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Neural stem cell-based in vitro bioassay for the assessment of neurotoxic potential of water samples

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Journal of Environmental Sciences 2021年第3期33卷 72-86页

作者： muhammad Irfan Masood Natalie Tamara Hauke muhammad jawad Nasim muhammad Sarfraz Mahrukh Naseem Karl Herbert Schäfer Division of Bioorganic Chemistry School of PharmacySaarland UniversityD-66123 SaarbrückenGermany Applied Life Sciences University of Applied Sciences Kaiserslautern66482 ZweibrückenGermany ENS Group University of Applied Sciences Kaiserslautern66482 ZweibrückenGermany Abwasserverband Bergstrasse Altau 1069469 WeinheimGermany Institute of Pharmaceutical Sciences University of Veterinary and Animal Sciences54000 LahorePakistan Department of Zoology University of BalochistanQuetta 87550Pakistan

Intensive agriculture activities,industrialization and growing numbers of wastewater treatment plants along river banks collectively contribute to the elevated levels of neurotoxic pollutants in natural water reservoirs across *** established an in vitro bioassay based upon neural stem cells isolated from the subventricular zone of the postnatal mouse to evaluate the neurotoxic potential of raw wastewater,treated sewage effluent,groundwater and drinking *** toxic potential of water samples was evaluated employing viability,proliferation,differentiation and migration *** found that raw wastewater could reduce the viability and proliferation of neural stem cells,and decreased the neuronal and astrocyte differentiation,neuronal neurite growth,astrocyte growth and cell *** sewage water also showed inhibitory effects on cell proliferation and *** results indicated that relatively high concentrations of nitrogenous substances,pesticides,mercuric compounds,bisphenol-A,and phthalates,along with some other pollutants in raw wastewater and treated sewage water,might be the reason for the neuroinhibitory effects of these water *** model successfully predicted the neurotoxicity of water samples collected from different sources and also revealed that the incomplete removal of contaminants from wastewater can be problematic for the developing nervous *** presented data also provides strong evidence that more effective treatments should be used to minimize the contamination of water before release into major water bodies which may be considered as water reservoirs for human usage in the future.

关键词： Neural stem cells Subventricular zone Neurotoxicity Bioassay Treated sewage effluents Pesticides

Clinical relevance of circulating non-coding RNAs in metabolic diseases:Emphasis on obesity,diabetes,cardiovascular diseases and metabolic syndrome

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Genes & Diseases 2023年第6期10卷 2393-2413页

作者： Abdullahi Dandare muhammad jawad Khan Aisha Naeem Afrose Liaquat Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Biochemistry Usmanu Danfodiyo UniversitySokoto 840104Nigeria Ministry of Public Health POB42DohaQatar Department of Oncology Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA Shifa College of Medicine Shifa Tameer-E-Millat UniversityIslamabad 45550Pakistan

Non-coding RNAs(ncRNAs)participate in the regulation of several cellular processes including transcription,RNA processing and genome *** aberrant expression of ncRNAs is associated with several pathological *** this review,we focused on recent information to elucidate the role of various regulatory ncRNAs i.e.,micro RNAs(miRNAs),circular RNAs(circRNAs)and long-chain non-coding RNAs(lncRNAs),in metabolic diseases,e.g.,obesity,diabetes mellitus(DM),cardiovascular diseases(CVD)and metabolic syndrome(MetS).The mechanisms by which ncRNAs participated in disease pathophysiology were also *** regulate the expression of genes at transcriptional and translational *** modulate the regulation of gene expression via miRNA sponging activity,interacting with RNA binding protein and polymerase II transcription *** regulate the expression of genes by acting as a protein decoy,miRNA sponging,miRNA host gene,binding to miRNA response elements(MRE)and the recruitment of transcriptional element or chromatin *** examined the role of ncRNAs in the disease pathogenesis and their potential role as molecular markers for diagnosis,prognosis and therapeutic *** showed the involvement of ncRNAs in the onset of obesity and its progression to MetS and ***-192,miRNA-122,and miRNA-221 were dysregulated in all these metabolic *** ncRNAs,implicated in at least three diseases include miRNA-15a,miRNA-26,miRNA-27a,miRNA-320,and *** of ncRNAs increased the risk of development of DM and MetS and its progression to CVD in obese ***,these molecules are potential targets to arrest or delay the progression of metabolic diseases.

关键词： Biomarkers CircRNAs LncRNAs Metabolic diseases miRNAs Non-coding RNAs Therapeutic targets

Identification of hsa_circ_0092576 regulatory network in the pathogenesis of coronary heart disease

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Genes & Diseases 2023年第1期10卷 26-28页

作者： Abdullahi Dandare muhammad Rafiq Afrose Liaquat Afraz Ahmad Raj muhammad jawad Khan Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Biochemistry Usmanu Danfodiyo University SokotoSokoto P.M.B.2346Nigeria Department of Biochemistry Shifa College of MedicineShifa Tameer-E-Millat UniversityIslamabad 45550Pakistan Department of Psychosomatic Medicine and Psychotherapy University Medical CenterGottingen 37075Germany

Cardiovascular diseases(CVDs)are responsible for 30%of all deaths *** heart disease(CHD),is the most common form of CVD,accounting for 46%of male and 38%female cardiovascular deaths.1 CHD is characterized by chronic inflammation and endothelial injuries in coronary arteries,and subsequent development of atherosclerotic plaques which eventually leads to myocardial ischemia.

