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Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin ma Yang Qu Jiaxin Ren Yingying Sun Zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang ma Qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng Dong He Qiang Sun Xuhang ma Francesco Lamberti Zhubing He Department of materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （niOx） based perovskite solar cells often suffer from severe interfacial reactions between the niOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered niOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated niOxthin film surfaces from materials to *** sputtered niOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced ni3+or ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered niOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered niOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DmacPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered niOxbased PSCs so far.

关键词： Perovskite

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Integration of Electrical Properties and Pola.iza.ion Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang Yuefeng Yan Zhen Wang Guansheng ma Dechang Jia Xiaoxiao Huang Yu Zhou State Key Laboratory of Precision Welding&Joining of materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration materials&Green manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and pola.iza.ion has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and pola.iza.ion to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the pola.iza.ion center to increase dipole pola.iza.ion,interface pola.iza.ion and defect-induced pola.iza.ion due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole pola.iza.ion Conduction loss Impedance matching

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HyperDB：A Hyperspectral Land Class Database Designed for an Image Processing System

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Tsinghua Science and Technology 2017年第1期22卷 112-118页

作者： Yizhou Fan Ding ni Hongbing ma Department of Electronic Engineering Tsinghua UniversityBeijing 100084 China

Hyperspectral remote sensing is becoming more and more important amongst remote sensing techniques. In this paper, we present a hyperspectral database（Hyper DB） designed to cooperate with an embedded hyperspectral image processing system developed by the authors. Hyperspectral data are recognized and categorized by their land coverage class and band information, and can be imported from various sources such as airborne and spaceborne sensors carried by airplanes or satellites, as well as handhold instruments based on in situ ground observations. Spectral library files can be easily stored, indexed, viewed, and exported. Since Hyper DB follows standard design principles—independence, data safety, and compatibility—it satisfies the practical demand for managing categorized hyperspectral data, and can be readily expanded to other peripheral applications.

关键词： hyperspectral database spectral library image processing

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Collision-induced Rotational Energy Transfer in an Atom-Diatom System

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Chinese Journal of Chemical Physics 2008年第5期21卷 457-462页

作者： Yan-qing ni Jian Li Feng-cai ma Department of Physics Liaoning University Shenyang 110036 China Department of Science Shenyang Institute of Aeronautical Engineering Shengyang 110036 China

As a further theoretical study of the collision-induced quantum interference on rotational energy transfer in an atom-diatom system, based on the first-Born approximation of time-dependent perturbation theory, taking into account the anisotropic Lennard-Jones interaction potential and the long-range interaction potential, the differential interference angles in singlet-triplet mixed states of CO A^1Π（v=9）-e3∑-（v=1） system in collision with He, Ne, Ar, and other partners were calculated theoretically. The relationships of differential interference angle versus impact parameters, including collision parameter b and velocity, are obtained.

关键词： Rotational energy transfer Collision-induced quantum interference Interference angle

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A Caching Strategy Based on many-to-many matching Game in D2D Networks

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Tsinghua Science and Technology 2021年第6期26卷 857-868页

作者： Kaihang Yu Zhonggui ma Runyu ni Tao Zhang School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China Key Lab of Information Network Security Ministry of Public SecurityShanghai 201204China

Wireless edge caching has been proposed to reduce data traffic congestion in backhaul links, and it is being envisioned as one of the key components of next-generation wireless networks. This paper focuses on the influences of different caching strategies in Device-to-Device(D2D) networks. We model the D2D User Equipments(DUEs) as the Gauss determinantal point process considering the repulsion between DUEs, as well as the caching replacement process as a many-to-many matching game. By analyzing existing caching placement strategies, a new caching strategy is proposed, which represents the preference list of DUEs as the ratio of content popularity to cached probability. There are two distinct features in the proposed caching strategy.(1) It can cache other contents besides high popularity contents.(2) It can improve the cache hit ratio and reduce the latency compared with three caching placement strategies: Least Recently Used(LRU), Equal Probability Random Cache(EPRC), and the Most Popular Content Cache(MPC). Meanwhile, we analyze the effect of caching on the system performance in terms of different content popularity factors and cache capacity. Simulation results show that our proposed caching strategy is superior to the three other comparison strategies and can significantly improve the cache hit ratio and reduce the latency.

关键词： caching strategy Device-to-Device(D2D)networks Gauss determinantal point process many-to-many matching game

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Energy-optimal trajectory planning for solar-powered aircraft using soft actor-critic

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Chinese Journal of Aeronautics 2022年第10期35卷 337-353页

作者： Wenjun ni Ying BI Di WU Xiaoping ma Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

High-Altitude Long-Endurance(HALE)solar-powered Unmanned Aircraft Vehicles(UAVs)can utilize solar energy as power source and maintain extremely long cruise endurance,which has attracted extensive attentions from *** optimization is a promising way to achieve superior flight time because of the finite solar energy absorbed in a *** this work,a method of trajectory optimization and guidance for HALE solar-powered aircraft based on a Reinforcement Learning(RL)framework is *** to flight and environment information,a neural network controller outputs commands of thrust,attack angle,and bank angle to realize an autonomous flight based on energy *** validity of the proposed method was evaluated in a 5-km radius area in simulation,and results have shown that after one day-night cycle,the battery energy of the RL-controller was improved by 31%and 17%compared with those of a Steady-State(SS)strategy with a constant speed and a constant altitude and a kind of statemachine strategy,*** addition,results of an uninterrupted flight test have shown that the endurance of the RL controller was longer than those of the control cases.

