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Exploring Novel Therapeutic Breakthroughs for Cancers:Potential Roles of miRNAs

Proceedings of Anticancer Research 2024年第5期8卷 11-24页

作者： muhammad Abubakar Rooma Ayyoub Baqaur Rehman muhammad naeem Kiani Usama Ahmed Jawaria Farooq Areeb Anwar Usmani Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060PR China Department of Zoology The Government Sadiq College Women University BahawalpurPakistan Research Coordinator Department of SurgeryAga Khan University and Hospital KarachiPakistan

MicroRNAs(miRNAs)are small non-coding RNAs,19-25 nucleotides in length,that regulate gene *** are involved in various cellular,biological,and pathological activities,including the development and progression of malignant *** studies have highlighted the significant roles of miRNA deregulation in various cancer types,involving critical pathways such as gene deletions and amplifications,abnormal epigenetic changes,and dysfunctional miRNA regulatory *** can function both as oncogenes and tumor suppressor genes in different *** cancer hallmarks are associated with deregulated miRNAs,including resistance to cell death,metastasis,sustained proliferative signaling,promotion of angiogenesis,and the suppression of growth *** research has demonstrated that miRNAs contribute to drug resistance in tumor cells by targeting genes linked to drug resistance or by influencing genes that regulate the cell cycle,apoptosis,and proliferation.A single miRNA often has tissue-specific regulatory functions and can affect multiple *** miRNA types have been identified as potential biomarkers for tumor diagnosis and critical targets for novel therapeutic *** review aims to explore the role of miRNAs in cancer progression,metastasis,and potential therapeutic interventions.

关键词： MicroRNAs Cancer Treatment

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TMPRSS2 Polymorphism and Its Correlation with SARS-CoV-2 Susceptibility - A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第5期8卷 329-335页

作者： Saleem Awan Anum Siraj Amber Khan Arifa Anwar muhammad naeem Kiani Saira Yahya Department of Biosciences Shaheed Zulfikar Ali Bhutto Institute of Science and Technology(SZABIST)UniversityKarachiPakistan Department of Plant Breeding and Genetics Sindh Agriculture UniversityTandojamPakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060Guangdong ProvinceChina

Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus affected more people than SARS-CoV-1 and related *** genetic factors,besides respiratory droplets and direct exposure to the virus,are found highly responsible for transmitting SARS-CoV-2 ***:The objective of this study was to determine the plasma levels of the TMPRSS2 gene and its role in SARS-CoV-2 ***:A total of 100 patients,i.e.50 SARS-CoV-2 positive patients as the case group and 50 SARS-CoV-2 negative samples as the control group,were selected randomly and included in this case-control study to determine the association between TMPRSS2 gene and susceptibility to SARS-CoV-2 infection and severity of coronavirus disease 2019(COVID-19).The TMPRSS2 levels of case and control samples were measured through an enzyme-linked immunosorbent assay(ELISA).Following the genomic DNA extraction,a set of reverse and forward primers of human TMPRSS2 gene primers were used for the amplification of the TMPRSS2 ***:In the control group,the ratio of men to women was more or less the same while in the case group 62%of the population were *** TMPRSS2 level was found to be 4.70±7.7 ng/ml in case samples while it was 4.73±5.7 ng/ml in control ***:The levels of TMPRSS2 in plasma samples of both controls and cases were found to be the same indicating that the entry of SARS-CoV-2 is not dependent on the plasma levels of this protein.

关键词： TMPRSS2 SARS-CoV-2 ACE2 Gene COVID-19 Expression

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Diabetes mellitus:Is Pakistan the epicenter of the next pandemic?

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Chronic Diseases and Translational Medicine 2024年第1期10卷 75-77页

作者： muhammad Bilal Shahid Mahnoor Saeed Hamza naeem Usha Kumari King Edward Medical University LahorePakistan Dow University of Health Sciences KarachiPakistan

To the Editor,Diabetes mellitus(DM)is an endocrine disorder of chronic hyperglycemia diagnosed by fasting blood sugar levels of≥126 mg/dL or glycated hemoglobin(HbA1c)levels of≥6.5%.Type 1 DM involves a lack of insulin secretion by the pancreas,whereas the human body's resistance to insulin combined with impaired function of beta cells causes type 2 DM.

