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Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

World Journal of Diabetes 2020年第7期11卷 309-321页

作者： Banu Buyukaydin Eray Metin Guler Tahsin Karaaslan Atilla Olgac Mehmet Zorlu muharrem kiskac Abdurrahim Kocyigit Department of Internal Medicine Bezmialem Vakif University Medical FacultyIstanbul 34093Turkey Department of Medical Biochemistry Bezmialem Vakif University Medical FacultyIstanbul 34093Turkey Department of Nephrology Istanbul Medeniyet University Medical FacultyIstanbul 34093Turkey

BACKGROUND Diabetic polyneuropathy is a very common complication of *** studies are available in terms of *** examination methods with low reliability are still not standardized and generally time ***,easy-to-access methods are *** markers are one of the subjects of *** aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of *** To determine the place and availability of visfatin and thiol-disulfide homeostasis in this *** A total of 392 patients with type 2 diabetes mellitus were included in the *** polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and *** biochemical parameters,oxidative stress markers,visfatin,and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical *** Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration(P<0.005).Neuropathy related symptoms were present in 20.7%of the patients,but neuropathy related findings were observed in 43.9%of the *** glucose,glycated hemoglobin,and visfatin were positively correlated with each ***,these parameters were positively correlated with the total oxidative stress *** and native thiol was positively correlated with total antioxidant status and negatively with oxidant *** thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status(P<0.005).There was no correlation between visfatin and thiol-disulphide(P=0.092,r=0.086).However,a significant negative correlation was observed between visfatin and total with native thiol(P<0.005,r=-0.

关键词： Diabetic neuropathy Diabetic foot Early detection Oxidative stress Thioldisulfide Visfatin protein

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Effect of sintering temperature on pore ratio and mechanical properties of composite structure in nano graphene reinforced ZA27 based composites

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International Journal of Minerals,Metallurgy and Materials 2020年第2期27卷 232-243页

作者： muharrem Pul Department of Electric and Energy Kirikkale University Kirikkale 71450 Turkey

Nano graphene platelet(Gr)reinforced nano composites with a zinc–aluminum alloy(ZA27)matrix were produced by powder metallurgy at four different mass ratios(0.5wt%,1.0wt%,2.0wt%and 4.0wt%)and three different sintering temperatures(425,450,and 475°C).In order to investigate the effect of sintering temperatures and nano graphene reinforcement materials on the composite structure,the microstructures of the composite samples were investigated and their densities were determined with a scanning electron ***,transverse rupture,and abrasion wear tests were performed to determine the mechanical *** to the test results,the porosity increased and the mechanical strength of the nano composites decreased as the amount of nano graphene reinforcement in ZA27 ***,when the composites produced in different reinforcement ratios were evaluated,the increase in sintering temperature increased the mechanical structure by positively affecting the composite structure.

关键词： nanocomposite zinc aluminum alloy graphene microstructure sintering mechanical property

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Aldol Condensation and Michael Addition of 4,4-Dimethyl- cyclohexane-l,3-dione and Aromatic Aldehydes, Unconventional Substituent Effects

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Chinese Journal of Chemistry 2011年第11期29卷 2355-2360页

作者： Kaya, muharrem Chemistry Department Faculty of Arts and Science Dumlupmar University 43100 Kutahya Turkey

By the cyclization of 4,4-dimethylcyclohexane-1,3-dione with different aromatic aldehydes, the xanthene regio- isomers were obtained. The diversity of xanthene isomers could be determined. The electronic and steric ef... 详细信息

关键词： aldol reaction Michael addition xanthene regioselectivity substituent effects X-ray diffraction

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Hydrostatic pressure and temperature effects on the binding energy and optical absorption of a multilayered quantum dot with a parabolic confinement

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Chinese Physics B 2016年第12期25卷 408-417页

作者： Sami Ortakaya muharrem Kirak Department of Physics Erciyes University 38039 Kayseri Turkiye Faculty of Education Bozok University 66200 Yozgat Turkiye

The influence of hydrostatic pressure, temperature, and impurity on the electronic and optical properties of spherical core/shell/well/shell （CSWS） nanostructure with parabolic confinement potential is investigated theoretically. The energy levels and wave functions of the structure are calculated by using shooting method within the effective-mass approximation. The numerical results show that the ground state donor binding energy as a function layer thickness very sensitively depends on the magnitude of pressure and temperature. Also, we investigate the probability distributions to understand clearly electronic properties. The obtained results show that the existence of the pressure and temperature has great influence on the electronic and optical properties.

