检索结果-南通市图书馆

Analysis of Genetic Alterations in TP53 Gene in Breast Cancer - A Secondary Publication

Proceedings of Anticancer Research 2024年第3期8卷 25-35页

作者： Baqaur Rehman muhammad Abubakar muhammad naeem kiani Rooma Ayyoub Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China

Tumor protein p53 (TP53) mediates DNA repair and cell proliferation in growing cells. The TP53 gene is a tumor suppressor that regulates the expression of target genes in response to multiple cellular stress factors. Key target genes are involved in crucial cellular events such as DNA repair, cell cycle regulation, apoptosis, metabolism, and senescence. TP53 genetic variants and the activity of the wild-type p53 protein (WT-p53) have been linked to a wide range of tumorigenesis. Various genetic and epigenetic alterations, including germline and somatic mutations, loss of heterozygosity, and DNA methylation, can alter TP53 activity, potentially resulting in cancer initiation and progression. This study was designed to screen three reported mutations in the DNA-binding domain of the p53 protein in breast cancer, to evaluate the relative susceptibility and risk associated with breast cancer in the local population. Genomic DNA was isolated from 30 breast tumor tissues along with controls. Tetra and Tri ARMS PCR were performed to detect mutations in the TP53 coding region. For SNPs c.637C>T and c.733C>T, all analyzed cases were homozygous for the wild-type allele ‘C,’ while for SNP c.745A>G, all cases were homozygous for the wild-type allele ‘A.’ These results indicate no relevance of these three SNPs to cancer progression in our study cohort. Additionally, the findings from whole exon sequencing will help to predict more precise outcomes and assess the importance of TP53 gene mutations in breast cancer patients.

关键词： Breast cancer p53 Gene expression Mutation SNPs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TMPRSS2 Polymorphism and Its Correlation with SARS-CoV-2 Susceptibility - A Secondary Publication

引用

Journal of Clinical and Nursing Research 2024年第5期8卷 329-335页

作者： Saleem Awan Anum Siraj Amber Khan Arifa Anwar muhammad naeem kiani Saira Yahya Department of Biosciences Shaheed Zulfikar Ali Bhutto Institute of Science and Technology(SZABIST)UniversityKarachiPakistan Department of Plant Breeding and Genetics Sindh Agriculture UniversityTandojamPakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060Guangdong ProvinceChina

Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus affected more people than SARS-CoV-1 and related *** genetic factors,besides respiratory droplets and direct exposure to the virus,are found highly responsible for transmitting SARS-CoV-2 ***:The objective of this study was to determine the plasma levels of the TMPRSS2 gene and its role in SARS-CoV-2 ***:A total of 100 patients,i.e.50 SARS-CoV-2 positive patients as the case group and 50 SARS-CoV-2 negative samples as the control group,were selected randomly and included in this case-control study to determine the association between TMPRSS2 gene and susceptibility to SARS-CoV-2 infection and severity of coronavirus disease 2019(COVID-19).The TMPRSS2 levels of case and control samples were measured through an enzyme-linked immunosorbent assay(ELISA).Following the genomic DNA extraction,a set of reverse and forward primers of human TMPRSS2 gene primers were used for the amplification of the TMPRSS2 ***:In the control group,the ratio of men to women was more or less the same while in the case group 62%of the population were *** TMPRSS2 level was found to be 4.70±7.7 ng/ml in case samples while it was 4.73±5.7 ng/ml in control ***:The levels of TMPRSS2 in plasma samples of both controls and cases were found to be the same indicating that the entry of SARS-CoV-2 is not dependent on the plasma levels of this protein.

