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Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Surgery 2022年第5期14卷 429-441页

作者： Rupaly Pande shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom

BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same *** resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these *** To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for *** This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and *** comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were *** N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other *** imaging diagnosed PALN positivity in one *** and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo

关键词： Para-aortic lymph node Pancreatectomy Survival Pancreatic adenocarcinoma Chemotherapy Lymph node sampling

负载干细胞诱导因子的心肌补片对心肌梗死治疗的研究

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负载干细胞诱导因子的心肌补片对心肌梗死治疗的研究

Electrical features of radio-frequency atmospheric pressure helium discharge with and without dielectric electrodes

中国生理学会张锡钧基金会第十四届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十二届全国青年生理学工作者学术会议

作者：张悦 muhammad.shafiq 赵环环徐哲龙孔德领天津医科大学生理学与病理生理学系南开大学国家药物化学重点实验室生命科学学院韩国技术科学研究院

实验目的:21世纪心血管疾病(Cardiovascular Disease,CVD)尤其是心肌梗死(Myocardial Infarction,MI)由于其较高的死亡率,已经成为威胁人类生命健康的第一杀手。近年来,生物活性材料联合干细胞对MI治疗的研究已成为热点。神经肽P物质(Ne... 详细信息

实验目的:21世纪心血管疾病(Cardiovascular Disease,CVD)尤其是心肌梗死(Myocardial Infarction,MI)由于其较高的死亡率,已经成为威胁人类生命健康的第一杀手。近年来,生物活性材料联合干细胞对MI治疗的研究已成为热点。神经肽P物质(Neuropeptide Substance P,SP)具有动员内源性的CD105+干细胞归巢,调节炎症反应,促进损伤组织修复等功效。但由于SP

关键词：心肌梗死细胞诱导生物活性材料

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Plasma Science and Technology 2019年第2期21卷 60-67页

作者： H ASHRAF S Z A SHAH H I A QAZI M A KHAN S HUSSAIN M A BADAR S NIAZ M shafiq Department of Physics University of Sargodha Department of Physics Quaid-i-Azam University

A comparative study of radio-frequency atmospheric pressure glow discharge(rf APGD)generated in helium with and without dielectric electrodes to investigate the effect of electrodes insulation on electrical features of APGD is presented. In the α mode, both the rf APGDs remain volumetric, stable and uniform. In the γ mode, the APGD without dielectric electrodes shrinks into a constricted plasma column whereas APGD with dielectric electrodes remains stable and retains the same volume without plasma constriction even at higher densities of discharge current. A comparison of electrical features of both rf APGDs in normal and abnormal glow discharge regimes is presented. In both APGDs with and without dielectric electrodes,impedance measurements have been performed and compared with equivalent circuit *** measured impedance data is found to be in good agreement with simulated data.

关键词： radiofrequency atmospheric pressure glow discharge dielectric electrodes plasma stability control

Value of Pulsed Tissue Doppler Imaging in Predicting the Presence of Significant Coronary Artery Insufficiency

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World Journal of Cardiovascular Diseases 2020年第5期10卷 305-312页

作者： Hossam Eldin M. Mahmoud Ahlam M. Sabra Mohammad shafiq Awad Ahmed Hussein Internal Medicine Department Faculty of Medicine South Valley University Qena Egypt Cardiology Department Faculty of Medicine Beni Suef University Beni Suef Egypt Internal Medicine Department Faculty of Medicine Sohag University Sohag Egypt

