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Synthesis and anticholinesterase activity of a novel series of acetazolamide condensed 1,4-dihydropyridines

Carbon Resources Conversion 2019年第3期2卷 191-197页

作者： mudduluru niranjan babu Karthikeyan Elumalai Sivaneswari Srinivasan Kalpana Eluri Manogaran Elumalai Srinivasan Sivannan Department of Phytochemistry Seven Hills College of PharmacyTirupati 517561India Department of Medicinal Chemistry Seven Hills College of PharmacyTirupati 517561India Department of Pharmaceutics K.K.College of PharmacyChennai 600122India Faculty of Pharmaceutical Sciences UCSI UniversityCherasKuala Lumpur 56000Malaysia Department of Pharmacy Practice Togari Veeramallappa Memorial College of PharmacyBallariIndia

A novel Acetazolamide condensed 1,4-dihydropyridines was set up by treating of N-(5-acetamido-1,3,4-thiadiazol-2-ylsulfonyl)-3-oxobutanamide with an aryl aldehyde and 25-30%alkali with sight amount of barium nitrate as a *** of the synthetic structure of the titled compounds(4-16)was substantiated by thin-layer chromatography(TLC),IR,^(1)H NMR,^(13)C NMR,Mass spectra(MS)and elemental analysis(C,H,and N)were *** titled compounds were assessed for anticholinesterase activity against acetylcholinesterase and butyl cholinesterase *** titled compound produced weak,moderate,or high anticholinesterase ***,compound 8 demonstrated the best anticholinesterase activity of all the 1,4-dihydropyridines,with an IC_(50) estimation of 0.08μM and 2.9μM.

关键词： Acetazolamide Anticholinesterase 1,4-Dihydropyridines Acetylcholinesterase Butyl cholinesterase

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Status of Micro and Macro Nutrients in Patients with Type 2 Diabetes Mellitus Suggesting the Importance of Cation Ratios

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Journal of Diabetes Mellitus 2016年第3期6卷 191-196页

作者： Ramesh Ramaswamy niranjan Gopal Sony Joseph Sathish babu Murugaiyan M. Joseph Densely Jose V. Kuzhandaivelu A. Velayutharaj Department of Biochemistry Mahatma Gandhi Medical College and Research Institute SBV Pillaiyarkuppam India Department of Chemistry Regional Research Center in Chemistry (M. G. University) M. A College Kothamangalam India Department of Biochemistry Chennai Medical College Hospital & Research Centre Trichy India

Background: Type 2 Diabetes Mellitus (T2DM) is a chronic polymetabolic disorder characterized by chronic hyperglycemia resulting from resistance to insulin action or inadequacy of insulin secretion. Role of the micro & macro nutrients in the pathogenesis of T2DM has not been studied thoroughly. The aim of this study was to evaluate the status of calcium, magnesium, zinc and chromium in relation to HbA1c in a group of subjects with T2DM patients. Methodology: The study comprised of seventy three patients with T2DM, attending the OP of a tertiary care medical college hospital. Thirty four individuals were with HbA1c 7%). Cation ratios were significantly associated with the glycemic control in T2DM.

关键词： T2DM HbA1c Trace Elements Cation Ratio

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