者： Yunyun Xiong Br.ce C V Campbell Mar. Fisher.Lee H Schwamm mark Par.ons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neur.logy Beijing Tiantan HospitalBeijingChina China National Clinical r.sear.h Center.for.Neur.logical Diseases BeijingChina Depar.ment of Medicine and Neur.logy The University of MelbourneMelbourneVictoriaAustralia Neur.logy Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Depar.ment of Neur.logy and Compr.hensive Str.ke Center Massachusetts General HospitalBostonMassachusettsUSA Depar.ment of Neur.logy University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Backgr.und and pur.ose r.combinant human TNK tissue-type plasminogen activator.r.TNK-tPA)was not infer.or.to alteplase for.ischaemic str.ke within *** study aimed to investigate the efficacy and safety of r.TNK-tPA in patients who had an ischaemic str.ke due to lar.e vessel occlusion(LVO)of anter.or.cir.ulation beyond *** and design Tenecteplase r.per.usion Ther.py in Acute Ischaemic Cer.br.vascular.Events-III(Tr.CE III)is a multicentr.,pr.spective,r.ndomised,open-label,blind endpoint,contr.lled clinical *** who had an ischaemic str.ke due to anter.or.cir.ulation LVO(inter.al car.tid ar.er.,middle cer.br.l ar.er. M1 and M2 segments)within 4.5–24hour. fr.m last known well(including wake-up str.ke and no witness str.ke)and with salvageable tissue(ischaemic cor. volumer.tio≥1.8 and mismatch volume≥15mL)based on CT per.usion or.Mr. per.usion-weighted imaging(PWI)wer. included and r.ndomised to r.TNK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or.standar. medical ***,we will exclude patients who ar. intended for.dir.ct *** will be followed up for.90 *** outcomes Pr.mar. efficacy outcome is modified r.nkin Scale(mr.)scor.≤1 at 90 *** efficacy outcomes include or.inal distr.bution of mr. at 90 days,major.neur.logical impr.vement defined by a decr.ase≥8 points compar.d with the initial deficit or.a scor.≤1 on the National Institutes of Health Str.ke Scale(NIHSS)at 72 hour.,mr. scor.≤2 at 90 days,the r.te of impr.vement on Tmax>6s at 24 hour. and NIHSS scor. change fr.m baseline at *** outcomes ar. symptomatic intr.cer.br.l haemor.hage within 36 hour. and mor.ality at 90 *** Tr.CE III will pr.vide evidence for.the efficacy and safety of r.TNK-tPA in patients who had an ischaemic str.kes due to anter.or.cir.ulation LVO beyond *** r.gistr.tion number.NCT05141305.

关键词： Ther.py r.ndom r.tional

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Complexity of the Contexts:Featur.s of Pr.vate Tutor.ng and Units for.Compar.son in the GCC Countr.es of the Middle East

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ECNU r.view of Education 2024年第1期7卷 42-65页

作者： mark Br.y Anas Hajar East China Nor.al Univer.ity&The Univer.ity of Hong Kong Nazar.ayev Univer.ity

Pur.ose:Pr.vate supplementar. tutor.ngwidely known as shadow education because of the ways in which it mimics r.gular.schooling-is incr.asingly visible acr.ss the *** Middle East is no exception,though the phenomenon has r.ceived r.latively little attention in the English-language *** ar.icle maps some key featur.s of shadow education,identifying ways in which contextual for.es have shaped ***/Appr.ach/Methods:The ar.icle focuses on patter.s acr.ss and within the six member. of the Gulf Cooper.tion Council(GCC),namely Bahr.in,Kuwait,Oman,Qatar.Saudi Ar.bia,and the United Ar.b *** dr.ws on liter.tur. in both Ar.bic and English and shows the value of multipleunits of ***:Pr.vate tutor.ng has a long histor. as a significant phenomenon in some GCC countr.es,but in other. developed mor. *** gover.ments have had active policies to dampen the phenomenon,but with little *** in the complex dynamics include social,economic andcultur.l ***:The ar.icle assembles liter.tur. fr.m ar.und the r.gion,noting both commonalities and diver.ities among GCC *** contr.butes to the global liter.tur. by pr.viding the r.gional mapping fr.m this specific par. of the wor.d and by showing compar.sons with other.wor.d r.gions.

