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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.y.ñez-muñoz Heidi R.Fuller School of Pharmacy.and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy.SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery.that humans have a“back-up”gene,SMN2,which can produce low levels(approximately.10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally.classified according to age of sy.ptom onset and developmental milestones achieved,with life expectancy.and severity.vary.ng between ***,SMN2 copy.number is used as a proxy.for the prediction of disease severity.with higher SMN2 copy.number ty.ically.being associated with reduced severity.of SMA,although this relationship is not absolute:some individuals with low SMN2 copy.number have less severe SMA phenoty.es and vice ***,the etiology.of SMA is further complicated by.other factors,such as non-ty.ical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

A Hy.rid Low Temperature Surface Alloy.ng Process for Austenitic Stainless Steels

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材料热处理学报 2004年第5期25卷 307-310页

作者： y.sun SchoolofMaterialsEngineering NanyangTechnologicalUniversitySingapore639798

This paper describes a novel, hy.rid process developed to engineer the surfaces of austenitic stainless steels at temperatures below 450°C for the improvement in wear and corrosion resistance. The process is carried out in the plasma of a glow discharge containing both nitrogen and carbon reactive species, and facilitates the incorporation of both nitrogen and carbon into the austenite surface to form a dual-lay.r structure comprising a nitrogen-rich lay.r on top of a carbon-rich lay.r. Both lay.rs can be precipitation-free at sufficiently.low processing temperatures, and contain nitrogen and carbon respectively.in supersaturated fee austenite solid solutions. The resultant hy.rid structure offers several advantages over the conventional low temperature nitriding and the newly.developed carburizing processes in terms of mechanical and chemical properties, including higher surface hardness, a hardness gradient from the surface towards the lay.r-core interface, uniform lay.r thickness, and much enhanced corrosion resistance. This paper discusses the main features of this hy.rid process and the various structural and properties characteristics of the resultant engineered surfaces.

关键词：奥氏体不锈钢表面铸合等离子体渗氮等离子体渗碳磨损腐蚀

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusny.h Department of Anatomy.and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply.secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embry.nic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analy.is in *** cortical hem produces several ty.es of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly.important for the development of the hippocampus,which is involved in learning and memory.and the neocortex,which is the most complex brain region that mediates multiple ty.es of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Exercise preconditioning alleviates ischemia-induced memory.deficits by.increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y.y.u Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key.Laboratory.of CNS Regeneration(Ministry.of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key.Laboratory.of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and sy.aptogenesis,and has been widely.used for functional rehabilitation after *** this study.we determined whether exercise training before disease onset can alleviate the severity.of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 day. of treadmill exercise training before surgery.for middle cerebral artery.*** found that this exercise pre-conditioning strategy.effectively.attenuated brain infarct area,inhibited gliogenesis,protected sy.aptic proteins,and improved novel object and spatial memory.*** analy.is showed that circulating adiponectin play. a critical role in these preventive effects of *** activation of adiponectin receptors by.Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary.our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory.function middle cerebral artery.occlusion prefrontal cortex sy.aptic proteins treadmill exercise

Effect of post-bond heat treatment on the microstructure and high temperature mechanical property.of a TLP bonded γ'-strengthened co-based single cry.tal superalloy

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Journal of Materials Science & Technology 2021年第21期80卷 244-258页

作者： S.y.Wang y.sun C.y.Cui X.F.sun y.Z Zhou y.M.Ma H.L.An Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China Harbin Welding Institute China Academy of Machinery Science and TechnologyHarbin 150028China

Post-bond heat treatment(PBHT) applied to a transient liquid phase(TLP) bonding joint is an effective approach to remove the brittle borides and improve its ***,we proposed two ty.es of PBHT strategies to obtain a TLP bonded γ'-strengthened Co-based single cry.tal superalloy.and the microstructural characteristics and tensile properties of the two heat treated joints were compared to identify.the optimal PBHT *** evolution of the brittle boride in the joint after the PBHT was studied by.using in-situ *** experimental results allowed to provide a theoretic model to quantitatively.evaluate the distribution of the brittle phase after the optimal PBHT and analy.e the joint fractures to understand the failure *** obtained results revealed that a post-bond solid solution treatment performed to the joint at a high temperature(over 1275℃) could decrease the area fraction of the boride from 7.2 % to 1.4 % and increase the elongation from 1.9 % to 7.8 %.This work emphasizes the relevance of solid solution temperature when a PBHT strategy.is applied.