关键词： TMPRSS2 SARS-CoV-2 ACE2 Gene COVID-19 Expression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring Novel Therapeutic Breakthroughs for Cancers:Potential Roles of miRNAs

引用

Proceedings of Anticancer Research 2024年第5期8卷 11-24页

作者： muhammad Abubakar Rooma Ayyoub Baqaur Rehman muhammad naeem kiani Usama Ahmed Jawaria Farooq Areeb Anwar Usmani Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060PR China Department of Zoology The Government Sadiq College Women University BahawalpurPakistan Research Coordinator Department of SurgeryAga Khan University and Hospital KarachiPakistan

MicroRNAs(miRNAs)are small non-coding RNAs,19-25 nucleotides in length,that regulate gene *** are involved in various cellular,biological,and pathological activities,including the development and progression of malignant *** studies have highlighted the significant roles of miRNA deregulation in various cancer types,involving critical pathways such as gene deletions and amplifications,abnormal epigenetic changes,and dysfunctional miRNA regulatory *** can function both as oncogenes and tumor suppressor genes in different *** cancer hallmarks are associated with deregulated miRNAs,including resistance to cell death,metastasis,sustained proliferative signaling,promotion of angiogenesis,and the suppression of growth *** research has demonstrated that miRNAs contribute to drug resistance in tumor cells by targeting genes linked to drug resistance or by influencing genes that regulate the cell cycle,apoptosis,and proliferation.A single miRNA often has tissue-specific regulatory functions and can affect multiple *** miRNA types have been identified as potential biomarkers for tumor diagnosis and critical targets for novel therapeutic *** review aims to explore the role of miRNAs in cancer progression,metastasis,and potential therapeutic interventions.

关键词： MicroRNAs Cancer Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks

引用

Computers, Materials & Continua 2025年第1期82卷 1151-1169页

作者： Khalil Ullah Song Jian muhammad naeem Ul Hassan Suliman Khan Mohammad Babar Arshad Ahmad Shafiq Ahmad Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Department of Computer Science Abbottabad University of Science and TechnologyHavelianAbbottabad22500Pakistan Department of Computing and Electronics Engineering Middle East CollegeMuscat124Oman Department of CS&IT Pak-Austria Fachhochschule Institute of Applied Sciences and Technology MangHaripur22621Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile *** networks are sufficiently scaled to interconnect billions of users and *** in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous *** continuously improves its network functionality to support these *** input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in *** article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial *** technique aims to create long-lasting and secure NextG networks using this extended *** viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this ***,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques.

关键词： Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correction:Deep Learning-Enhanced Brain Tumor Prediction via Entropy-Coded BPSO in CIELAB Color Space

引用

Computers, Materials & Continua 2025年第1期82卷 1461-1461页

作者： Mudassir Khalil muhammad Imran Sharif Ahmed naeem muhammad Umar Chaudhry Hafiz Tayyab Rauf Adham E.Ragab Department of Computer Engineering Bahauddin Zakariya UniversityMultan60000Pakistan Department of Computer Science Kansas State UniversityManhattanKS 66506USA Department of Computer Science University of Management and TechnologyLahore54000Pakistan Independent Researcher BradfordBD80HSUK Industrial Engineering Department Collage of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia

In the article“Deep Learning-Enhanced Brain Tumor Prediction via Entropy-Coded BPSO in CIELAB Color Space”by Mudassir Khalil,muhammad Imran Sharif,Ahmed naeem,muhammad Umar Chaudhry,Hafiz Tayyab Rauf,Adham *** Computers,Materials&Continua,2023,Vol.77,No.2,pp.2031–***:10.32604/cmc.2023.043687,URL:https://***/cmc/v77n2/54831,there was an error regarding the affiliation for the author Hafiz Tayyab *** of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,ST42DE,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”.

关键词： Deep Code CIELAB

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

V-Shaped Monopole Antenna with Chichena Itzia Inspired Defected Ground Structure for UWB Applications

引用

Computers, Materials & Continua 2020年第10期65卷 19-32页

作者： naeem Ahmad Jan Saad Hassan kiani Fazal muhammad Daniyal Ali Sehrai Amjad Iqbal muhammad Tufail Sunghwan Kim Department of Electrical Engineering Iqra National UniversityPeshawar25000Pakistan Department of Electrical Engineering City University of Science and Information TechnologyPeshawar25000Pakistan Department of Electrical Engineering Multimedia UniversityCyberjaya63100Malaysia Department of Mechatronics Engineering University of Engineering and TechnologyPeshawar25000Pakistan Department of Electrical Engineering University of UlsanUlsan44610Korea

