Synthesis and evaluation of in vitro antibacterial activity of novel 2,5-disubstituted-l,3,4-thiadiazoles from fatty acids

作     者：Mudasir R.Banday Abdul Rauf 

作者机构：Department of ChemistryAligarh Muslim UniversityAligarh 202002India 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第12期

页      面：1427-1430页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Authors are thankful to Chairman Department of Chemistry A.M.U Aligarh for providing necessary research facilities 

主　　题：Aroylthiosemicarbazide 1,3,4-Thiadiazole Antibacterial activity 

摘      要：A series of new 1-（alkenoyl/hydroxyalkenoyl）-4-benzoyl-thiosemicarbazides 2a-d and 2-benzamide-5-alkenyl/hydroxyalk- enyl-1,3,4-thiadiazoles 3a-d were synthesized from fatty acid hydrazides. Structure of all these compounds was confirmed by IR, IH NMR, Sac NMR, mass spectra and elemental analysis. The bioassay results indicate that some compounds 2e, 2d, 3e and 3d have good antibacterial activity.