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Analysis and calculation of thermal conductivity of rock in deep strata

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Journal of Central South University of Technology 2005年第z1期12卷 114-119页

作者： LIU Dun-wen GU De-sheng dai Ta-gen Herbert Henkel School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China School of Geoscience and Environmental Engineering Central South University Changsha 410083 China Department of Land and Water Resources Engineering Royal Institute of Technology (KTH) Stockholm S10044 Sweden

The thermal conductivity of rock is an important parameter for the deep mine and the geothermal development. It is often not possible to measure the thermal conductivity of the rocks present in the deep strata, and the usual approach is to calculate thermal conductivity including mineralogy and porosity. The compositions of core samples from the MID01 borehole in the Bjorko area were determined, and the mineral composition was classified. The calculation of the thermal conductivity of rock in the borehole was carried out, and the main factors for the thermal conductivity of rock were analyzed. The results show that the calculated thermal conductivity of rock is reliable and useful for the design and calculation of geothermal development in the Bjorko area.

关键词： thermal conductivity of rock thermal conductivity calculation mineral composition rock porosity

Potential Function of MMP3 gene in Degradation of Extracellular Matrix Complex in Colorectal Carcinoma

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Biomedical and Environmental Sciences 2021年第1期34卷 66-70页

作者： dai Xiao Yong SONG An Yi mu Lan WANG Li Jun HUANG Lai Qiang Shenzhe n Key Laboratory of gene and An tibody Therapy Cen ter for Biotech no logy and Biomedici neState Key Laboratory of Chemical On coge no micsz Tsin ghua-Berkeley She nzhen In stitute(TBSI)Z Tsin ghua She nzhe n In ter natio nal Graduate SchoolTsinghua UniversityShenzhen 518055GuangdongChina Department of Chemistry Tsinghua UniversityBeijing 100084China

Colorectal cancer(CRC)is a kind of malignant tumor that occurs in the digestive *** occurs globally and has high rates of morbidity and *** incidence and mortality are second only to gastric cancer,esophageal cancer,and primary liver cancer in digestive system *** CRC cases are adenomas.A few are squamous epithelial cancers,which can spread to adjacent tissues and organs through lymph and blood circulation,or *** occurrence of CRC is related to factors that include gene mutation.

关键词： mortality Carcinoma Colorectal

New Mechanical Feature of Two-Solitary Wave to the KdV Equation

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Chinese Physics Letters 2012年第4期29卷 1-2页

作者： dai Zheng-De WU Feng-Xia LIU Jun mu Gui School of Mathematics and Statistics Yunnan UniversityKunming 650091 College of Mathematics and Information Science Qujing Normal UniversityQujing 655000

New breather solitary solution and two-solitary solutions depending on constant equilibrium solution to the Korteweg de Vries equation are obtained by using an extended homoclinic test approach.A new mechanical feature of a two-solitary wave,namely,dependence of propagation direction and shape on position of equilibrium point,is investigated.

关键词： solitary equilibrium equation

A Zn(II) 5-Aminoisophthalate Coordination Polymer

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Chinese Journal of Structural Chemistry 2007年第5期26卷 529-532页

作者： TANG En dai Yu-Mei LI Zhao-Ji WANG Xiao-Qin YIN Pei-Xiu YAO Yuan-gen State Key Laboratory of Structural Chemistry Fujian Institute of Research on theStructure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210093 China College of Chemistry ＆ Material Science FujianNormal University Fuzhou Fujian 350007 China

The title compound, [Zn（AIP）（4,4-bipy）0.5（H2O）]n·0.75nH2O 1, was synthesized via the hydrothermal reaction of Zn（OAc）2 with 5-aminoisophthalic acid （H2AIP） and characterized by elemental analysis and infrared spectra. The complex crystallizes in monoclinic system, space group P21/c with a = 12.672（1）, b = 7.6557（4）, c = 16.181（1）A, β = 109.187（2）°, V = 1482.6（2）A^3, Z = 1, C52H52N8O23Zn4, Mr = 1418.58, Dc = 1.589 g/cm^3, F（000） = 724 and μ（MoKα） = 1.685mm-1. The final R = 0.0702 and wR = 0.1524 for 1847 observed reflections with Ⅰ〉 2σ（Ⅰ）, and R = 0.0873 and wR = 0.1664 for all data. X-ray diffraction studies reveal that the title compound has an interesting 2D microporous architecture with guest water molecules inside the channel.