Due to rapid growth in wireless communication technology,higher bandwidth requirement for advance telecommunication systems,capable of operating on two or higher bands with higher channel capacities and minimum distortion losses is *** this paper,a compact Ultra-Wideband(UWB)V-shaped monopole antenna is *** response is achieved by modifying the ground plane with Chichen Itzia inspired rectangular staircase *** proposed V-shaped is designed by incorporating a rectangle,and an inverted isosceles triangle using FR4 *** size of the antenna is 25 mm×26 mm×1.6 *** proposed V-shaped monopole antenna produces bandwidth response of 3 GHz Industrial,Scientific,and Medical(ISM),Worldwide Interoperability for Microwave Access(WiMAX),(IEEE 802.11/HIPERLAN band,5G sub 6 GHz)which with an additional square cut amplified the bandwidth response up to 8 GHz ranging from 3.1 GHz to 10.6 GHz attaining UWB defined by Federal Communications Commission(FCC)with a maximum gain of 3.83 *** antenna is designed in Ansys *** for key performance parameters of the antenna are *** measured results are in good agreement with the simulated *** to flat gain,uniform group delay,omni directional radiation pattern characteristics and well-matched impedance,the proposed antenna is suitable for WiMAX,ISM and heterogeneous wireless systems.

关键词： V-shape monopole gain staircase ultra-wideband omni-directional defected ground structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of a Compact Monopole Antenna for UWB Applications

引用

Computers, Materials & Continua 2021年第1期66卷 35-44页

作者： naeem Ahmad Jan Saad Hassan kiani Daniyal Ali Sehrai muhammad Rizwan Anjum Amjad Iqbal Mujeeb Abdullah Sunghwan Kim Department of Electrical Engineering Iqra National UniversityPeshawar25000Pakistan Department of Electrical Engineering City University of Science and Information TechnologyPeshawar25000Pakistan Department of Electronic Engineering The Islamia University of BahawalpurBahawalpur63100Pakistan Department of Electrical Engineering Multimedia UniversityCyberjaya63100Malaysia Department of Computer Science Bacha Khan UniversityCharsadda24420Pakistan School of Electrical Engineering University of UlsanUlsan44610Korea

In this paper,a low cost,highly efficient and low profile monopole antenna for ultra-wideband(UWB)applications is presented.A new inverted triangular-shape structure possessing meander lines is designed to achieve a wideband response and high *** design the proposed structure,three steps are utilized to achieve an UWB *** bandwidth of the proposed antenna is improved with changing meander lines parameters,miniaturization of the ground width and optimization of the feeding *** measured and simulated frequency band ranges from 3.2 to 12 GHz,while the radiation patterns are measured at 4,5.3,6 and 8 GHz frequency *** overall volume of the proposed antenna is 26×25×1.6 mm^(3);whereas the FR4 material is used as a substrate with a relative permittivity and loss tangent of 4.3 and 0.025,*** peak gain of 4 dB is achieved with a radiation efficiency of 80 to 98%for the entire *** modelling of proposed antenna is performed in ANSYS HFSS 13 software.A decent consistency between the simulated and measured results is accomplished which shows that the proposed antenna is a potential candidate for the UWB applications.

关键词： Ultra-wideband(UWB) meander lines monopole antenna high efficiency high gain ANSYS HFSS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spherical uncertain linguistic Hamacher aggregation operators and their application on achieving consistent opinion fusion in group decision making

引用

International Journal of Intelligent Computing and Cybernetics 2021年第4期14卷 550-579页

作者： muhammad Qiyas Saleem Abdullah muhammad naeem Mathematics Abdul Wali Khan UniversityMardanPakistan Abdul Wali Khan University MardanPakistanand Department of Preparatory Year Umm Al-Qura UniversityMakkahSaudi Arabia

Purpose-The aim of this research is to establish a new type of aggregation operator based on Hamacher operational law of spherical uncertain linguistic numbers(SULNs).Design/methodology/approach-First,the authors define spherical uncertain linguistic sets and develop some operational laws of ***,the authors extended these operational laws to the aggregation operator and developed spherical uncertain linguistic Hamacher averaging and geometric aggregation ***-The authors were limited in achieving a consistent opinion on the fusion in group decision-making problem with the SULN ***/value-In order to give an application of the introduced operators,the authors first constrict a system of multi-attribute decision-making algorithm.

