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Enhanced DDoS Detection Using Advanced Machine Learning and Ensemble Techniques in Software Defined Networking

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Computers, Materials & Continua 2024年第11期81卷 3003-3031页

作者： Hira Akhtar butt Khoula Said Al Harthy Mumtaz ali Shah Mudassar Hussain Rashid Amin Mujeeb Ur Rehman Department of Computer Science University of Management and TechnologySialkot51040Pakistan Department of Computer Science and Creative Technologies Global College of Engineering and TechnologyMuscat2546Sultanate of Oman Department of Computer Science University of WahWah Cantt47040Pakistan Department of Computer Science and IT University of ChakwalChakwal48800Pakistan

Detecting sophisticated cyberattacks,mainly Distributed Denial of Service(DDoS)attacks,with unexpected patterns remains challenging in modern *** detection systems often struggle to mitigate such attacks in conventional and software-defined networking(SDN)*** Machine Learning(ML)models can distinguish between benign and malicious traffic,their limited feature scope hinders the detection of new zero-day or low-rate DDoS attacks requiring frequent *** this paper,we propose a novel DDoS detection framework that combines Machine Learning(ML)and Ensemble Learning(EL)techniques to improve DDoS attack detection and mitigation in SDN *** model leverages the“DDoS SDN”dataset for training and evaluation and employs a dynamic feature selection mechanism that enhances detection accuracy by focusing on the most relevant *** adaptive approach addresses the limitations of conventional ML models and provides more accurate detection of various DDoS attack *** proposed ensemble model introduces an additional layer of detection,increasing reliability through the innovative application of ensemble *** proposed solution significantly enhances the model’s ability to identify and respond to dynamic threats in *** provides a strong foundation for proactive DDoS detection and mitigation,enhancing network defenses against evolving *** comprehensive runtime analysis of Simultaneous Multi-Threading(SMT)on identical configurations shows superior accuracy and efficiency,with significantly reduced computational time,making it ideal for real-time DDoS detection in dynamic,rapidly changing *** results demonstrate that our model achieves outstanding performance,outperforming traditional algorithms with 99%accuracy using Random Forest(RF)and K-Nearest Neighbors(KNN)and 98%accuracy using XGBoost.

关键词： Table 1(continued)OSI layer Possible DDoS attack Data link MAC Address Flooding Physical Cable disconnection JaMMING physical impersonation

Web GIS-Based Temporal Analysis of Climatic Factors Impacting Heat Stroke in Karachi

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Journal of Geographic Information System 2024年第1期16卷 61-69页

作者： ali Atif Mahnoor Rehman muhammad butt Syed Mahmood Shahid Ghazi Rashid Mehmood Department of Management Victoria University Sydney Australia Department of Geography Government College University Lahore Pakistan Department of Space Science University of the Punjab Lahore Pakistan Centre of Geographic Information System University of The Punjab Lahore Pakistan

This study focuses on the impact of climate change, specifically the increasing threat of heatwaves, in Pakistan, with a particular emphasis on the city of Karachi. The Pakistan Meteorological Department (PMD) analysed a century of climatic data to reveal warming trends, attributing them to human-induced factors. The vulnerability of Pakistan to climate change is highlighted, given its warm climate and location in a region where temperature increases are expected to surpass global averages. The study examines the past three decades, noting a significant rise in the frequency of hot days, especially in Karachi, where heatwaves have become more prevalent. The aims and objectives of the study involve identifying temporal changes in temperature, rainfall, humidity, and wind speed from 1984 to 2014 in Karachi. The literature review emphasizes the health implications of heatwaves, citing increased mortality during such events globally. The study incorporates a comprehensive temporal analysis, addressing gaps in previous research by considering multiple climate indicators responsible for heatwaves. The methodology involves statistical analyses, including linear regression and Pearson correlation, applied to temperature data and urbanization parameters. Results indicate an increasing trend in heat index temperature, with heatwave vulnerability peaking in the last three decades. Heat Index Temperature Anomalies show a clear surge, emphasizing the need for new indices to control critical heat stress conditions. The study concludes that tropical climate variability, particularly heat index, is linked to extreme hot days, urging measures to reduce population vulnerability. The findings underscore the importance of policy strategies, such as integrated coastal zone management, to mitigate the adverse health effects of heatwaves in Karachi’s vulnerable population.