关键词： hydrothermal reaction crystal structure Zn(Ⅱ) complex 5-aminoisophthalic acid

AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1931-1946页

作者： Qingqing dai Yuhang Yan Xiangli Ning gen Li Junlin Yu Ji Deng Lingling Yang Guo-Bo Li Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Department of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengdu 610041China College of Food and Bioengineering Xihua UniversityChengdu 610039China

We herein describe AncPhore,a versatile tool for drug discovery,which is characterized by pharmacophore feature analysis and anchor pharmacophore(i.e.,most important pharmacophore features)steered molecular fitting and virtual *** analyses of numerous protein-ligand complexes using AncPhore revealed that anchor pharmacophore features are biologically important,commonly associated with protein conservative characteristics,and have significant contributions to the binding *** evaluation of AncPhore showed that it had substantially improved prediction ability on different types of target proteins including metalloenzymes by considering the specific contributions and diversity of anchor pharmacophore *** demonstrate the practicability of AncPhore,we screened commercially available chemical compounds and discovered a set of structurally diverse inhibitors for clinically relevant metallo-β-lactamases(MBLs);of them,4 and 6 manifested potent inhibitory activity to VIM-2,NDM-1 and IMP-1 *** analyses of VIM-2:4 complex revealed the precise inhibition mode of 4 with VIM-2,highly consistent with the defined anchor pharmacophore ***,we also identified new hit compounds by using AncPhore for indoleamine/tryptophan 2,3-dioxygenases(IDO/TDO),another class of clinically relevant *** work reveals anchor pharmacophore as a valuable concept for target-centered drug discovery and illustrates the potential of AncPhore to efficiently identify new inhibitors for different types of protein targets.

关键词： Anchor pharmacophore Metalloenzyme Virtual screening Metallo-b-lactamase Indoleamine 2,3-dioxygenase Tryptophan 2,3-dioxygenase

A Co(II) 3,5-Diaminobenzoate Coordination Polymer

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Chinese Journal of Structural Chemistry 2006年第8期25卷 971-974页

作者： dai Yu-Mei TANG En LI Zhao-Ji WANG Xiao-Qin YIN Pei-Xiu YAO Yuan-gen College of Chemistry ＆ Material Science Fujian Normal University Fuzhou 350007 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China College of Chemistry ＆ Chemical Engineering Fuzhou University Fuzhou 350002 China

The title compound, [Co（C7N2H7O2）2]n·nH2O 1, was synthesized via the hydrothermal reaction of Co（OAc）2 with 3,5-diaminobenzoic acid and characterized by elemental analysis and infrared spectra. The crystal crystallizes in the monoclinic system, space group P21/c with a = 7.456（3）, b = 9.972（3）, c = 10.391（3）A, β= 106.435（2）°, V = 741.0（4） A^3, Z = 2, C14H16CoN4O5, Mr = 379.24, Dc = 1.700 g/cm^3, F（000） = 390 and μ（MoKa） = 1.194 mm^-l. The final R = 0.0324 and wR = 0.0886 for 1516 observed reflections with I 〉 2σ（I） and R = 0.0337 and wR = 0.0899 for all data. X-ray diffraction studies reveal that the title compound has an interesting 3D microporous architecture with guest water molecules inside the channel. Each Co atom, adopting a distorted octahedral geometry, is coordinated by two O atoms from two 3,5-diaminobenzoate ligands and four N atoms from four symmetry-related 3,5-diaminobenzoate ligands.

