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Genome-wide association study identifies 12 new genetic loci associated with growth traits in pigs

Journal of Integrative Agriculture 2024年第1期23卷 217-227页

作者： mu Zeng Binhu Wang Lei Liu Yalan Yang Zhonglin Tang Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding/Key Laboratory of Animal Molecular Design and Precise Breeding of Guangdong Higher Education Institutes School of Life Science and EngineeringFoshan UniversityFoshan 528231China Kunpeng Institute of Modern Agriculture at Foshan Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesFoshan 528200China Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agriculture/Key Laboratory of Livestock and Poultry Multi-omics of Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China

Growth traits are among the most important economic traits in pigs and are regulated by polygenes with complex regulatory *** the major indicators of growth performance,the backfat thickness(BFT),loin eye area(LEA),and days to 100 kg(D100)traits are commonly used to the genetics improvement in ***,the available genetic markers for these traits are *** uncover novel loci and candidate genes associated with growth performance,we collected the phenotypic information of BFT,LEA,and D100 in 1,186 pigs and genotyped all these individuals using the Neogen GGP porcine 80K *** performed a genome-wide association study(GWAS)using 4 statistical models,including mixed linear models(MLM),fixed and random model circulating probability unification(FarmCPU),settlement of MLM under progressively exclusive relationships(SUPER),Bayesian-information and linkage-disequilibrium Iteratively nested keyway(Blink),and identified 5,3,and 6 high-confidence single nucleotide polymorphisms(SNPs)associated with BFT,LEA,and D100,*** annotation and quantitative trait locus(QTL)mapping analysis suggested that6 genes(SKAP2,SATB1,PDE7B,PPP1R16B,WNT3,and WNT9B)were potentially associated with growth performance in *** analysis suggested that the expression of Src Kinase Associated Phosphoprotein 2(SKAP2)was higher in prenatal muscles than in postnatal muscles,and the expression of Phosphodiesterase 7B(PDE7B)continuously increased during the prenatal stages and gradually decreased after birth,implying their potential roles in prenatal skeletal muscle ***,this study provides new candidate loci and genes for the genetic improvement of pigs.

关键词： GWAS pig growth trait QTL mapping skeletal muscle

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Alternative splicing and related RNA binding proteins in human health and disease

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Signal Transduction and Targeted Therapy 2024年第3期9卷 839-871页

作者： Yining Tao Qi Zhang Haoyu Wang Xiyu Yang Haoran mu Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of Medicine200000 ShanghaiChina Shanghai Bone Tumor Institution 200000 ShanghaiChina Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory for Tumor Microenvironment and InflammationShanghai Jiao Tong University School of Medicine200000 ShanghaiChina

Alternative splicing(AS)serves as a pivotal mechanism in transcriptional regulation,engendering transcript diversity,and modifications in protein structure and *** varying tissues,developmental stages,or under specific conditions,AS gives rise to distinct splice *** implies that these isoforms possess unique temporal and spatial roles,thereby associating AS with standard biological activities and *** these,AS-related RNA-binding proteins(RBPs)play an instrumental role in regulating alternative splicing *** physiological conditions,the diversity of proteins mediated by AS influences the structure,function,interaction,and localization of proteins,thereby participating in the differentiation and development of an array of tissues and *** pathological conditions,alterations in AS are linked with various diseases,particularly *** changes can lead to modifications in gene splicing patterns,culminating in changes or loss of protein *** instance,in cancer,abnormalities in AS and RBPs may result in aberrant expression of cancer-associated genes,thereby promoting the onset and progression of *** and RBPs are also associated with numerous neurodegenerative diseases and autoimmune ***,the study of AS across different tissues holds significant *** review provides a detailed account of the recent advancements in the study of alternative splicing and AS-related RNA-binding proteins in tissue development and diseases,which aids in deepening the understanding of gene expression complexity and offers new insights and methodologies for precision medicine.