关键词： IPCC Heat Wave Heat Index PMD

Towards Foreign Tourist at Heritage Sites Using GIS: A Case Study of Lahore

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Journal of Geographic Information System 2022年第5期14卷 516-526页

作者： Atif ali Raheema Elahi muhammad Atif butt Rashid Mehmood Kashif Shafique Syed Amer Mahmood Department of Space Science University of the Punjab Lahore Pakistan Department of Civil Engineering Ryerson University Toronto Canada Department of Geography Forman Christian College University Lahore Pakistan

Pakistan is potentially a good tourist destination for cultural and heritage overs because the Indus and Gandhara Civilizations, and a great Mughals heritage also exists in Pakistan particularly in Lahore city. Tourism is the fastest growing industry in modern world. This study is based on the number of foreign tourist who visited the heritage sites of Lahore. The purpose of the study is to examine the number of foreign tourist who visited the heritage sites of the Lahore at Shalimar Gardens, Lahore Fort and Lahore Museum and to find the tourism trend in Lahore whether it is declining or growing high. The secondary source of data was used and data was collected from archeology department, Lahore Museum and Pakistan Year Book of Statics 2014. Tools used for research purpose were Microsoft excel, Microsoft word and ARC GIS. The number of foreign tourists that visited Lahore fort were highest in 2006 i.e. 21,178 this is the highest number of tourists who visited Lahore Fort in 15 years and 2906 lowest number of foreign tourist who visited Lahore fort, at Shalimar Gardens highest number of foreign tourists was 8558 in 2000 and the lowest number was 309 in 2013 and at Lahore Museum in 7242 tourists is the highest number of Foreign tourist who visited museum in 2000 and the lowest number of foreign tourists that visited Lahore Museum was 1825 in 2010. The trend of foreign tourism in Lahore is declining after the incident of nine eleven due to terrorism. But now with the efforts of government and work of Walled city authority foreign tourism industry is growing in Lahore as it is the Queen of cities having major and attractive heritage places for tourist.

关键词： Temporal Analysis foreign Tourism Lahore Fort Shalimar Gardens Lahore Museum

Curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds

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Burns & Trauma 2021年第1期9卷 272-287页

作者： Maryam Azam Hafiz Ghufran Hira butt Azra Mehmood Ramla Ashfaq Asad M.Ilyas muhammad R.Ahmad Sheikh Riazuddin National Centre of Excellence in Molecular Biology 87-West Canal Bank RoadUniversity of the PunjabLahorePakistan Jinnah Burn and Reconstructive Surgery Centre Maulana Shaukat Ali RdQuaid-i-Azam CampusLahorePakistan

