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Chemosensitizing Effect of Monk Fruit Extract on Human Bladder Cancer Cells

Journal of Cancer Therapy 2024年第6期15卷 250-264页

作者： Sensuke Konno Jonathan Wong Andrew Penunuri Kelvin Zheng muhammad choudhury Department of Urology New York Medical College Valhalla New York USA

The outcomes of chemotherapy have been unsatisfactory with the palpable side effects. We hypothesized that natural products might help improve chemotherapy with few side effects. Recently, we came across the bioactive extracts of monk fruit (Siraitia grosvenori) with anticancer activity. We then investigated if these extracts might have chemosensitizing effect to improve the efficacy of drugs clinically used today. Four different drugs, cisplatin (CPL), carboplatin (CBL), mitomycin C (MMC), and gemcitabine (GEM), were used in this study. Human bladder cancer T24 cells were treated with each drug itself or drug combined with either LLE or MOG (two types of monk fruit extracts). Cell viability was determined to assess anticancer effect and also explored the anticancer mechanism of such combinations, focusing on the status of glycolysis, cell cycle, and chromatin structure. Cell viability test showed that all drugs had anticancer activity, reducing cell viability, but only CPL showed the enhanced anticancer effect when combined with LLE (not with MOG). The rest of three drugs had no such effects with LLE or MOG. The CPL/LLE combination was found to disrupt glycolysis, by inhibiting hexokinase activity, resulted in the decreased ATP synthesis. This combination also blocked the cell cycle progression, due to a G1 cell cycle arrest. Moreover, the two epigenetic regulators, DNA methyltransferase and histone deacetylase, were inactivated with the combination, indicating chromatin modifications. Ultimately, these treated cells were found to undergo apoptosis. In conclusion, anticancer activity of CPL can be significantly enhanced with LLE. This chemosensitizing effect is attributed to the glycolysis inhibition, a G1 cell cycle arrest, and chromatin modifications, ultimately leading to apoptosis. Thus, certain natural products such as LLE could be used as an adjuvant agent in current chemotherapy, improving the drug efficacy but minimizing side effects.

关键词： Monk Fruit Anticancer Bladder Cancer Chemosensitization Lakanto

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Potential Anticancer Effect of Bioactive Extract of Monk Fruit (Siraitia grosvenori) on Human Prostate and Bladder Cancer Cells

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Journal of Cancer Therapy 2023年第5期14卷 211-224页

作者： Rogerio Haung Akhil Saji muhammad choudhury Sensuke Konno Department of Urology New York Medical College Valhalla USA

Prostate and bladder cancers are the two prevalent urological cancers, and several therapeutic options are currently available but the outcomes have not been satisfactory. To find the better therapeutic option, we investigated if the bioactive extracts of monk fruit, mogrosides, with potential anticancer activity might have anticancer effect against prostate and bladder cancer cells. Four of commercial products made of mogrosides known as Lakantoò (LKT) products, LK1, LK2, LLE, and MOG, were then tested. A dose-dependent study at given concentrations of four products showed that LK1 and LK2 had little effects, while LLE and MOG showed a significant cell viability reduction in both PC-3 and T24 cells. To explore the anticancer mechanism of such products, cell cycle analysis was first performed. Such analysis revealed that LLE and MOG, not LK1 and LK2, led to a G1 cell cycle arrest. Potential induction of endoplasmic reticulum (ER) stress was next examined because it is known to be linked to a cell cycle arrest. The three key regulators involved in ER stress were all up-regulated with LLE or MOG, indicating induction of ER stress. As ER stress is also known to induce apoptosis, this possibility was tested. The two apoptotic regulators were modulated in a specific manner with LLE or MOG, indicating induction of apoptosis. Lastly, to validate anticancer effect of LLE or MOG, anticancer effect of four chemotherapeutic drugs was also assessed in comparison with that of LLE/MOG. None of drugs had any effects but two products showed significant anticancer effect. In conclusion, two monk fruit products, LLE and MOG, demonstrated anticancer activity against PC-3 and T24 cells, significantly reducing cell viability and ultimately inducing apoptosis. Therefore, these two LKT products with few side effects may have clinical implications in the treatment of urological cancers.