关键词： organs alterations thereby

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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing

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Food Science and Human Wellness 2024年第1期13卷 75-89页

作者： Xiaofei Wang Xiaowen Cheng Huiling Liu Xiaohuan mu Hao Zheng National Engineering Technology Research Center for Fruit and Vegetable Processing Key Open Laboratory of Fruit and Vegetable ProcessingMinistry of Agriculture and Rural AffairsBeijing Key Laboratory of Food Non-Thermal ProcessingCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Due to the complex natures of dietary food components,it is difficult to elucidate how the compounds affect host *** food often selectively presents its mechanism of action on different cell types,and participates in the modulation of targeted cells and their microenvironments within ***,the limitations of traditional in vitro assays or in vivo animal experiments cannot comprehensively examine cellular heterogeneity and the tissue-biased ***-cell RNA sequencing(sc RNA-seq)has emerged as an indispensable methodology to decompose tissues into different cell types for the demonstration of transcriptional profiles of individual *** RNA-seq applications has been summarized on three typical organs(brain,liver,kidney),and two representative immune-and tumor related health *** everincreasing role of sc RNA-seq in dietary food research with further improvement can provide sub-cellular information and the coupling between other cellular *** this review,we propose utilizing sc RNAseq to more effectively capture the subtle and complex effects of food chemicals,and how they may lead to health problems at single-cell *** novel technique will be valuable to elucidate the underlying mechanism of both the health benefits of food nutrients and the detrimental consequences food toxicants at the cellular level.

关键词： Dietary food Cellular heterogeneity Single-cell RNA sequencing Food nutrients Food toxicants

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The journey towards physiology and pathology: Tracing the path of neuregulin 4

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Genes & Diseases 2024年第2期11卷 687-700页

作者： Min Chen Jieying Zhu Hongyang Luo Wangjing mu Liang Guo School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Neuregulin 4 (Nrg4),an epidermal growth factor (EGF) family member,can bind to and activate the ErbB4 receptor tyrosine ***4 has five different isoforms by alternative splicing and performs a wide variety of ***4 is involved in a spectrum of physiological processes including neurobiogenesis,lipid metabolism,glucose metabolism,thermogenesis,and *** pathological processes,Nrg4 inhibits inflammatory factor levels and suppresses apoptosis in inflammatory *** addition,Nrg4 could ameliorate obesity,insulin resistance,and cardiovascular ***,Nrg4 improves non-alcoholic fatty liver disease (NAFLD) by promoting autophagy,improving lipid metabolism,and inhibiting cell death of ***,Nrg4 is closely related to the development of cancer,hyperthyroidism,and some other ***,elucidation of the functional role and mechanisms of Nrg4 will provide a clearer view of the therapeutic potential and possible risks of Nrg4.

关键词： Angiogenesis Cardiovascular diseases Inflammation Insulin resistance Lipid and glucose metabolism NAFLD Neurobiogenesis Obesity

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Study on the performance of lightweight roadway wall thermal insulation coating containing EP-GHB mixed ceramsite

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Building Simulation 2024年第5期17卷 785-798页

作者： Yongliang Zhang Shili Yin Hongwei mu Xilong Zhang Qinglei Tan Bing Shao Key Lab of Industrial Fluid Energy Conservation and Pollution Control Ministry of EducationQingdao University of TechnologyQingdaoShandong266520China College of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdaoShandong266520China

As the mining depth increases,the problem of high-temperature thermal damage mainly caused by heat dissipation of surrounding rock is becoming more and more *** is very important to solve the environmental problem of mine heat damage to improve the efficiency of mineral resource exploitation and protect the physical and mental health of *** can apply thermal insulation coating on the walls of mine roadways as a means of implementing active heat *** this paper,expanded perlite(EP)and glazed hollow bead(GHB)are used as the main thermal insulation materials,ceramsite and sand as aggregate,plus glass fiber and sodium dodecyl sulfate to develop a new lightweight composite thermal insulation coating through orthogonal experiment *** to the plate heat flow meter method and mechanical test method,the thermal insulation and mechanical properties of EP-GHB mixed ceramsite coating were studied by making specimens with different parameter ratios,and according to the analysis of the experimental results,the optimal mix ratio of the coating was *** addition,Fluent numerical simulation software was used to establish the roadway model,and the thermal insulation effect of the coating in the roadway under different working conditions was *** results show that the thermal conductivity of the prepared composite thermal insulation coating material is only 8.5% of that of ordinary cement mortar,and the optimal thickness of adding thermal insulation coating is 0.2 m,which can reduce the outlet air temperature of the roadway with a length of 1000 m by 4.87 K at this *** thermal insulation coating developed in this study has the advantages of simple technology and strong practicability,and has certain popularization and application value in mine heat damage control.