关键词： Transient liquid phase(TLP) γ'-strengthened co-based single cry.tal superalloy Heat treatment sequence Brittle boride Tensile property

Effect of electric boundary.conditions on crack propagation in ferroelectric ceramics

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Acta Mechanica Sinica 2014年第2期30卷 153-160页

作者： F.-X. Li y.sun R.K.N.D.Rajapakse State Key.Laboratory.for Turbulence and Complex Sy.tems College of EngineeringPeking University Faculty.of Applied Sciences Simon Fraser University

In this paper, the effect of electric boundary.conditions on Mode I crack propagation in ferroelectric ceramics is studied by.using both linear and nonlinear piezoelectric fracture mechanics. In linear analy.is, impermeable cracks under open circuit and short circuit are analy.ed using the Stroh formalism and a rescaling method. It is shown that the energy.release rate in short circuit is larger than that in open circuit. In nonlinear analy.is, permeable crack conditions are used and the nonlinear effect of domain switching near a crack tip is considered using an energy.based switching criterion proposed by.Hwang et al.（Acta Metal. Mater.,1995）. In open circuit, a large depolarization field induced by.domain switching makes switching much more diffcult than that in short circuit. Analy.is shows that the energy.release rate in short circuit is still larger than that in open circuit, and is also larger than the linear result. Consequently.whether using linear or nonlinear fracture analy.is, a crack is found easier to propagate in short circuit than in open circuit, which is consistent with the experimental observations of Kounga Njiwa et al.（Eng. Fract. Mech., 2006）.

关键词： Ferroelectric ceramics Crack propagation En-ergy.release rate Electric boundary.conditions Domain switching

Cloud computing for integrated stochastic groundwater uncertainty.analy.is

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International Journal of Digital Earth 2013年第4期6卷 313-337页

作者： y.ng Liu Alexander y.sun Keith Nelson Wesley.E.Hipke National Center for Supercomputing Applications University of Illinois at Urbana-ChampaignUrbanaILUSA Bureau of Economic Geology University of Texas at AustinAustinTXUSA Arizona Department of Water Resources PhoenixAZUSA

One of the major scientific challenges and societal concerns is to make informed decisions to ensure sustainable groundwater availability.when facing deep uncertainties.A major computational requirement associated with this is on-demand computing for risk analy.is to support timely.*** paper presents a scientific modeling service called‘ModflowOnAzure’which enables large-scale ensemble runs of groundwater flow models to be easily.executed in parallel in the Windows Azure *** technical issues were addressed,including the conjunctive use of desktop tools in MATLAB to avoid license issues in the cloud,integration of Dropbox with Azure for improved usability.and‘Drop-and-Compute,’and automated file exchanges between desktop and the *** scientific use cases are presented in this paper using this service with significant computational *** case is from Arizona,where six plausible alternative conceptual models and a streamflow stochastic model are used to evaluate the impacts of different groundwater pumping *** case is from Texas,where a global sensitivity.analy.is is performed on a regional groundwater availability.*** of both cases show informed uncertainty.analy.is results that can be used to assist the groundwater planning and sustainability.study.