关键词： coronary injuries inflammation

Provision of primary care by specialist physicians:a systematic review

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Family Medicine and Community Health 2020年第1期8卷 20-23页

作者： muhammad jawad Hashim Department of Family Medicine United Arab Emirates UniversityAl AinUnited Arab Emirates

Patients with stable chronic diseases such as diabetes and hypertension can be safely managed at the primary care *** many such patients continue to follow-up with specialists at a higher expense with no added *** introduce a new term to describe this phenomenon:scope inversion,defined as the provision of primary care by specialist *** aimed to quantify the extent of scope inversion by conducting a systematic *** and five other databases were searched using the keywords‘specialist AND(routine OR primary)AND provi*’as well as other *** search was limited to human research without restrictions on language or date of *** inclusion criterion was studies on rates of the provision of routine primary care by specialist *** observational studies met the inclusion criteria.A wide range of primary care involvement was observed among specialists,from 2.6%to 65%of clinic *** children,41.3%of visits with specialists were routine follow-ups for conditions such as allergic rhinitis and seborrhoeic dermatitis which could be managed in primary *** quality was moderate to low across the studies due to limitations of source data and varying definitions of primary *** physicians provide primary care to patients in a substantial proportion of clinic *** inversion is wasteful as it diverts patients to more expensive care without improving outcomes.A systems approach is needed to mitigate scope inversion and its harmful effects on healthcare service delivery.

关键词： routine physician involvement

CASIA-Iris-Africa:A Large-scale African Iris Image Database

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Machine Intelligence Research 2024年第2期21卷 383-399页

作者： jawad muhammad Yunlong Wang Junxing Hu Kunbo Zhang Zhenan Sun School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Research on Intelligent Perception and Computing National Laboratory of Pattern RecognitionInstitute of AutomationChinese Academy of SciencesBeijing 100190China

Iris biometrics is a phenotypic biometric trait that has proven to be agnostic to human natural physiological *** on iris biometrics has progressed tremendously,partly due to publicly available iris *** databases have been available to researchers that address pressing iris biometric challenges such as constraint,mobile,multispectral,synthetics,long-distance,contact lenses,liveness detection,***,these databases mostly contain subjects of Caucasian and Asian docents with very few *** many investigative studies on racial bias in face biometrics,very few studies on iris biometrics have been published,mainly due to the lack of racially diverse large-scale databases containing sufficient iris samples of Africans in the public ***,most of these databases contain a relatively small number of subjects and labelled *** paper proposes a large-scale African database named Chinese Academy of Sciences Institute of Automation(CASIA)-Iris-Africa that can be used as a complementary database for the iris recognition community to mediate the effect of racial biases on *** database contains 28717 images of 1023 African subjects(2046 iris classes)with age,gender,and ethnicity attributes that can be useful in demographically sensitive studies of *** of specific application protocols are incorporated with the database to ensure the database’s variability and *** results of some open-source state-of-the-art(SOTA)algorithms on the database are presented,which will serve as baseline *** relatively poor performances of the baseline algorithms on the proposed database despite better performance on other databases prove that racial biases exist in these iris recognition algorithms.

关键词： African iris recognition racial bias iris image database biometrics iris recognition

Transmission dynamics of Hand-Foot-Mouth Disease with partial immunity through non-integer derivative

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International Journal of Biomathematics 2023年第6期16卷 149-173页

作者： Rashid Jan Salah Boulaaras Sultan Alyobit muhammad jawad Department of Mathematics University of Swabi Swabi 23561Khyber PakhtunkhwaPakistan Department of Mathematics College of Sciences and Arts Qassim UniversityAr RassSaudi Arabia Department of Mathematics College of Science 8 Arts King Abdulaziz UniversityRabighSaudi Arabia

In this paper,we formulate the transmission phenomena of Hand-Foot-Mouth Disease(HFMD)through non-integer *** interrogate the biological meaningful results of the recommended system of *** basic reproduction number is determined through next generation method and the impact of different parameters on the reproduction number is examined with the help of partial rank correlation coeficient(PRCC)*** addition,we concentrated on qualitative analysis and dynamical behavior of HFMD ***'s and Schaefer's fixed-point theorems are used to analyze the uniqueness and existence of the solution of the proposed HFMD *** HFMD system's Ulam-Hyers stability has been confirmed to be *** highlight the impact of the parameters on the dynamics of HFMD,we performed several simulations through numerical scheme to conceptualize the transmission route of the *** be more specific,numerical simulations are used to visualize the effect of input parameters on the systems *** have shown the key input parameters of the system for the control of infection in the society.