Background: Coronary artery disease (CAD) is a paramount cause of death. Global and regional left ventricular (LV) systolic function is an important non-invasive marker of CAD. We can use tissue Doppler imaging (TDI) to measure the low velocities generated by myocardium which are: S'-wave, E'-wave, and A'-wave. We aimed to examine the value of the S'-wave dispersion of TDI across mitral valve annular velocities to predict angiographically significant coronary artery obstruction. Patients and Methods: We included 100 patients with symptoms suggesting CAD. All patients had undergone full history taken and clinical examination;ECG, echocardiographic with assessment of LV function, and Doppler derived mitral valve velocities;TDI with measuring of S'-wave and coronary angiography. Lesions with ≥70% or more stenosis in major epicardial artery or ≥50% stenosis in the left main coronary artery were considered significant. Patients were classified into two groups according to the presence or absence of significant coronary stenosis. Results: Clinical and conventional echocardiographic and Tissue Doppler measures were comparable between the two groups;there was statisticallysignificant difference between Group I and Group II (P value;patients with significant coronary arteries lesions have higher S' wave dispersion as compared with patients with normal or mild significant coronary lesions. Conclusion: S'-wave dispersion may consider a good predictor of angiographically significant coronary artery disease.

关键词： Tissue Doppler Imaging TDI CAD Mitral Annular Velocities S'-Wave Dispersion Coronary Artery Disease Coronary Angiography

Multiple Calcifying Epitheliomas of Malherbe’s of Axilla: A Case Report of Rare Variety

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Surgical Science 2014年第6期5卷 242-245页

作者： Mushtaq Chalkoo Shahnawaz Ahangar Naseer Awan Mujahid Ahmad Mir Aarif Bashir Nida shafiq Department of General Surgery Government Medical College Srinagar India

Pilomatrixoma, a rare benign tumour of sebaceous gland is commonly known as calcifying epithelioma of Malherbe or Tricholemmal cyst. We came across even the rarest form of this benign tumour of skin. Our case report was interestingly detected at a higher age group, unusual site of the body, multiple in nature following postoperative incision drainage of abscess in left axilla.

关键词： Epithelioma Axilla Multiple Postsurgical

Correction to:Heparin/Growth Factors‑Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin‑Based Nerve Guidance Conduits

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Advanced Fiber Materials 2023年第2期5卷 696-696页

作者： Yasuhiro Ikegami muhammad.shafiq Shinichi Aishima Hiroyuki Ijima Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu University744 MotookaNishi‑KuFukuoka 819‑0395Japan Department of Biotechnology Faculty of Science and TechnologyUniversity of Central Punjab(UCP)Lahore 54000Pakistan Department of Pathology and Microbiology Faculty of MedicineSaga UniversityNabeshima 5‑1‑1Saga 849‑8501Japan

Correction to:Advanced Fiber Materials https://***/10.1007/s42765-022-00244-6 In this article the affiliation details for Author muhammad.shafiq were incorrectly *** should have been assigned as shown *** original art... 详细信息

关键词： fibers details Regeneration

Effect of Growth Media, pH and Temperature on Yeast to Hyphal Transition in <i>Candida albicans</i>

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Open Journal of Medical Microbiology 2013年第3期3卷 185-192页

作者： Sayyada Ghufrana Nadeem Amna shafiq Shazia T. Hakim Yasmeen Anjum Shahana U. Kazm Department of Botany Jinnah University for Women Karachi Pakistan IIDRL Department of Microbiology University of Karachi Karachi Pakistan Mycology Research and Reference Institute Department of Microbiology Jinnah University for Women Karachi Pakistan

The transition of C. albicans from unicellular yeast form to filamentous form i.e., pseudohyphae and hyphae is referred to as morphogenesis. C. albicans has the ability to respond to environmental conditions and accordingly changing its cell morphology. Three main morphological forms of C. albicans are unicellular yeast, pseudohyphae and hyphae. The effect of different growth media (Horse serum medium, RPMI-1640, MSGB), incubation temperatures (34°C, 37°C, 40°C) and pH values (5.4, 6.4, 7.4) on germ tube production by C. albicans was evaluated. Horse serum medium noticeably promotes filamentation while RPMI-1640 medium shows moderate filamentation and MSGB media shows moderately low filamentation. The germ tube of C. albicans developed early in 1.5 hr at high temperature i.e., 40°C. Incubation temperature of 37°C was associated with highest germ tube formation while 34°C shows low filamentation. A pH of 5.4 also induces low filamentation, pH 6.4 gives moderately lower than pH 7.4. A pH of 7.4 was best suited for germ tube induction. The peak of mycelium production appears between 1.5 and 6 hr after inoculation of C. albicans culture. These results suggested that environmental factors are important in selectively favoring yeast or hyphal form, most important being the growth medium, incubation temperature and external pH value.