关键词： Monk Fruit Mogroside Anticancer Prostate Cancer Bladder Cancer Lakanto

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Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： Vishal Singh Arnab choudhury Hyung Jin Ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

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Evolution of tectonic landscapes and deformation in the southeast Kumaun and western Nepal Himalaya

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Journal of Mountain Science 2024年第8期21卷 2592-2617页

作者： Khayingshing LUIREI Girish Ch.KOTHYARI Param K GAUTAM Ambar SOLANKI Atul Kumar PATIDAR Sentisenla JAMIR Anirudh DATTA Tanupriya choudhury Wadia Institute of Himalayan Geology Dehradun 248001India Department of Petroleum Engineering and Earth Sciences University of Petroleum and Energy StudiesDehradun248007India Department of Geology Nagaland UniversityKohima 797004India Academy of Scientific and Innovative Research Ghaziabad 201002India CSE Department Graphic Era deemed to be UniversityDehradun 248002India CSE Department Symbiosis Institute of TechnologySymbiosis International(Deemed University)Pune 412114India

The area of the present investigation’s expanse constitutes the southernmost extent of the southeast Kumaun Himalaya and western Nepal *** approaches have been employed to understand the landforms associated with tectonic deformation,through detailed field investigation supplemented by the geodetic,chronological,and morphometric *** morphogenic expressions of the Main Boundary Thrust(MBT)are reflected in the form of~25 km long E-W trending north dipping fault *** deformation along the strike length of the Himalayan Frontal Thrust(HFT)is noticed in the form of uplifted and incised fill terraces,and strath *** deformation within the fluvial sequences in the study area can be visualized in the form of sheared boulders and pebbles,tilted and faulted terrace ***,the chronological data of fluvial landforms in the study area suggests two major phases of tectonic deformations that have occurred around 58.7±10.8 ka and 3.88±0.4 *** chronology of late-Quaternary landforms advocates that the initial stage of aggradations in the Himalayan foothills commenced around 75.1±0.58 *** aggradational landforms resulted from the diverse depositional regime as evident from the nature of the sediment sequences from clasts dominated to thick mud *** rate of deformation in the southeastern Kumaun and western Nepal Himalaya is±7 mm/yr,as per the data obtained from the Persistent Scatterer Interferometric Synthetic Aperture Radar(PSInSAR).The landform deformation pattern,phase of incision and aggradation,frequent occurrence of landslides,and recent past earthquake activity within the wide zone of the HFT,the MBT,and Ramgarh Thrust suggests that the southernmost front of the Kumaun Himalaya is active and has potential for future *** foothill zone of Himalayan towns are actively growing in terms of population and infrastructural ***,such intradisciplinary studies for tectonically active r

关键词： MBT HFT Fault trace Quaternary deposits sheared boulders

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Possible Chemosensitizing and Potent Anticancer Effects of D-Fraction in Combination with Vitamin C on Three Prevalent Urologic Cancer Cells

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Journal of Cancer Therapy 2014年第14期5卷 1402-1411页

作者： Drew Freilich Eric Moskowitz Nicholas Feuer muhammad choudhury John Phillips Sensuke Konno Department of Urology New York Medical College Valhalla USA