关键词： MODFLOW groundwatersustainability uncertainty.naly.is global sensitivity.analy.is cloudcomputing WindowsAzure Dropbox alternative conceptual model cy.erinfrastructure eScience

Surface finish effect on dry.sliding wear behavior of thermally.oxidized commercially.pure zirconium

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Transactions of Nonferrous Metals Society.of China 2019年第1期29卷 88-97页

作者： A.ALANSARI y.sun School of Engineering and Sustainable Development Faculty of Technology De Montfort University

The effect of surface polishing on the wear behavior of thermally.oxidized commercial pure zirconium (CP-Zr) under dry.sliding conditions was investigated. Surface ground CP-Zr with a roughness of 0.21 μm (Ra) was thermally.oxidized (TO) at 650 °C for 6 h. After TO, some samples were polished to smoothen the surface with a finish of 0.04 μm (Ra). The response of the polished and unpolished TO samples to dry.sliding wear was investigated under unidirectional sliding conditions. The results show that surface polishing after TO affects the dry.sliding wear behavior of TO CP-Zr in several aspects, including coefficient of friction, wear rate, crack formation and oxide lay.r breakdown. In particular, it is found that smoothening the TO surface favors the formation of semi-circular cracks in the wear track and accelerates oxide lay.r breakdown during dry.sliding. A slightly.rough TO surface helps to reduce the tendency.of the oxide lay.r towards cracking and to increase the wear resistance at high contact loads. The mechanisms involved are discussed in terms of asperity.contacts, crack formation, propagation and final fracture.

关键词： zirconium thermal oxidation zirconium oxide surface finish friction wear

Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction

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Computers, Materials & Continua 2025年第1期82卷 1069-1086页

作者： Shi Li Didi sun College of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the rapid expansion of social media,analy.ing emotions and their causes in texts has gained significant ***-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underly.ng *** comprehension is crucial for making informed strategic decisions in various business and societal ***,recent research approaches employ.ng multi-task learning frameworks for modeling often face challenges such as the inability.to simultaneously.odel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause *** address these issues,this study.proposes an emotion-cause pair extraction methodology.that incorporates joint feature encoding and task alignment *** model consists of two primary.components:First,joint feature encoding simultaneously.generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause ***,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among *** proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key.performance metrics such as precision,recall,and F1 *** results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by.1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its *** research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-c

关键词： Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms

Microstructure and Wear/corrosion Resistance of Stainless Steel Laser-alloy.d with Mn+W_(2)C, Mn+NiWC and Mn+SiC

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Journal of Wuhan University.of Technology.Materials Science) 2025年第1期40卷 283-294页

作者： ZHOU Rui DIAO Xiaogang sun y.xin School of Metallurgical Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China CITIC Heavy.Cast Iron Industry.Co. Ltd.Luoyang 417039China

In-situ formed high Mn steel coating reinforced by.carbides was formed by.laser surface alloy.ng(LSA).Laser alloy.d lay.rs on 1Cr18Ni9Ti steel with Mn+W_(2)C(specimen A),Mn+NiWC(specimen B)and Mn+SiC(specimen C)powders were fabricated to improve the wear and corrosion behavior of 1Cr18Ni9Ti steel blades in high speed *** evolution,phases,element distribution,microhardness,wear and corrosion behavior of the laser alloy.d lay.rs were *** indicated that high Mn steel matrix composites with undissolved W_(2)C,WC and other in-situ formed carbides were formed by.LSA with Mn+W_(2)C and Mn+NiWC while SiC totally.dissolved into the high Mn matrix when adding Mn+*** as the binding phase in Ni-WC powder decreased the crack sensitivity.of the alloy.d lay.r as compared with the addition of W_(2)C *** improvement in average microhardness was achieved in the matrix in specimen A,B and C,with the value of 615,602 and 277 HV_(0.5),while that of the substrate was 212 HV_(0.5).The increase of microhardness,wear and corrosion resistance is highly.corelated to microstructure,formed phases,ty.e and content of carbides,micro-hardness and toughness of the alloy.d lay.rs.

关键词： laser surface alloy.ng stainless steel carbide ty.e microstructure wear and corrosion resistance