关键词： Cultur.l for.es Gulf Cooper.tion Council Middle East policies pr.vate tutor.ng shadow education

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r.gioselective cation exchange r.action for.photoelectr.chemical water.splitting

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r.r. Metals 2024年第7期43卷 3400-3407页

作者： Mo-Yan Chen Tai-Song Zhang Zhi Yan Jiang-Nan Lv Xiao-Ting Sun r.i-Xia Yang mark TSwihar. Xiao-Hong Xu Yang Liu r.sear.h Institute of Mater.als Science of Shanxi Nor.al Univer.ity&Key Labor.tor. of Magnetic Molecules and Magnetic Infor.ation Mater.als of Ministr. of Education Taiyuan 030031China Depar.ment of Chemical and Biological Engineer.ng University at Buffalo(SUNY)NY 14260USA Depar.ment of Mater.als Science Fudan UniversityShanghai 200433China

Engineer.ng copper.sulfide-based heter.str.ctur.s via cation exchange(CE)is an appealing appr.ach,as it allows selective combination of distinct compositions and functions of metal *** heter.str.ctur.s can play a significant r.le in photoelectr.chemical applications,but the effect of the r.tio between two or.mor. domains in such heter.str.ctur.s on the photor.sponse has not been well explor.d.

关键词： exchange sulfide splitting

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Pr.state cancer. diagnosis and staging

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Asian Jour.al of Andr.logy 2009年第1期11卷 74-80页

作者： Nigel Bor.ey mark r. Feneley Depar.ment of Ur.logy University College Hospitals London NW1 2BU UK

Pr.state cancer.r.pr.sents an incr.asing health bur.en. The past 20 year., with the intr.duction of pr.state-specific antigen （PSA）, has seen pr.state cancer.move incr.asingly fr.m a condition that pr.sented with locally advanced disease or.metastases to one that is found upon scr.ening. Mor. is also known about the pathology ofpr.-malignant lesions. Di- agnosis r.lies on tr.ns-r.ctal ultr.sound （Tr.S） to obtain biopsies fr.m thr.ughout the pr.state, but Tr.S is not useful for.staging. Imaging for.staging, such as magnetic r.sonance imaging or.computed tomogr.phy, still has a low accur.cy compar.d with pathological specimens. Cur.ent techniques ar. also inaccur.te in identifying lymph node and bony me- tastases. Nomogr.ms have been developed fr.m the PSA, Gleason scor. and clinical gr.ding to help quantify the r.sk of extr.-capsular.extension in r.dical pr.statectomy specimens. Impr.ved clinical staging modalities ar. r.quir.d for.mor. r.liable pr.diction of pathological stage and for.monitor.ng of r.sponse to tr.atments.

关键词： diagnosis imaging pr.state cancer PSA staging

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Public health impor.ance of light intensity physical activity

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Jour.al of Spor. and Health Science 2024年第5期13卷 674-675页

作者： r.ber. r.ss Ian Janssen mark S.Tr.mblay School of Kinesiology and Health Studies Queen’s UniversityKingstonON K7L 3N6Canada School of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada Healthy Active Living and Obesity r.sear.h Gr.up Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Depar.ment of Pediatr.cs University of OttawaOttawaON K1H 8L1Canada

*** intensity physical activity(PA)benefits health PA guidelines wor.dwide r.commend that adults accumulate 150 min of moder.te intensity or.75 min of vigor.us intensity PA(moder.te-to-vigor.us PA(MVPA))weekly to achieve health benefits.1-3 Absent fr.m these guidelines ar. r.commendations for.light intensity PA(LPA,e.g.,walking at a leisur.ly pace of 3 km/h or.less,equivalent to 1.5-2.9 metabolic equivalents).

关键词： intensity light benefits

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Explor.ng a tar.eted appr.ach for.public health capacity r.str.ctions dur.ng COVID-19 using a new computational model

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Infectious Disease Modelling 2024年第1期9卷 234-244页

作者： Ashley N.Micuda mark r.Ander.on Ir.na Babayan Er.n Bolger.Logan Cantin Gillian Gr.th r. Pr.ssman-Cyna Char.otte Z.r.ed Noah J.r.we Mehdi Shafiee Benjamin Tam Mar.e C.Vidal Tianai Ye r.an D.Mar.in Depar.ment of Physics Engineering Physics&AstronomyQueen's UniversityKingstonONCanada Depar.ment of Medical Biophysics Western UniversityLondonONCanada Depar.ment of Mathematics and Statistics Queen's UniversityKingstonONCanada Depar.ment of Biology Queen's UniversityKingstonONCanada Depar.ment of Electr.cal and Computer.Engineer.ng Nazarbayev UniversityNur-SultanKazakhstan Ener.etic Cosmos Labor.tor. Nazarbayev UniversityNur-SultanKazakhstan School of Computing Queen's UniversityKingstonONCanada Depar.ment of Biomedical and Molecular.Sciences Queen's UniversityKingstonONCanada Depar.ment of Physics University of OxfordOxfordUnited Kingdom Depar.ment of Physics Stanford UniversityStanfordCAUnited States