关键词： Multi-attribute group decision making Spherical fuzzy set Spherical uncertain linguistic Hamacher averaging operators Spherical uncertain linguistic Hamacher geometric operators

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of different catalysts and growth temperature on the photoluminescence properties of zinc silicate nanostructures grown via vapor-liquid-solid method

引用

Chinese Physics B 2022年第5期31卷 657-665页

作者： Ghfoor muhammad Imran Murtaza Rehan Abid naeem Ahmad Department of Physics International Islamic UniversityIslamabad 44000Pakistan

We explore the photoluminescence properties of zinc silicate(Zn_(2)SiO_(4)) nanostructures synthesized by vapor-liquidsolid(VLS)mode of growth using three different catalysts(Sn,Ag,and Mn).Different catalysts significantly influence the growth rate which in turn has an impact on the structure and hence the photoluminescence of the prepared zinc silicate ***_(2)SiO_(4) has a wide bandgap of about 5.5 eV and in its pure form,it does not emit in visible region due to its inner shell electronic transitions between the 3 d5 energy ***,the incorporation of different catalysts(Sn,Ag and Mn)at different growth temperatures into the Zn_(2)SiO_(4) crystal growth kinetics provides wide visible spectral range of photoluminescence(PL)*** analysis shows broad multi-band spectrum in the visible region and distinct colors(red,yellow,green,blue,cyan and violet)are obtained depending on the crystalline structure of the prepared *** allowed transitions due to the effect of different catalysts on zinc silicate lattice offer a huge cross-section of absorption that generates strong *** correlation between the structural and optical properties of the synthesized nanostructures is discussed in *** synthesized photoluminescent nanostructures have potential applications in solidstate lighting and display devices.

关键词： nanostructures vapor-liquid-solid growth mode photoluminescence spectra fluorescence microscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Radio resource management in energy harvesting cooperative cognitive UAV assisted IoT networks:A multi-objective approach

引用

Digital Communications and Networks 2024年第4期10卷 1088-1102页

作者： muhammad Rashid Ramzan muhammad naeem Omer Chughtai Waleed Ejaz Mohammad Altaf Department of Electrical and Computer Engineering COMSATS University Islamabad(CUI)Wah CampusPakistan Department of Electrical Engineering Lakehead UniversityBarrieONL4M 3X9Canada

Cooperative communication through energy harvested relays in Cognitive Internet of Things(CIoT)has been envisioned as a promising solution to support massive connectivity of Cognitive Radio(CR)based IoT devices and to achieve maximal energy and spectral efficiency in upcoming wireless *** this work,a cooperative CIoT system is contemplated,in which a source acts as a satellite,communicating with multiple CIoT devices over numerous *** Aerial Vehicles(UAVs)are used as relays,which are equipped with onboard Energy Harvesting(EH)*** adopted a Power Splitting(PS)method for EH at relays,which are harvested from the Radio frequency(RF)*** conjunction with this,the Decode and Forward(DF)relaying strategy is used at UAV relays to transmit the messages from the satellite source to the CIoT *** developed a Multi-Objective Optimization(MOO)framework for joint optimization of source power allocation,CIoT device selection,UAV relay assignment,and PS ratio *** formulated three objectives:maximizing the sum rate and the number of admitted CIoT in the network and minimizing the carbon dioxide *** MOO formulation is a Mixed-Integer Non-Linear Programming(MINLP)problem,which is challenging to *** address the joint optimization problem for an epsilon optimal solution,an Outer Approximation Algorithm(OAA)is proposed with reduced *** simulation results show that the proposed OAA is superior in terms of CIoT device selection and network utility maximization when compared to those obtained using the Nonlinear Optimization with Mesh Adaptive Direct-search(NOMAD)algorithm.

关键词： Cooperative communication Energy harvesting Power splitting Unmanned aerial vehicles Cognitive radio Internet of things Multi-objective optimization Relay assignment Power allocation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：