关键词： Candida albicans Filamentation Germ Tube Morphogenesis Pathogenesis

Study of Wavelet Methodology and Chaotic Behavior of Produced Particles in Different Phase Spaces of Relativistic Heavy Ion Collisions

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Journal of Applied Mathematics and Physics 2017年第5期5卷 1130-1149页

作者： M. Ayaz Ahmad Vyacheslav V. Lyashenko Zhanna V. Deineko Jalal Hasan Baker shafiq Ahmad Physics Department Faculty of Science University of Tabuk Tabuk Saudi Arabia Department of Informatics Kharkiv National University of Radio-Electronics Kharkiv Ukraine Department of Media Systems and Technology Kharkiv National University of Radio Electronics Kharkiv Ukraine Department of Physics Aligarh Muslim University Aligarh India

We applied the wavelet methodology for our earlier published research work of the chaotic behavior so called multiplicity fluctuations of secondary charged particles produced during the nucleus-nucleus (A-A) collisions at an energy of the order of ≈ 409 GeV in a new fashion. We illustrated the wavelet coherency in a relation of chaotic behavior for above said data of secondary charged pions in different phase spaces of collisions such as: η-space, φ-space (in one dimension) and ηφ-space (in two dimensions) respectively. We have shown the changes in the wavelet coherence when there are different values of two parameters “q” and “p”. We discussed our new results for the comparison purpose and findings were in the good agreements.

关键词： Wavelet Coherence Morlet Wavelet Dynamics of Nucleus-Nucleus (A-A) Collisions Phase Space Normalized Factorial Moments (SFMs)

Hydro-meteorological characteristics of Chitral River basin at the peak of the Hindukush range

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Natural Science 2013年第9期5卷 987-992页

作者： Salma Khalid shafiq Ur Rehman Syed Mushtaq Ali Shah Alia Naz Beena Saeed Sadia Alam Farman Ali Hasina Gul Department of Agriculture Abdul Wali Khan University Mardan Pakistan Department of Agronomy University of Agriculture Peshawar Pakistan Department of Biotechnology Abdul Wali Khan University Mardan Pakistan Department of Environmental Sciences Abdul Wali Khan University Mardan Pakistan Department of Environmental Sciences University of Peshawar Peshawar Pakistan Regional Meteorological Centre Peshawar Pakistan

This paper presents the impact of mean maximum temperature on Chitral river basin situated at Chitral district and high altitude (>6000 m) peaks of the Hindukush range under changing climate in Pakistan. The analysis of Chitral River as one of the tributary of Kabul River—the second largest river of Pakistan—revealed that change in temperature has a profound influence on the snow/glacial melt in comparison to the mean monthly rainfall. This is because the studied river is faded by the snow and glacial melt and receives a lot of snowfall from winter (DecFeb) to pre-monsoon (April-May). In monsoon period (Jul-Sep), 30% of the time the discharge rate remains above the mean while 60% of the time the discharge is less than the mean in the pre-monsoon (April-May) period. It means that 10% of the time the discharge is in reach of 300% to 900% of the mean flow, showing a rise in water yield and river discharge rate due to increase in mean monthly maximum temperature. Due to this significant increase (p < 0.05), the glaciers start melting faster and disappear in early summer, hence, reducing their residency period to convert into ice. This shows the signals of changing climate transfer into hydrological changes in Pakistan. Our findings are important for agriculture, hydropower and water management sectors for future planning especially in dry season for sustainable food security and for operation of ydrological installations in the country.

关键词： Mean Maximum Temperature Mean Rainfall River Discharge Climate Change Chitral