关键词： high-temperature mine thermal insulation coating orthogonal experimental optimal fit ratio numerical simulation

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Attitude control of multi-spacecraft systems on SO(3)with stochastic links failure

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Chinese Journal of Aeronautics 2024年第3期37卷 320-331页

作者： KANG Zeyu SHEN Qiang WU Shufan Chris J.DAMAREN mu Zhongcheng School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China Institute for Aerospace Studies University of TorontoTorontoOntario M3H 5T6Canada

In this paper,for multi-Spacecraft System(MSS)with a directed communication topology link and a static virtual leader,a controller is proposed to realize attitude consensus and attitude stabilization with stochastic links failure and actuator ***,an MSS attitude error model suitable for a directed topology link and with a static virtual leader based on SO(3)is derived,which considers that the attitude error on SO(3)cannot be defined based on algebraic ***,we design a controller to realize the MSS on SO(3)with attitude consensus and attitude stabilization under stochastic links failure and actuator ***,the simulation results of a multi-spacecraft system with stochastic links failure and a static virtual leader spacecraft are demonstrated to illustrate the efficiency of the attitude controller.

关键词： multi-spacecraft systems Attitude consensus Attitude stabilization Stochastic links failure Super-martingale convergence

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A Pre-Selection-Based Ant Colony System for Integrated Resources Scheduling Problem at Marine Container Terminal

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Computers, Materials & Continua 2024年第8期80卷 2363-2385页

作者： Rong Wang Xinxin Xu Zijia Wang Fei Ji Nankun mu School of Electronic and Information Engineering South China University of TechnologyGuangzhou510641China School of Computer Science and Technology Ocean University of ChinaQingdao266100China School of Computer Science and Cyber Engineering Guangzhou UniversityGuangzhou510006China School of Computer Science Chongqing UniversityChongqing400044China

Marine container terminal(MCT)plays a key role in the marine intelligent transportation system and international logistics ***,the efficiency of resource scheduling significantly influences the operation performance of *** solve the practical resource scheduling problem(RSP)in MCT efficiently,this paper has contributions to both the problem model and the algorithm ***,in the problem model,different from most of the existing studies that only consider scheduling part of the resources in MCT,we propose a unified mathematical model for formulating an integrated *** new integrated RSP model allocates and schedules multiple MCT resources simultaneously by taking the total cost minimization as the ***,in the algorithm design,a pre-selection-based ant colony system(PACS)approach is proposed based on graphic structure solution representation and a pre-selection *** the one hand,as the RSP can be formulated as the shortest path problem on the directed complete graph,the graphic structure is proposed to represent the solution encoding to consider multiple constraints and multiple factors of the RSP,which effectively avoids the generation of infeasible *** the other hand,the pre-selection strategy aims to reduce the computational burden of PACS and to fast obtain a higher-quality *** evaluate the performance of the proposed novel PACS in solving the new integrated RSP model,a set of test cases with different sizes is *** results and comparisons show the effectiveness and efficiency of the PACS algorithm,which can significantly outperform other state-of-the-art algorithms.