Chemotherapy is currently one of the most common therapeutic options for cancer patients despite the poor efficacy with considerable side effects. We then examined if D-fraction (DF), a bioactive mushroom extract, could potentiate (poor) anticancer effects of those drugs?in vitro. Three urologic cancers, prostate, bladder, and kidney cancers, were tested with various chemotherapeutic drugs and their combinations with DF. Compared to individual drugs alone, combinations of drugs and DF have improved anticancer activity, resulting in the significant (P < 0.05) cell viability reduction in all three cancer cells. As vitamin C (VC) has been postulated to potentiate the bioactivity of DF, this possibility was also examined. The specific combination of DF (300 μg/ml) and VC (200 μM) indeed led to the drastic (≥90%) viability reductions in all three cancer cells. To have a better understanding of such a profound viability reduction, the effect of DF/VC combination on cell cycle was examined next. Cell cycle analysis indicated that this combination induced a G1cell cycle arrest, which was also confirmed by the down-regulation of specific cell cycle regulators (CDK2, CDK4, and cyclin D1) detected on western blots. Moreover, it was crucial to address if the DF/VC-induced viability reduction could be also linked to apoptosis. Western blot analysis revealed that anti-apoptotic bcl-2 was down-regulated while pro-apoptotic Bax was up-regulated with DF/VC combination in all cancer cells, indicating induction of apoptosis. Therefore, the DF/VC combination could ultimately induce apoptosis, accounting for the severe cell viability reduction. In conclusion, DF appears to be a promising agent with chemosensitizing effect, enhancing the efficacy of chemotherapeutic drugs, and its combination with VC exhibits a potent anticancer effect, which is far superior to any combinations of drugs and DF tested in three prevalent urologic cancer cells.

关键词： Mushroom Extract Chemosensitizing Effect Anticancer Effect Combination Therapy Urologic Cancers

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Dynamic analysis of buried pipeline with and without barrier system subjected to underground detonation

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Defence Technology（防务技术） 2023年第11期29卷 95-105页

作者： Chaidul Haque Chaudhuri Deepankar choudhury Department of Civil Engineering Indian Institute of Technology BombayMumbai400076India

Failure of pipe networks due to blast loads resulting from terrorist attacks or construction facilities, may cause economic loss, environmental pollution, source of firing or even it may lead to a disaster. The present work develops a closed-form solution of buried pipe with barrier system subjected to subsurface detonation. The solution is derived based on the concept of double-beam system. Euler Bernoulli's beams are used to simulate the buried pipe and the barrier system. Soil is idealized as viscoelastic foundation along with shear interaction between discrete Winkler springs(advanced soil model). The finite SineFourier transform is employed to solve the coupled partial differential equations. The solution is validated with past studies. A parametric study is conducted to investigate the influence of TNT charge weight, pipe material, damping ratio and TNT offset on the response of buried pipe with and without barrier system. Further a statistical analysis is carried out to get the significant soil and pipe input parameters. It is perceived that peak pipe displacements for both the cases(with and without barrier) are increases with increasing the weight of TNT charge and decreases with increasing the damping ratio and TNT offset. The deformation of pipe also varies with pipe material. Pipe safety against blast loads can be ensured by providing suitable barrier layer. The present study can be utilized in preliminary design stage as an alternative to expensive numerical analysis or field study.

关键词： Buried pipeline Subsurface detonation Analytical solution Viscoelastic foundation Protective barrier

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Community-acquired multidrug-resistant pneumonia,bacteraemia,and infective endocarditis:A case report

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World Journal of Critical Care Medicine 2024年第1期13卷 85-91页

作者： Basavaraj Jatteppanavar Arnab choudhury Prasan Kumar Panda Mukesh Bairwa Department of Medicine All India Institute of Medical SciencesRishikesh 249203India

BACKGROUND The prevalence of multidrug-resistant(MDR)bacteria has increased globally,with extensive drug-resistant(XDR)bacteria posing a threat to *** SUMMARY This case report describes a young man admitted for suspected tropical fever infections who experienced rapid deterioration in *** negative results for tropical fever infections,he had neutrophilic leucocytosis,acute kidney injury,and chest imaging findings suggestive of bilateral *** day two,he was diagnosed with infective endocarditis with possible rheumatic heart disease and MDR methicillin-resistant Staphylococcus aureus bacteraemia,and communityacquired *** treatment with broad-spectrum antibiotics,he did not respond and succumbed to death on day *** This case highlights that clinicians/public should be aware of MDR communityacquired pneumonia,bacteraemia,and endocarditis which ultimately culminate in high rates of morbidity and *** identification of pathogenic strain and prompt antibiotic treatment are a mainstay for the management and prevention of early ***,route cause analysis of communityacquired MDR/XDR pathogens is a global need.