关键词： Flight strategy Guidance and control Reinforcement learning Solar powered aeroplane Trajectory generation

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Shape Memory Alloy-Reinforced Metal-matrix Composites:A Review

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Acta Metallurgica Sinica(English Letters) 2014年第5期27卷 739-761页

作者： D.R.ni Z.Y.ma Shenyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of Sciences

Metal-matrix composites reinforced with shape memory alloys （Sma, including long fiber, short fiber, and particle） are ＂intelligent materials＂ with many special physical and mechanical properties, such as high damping property, high tensile strength, and fatigue resistance. In this review article, the fabrication method, microstructure, interface reaction, modeling, and physical and mechanical properties of the composites are addressed. Particular emphasis has been given to （a） fabrication and microstructure of aluminum matrix composites reinforced with Smas, and （b） shape memory effect on the physical and mechanical properties of the composites. While the bulk of the information is related to aluminum matrix composites, important results are now available for other metal-matrix composites.

关键词： Metal-matrix composites Shape memory alloy Fabrication method Microstructure Interface reaction Mechanical properties

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NASICON-Structured NaTi2（PO4）3 for Sustainable Energy Storage

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Nano-Micro Letters 2019年第3期11卷 119-154页

作者： Mingguang Wu Wei ni Jin Hu Jianmin ma School of Physics and Electronics Hunan UniversityChangsha410082People’s Republic of China Faculty of Technology University of Oulu90014OuluFinland Panzhihua University Panzhihua617000People’s Republic of China Key Laboratory of materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou450002People’s Republic of China

Several emerging energy storage technologies and systems have been demonstrated that feature low cost,high rate capability,and durability for potential use in large-scale grid and high-power *** to its outstanding ion conductivity,ultrafast Na-ion insertion kinetics,excellent structural stability,and large theoretical capacity,the sodium superionic conductor(NASICON)-structured insertion material NaTi2(PO4)3(NTP)has attracted considerable attention as the optimal electrode material for sodium-ion batteries(SIBs)and Na-ion hybrid capacitors(NHCs).On the basis of recent studies,NaTi2(PO4)3 has raised the rate capabilities,cycling stability,and mass loading of rechargeable SIBs and NHCs to commercially acceptable *** this comprehensive review,starting with the structures and electrochemical properties of NTP,we present recent progress in the application of NTP to SIBs,including non-aqueous batteries,aqueous batteries,aqueous batteries with desalination,and sodium-ion hybrid *** a thorough discussion of the unique NASICON structure of NTP,various strategies for improving the performance of NTP electrode have been presented and summarized in ***,the major challenges and perspectives regarding the prospects for the use of NTP-based electrodes in energy storage systems have also been summarized to offer a guideline for further improving the performance of NTP-based electrodes.

关键词： NaTi2(PO4)3 Sodium superionic conductor Anode Batteries Hybrid capacitors

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Fabric characteristics of in situ sand with/without liquefaction verified by anisotropy of magnetic susceptibility

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第5期15卷 1274-1283页

作者： Xueqian ni Junnan ma Hide Sakaguchi Feng Zhang School of Civil Engineering Central South UniversityChangsha410075China Department of Civil Engineering Nagoya Institute of TechnologyNagoya466-8555Japan Ocean Policy Research Institute The Sasakawa Peace FoundationTokyo105-8524Japan

It is well known that fabric of sand may significantly affect mechanical behaviors and liquefaction resistance of *** optical techniques are currently utilized to visualize the fabric,especially the distribution of the long axis of soil ***,none of these methods provides an ideal solution in laboratory tests and in situ *** this study,anisotropy of magnetic susceptibility(AMS)was first proposed as a convenient and efficient way to evaluate the liquefaction of clean *** first,investigations with scanning electron microscopy(SEM)and AMS were simultaneously conducted on two groups of soil specimens with different initial fabrics to verify the feasibility of the AMS ***,80 in situ samples were collected to analyze the feature of liquefied and non-liquefied sand layers through AMS *** is clearly known from the test results that the natural sedimentary fabric was destroyed during liquefaction and the fabric anisotropy was greatly changed after *** feasibility of evaluating soil fabric using the AMS survey was verified by the laboratory ***,the applicability of AMS in detecting liquefied layer in situ was confirmed for the first time.

关键词： Sand liquefaction Soil fabric Anisotropy of magnetic susceptibility(AMS) Geotechnical seismic engineering

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