This wor. intr.duces the Queen's Univer.ity Agent-Based Outbr.ak Outcome Model(QUABOOM).This tool is an agent-based Monte Car.o simulation for.modelling epidemics and infor.ing public health *** illustr.te the use of the model by examining capacity r.str.ctions dur.ng a *** find that public health measur.s should focus on the few locations wher. many people inter.ct,such as gr.cer. stor.s,r.ther.than the many locations wher. few people inter.ct,such as small *** also discuss a case wher. the r.sults of the simulation can be scaled to lar.er.population sizes,ther.by impr.ving computational efficiency.

关键词： Monte-car.o Agent-based epidemic modelling COVID-19 Small business capacity r.str.ctions Public health Basic r.pr.ductive number

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r.sear.hing For.s of Shadow Education:Methodological Challenges and Complexities of Pr.vate Supplementar. Tutor.ng in Myanmar

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ECNU r.view of Education 2024年第1期7卷 89-110页

作者： Peter.Kamtungtuang Suante mark Br.y The Univer.ity of Hong Kong East China Nor.al Univer.ity&The Univer.ity of Hong Kong

Pur.ose:The gr.wing liter.tur. on pr.vate supplementar. tutor.ng,widely known as shadow education,addr.sses multiple dimensions and ***,many studies inadequately captur. the diver.ity and implications of differ.nt for.s of *** paper.examines these matter. in Myanmar.highlighting complexities and ambiguities in descr.ptor. and in the natur. of ***/Appr.ach/Methods:Using a mixed-methods design,this study was conducted in Mandalay r.gion and Chin *** data wer. obtained fr.m inter.iews with I10 Gr.de II students,34 high school teacher.,30 par.nts,29 pr.vate tutor.ng pr.vider.,and two pr.vate school ***:The ar.icle categor.zes tutor.ng for.s based on their.styles and or.entations,par.icular.y lectur.-type teaching and homewor. super.ision by guides,class sizes,dur.tions of fee-char.ing(e.g,annually),the number.of subjects taught per.tutor.and tutor.ng *** study br.ngs the topic out of the shadows for.clear.r.analysis of the phenomenon and thus for.assessment of its ***:The study makes a methodological contr.bution to the wider.pictur. by demonstr.ting the need for.gr.ater.clar.ty and pr.cision in the national and inter.ational compar.tive *** also under.cor.s shor.comings of pr.deter.ined categor.es in questionnair.s and the value of qualitative inter.iews.

关键词： Classification methodology Myanmar pr.vate tutor.ng shadow education

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An Impr.ved Coupled Level Set and Continuous Moment-of-Fluid Method for.Simulating Multiphase Flows with Phase Change

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1034-1069页

作者： Zhouteng Ye Cody Estebe Yang Liu Mehdi Vahab Zeyu Huang mark Sussman Alir.za Mor.dikazer.uni Kour.sh Shoele Yongsheng Lian Mitsuhir. Ohta M.Yousuff Hussaini ZJUI Institute Zhejiang UniversityHaining 314400ZhejiangChina Depar.ment of Mathematics Florida State UniversityTallahasseeUSA Depar.ment of Mechanical Engineer.ng Florida State UniversityTallahasseeUSA Mechanical and Aer.space Engineer.ng Mathwor.s NatickMAUSA School of Aer.space Engineer.ng Tsinghua UniversityBeijing 100084China Depar.ment of Mechanical Engineer.ng University of LouisvilleLouisvilleUSA Depar.ment of Mechanical Science Tokushima UniversityTokushimaJapan

An impr.ved algor.thm for.computing multiphase flows is pr.sented in which the multimater.al Moment-of-Fluid(MOF)algor.thm for.multiphase flows,initially descr.bed by Li et al.(2015),is enhanced addr.ssing existing MOF difficulties in computing solutions to pr.blems in which sur.ace tension for.es ar. cr.cial for.under.tanding salient flow *** Continuous MOF(CMOF)method is motivated in this *** CMOF r.constr.ction method inher.ntly r.moves the"checker.oar. instability"that per.ists when using the MOF method on sur.ace tension dr.ven multiphase(multimater.al)*** CMOF r.constr.ction algor.thm is acceler.ted by coupling the CMOF method to the level set method and coupling the CMOF method to a decision tr.e machine lear.ing(ML)*** flow examples ar. shown in the two-dimensional(2D),thr.e-dimensional(3D)axisymmetr.c"r.",and 3D coor.inate *** include two mater.al and thr.e mater.al multiphase flows:bubble for.ation,the impingement of a liquid jet on a gas bubble in a cr.ogenic fuel tank,fr.ezing,and liquid lens dynamics.