关键词： Antibiotic resistance Community-acquired infections Infective endocarditis Methicillin-resistant staphylococcus aureus Rheumatic heart disease Case report

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Human leukocyte antigen B polymorphism and association between HLA-B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

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Rheumatology & Autoimmunity 2022年第1期2卷 15-21页

作者： Md Kamrul H.Sajib Shamim Ahmed Syed A.Haq Minhaj R.choudhury Mohammed Uddin Furkan Uddin muhammad S.A.Khan Mohammad M.Zaman Department of Rheumatology Dhaka Medical College HospitalDhakaBangladesh Department of Rheumatology Bangabandhu Sheikh Mujib Medical UnivesityDhakaBangladesh Department of Human Genetics Mohammed Bin Rashid University of Medicine and Health SciencesCollege of MedicineDubaiUAE Genetics and Genomic Department NeuroGen HealthcareDhakaBangladesh Department of Medicine Sheikh Hasina Institute of Burn and Plastic SurgeryDhakaBangladesh Advisor(Research and Publication) World Health OrganizationDhakaBangladesh

Objectives:To determine the association of Human leukocyte antigen B(HLA‑B)alleles with ankylosing spondylitis and the allelic association of HLAB27 with endoplasmic reticulum aminopeptidase 1(ERAP1)single-nucleotide polymorphism(SNP)rs30187 in patients with ankylosing spondylitis(AS).Methods:We studied 48 consecutively enrolled well-defined AS patients and 48 healthy controls recruited from the outpatient clinic of the rheumatology department of Bangabandhu Sheikh Mujib Medical University(BSMMU),Dhaka,*** genotype HLA-B alleles from peripheral blood DNA,we designed sequence-specific primers for polymerase chain ***'s sequencing method was used to detect the ERAP1 rs30187 *** HLA-B allele distributions were compared between cases and *** infer an allelic association between HLA-B27 and ERAP1,allele distributions from both loci were compared using ***-squared test or Fisher's exact test was used to quantify the association,and their strength of association was tested by odds ratio(OR)with 95%confidence interval(CI).Results:The frequency of HLA-B27 was found to be higher in AS patients(60.4%)than in healthy controls(8.3%).HLA-B27 allele had an OR of 16.8(95%CI=5.2–54.4)for the development of ***,4%of AS patients had both HLA-B27 and *** significant association was found between ERAP1 rs30187 SNP and HLA-B27 in patients with AS(OR=1.7,95%CI=0.5–5.6).Conclusions:HLA-B27 was significantly associated with AS in patients in ***,no association between ERAP1 rs30187 SNP and HLA-B27 was observed.

关键词： AS Bangladesh ERAP1 rs30187 SNP HLA-B HLA-B27

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HLA-DQ and-DR alleles in patients with SLE:A tertiary hospital-based case–control study in Bangladesh

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Rheumatology & Autoimmunity 2023年第1期3卷 43-49页

作者： muhammad S.A.Khan Shamim Ahmed Iftekhar H.Bandhan Farhana Zaman MdKamrul H.Sajib Shirin Tarafder Minhaj R.choudhury Syed A.Haq Mohammad M.Zaman Sheikh Hasina National Institute of Burn and Plastic Surgery DhakaBangladesh Department of Rheumatology Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh Upazilla Health Complex BancharampurB-BariaBangladesh Department of Community Medicine Universal Medical CollegeDhakaBangladesh Department of Rheumatology Dhaka Medical College HospitalDhakaBangladesh Green Life Center for Rheumatic Care and Research DhakaBangladesh World Health Organization DhakaBangladesh