关键词： multilayers impurity pressure nonlinear optics

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Etiology and portal vein thrombosis in Budd-Chiari syndrome

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World Journal of Gastroenterology 2008年第18期14卷 2858-2862页

作者： Oguz Uskudar Meral Akdogan Nurgul Sasmaz Sevinc Yilmaz muharrem Tola Burhan Sahin Turkiye Yuksek htisas Hospital clinics of gastroenterology Ankara 06010 Turkey Turkiye Yuksek htisas Hospital hematology unit Ankara 06010 Turkey Turkiye Yuksek htisas Hospital clinics of radiology Ankara 06010 Turkey

AIM: To research the etiology, portal vein thrombosis and other features of Budd-Chiari syndrome (BCS) patients prospectively. METHODS: A total of 75 patients (40 female, 35 male) who were diagnosed between January 2002 and July 2004 as having BCS were studied prospectively. Findings from on physical examination, ultrasonography, duplex ultrasonography and venography were analyzed. Hemogram and blood chemistry were studied at the time of diagnosis and on each hospital visit. Bone marrow examination and immune phenotyping were performed by a hematologist when necessary. Protein C, S, antithrombin Ⅲ, activated protein C resistance, and anticardiolipin antibodies, antinuclear antibodies, and anti ds-DNA were studied twice. The presence of ascite, esophageal varices, and portal thrombosis were evaluated at admission and on every visit. RESULTS: At least one etiological factor was determined in 54 (72%) of the patients. The etiology could not be defined in 21 (28%) patients. One etiological factor was found in 39, 2 factors in 14 and 3 factors in 1 patient. The most common cause was the web (16%), the second was Hydatid disease (11%), the third was Behcet’s disease (9%). Portal vein thrombosis was present in 11 patients and at least one etiology was identified in 9 of them (82%). CONCLUSION: Behcet’s disease and hydatid disease are more prominent etiological factors in Turkey than in other countries. Patients with web have an excellent response to treatment without signs of portal veinthrombosis while patients having thrombofilic factors more than one are prone to develop portal vein thrombosis with worse clinical outcome.

关键词： Budd-Chiari syndrome Etiology Web Behcet's disease Portal thrombosis

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Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver

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World Journal of Gastroenterology 2008年第33期14卷 5204-5209页

作者： Fahrettin Yildiz Sacit Coban Alpaslan Terzi Mustafa Ates Nurten Aksoy Hale Cakir Ali Riza Ocak muharrem Bitiren Harran University Medical Faculty Department of General SurgerySanli Urfa 63300 Turkey Gaziantep University Medical Faculty Department of General SurgeryGaziantep 27310 Turkey Malatya State Hospital Department of General Surgery Malatya 44100 Turkey Harran University Medical Faculty Department of BiochemistrySanli Urfa 63300 Turkey Harran University Medical Faculty Department of Pathology Sanli Urfa 63300 Turkey

AIM: To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. METHODS: Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sati-va (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before isch-emia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrifi ced. Serum aspartate aminotransfera-se (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxida-tive status (TOS), oxidative stress index (OSI) and my-eloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy. RESULTS: The levels of liver enzymes in group 3 weresignifi cantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were signifi cantly lower in group 3 than the group 2. Histo-logical tissue damage was milder in the NS treatment group than that in the control group. CONCLUSION: Our results suggest that Nigella sa-tiva treatment protects the rat liver against to hepatic ischemia-reperfusion injury.

关键词： Nigella sativa Ischemia reperfusion injury Liver

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Interaction between seed size and NaCl on germination and early seedling growth of some Turkish cultivars of chickpea(Cicer arietinum L.)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第5期9卷 371-377页

作者： muharrem KAYA Gamze KAYA Mehmet Demir KAYA Mehmet ATAK Sevil SAGLAM Khalid Mahmood KHAWAR Cemalettin Yasar CIFTCI Department of Field Crops Faculty of AgricultureSuleyman Demirel University Central Research Institute for Field Crops Ministry of Agriculture and Rural Affairs Department of Field Crops Faculty of AgricultureMustafa Kemal University Department of Field Crops Faculty of AgricultureUniversity of Ankara

Chickpea is an important food legume crop of Turkey and is largely grown for human consumption on low moisture or salt-affected soils. The objective of the study was to find the effects of NaCl stress at electrical conductivities of 4.5, 8.6, 12.7 and 16.3 dS/m and seed sizes （7, 8 and 9 mm） on germination and early seedling growth of three popular chickpea cultivars （AKN-97, Gokce and Uzunlu-99）. Mean frequency of germination, germination time, germination index, root length, shoot length and seedling fresh weight showed seed size-dependent responses ofcultivars to salt stress. In general, small seeds germinated and grew more rapidly compared to medium and large seeds of the same cultivars against all levels of salt stress, with the best results in cultivar Uzunlu-99. No effect of NaCl treatments was observed on frequency of germination; however, a drastic decrease in early seedling growth was recorded at increased NaC1 concentrations. Regression analysis results showed a significantly positive relationship （P〈0.01） between seed size and mean germination time, whereas a significantly negative relationship was recorded between seed size and germination index, root length, shoot length. Moreover, linear regression values apparently confirmed that increased seed size in each cultivar affected decreased germination index, root and shoot lengths with enhanced mean germination time. Thus, it was concluded that the use of small seeds could considerably reduce the production costs of chickpea in salt-affected soils.