关键词： impaired Diabetes mellitus

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National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed muhammad Atique Usman Iqbal Aujla muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan muhammad Shoaib Khan muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

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Bioconvection Cross Diffusion Effects on MHD Flow of Nanofluids over Three Different Geometries with Melting

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 1023-1039页

作者： Tahir kamran muhammad Imran muhammad N.naeem Mohsan Raza Department of Mathematics Government College University FaisalabadFaisalabad38000Pakistan

Currently,nanofluid is a hot area of interest for *** nanofluid with bioconvection phenomenon attracted the researchers owing to its numerous applications in the field of nanotechnology,microbiology,nuclear science,heat storage devices,biosensors,biotechnology,hydrogen bomb,engine of motors,cancer treatment,the atomic reactor,cooling of devices,and in many *** article presents the bioconvection cross-diffusion effects on the magnetohydrodynamic flow of nanofluids on three different geometries(cone,wedge,and plate)with mixed *** temperature-dependent thermal conductivity,thermal diffusivity,and Arrhenius activation energy applications are considered on the fluid flow with melting *** flow is analyzed under thermal and solutal Robin’s *** problem is formulated in the mathematical formulation of partial differential equations(PDEs).The similarity transformations are applied to diminish the governing nonlinear coupled boundary value problems into higher-order non-linear ordinary differential equations(ODEs).The resulting expressions/equation numerically tackled utilizing the famous bvp4c package by MATLAB for various interesting *** results were physically and numerically calculated through graphics and tables for the velocity field,energy distribution,nanoparticles concentration,and microorganisms profile for numerous *** the obtained results,we discern that the transfer of heat and mass coefficient is high over a plate and cone in the flow,*** velocity profile is reduced via a larger magnetic *** thermal conductivity enhances the thermal *** thermophoresis enhanced the concentration of *** microorganisms’Biot number boosts the microorganism’s profile.

关键词： MHD nano-fluids bioconvection heat flux MATLAB

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Electromechanical Fields and Their Influence on the Internal Quantum Efficiency of GaN-Based Light-Emitting Diodes

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Acta Mechanica Solida Sinica 2018年第3期31卷 383-390页

作者： muhammad Usman Kiran Saba Adnan Jahangir muhammad kamran Nazeer muhammad Department of Engineering Sciences Ghulam Ishaq Khan Institute of Engineering Sciences and Technology Swabi 23460 Pakistan Department of Mathematics COMSATS Institute of Information Technology Wah Cantt 47040 Pakistan Department of Electrical Engineering COMSATS Institute of Information Technology Wah Cantt 47040 Pakistan

The effect ofelectromechanical fields, i.e., polarization fields, on the efficiency droop of GaN-based light-emitting diodes is presented using both experimental and numerical analyses. The role of incorporating such polarization charge density in device performance is numerically investigated and further compared with the experimental results of internal quantum efficiency of three different devices in consideration.

关键词： Optoelectronic devices Photonic bandgap materials Visible and ultraviolet sources Light-emitting devices

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Heat Transfer Enhancement of an Automobile Engine Radiator using ZnO Water Base Nanofluids

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Journal of Thermal Science 2020年第4期29卷 1010-1024页

作者： muhammad QASIM muhammad SAJID kamran muhammad AMMAR muhammad ALI JAMAL muhammad YASAR JAVAID Department of Mechanical Engineering University of Engineering and TechnologyLahore 54890Pakistan Department of Chemical Engineering Technology Government College UniversityFaisalabad 38000Pakistan Department of Mechanical Engineering Technology Government College UniversityFaisalabad 38000Pakistan

In this research paper, the forced convective heat transfer enhancement of a Suzuki Mehran(VXR) 2016 radiator(heat exchanger) along with pressure drop and friction factor by utilizing Zinc oxide(Zn O) water based nanofluids has been experimentally studied. Three types of nanofluids with different volumetric concentrations of Zn O nanoparticles(0–0.3%) were employed in order to understand its effect on heat transfer enhancement. The experimental setup was completely designed as closely as possible to the car cooling system. The experimentation has been done under laminar flow conditions(186≤Re≤1127) at different fluid volume flow rates(2–12 L/min) and constant fluid inlet temperature(70°C) to the automobile radiator. A maximum enhancement in heat transfer rate, overall heat transfer coefficient and Nusselt number was obtained up to 41%, 50% and 31% by using nanofluid with 0.2% volumetric concentration of nanoparticles respectively. On the other hand, the mean enhancement in pressure drop and friction factor was obtained up to 47% and 46% by using nanofluid with the same volumetric concentration of nanoparticles i.e. 0.2% respectively. The experimental results also revealed that the heat transfer rate, overall heat transfer coefficient and Nusselt number of nanofluids increases by increasing the volume flow rates and volumetric concentration of nanoparticles. However, these thermal performance parameters of nanofluids started to decline when the volumetric concentration of nanoparticles was increased from 0.2% to 0.3%. Furthermore, pressure drop and friction factor of nanofluids increase by increasing the volumetric concentration of nanoparticles, while pressure drop increases and friction factor decreases by increasing the volume flow rate of nanofluids respectively. At the end, the thermal efficiency of automobile radiator with high cooling rates was obtained by using nanofluid with 0.2% volumetric concentration of nanoparticles.