Background:Following recent findings from our group that curcumin preconditioning augments the therapeutic efficacy of adipose-derived stem cells in the healing of diabetic wounds in rats,we aimed to investigate the regenerative effects of curcumin preconditioned adipose-derived mesenchymal stem cells(ASCs)for better recovery of acid inflicted burns in this ***:ASCs were preconditioned with 5μM curcumin for 24 hours and assessed for proliferation,migration,paracrine release potential and gene expression comparative to naive ***,the healing capacity of curcumin preconditioned ASCs(Cur-ASCs)versus naive ASCs was examined using acidic wounds in *** this,acid inflicted burns of 20 mm in diameter were made on the back of male Wistar ***,2×10^(6) cells of Cur-ASCs and naive ASCs were intradermally injected in the wound periphery(n=6)for comparison with an untreated saline ***-transplantation,wounds were macroscopically analysed and photographed to evaluate the percentage of wound closure and period of *** wound biopsies were excised and used for histological evaluation and expression analysis of wound healing markers at molecular level by quantitative PCR and western ***:We found that Cur-ASCs exhibited greater proliferation,migration and paracrine potential in ***,Cur-ASCs showed more effective recovery than naive ASCs as exhibited by gross morphology,faster wound closure and earlier ***’s trichrome and hematoxylin and eosin staining demonstrated the improved architecture of the healing burns,as evidenced by reduced infiltration of inflammatory cells,compact collagen and marked granulation in Cur-ASC treated *** these findings,molecular assessment showed significantly reduced expressions of pro-inflammatory factors(interleukin-1 beta,interleukin-6,tumor necrosis factor alpha)a with striking upsurge of an oxidative marker(superoxide dismutase 1),p

关键词： Adipose-derived stem cells Curcumin preconditioning Acidic burn Wound healing

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed muhammad Atique Usman Iqbal Aujla muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq ali Bangash Amna Subhan butt Osama Tariq butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan muhammad Shoaib Khan muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

Risk factors and outcomes of peptic ulcer bleed in a Pakistani population:A single-center observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 1-9页

作者： Nazish butt muhammad Tayyab Usmani Nimrah Mehak Saba Mughal Fakhar ali Qazi-Arisar Ghulam Mohiuddin Gulzar Khan Department of Gastroenterology Jinnah Postgraduate Medical CentreKarachi 75505SindhPakistan National Institute of Liver&GI Diseases Dow University of Health SciencesKarachi 75330SindhPakistan School of Public Health Dow University of Health SciencesKarachi 75330SindhPakistan

BACKGROUND Peptic ulcer disease(PUD)remains a significant healthcare burden,contributing to morbidity and mortality *** advancements in therapies,its prevalence persists,particularly in regions with widespread nonsteroidal antiinflammatory drugs(NSAIDs)use and Helicobacter pylori *** To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal(GI)bleeding in Pakistani *** This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December *** on demographics,symptoms,length of stay,mortality,re-bleed,and Forrest classification was *** The mean age of patients was 53 years,and the majority was men(68.3%).Hematemesis(82.4%)and epigastric pain(75.4%)were the most common presenting *** patients(73.2%)were discharged within five *** mortality rates at one week and one month were 10.6%and 14.8%,***-bleed within 24 h and seven days occurred in 14.1%and 18.3%of patients,*** ulcers were Forrest class(FC)Ⅲ(72.5%).Antiplatelet use was associated with higher mortality at 7 and 30 d,while alternative medications were linked to higher 24-hour re-bleed *** use was associated with more FCⅢ***-bleed at 24 h and 7 d was strongly associated with one-week or one-month *** Antiplatelet use and rebleeding increase the risk of early mortality in PUD-related upper GI bleeding,while alternative medicines are associated with early rebleeding.

关键词： Non variceal bleed Mortality Re-bleed Forrest classification Antiplatelets Alternative medicines

Early repolarization syndrome: A cause of sudden cardiac death

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World Journal of Cardiology 2015年第8期7卷 466-475页

作者： Abdi ali Nida butt Azeem S Sheikh Core Medical Trainees Wrexham Maelor Hospital Department of Cardiology Wrexham Maelor Hospital

Early repolarization syndrome(ERS), demonstrated as J-point elevation on an electrocardiograph, was formerly thought to be a benign entity, but the recent studies have demonstrated that it can be linked to a considerable risk of life- threatening arrhythmias and sudden cardiac death(SCD). Early repolarization characteristics associated with SCD include high-amplitude J-point elevation, horizontal and/or downslopping ST segments, and inferior and/or lateral leads location. The prevalence of ERS varies between 3% and 24%, depending on age, sex and J-point elevation(0.05 m V vs 0.1 m V) being the main *** patients are sporadic and they are at a higher risk of having recurrent cardiac events. Implantable cardioverter-defibrillator implantation and isoproterenol are the suggested therapies in this set of patients. On the other hand, asymptomatic patients with ERS are common and have a better prognosis. The risk stratification in asymptomatic patients with ERS still remains a grey area. This review provides an outline of the up-to-date evidence associated with ERS and the risk of life- threatening arrhythmias. Further prospective studies are required to elucidate the mechanisms of ventricular arrhythmogenesis in patients with ERS.