关键词： hydrothermal reaction crystal structure Co(Ⅱ) complex 3,5-diaminobenzoic acid

Identifying human-induced influence on microbial community:A comparative study in the effluent-receiving areas in Hangzhou Bay

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Frontiers of Environmental Science & Engineering 2019年第6期13卷 103-113页

作者： Yuhan Zheng Zhiguo Su Tianjiao dai Feifei Li Bei Huang Qinglin mu Chuanping Feng Donghui Wen School of Water Resource and Environmental Science China University of Geosciences(Beijing)Beijing 100083China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China Zhejiang Provincial Zhoushan Marine Ecological Environmental Monitoring Station Zhoushan 316021China

Microbial community structure is afiected by both natural processes and human *** coastal area,anthropegenetic activity can usually lead to the discharge of the effluent from wastewater treatment plant(WWTP)to sea,and thus the water quality chronically turns worse and marine ecosystem becomes *** play key roles in pollutants degradation and ecological restoration;however,there are few studies about how the WWTP effluent disposal influences coastal microbial *** this study,sediment samples were collected from two WWTP effluentreceiving areas(abbreviated as JX and SY)in Hangzhou ***,based on the high-throughput sequencing of 16S rRNA gene,microbial community structure was ***,several statistical analyses were conducted to reveal the microbial community characteristics in response to the effluent *** PCoA,the significant difference of in microbial community structure was determined between JX and SY;using RDA,water COD and temperature,and sediment available phosphate and ammonia nitrogen were identified as the key environmental factors for the community difference;using LDA effect size analysis,the most distinctive microbes were found and their correlations with environmental factors were investigated;and according to detrended beta-nearesttaxon-index,the sediment microbial communities were found to follow"niche theory".An interesting and important finding was that in SY that received more and toxic COD,many distinctive microbes were related to the groups that were capable of degrading toxic organic *** study provides a clear illustration of eco-environmental deterioration under the long-term human pressure from the view of microbial ecology.

关键词： Microbial community structure Effluent-receiving area High-throughput sequencing Costal sediments Wastewater treatment plant(WWTP)

Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux

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World Journal of Gastroenterology 2014年第42期20卷 15715-15726页

作者： Yun-Xiang Chu Wei-Hong Wang Yun dai Gui-gen Teng Shu-Jun Wang Department of Gastroenterology Peking University First Hospital

AIM: To investigate esophageal Helicobacter pylori (H. pylori) colonization on esophageal injury caused by reflux and the related mechanisms.

关键词： Helicobacter pylori Esophagus Metaplasia Adenocarcinoma Animal model

Writing and erasing MYC ubiquitination and SUMOylation

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genes & Diseases 2019年第4期6卷 359-371页

作者： Yingxiao Chen Xiao-Xin Sun Rosalie C.Sears mu-Shui dai Departments of Molecular&Medical genetics School of MedicineOHSU Knight Cancer InstituteOregon Health&Science University3181 SW Sam Jackson Park RoadPortlandOR 97239USA

The transcription factor c-MYC(MYC thereafter)controls diverse transcription programs and plays a key role in the development of many human *** develop multiple mechanisms to ensure that MYC levels and activity are precisely controlled in normal physiological *** a short half-lived protein,MYC protein levels are tightly regulated by the ubiquitin proteasome *** a dozen of ubiquitin ligases have been found to ubiquitinate MYC whereas a number of deubiquitinating enzymes counteract this *** studies show that SUMOylation and deSUMOylation can also regulate MYC protein stability and ***,evidence suggests an intriguing crosstalk between MYC ubiquitination and *** of the MYC ubiquitination-SUMOylation regulatory network may contribute to *** review is intended to provide the current understanding of the complex regulation of the MYC biology by dynamic ubiquitination and SUMOylation and their crosstalk.

关键词： deSUMOylating enzymes Deubiquitinating enzymes MYC SUMO SUMOylation Ubiquitination