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Chinese Chemical Letters 2008年第12期19卷 1427-1430页

作者： mudasir r.banday Abdul rauf Department of Chemistry Aligarh Muslim UniversityAligarh 202002India

A series of new 1-（alkenoyl/hydroxyalkenoyl）-4-benzoyl-thiosemicarbazides 2a-d and 2-benzamide-5-alkenyl/hydroxyalk- enyl-1,3,4-thiadiazoles 3a-d were synthesized from fatty acid hydrazides. Structure of all these compounds was confirmed by Ir, IH NMr, Sac NMr, mass spectra and elemental analysis. The bioassay results indicate that some compounds 2e, 2d, 3e and 3d have good antibacterial activity.

关键词： Aroylthiosemicarbazide 1,3,4-Thiadiazole Antibacterial activity

DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with β-sitosterol:In vitro antimicrobial activity

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Chinese Chemical Letters 2010年第6期21卷 646-650页

作者： Nida N.Farshori mudasir r.banday Zeeshan Zahoor Abdul rauf Department of Chemistry Aligarh Muslim UniversityAligarh 202002India Department of Biochemistry Aligarh Muslim UniversityAligarh 202002India

A new series of fatty alkenoates were synthesized using an appropriate synthetic route involving DCC and DMAP as catalysts. Compounds were characterized by their spectral *** the synthesized compounds were evaluated for their in vitro antimicrobial *** minimum inhibitory concentration(MIC),minimum bacterial concentration(MBC) and minimum fungicidal concentration(MFC) were determined for test compounds as well as for reference *** the compounds tested, compounds having hydroxy group at the fatty acid chain showed the most potent antibacterial as well as antifungal activities.

关键词： Fatty acids β-Sitosterol DCC DMAP Ir NMr Mass Antimicrobial activity

Mechanistic insights toward identification and interaction of plant parasitic nematodes:A review

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Soil Ecology Letters 2024年第1期6卷 11-27页

作者： Bisma Jan Ali Haider Shah mudasir Ahmad Bhat Arif Tasleem Jan Ishfaq Ahmad Wani Ali Asghar Shah Section of Microbiology Baba Ghulam Shah Badshah UniversityRajouriJ&K185234India Department of Biotechnology Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Botany Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Zoology School of Biosciences and BiotechnologyBaba Ghulam Shah Badshah University RajouriJ&K185234India

Nematode identification serves as an important param-eter to study their behaviour,importance and *** of classical morphometric based identifica-tion methods prove to be lacking due to insufficient knowledge on morphological variations among closely related *** approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for nematode *** and certain protein-based nematode-associated molecular patterns(NAMPs),can be perceived by the host plants,and can initiate a signalling *** review primarily emphasizes on an updated account of different classical and modern tools used for the identification of *** we also summa-rize the mechanism of some important signalling pathways which are involved in the different plant nematode *** constitute most diverse and least studied group of soil inhabiting *** are ecologically and physiologically important,however,wide range of nematodes show harmful impact on the individuals that live within their *** parasitic nematodes(PPNs)are transparent,pseudocoelomate,free living or parasitic *** lack morphometric identification methods due to insufficient knowl-edge on morphological variations among closely related *** such,molecular approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for their *** invade the defense response of different plant species,parasitic nematodes have evolved different molecular *** and certain protein-based nematode-associated molecular patterns(NAMPs),can be perceived by the host plants,and can initiate a signaling *** overcome the host confrontation and develop certain nematode feeding sites,some members can inject effectors into

关键词： nematode identification plant nematode interaction DNA fingerprinting nematode-associated molecular patterns signaling path-ways

Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mrNAs,mirNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

Scope of technology in health care, special focus on nursing

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Journal of Integrative Nursing 2023年第4期5卷 300-310页

作者： Adil mudasir MALLA Ulfat AMIN Department of Computer Science and Engineering Islamic University of Science and TechnologyPulwamaJammu and KashmirIndia College of Nursing Islamic University of Science and TechnologyPulwamaJammu and KashmirIndia

Integrating artificial intelligence(AI)into health care reshapes nursing practices and education,enhancing patient care and clinical *** article discusses the transformative potential of AI in nursing,from streamlining documentation and diagnosis using AI applications to the evolution of *** utilization of AI in primary care through automated communication strategies and the emergence of humanistic AI solutions are *** nurses adapt to AI-driven health-care technologies,balancing present needs with future demands becomes *** provides substantial advantages,but it's crucial to address challenges to ensure the successful integration of technology in healthcare and maintain the delivery of high-quality patient care in our tech-driven healthcare environment.