关键词： Early repolarization syndrome Early repolarization Sudden cardiac death J-wave

Biotechnological leap in biopharmaceuticals:Current status and challenges ahead

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Journal of Coastal Life Medicine 2017年第1期5卷 36-46页

作者： Tazeen Iftikhar butt muhammad Shoaib Amjad Tatheer Fatima butt Wasi Haider butt Kainat Fatima Malik Sidra Sabir Department of Biotechnology Women University of Azad Jammu&KashmirBaghPakistan Department of Botany Women University of Azad Jammu&KashmirBaghPakistan Department of Botany Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan Department of Medicine Fatima Jinnah Medical UniversityLahorePakistan Department of Computer Engineering National University of Sciences and TechnologyIslamabadPakistan Department of Plant Science Quaid-i-Azam UniversityIslamabadPakistan

Fermentation based vaccine production system is replaced by edible vaccine technology. Plant derived vaccines are produced by using transgenic plants which have immunogenic properties. For combating infectious diseases especially in developing countries there is a practical need of new technology to produce and deliver inexpensive vaccines. We have best option of plant derived edible vaccines. There are many benefits of plant derived vaccinesi.e. they are cheaper, simple and easy to administer, more stable, extra versatile, with more acceptance power and highly efficient. Some plant derived vaccines are under clinical trials to use commercially and many are under research. This paper reviews the current status and future of this technology.

关键词： Plant-based vaccine Recombinant protein Transgenic plant Broad immune protection

Towards a Remote Sensing and GIS-Based Technique to Study Population and Urban Growth: A Case Study of Multan

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Advances in Remote Sensing 2018年第3期7卷 245-258页

作者： Atif ali Anam Khalid muhammad Atif butt Rashid Mehmood Syed Amer Mahmood Javed Sami Jahanzeb Qureshi Kashif Shafique Asdullah Khan Ghalib Rizwan Waheed Farhan ali Rais Mukhtar muhammad Azhar Department of Space Science University of the Punjab Lahore Pakistan

In recent decades, the migration rates of the large cities of Punjab have been risen up to a considerable level due to the lack of employment opportunities as well as lack of facilities in the rural areas of the province. It has caused an unprecedented and unplanned urbanization across the urban areas of the province. This study has been undertaken to perform fractal analysis about the sprawl in rapidly growing city. GIS and remote sensing data have been used in this study as an emerging technology which is cost effective as well as accurate at the same time. Landsat images have been taken for the study and the sprawl has been calculated with the analysis of the data of each decade for past more than 40 years. It has been observed that the built up area is 47.8 to 141.12 Sq. Km whereas the pattern of urban settlement has been classified as clustered and linear, following the roads network. The temporal population growth also seconded these results. The population growth rate and population density increase, are based on the pixel based extraction of the data from satellite imagery for the period of 2000 to 2014, which is taken as a decision support tool. In 2000, the population of the district increased from 2,071,694 (1981 census) to 2,939,907 and then in 2013, it became 4,384,191 at a rate to 2.93% upturn per annum. Moreover, the study also reveals the extent of the growth of other land uses as well which may be taken as a reference that in an agricultural country like Pakistan, the natural resources are being wasted (by urbanization of the fertile land). There must be some master planning to avoid such things in the other cities as well.

关键词： Urban Sprawl Population Growth Spatio-Temporal Remote Sensing Land Use Pakistan