关键词： Resource scheduling problem(RSP) ant colony system(ACS) marine container terminal(MCT) pre-selection strategy

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The role of hydrogen bonding in solubilizing camptothecin in hydrophilic and hydrophobic ionic liquids

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Green Chemical Engineering 2024年第4期5卷 489-500页

作者： Xiaotong Zhu Liwen mu Jiahua Zhu Xiaohua Lu Yuanhui Ji Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research School of Chemistry and Chemical Engineering Southeast University State Key Laboratory of Materials-oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University

Utilizing ionic liquid(IL)-water mixtures as selective extraction solvents for raw materials from natural sources represents an efficacious approach; however, elucidating the underlying mechanisms inherent in various types of IL-aqueous solutions continues to pose a significant challenge. In this study, molecular dynamics simulations and density functional theory calculations are employed to illuminate the influence of the functional anion within ILs and the water content on the solvation mechanism and phase separation phenomena observed during the extraction of camptothecin(CPT) using aqueous IL solutions. The simulation results show that the anions in ILs preferentially dissolve CPT through hydrogen bonding at low water concentrations. As the water concentration increases, the hydrophobic IL binds more tightly to CPT, enabling the water to self-aggregate. The anions in hydrophilic IL form hydrogen bonds with water instead, further enhancing the dissolution of CPT. This work reveals the mechanism of phase separation and solvation of different types of IL aqueous solutions, which is helpful in developing new drug extraction and purification technologies.

关键词： Ionic liquids Hydrogen bonding Molecular dynamics simulation Phase separation Quantum chemistry calculations

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Geometric prior guided hybrid deep neural network for facial beauty analysis

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 467-480页

作者： Tianhao Peng mu Li Fangmei Chen Yong Xu David Zhang The School of Computer Science and Technology Guizhou UniversityGuiyangChina Department of Automation Moutai InstituteRenhuaiGuizhouChina The School of Computer Science and Technology Harbin Institute of TechnologyShenzhenShenzhenChina The Information and Communication Engineering Department Dalian Minzu UniversityDalianChina The School of Data Science The Chinese University of Hong KongShenzhenShenzhenChina

Facial beauty analysis is an important topic in human *** may be used as a guidance for face beautification applications such as cosmetic *** neural networks(DNNs)have recently been adopted for facial beauty analysis and have achieved remarkable ***,most existing DNN-based models regard facial beauty analysis as a normal classification *** ignore important prior knowledge in traditional machine learning models which illustrate the significant contribution of the geometric features in facial beauty *** be specific,landmarks of the whole face and facial organs are introduced to extract geometric features to make the *** by this,we introduce a novel dual-branch network for facial beauty analysis:one branch takes the Swin Transformer as the backbone to model the full face and global patterns,and another branch focuses on the masked facial organs with the residual network to model the local patterns of certain facial ***,the designed multi-scale feature fusion module can further facilitate our network to learn complementary semantic information between the two *** model optimisation,we propose a hybrid loss function,where especially geometric regulation is introduced by regressing the facial landmarks and it can force the extracted features to convey facial geometric *** performed on the SCUT-FBP5500 dataset and the SCUT-FBP dataset demonstrate that our model outperforms the state-of-the-art convolutional neural networks models,which proves the effectiveness of the proposed geometric regularisation and dual-branch structure with the hybrid *** the best of our knowledge,this is the first study to introduce a Vision Transformer into the facial beauty analysis task.

关键词： deep neural networks face analysis face biometrics image analysis

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A commentary of"Artificial intelligence models bring new breakthroughs in global accurate weather forecasting":Top 10 Scientific Advances of 2023,China

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Fundamental Research 2024年第3期4卷 690-692页

作者： mu mu Bo Qin Guokun Dai Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Key Laboratoryof PolarAmospherecean-iceSystemfor Weatherand Climate Ministryof EducationFudan Universityhanghai200438China

Skillful weather forecasts have the potential to save lives,support emergency management,and mitigate economic and social losses,which capture the public's *** present framework of numerical weather prediction(NWP)can trace its origins back to the 1950s,by solving partial differential equations(PDEs)that describe atmospheric motion,to infer future atmospheric *** forecasts typically require several hours on a supercomputer with hundreds of nodes for the upcoming *** the various numerical models used by operational centers,the Integrated Forecasting System(IFS)from the European Centre for Medium-Range Weather Forecasts(ECMWF)stands out for its superior skills in medium-range weather *** quiet revolution of NwP has also been evaluated by the World Meteorological Organization as one of the most significant scientific,technological and social advances in the twentieth century[1].

关键词： weather forecasting breakthrough

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