关键词： Artificial intelligence in nursing artificial intelligence health-care innovative technologies

Synthesis of surface imprinted polymers based on wrinkled flower-like magnetic graphene microspheres with favorable recognition ability for BSA

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Journal of Materials Science & Technology 2021年第15期74卷 203-215页

作者： Zuoting Yang Ke Yang Yuhong Cui Tariq Shah mudasir Ahmad Qiuyu Zhang Baoliang Zhang School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi'an710129China Xi'an Key Laboratory of Functional Organic Porous Materials Northwestern Polytechnical UniversityXi'an710072China Sunresins New Materials Co.Ltd. Xi'an710072China

Nowadays,the employing of molecular imprinting technique in the analysis and separation of proteins from complex biological samples has been widely favored by *** enrich the types of surface protein imprinted materials and expand the application fields of graphene materials,novel surface molecular imprinted polymers(MIPs)based on magnetic graphene microspheres Fe_(3)O_(4)@r GO@MIPs are first synthesized in this ***_(3)O_(4)@r GO@MIPs are prepared by oxidative self-polymerization of dopamine on the surface of magnetic graphene(Fe_(3)O_(4)@r GO)composite *** serum albumin(BSA)is selected as protein ***_(3)O_(4)@r GO microspheres with wrinkled flower-like structure are obtained by compounding Fe_(3)O_(4)and graphene oxide in an appropriate ratio via the method of high-temperature reduction *** microspheres exhibit promising dispersibility,high external surface area,rich pore structure,and sufficient magnetic *** advantages not only prevent the agglomeration of imprinted microspheres in the aqueous phase,which is conducive to contact and static adsorption,but also increase the amount of protein ***,sufficient magnetic properties ensure fast and effective separation of the *** the adsorption capacity is increased,the separation procedure becomes *** binding capacity of Fe_(3)O_(4)@r GO@MIPs for BSA can reach 317.58 mg/g within 60 min,and the imprinting factor(IF)is *** importantly,Fe_(3)O_(4)@r GO@MIPs can specifically recognize the target BSA from the mixed proteins and the actual *** is no significant decrease in the adsorption amount,IF,and magnetic properties after eight *** is promising to be used in the separation of proteins from the actual biological samples.

关键词： Wrinkled Flower-like Magnetic graphene microspheres Dopamine BSA Surface protein imprinting

Exploring the region-wise diversity and functions of symbiotic bacteria in the gut system of wood-feeding termite,Coptotermes formosanus,toward the degradation of cellulose,hemicellulose,and organic dyes

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Insect Science 2022年第5期29卷 1414-1432页

作者： mudasir A.Dar rongrong Xie radhakrishna S.Pandit Blessing Danso Chenchen Dong Jianzhong Sun Biofuels Institute School of the Environment and Safety EngineeringJiangsu UniversityZhenjiangJiangsu ProvinceChina Department of Zoology Savitribai Phule Pune UniversityGaneshkhindPuneIndia

The wood-feeding termite Coptotermes formosanus represents a unique and impressive system for lignocellulose *** highly efficient digestion of lignocellulose is achieved through symbiosis with gut symbionts like *** extensive research during the last three decades,diversity of bacterial symbionts residing in individual gut regions of the termite and their associated functions is still *** this end,cellulose,xylan,and dye-decolorization bacteria residing in foregut,midgut,and hindgut regions of *** were enlisted by using enrichment and culture-dependent molecular methods.A total of 87 bacterial strains were successfully isolated from different gut regions of *** which belonged to 27 different species of 10 genera,majorly affiliated with Proteobacteria(80%)and Firmicutes(18.3%).Among the gut regions,37.9%of the total bacterial isolates were observed in the hindgut that demonstrated predominance of cellulolytic bacteria(47.6%).The majority of the xylanolytic and dye-decolorization bacteria(50%)were obtained from the foregut and midgut,*** represented by Dietza *** observed in the hindgut *** on species richness,the highest diversity was observed in midgut and hindgut regions each of which harbored seven unique bacterial *** members of Enterobacter,Klebsiella,and Pseudomonas were common among the gut *** lignocellulolytic activities of the selected potential bacteria signpost their assistance to the host for lignocellulose *** overall results indicate that *** harbors diverse communities of lignocellulolytic bacteria in different regions of the gut *** observations will significantly advance our understanding of the termite–bacteria symbiosis and their microbial ecology uniquely existed in different gut regions of ***,which may further shed a light on its potential values at termite-modeled biotechnology.