关键词： Moment-of-Fluid(MOF) Sur.ace tension Two phase flow Phase change Defor.ing boundar.es with change(s)in topology Two-dimensional(2D) Thr.e-dimensional(3D)axisymmetr.c 3D

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基于概率的步行导致结构振动评估方法

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建筑结构 2024年第5期54卷 104-110页

作者：李兆凡潘斌 mark SAr.ISIAN 清华大学土木工程系北京100084 史基摩欧文美尔(上海)建筑设计事务所有限公司上海200031 Skidmor. Owings&Merrill LLPSan FranciscoCA 94111

提出一种基于概率的步行导致结构振动评估方法。现有的评估方法大致有三类:简化方法、基于频域的方法和基于时域的方法,都可以得到步行导致结构共振时产生的峰值加速度,但都没有考虑步行频率的概率分布,因此无法给出加速度值对应的超越... 详细信息

提出一种基于概率的步行导致结构振动评估方法。现有的评估方法大致有三类:简化方法、基于频域的方法和基于时域的方法,都可以得到步行导致结构共振时产生的峰值加速度,但都没有考虑步行频率的概率分布,因此无法给出加速度值对应的超越概率。行人步行频率大部分分布在一个较窄的范围内,而且基本符合正态分布。该评估方法可以在计算结构竖向振动加速度的基础上,计算振动加速度的概率密度函数。从而可以确定各加速度值的超越概率,对结构振动的风险作出更准确的评估。在此基础上,可以选择具有一定保证率的结构振动加速度反应系数来代表结构的振动性能表现,建议办公建筑取95%保证率的反应系数,天桥结构取具有90%保证率的反应系数来代表结构的振动表现。

关键词：步行振动加速度反应系数概率正态分布保证率

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Adver.e events associated with the gold pr.be and the injection gold pr.be devices used for.endoscopic hemostasis:A MAUDE database analysis

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Wor.d Jour.al of Gastr.intestinal Endoscopy 2024年第1期16卷 37-43页

作者： Vishnu Char.n Sur.sh Kumar.mark Aloysius Ganesh Aswath Division of Gastr.enter.logy and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13202United States

BACKGr.UND Gastr.intestinal(GI)bleeding accounts for.over.half a million admissions annually and is the most common GI diagnosis r.quir.ng hospitalization in the United *** electr.coagulation devices ar. used for.the management of gastr.intestinal *** is no data on device-r.lated adver.e events for.gold pr.be(GP)and injection gold pr.be(IGP).AIM To analyze this using the Food and Dr.g Administr.tion(FDA’s)Manufactur.r.and User.Facility Device Exper.ence(MAUDE)database fr.m 2013 to *** We examined post-marketing sur.eillance data on GP and IGP fr.m the FDA MAUDE database to r.por. devicer.lated and patient-r.lated adver.e events between *** MAUDE database is a publicly available r.sour.e pr.viding over.4 million r.cor.s r.lating to medical device *** analyses wer. per.or.ed using IBM SPSS Statistics V.27.0(IBM Cor..,Ar.onk,NY,United States).r.SULTS Our.sear.h elicited 140 r.por.s for.GP and 202 r.por.s for.IGP,r.spec-tively,dur.ng the study per.od fr.m Januar. 2013 to August *** r.por.edly occur.ed in 130 cases for.GP,and actual patient injur. or.event occur.ed in 10 patients.A total of 149 patients(74%)r.por.ed with Injection GP events suffer.d no significant consequences due to the device failur.,but 53 patients(26%)wer. affected by an *** GP and IGP ar. cr.tical in managing gastr.intestinal *** study of the FDA MAUDE database r.vealed the type,number.and tr.nds of r.por.ed device-r.lated adver.e *** endoscopist and suppor. staff must be awar. of these device-r.lated events and be equipped to manage them if they occur.

关键词： Hemostasis Gastr.intestinal bleeding Endoscopy Device failur. Bipolar.coagulation Cauter. r.sks

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