关键词： ZnO nanoparticles heat transfer enhancement thermal efficiency automobile radiator

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Aggregation operators and CRITIC-VIKOR method for confidence complex q-rung orthopair normal fuzzy information and their applications

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CAAI Transactions on Intelligence Technology 2023年第1期8卷 40-63页

作者： Tahir Mahmood Zeeshan Ali muhammad naeem Department of Mathematics and Statistics International Islamic University IslamabadIslamabadPakistan Umm Al-Qura University MakkahSaudi Arabia

Supply chain management is an essential part of an organisation's sustainable *** the concentration of natural environment,public,and economic influence and feasibility of your suppliers and purchasers is becoming progressively familiar as all industries are moving towards a massive sustainable *** handle such sort of developments in supply chain management the involvement of fuzzy settings and their generalisations is playing an important *** in mind this role,the aim of this study is to analyse the role and involvement of complex q-rung orthopair normal fuzzy(CQRONF)information in supply chain *** major impact of this theory is to analyse the notion of confidence CQRONF weighted averaging,confidence CQRONF ordered weighted averaging,confidence CQRONF hybrid averaging,confidence CQRONF weighted geometric,confidence CQRONF ordered weighted geometric,confidence CQRONF hybrid geometric operators and try to diagnose various properties and ***,with the help of the CRITIC and VIKOR models,we diagnosed the novel theory of the CQRONF-CRITIC-VIKOR model to check the sensitivity analysis of the initiated ***,in the availability of diagnosed operators,we constructed a multi-attribute decision-making tool for finding a beneficial sustainable supplier to handle complex ***,the initiated operator's efficiency is proved by comparative analysis.

关键词： averaging/geometric aggregation operators complex q-rung orthopair normal fuzzy information confidence levels strategic decision-making methods

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Spherical uncertain linguistic Hamacher aggregation operators and their application on achieving consistent opinion fusion in group decision making

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International Journal of Intelligent Computing and Cybernetics 2021年第4期14卷 550-579页

作者： muhammad Qiyas Saleem Abdullah muhammad naeem Mathematics Abdul Wali Khan UniversityMardanPakistan Abdul Wali Khan University MardanPakistanand Department of Preparatory Year Umm Al-Qura UniversityMakkahSaudi Arabia

Purpose-The aim of this research is to establish a new type of aggregation operator based on Hamacher operational law of spherical uncertain linguistic numbers(SULNs).Design/methodology/approach-First,the authors define spherical uncertain linguistic sets and develop some operational laws of ***,the authors extended these operational laws to the aggregation operator and developed spherical uncertain linguistic Hamacher averaging and geometric aggregation ***-The authors were limited in achieving a consistent opinion on the fusion in group decision-making problem with the SULN ***/value-In order to give an application of the introduced operators,the authors first constrict a system of multi-attribute decision-making algorithm.

关键词： Multi-attribute group decision making Spherical fuzzy set Spherical uncertain linguistic Hamacher averaging operators Spherical uncertain linguistic Hamacher geometric operators

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Numerical Simulation of Reiner–Rivlin Nanofluid Flow under the Influence of Thermal Radiation and Activation Energy over a Rotating Disk

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Computer Modeling in Engineering & Sciences 2022年第6期131卷 1669-1692页

作者： Arfan Shahzad muhammad Imran muhammad Nawaz naeem Mohsan Raza Department of Mathematics Government College University FaisalabadFaisalabad38000Pakistan Department of Sciences&Humanities National University of Computer and Emerging SciencesChiniot-Faisalabad CampusFaisalabad38000Pakistan

In current study,the numerical computations of Reiner–Rivlin nanofluid flow through a rotational disk under the influence of thermal radiation and Arrhenius activation energy is *** innovative physical situations,the motile microorganisms are incorporated *** multiple slip effects are considered in the boundary *** bioconvection of motile microorganism is utilized alongside nanofluids to provide stability to enhanced thermal *** Bioconvection pattern in various nanoparticles accredits novel applications of biotechnology like the synthesis of biological polymers,biosensors,fuel cells,petroleum engineering,and the natural *** deploying some suitable similarity transformation functions,the governing partial differential equations(PDEs)of the flow problem are rehabilitated into dimensionless *** accomplished ordinary differential equations(ODEs)are solved numerically through the bvp4c scheme via a built-in function in computational MATLAB *** upshots of some prominent physical and bioconvection parameters including wall slip parameters,thermophoresis parameter,Brownian motion parameter,Reiner–Revlin nanofluid parameter,Prandtl number,Peclet number,Lewis number,bioconvection Lewis number,and the mixed convection parameter against velocity,temperature,nanoparticles concentration,and density of motile microorganism profiles are dichotomized and pondered through graphs and *** presented computations show that the velocity profiles are de-escalated by the wall slip parameters while the thermal and solutal fields are upgraded with augmentation in thermophoresis number and wall slip *** presence of thermal radiation enhances the temperature profile of *** concentration profile of nanoparticles is boosted by intensification in activation ***,the increasing values of bioconvection Lewis number and Peclet number decay the motile microorganisms’field.

关键词： Reiner-Rivlin nanofluid bioconvection motile swimming microorganisms rotational disk multiple slip conditions bvp4c

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