关键词： Hand-Foot-Mouth Disease fractional derivatives mathematical model threshold parameter numerical scheme dynamical behavior

Evaluating therapeutic potential of coriander seeds and leaves(Coriandrum sativum L.) to mitigate carbon tetrachloride-induced hepatotoxicity in rabbits

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 209-213页

作者： muhammad jawad Iqbal Masood Sadiq Butt Aamir Shehzad muhammad Asghar National Institute of Food Science & TechnologyFaculty of FoodNutrition and Home SciencesUniversity of AgricultureFaisalabadPakistan Department of Biochemistry Unirersity of AgricultureFaisalabadPakistan

Objective: To evaluate the hepatic and renal protective potential of coriander seeds and leaves using animal feed model. Methods: Coriander seeds-and leaves-based sauces were administrated to normal(Study Ⅰ) and carbon tetrachloride(2 mL/kg B.W.)-induced hepatotoxic rabbits(Study Ⅱ). Hepatic and renal biomarkers like aspartate aminotransferase,alanine aminotransferase. alkaline phosphatase, superoxide dismutase and catalase were measured. Results: Coriander leaves-based sauce exerted more decline(P<0.05) in serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels in the study Ⅱ as 18.32%. 19.91% and 21.24%, respectively. While, hepatic superoxide dismutase and catalase levels were raised significantly(P<0.05) in both studies. Renal parameters also depicted positive impact by the provision of developed sauces. Conclusions: Coriander seeds and leaves based sauces are effective in alleviating the hepato/renal toxicity. The hepatoprotective effect of coriander leaves is more pronounced as compared to coriander seeds.

关键词： Coriander seeds Coriander leaves Hepatoprotective potential Hepatotoxicity Rabbits

Integrated CWT-CNN for Epilepsy Detection Using Multiclass EEG Dataset

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Computers, Materials & Continua 2021年第10期69卷 471-486页

作者： Sidra Naseem Kashif Javed muhammad jawad Khan Saddaf Rubab muhammad Attique Khan Yunyoung Nam Robotics and Machine Intelligence Engineering School of Mechanical and Manufacturing EngineeringNational University of Sciences and Technology(NUST)Islamabad44000Pakistan National University of Sciences and Technology(NUST) Islamabad44000Pakistan Department of Computer Science HITEC University TaxilaTaxilaPakistan Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea

Electroencephalography is a common clinical procedure to record brain signals generated by human *** are useful in Brain controlled interfaces and other intelligent Neuroscience applications,but manual analysis of these brainwaves is complicated and time-consuming even for the experts of *** EEG analysis and classification techniques have been proposed to address this problem however,the conventional classification methods require identification and learning of specific EEG characteristics *** learning models can learn features from data without having in depth knowledge of data and prior feature *** of the great implementations of deep learning is Convolutional Neural Network(CNN)which has outperformed traditional neural networks in pattern recognition and image *** Wavelet Transform(CWT)is an efficient signal analysis technique that presents the magnitude of EEG signals as timerelated Frequency *** deep learning architectures suffer from poor performance when classifying EEG signals in the Time-frequency *** improve classification accuracy,we propose an integrated CWT and CNN technique which classifies five types of EEG signals *** compared the results of proposed integrated CWT and CNN method with existing deep learning models e.g.,GoogleNet,VGG16,***,the accuracy and loss of the proposed integrated CWT and CNN method have been cross validated using Kfold cross *** average accuracy and loss of Kfold cross-validation for proposed integrated CWT and CNN method are,76.12%and 56.02%*** model produces results on a publicly available dataset:Epilepsy dataset by UCI(Machine Learning Repository).

关键词： Deep learning electroencephalography epilepsy continuous wavelet transform

Circulating miR-548c-3p possesses good diagnostic potential for metabolic syndrome

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Genes & Diseases 2023年第3期10卷 683-686页

作者： Abdullahi Dandare Afrose Liaquat muhammad Rafiq Mbah Ntepe Leonel Javeres Sidra Younis muhammad jawad Khan Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Biochemistry Usmanu Danfodiyo University SokotoSokoto PMB 2346Nigeria Department of Biochemistry Shifa College of MedicineShifa Tameer-E-Millat UniversityIslamabad 45550Pakistan Institute of Medical Research and Medical Plant Studies Ministry of Scientific ResearchYaoindeCameroon Department of Biological Sciences National University of Medical SciencesRawalpindiPunjab 46000Pakistan

Studies have shown that dysregulated expression of miRNAs is a major underlying event in the onset and progression of many metabolic *** pathological role of miR-548c-3p in various cancer types,including breast cancer,glioma,prostate cancer,and gastric cancer,has been documented.1 However,experimental evidences validating the role of miR-548c-3p in the development of metabolic diseases are still lacking,and no data is available on its diagnostic potential for metabolic syndrome(MS).Recently,we predicted the involvement of miR-548c-3p in the pathogenesis of MS and its progression to cardiovascular diseases(CVD)via the regulation of target genes necessary for the proper function of insulin resistance,mTOR,and JAK/STAT signaling pathways.2 Therefore,we deemed it necessary to engage in wet laboratory analysis and validate these claims in patients with metabolic syndrome compared to healthy individuals.

关键词： JAK/STAT involvement diseases