关键词： bacterial symbionts Coptotermes formosanus culture-dependent gut regions lignocellulose termite

Further constituents from rhododendron lepidotum L

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Chinese Chemical Letters 2010年第3期21卷 332-336页

作者： mudasir Ahmad Tantry reehana Khan Seema Akbar Abdul Sami Shawl Mohammed Khalid Siddiqui Drug Standardisation research Unit Regional Research Institute of Unani Medicine(CCRUM)Naseem Bagh CampusUniversity of Kashmir Natural Product Chemistry Division Indian Institute of Integrative Medicine(CSIR) Central Council for research in Unani Medicine(CCrUM)

A unusual flavone glycoside named Shamimarin(1) and a new compound Acetoxy-8-methyl-chromen-2H-one(2) were isolated from aerial parts of rhododendron lepidotum *** with four known coumarins daphnin(3),daphnetin 8-O-β-D-glucopyrano-side (4),daphnetin(5) and umbelliferone(6).The structural elucidations were based on analyses of chemical and spectroscopic data by including ID and 2D NMr analyses.

关键词： rhododendron lepidotum Flavone Coumarin

Invasion by Conyza sumatrensis alters soil microbial community structure in urban ecosystems

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Ecological Processes 2016年第1期5卷 120-129页

作者： Nazima rasool Zafar A.reshi Damase P.Khasa mudasir roshan Manzoor A.Shah Biological Invasion Laboratory Department of BotanyUniversity of KashmirSrinagar 190006Jammu and KashmirIndia Canadian research Chair in Forest and Environmental Genomics and Institute of Integrative and Systems Biology Pavillon MarchandUniversite lavalQuebec G1V 0A6Canada

Introduction:Whether invasive plants stimulate or inhibit the soil microbial diversity is still an open *** large-scale invasion by Conyza sumatrensis(retz.)*** in the urban ecosystems of the Srinagar city of the Kashmir Himalayan region,limited information exists on its impact,particularly,on the belowground microbial *** present study was thus conducted to compare the soil microbial(bacterial and ascomycetous fungal)diversity between the sites invaded by *** and un-invaded(control)***:Soil metagenome was extracted from *** invaded and un-invaded plots at the three study sites.A total of six plots(5×5 m each in size),including three invaded by *** and three un-invaded plots were nested within each study *** after amplification was subject to denaturing gradient gel electrophoresis(DGGE);the bands were extracted from the DGGE gel,re-amplified,and sequenced for identification of the ***:The number of bacterial species was reduced in the invaded plots at two out of the three sites while as it was relatively higher in the un-invaded plots with many species exclusively found in these *** species richness was higher in the invaded plots compared to the un-invaded plots at all the three ***,more fungal species were found to occur exclusively in the invaded plots without being represented in the un-invaded ***:Invasion by *** alters soil microbial community structure in the urban ecosystems in the Kashmir *** this species does so and what benefits does it draw from such alteration promise to be an interesting future discourse.

关键词： Conyza sumatrensis DGGE Kashmir Himalaya Plant invasion Soil microbes

An unusual bioactive oleanane triterpenoid from rhododendron campanulatum ***

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Chinese Chemical Letters 2011年第5期22卷 575-579页

作者： mudasir Ahmad Tantry reehana Khan Seema Akbar Abdul rouf Dar Abdul Sami Shawl Mohammad Sarwar Alam Drug Standardisation research Unit Regional Research Institute of Unani Medicine(CCRUM)Naseem Bagh CampusUniversity of KashmirSrinagar 190006KashmirIndia Natural Product Chemistry Division Indian Institute of Integrative Medicine(CSIR)SanatnagarSrinagar 190005KashmirIndia Department of Chemistry Jamia Hamdard UniversityHamdard NagarNew Delhi 110062India Bioorganic Chemistry Division Indian Institute of Integrative Medicine(CSIR)Canal RoadJammu Tawi 180001JammuIndia

An unusual oleanane triterpene（1） was isolated from aerial parts of rhododendron *** compound had shown prominent antibacterial and immunomodulatory *** structure of the compound was determined by spectroscopic data... 详细信息

关键词： rhododendron campanulatum Oleanane triterpenoid Antibacterial Immunomodulatory