关键词： Chickpea (Cicer arietinum L.) NaCl stress Cultivar Seed size Germination

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Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study

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World Journal of Clinical Cases 2018年第3期6卷 20-26页

作者： Arif Emre Sami Akbulut Mehmet Sertkaya muharrem Bitiren Ilhami Taner Kale Ertan Bulbuloglu Cemil Colak Department of Surgery Kahramanmaras Sutcu Imam University Faculty of Medicine Department of Surgery and Liver Transplant Institute Inonu University Faculty of Medicine Department of Pathology Kahramanmaras Sutcu Imam University Faculty of Medicine Department of Biostatistics Inonu University Faculty of Medicine

AIM To evaluate whether there was any correlation between the clinical parameters and final pathological results among patients who underwent thyroid surgery. METHODS We retrospectively analyzed parameters, including age, sex, complete blood cell count parameters, nodule diameter, nodule localization, thyroid function testing, and pathology reports, in patients who underwent thyroid surgery. The patients were divided into malignant (n = 92) and benign (n = 413) groups depending on the final pathological results. Both groups were compared for demographic and clinicalparameters. The Kolmogorov-Smirnov normality test was used to determine if the quantitative variables had a normal distribution. The nonparametric MannWhitney U test was used to compare quantitative data that were not normally distributed, and Pearson's chisquared test was used to compare the qualitative data. The correlation between the final pathological results and fine-needle aspiration biopsy findings was calculated using the cross-tabulation *** This study included 406 women and 99 men aged between 15 and 85 years. No significant differences were found between the groups with respect to age, sex, white blood cell count, neutrophil count, lymphocyte count, thrombocyte count, red cell distribution width, platelet distribution width, mean platelet volume, platecrit, nodule localization, and thyroid function testing. On the other hand, there were significant differences between the groups with respect to nodule size (P = 0.001), cervical lymphadenopathy(P = 0.0001) and nodular calcification (P = 0.0001). Compared with the malignant group, the benign group had a significantly greater nodule size (35.4 mm vs 27.6 mm). The best cut-off point (≤ 28 mm) for nodule size, as determined by the receiver operating characteristic curve, had a sensitivity and specificity of 67.7% and 64.4%, respectively. The correlation between fine-needle aspiration biopsy and the final pathological results was assessed

关键词： Thyroid Thyroidectomy Histopathological findings Clinical features

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Simulated and experimental studies of a multi-band symmetric metamaterial absorber with polarization independence for radar applications

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Chinese Physics B 2022年第5期31卷 703-710页

作者： Hema O.Ali Asaad M.Al-Hindawi Yadgar I.Abdulkarim Ekasit Nugoolcharoenlap Tossapol Tippo FatihÖzkan Alkurt Olcay Altintas muharrem Karaaslan Department of Communication Engineering Sulaimani Polytechnic UniversitySulaimani 46001Iraq Medical Physics Department College of Medicals and Applied ScienceCharmo UniversityChamchamal 46023SulaimaniaIraq Department of Telecommunication Engineering Faculty of EngineeringRajamangala University of Technology RattanakosinPhutthamonthonNakornprathom 73170Thailand Department of Electrical and Electronics Engineering Iskenderun Technical UniversityHatay 31100Turkey

We develop a simple new design for a multi-band metamaterial absorber(MTMA)for radar *** Simulation Technology(CST)Studio Suite 2018 was used for the numerical analysis and absorption *** simulated results show four high peaks at 5.6 GHz,7.6 GHz,10.98 GHz,and 11.29 GHz corresponding to absorption characteristics of 100%,100%,99%,and 99%,***,two different structures were designed and compared with the proposed *** proposed structure remained insensitive for any incident angle and polarization angle from 0°to60°.Moreover,negative constitutive parameters were retrieved *** support the simulated results,the proposed design was fabricated by using a computer numerical control-based printed circuit board prototyping machine and tested experimentally in a microwave *** absorption mechanism of the proposed MTMA is presented through the surface current and electric field *** novelties of the proposed structure are a simple and new design,ease of fabrication,low cost,durability,suitability for real-time applications and long-term stability given the fabrication technique and non-destructive measurement method and very high *** proposed structure has potential applications in C and X band frequency ranges.

关键词： multi-band metamaterials absorber polarization-independent negative parameters

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Effects of glutamine and curcumin on bacterial translocation in jaundiced rats

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World Journal of Gastroenterology 2010年第34期16卷 4313-4320页

作者： Oguzhan Karatepe Ersin Acet muharrem Battal Gokhan Adas Ahu Kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali Servet Karahan Department of Surgery Okmeydani Education and Research Hospital Department of Biochemistry Istanbul Faculty of Medicine Istanbul 34725 Turkey Department of Infectious Disease Istanbul Faculty of Medicine Istanbul 34715 Turkey

AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice.

关键词： Obstructive jaundice Bacterial translocation Oxidative damage Glutamine Curcumin

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