Background:Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by the involvement of multiple organs and autoantibody *** study aimed to determine the association of human leukocyte antigen(HLA)-DQ and-DR alleles with SLE at a tertiary hospital in ***:This case-control study was conducted in the Department of Rheumatology,Bangabandhu Sheikh Mujib Medical University(BSMMU),Dhaka,*** patients who fulfilled the 1997 revised American College of Rheumatology classification criteria for SLE were considered cases(n=41).The controls(n=32)were selected from the hospital staff of BSMMU,including doctors and nurses who did not suffer from any known rheumatic diseases,and there was no such disease in their first-degree *** chain reaction using a sequence-specific primer(PCRSSP)in a low-resolution typing method was carried out on blood samples collected for HLA-DQ and-DR allele ***:The cases and controls had comparable mean ages(31 vs.32 years),and most cases were female(95.1%vs.34.4%).The most frequent clinical manifestations were mucocutaneous(85.4%),followed by musculoskeletal(70.7%)and constitutional symptoms(58.5%).The cases had a significantly higher frequency of HLA-DR2 allele compared with healthy controls(70.7%vs.43.8%;odds ratio:3.1;95%confidence interval:1.2-8.2).In addition,HLADQ6 allele was found to have a significant association with mucocutaneous manifestations of the cases(88.9%,P=0.03).Conclusions:Bangladeshi adults having HLA-DR2 may be more susceptible to ***-DQ6 allele might be associated with mucocutaneous manifestations of SLE.

关键词： alleles Bangladesh HLA-DQ HLA-DR systemic lupus erythematosus

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Tilapia Lake Virus(TiLV)disease:Current status of understanding

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Aquaculture and Fisheries 2022年第1期7卷 7-17页

作者： Nilav Aich Anirban Paul Tanmoy Gon choudhury Himadri Saha Department of Fisheries Government of TripuraTripura799006India ICAR-Central Institute of Freshwater Aquaculture KausalyagangaBhubaneswar751002India Department of Aquatic Health&Environment College of FisheriesCentral Agricultural University(Imphal)LembucherraTripura799210India

Tilapia Lake Virus(TiLV)disease is an emerging and transboundary disease of tilapia cultures,causing mortality up to 90%*** is a negative sense single stranded RNA virus belongs to family Amnoonviridae,genus Tilapinevirus and species Tilapia *** first TiLV outbreak to fishes was reported from Israel followed by other countries viz.,Ecuador,Colombia,Egypt,Thailand,Chinese Taipei,India,Malaysia,Bangladesh,Uganda,Tanzania,Peru,Mexico,Philippines,Indonesia,and *** the life stages of Tilapia(belonging to the family Cichlidae)are vulnerable to TiLV ***,river barb and giant gourami have also been found susceptible to TiLV *** virus infects the vital organs of the fish,including eyes,brain,and *** notable pathological finding of this disease includes syncytial cell formation and massive hepatocellular necrosis with pyknotic and karyolytic nuclei in the liver cells of infected *** disease is very contagious and spreads through both horizontal and vertical *** sensitive and rapid molecular diagnostic tools like reverse transcriptase polymerase chain reaction(RT-PCR),RT-quantitative PCR(RT-qPCR),loop-mediated isothermal amplification(LAMP)have been developed for early detection of the *** date,no comprehensive control measures have been developed throughout the globe,although aggressive work on this line is going *** of strict good management practices,including quarantine protocols,are the only available option to combat the outbreak and spread of the *** review emphasizes the etiology,occurrence and distribution,mode of transmission,pathology and pathogenesis,diagnosis,possible control measures,and challenges of TiLV disease.

关键词： Co-habitation Diagnosis Tilapinevirus Syncytial Tilapia lake virus

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