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Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis

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World Journal of Clinical Cases 2019年第12期7卷 1367-1382页

作者： Lavinia alice Balaceanu Department of Internal Medicine Carol Davila University of Medicine and Pharmacy Sf. Ioan Clinical Emergency Hospital

Hepatocellular carcinoma (HCC) is the 5th most frequently diagnosed cancer in the world, according to the World Health Organization. The incidence of HCC is between 3/100000 and 78.1/100000, with a high incidence reported in areas with viral hepatitis B and hepatitis C, thus affecting Asia and Africa predominantly. Several international clinical guidelines address HCC diagnosis and are structured according to the geographical area involved. All of these clinical guidelines, however, share a foundation of diagnosis by ultrasound surveillance and contrast imaging techniques, particularly computed tomography, magnetic resonance imaging, and sometimes contrast-enhanced ultrasound. The primary objective of this review was to systematically summarize the recent published studies on the clinical utility of serum biomarkers in the early diagnosis of HCC and for the prognosis of this disease.

关键词： Hepatocellular carcinoma Biomarkers Imaging Ultrasonography Computed tomography Magnetic resonance imaging

Energy tunnels:concept and design aspects

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Underground Space 2018年第4期3卷 268-276页

作者： Marco Barla alice Di Donna Department of Structural Building and Geotechnical EngineeringPolitecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItaly

Geotechnical structures are increasingly employed as energy geostructures in Europe and *** being constructed for their primary structural role,they are equipped to exchange heat with the ground and supply thermal energy for heating and cooling of buildings and de-icing of *** technology can play a fundamental role in the current challenge of addressing the increasing need for clean and renewable sources of *** study investigates the possibility of thermal activation of tunnel ***,attention will be paid on a new energy segment,which can be used together with tunnel boring machine tunneling to create so-called energy *** and mechanical designs need to be developed by making effective use of computational methods to quantify the exploitable heat and assess the possible consequences on the surrounding ground and the structure *** on how to proceed in this direction will be provided in this study,showing how thermo-hydro and thermo-mechanical numerical analyses can be used to achieve a proper and effective design of energy *** examples of possible applications will also be presented.

关键词： Energy tunnel Geothermal energy Heating and cooling Geotechnical design

National Carbon Capture Center:advancing fossil energy technology solutions

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Clean Energy 2020年第3期4卷 300-304页

作者： Jo alice Driggers Southern Company National Carbon Capture CenterWilsonvilleALUSA

Introduction The National Carbon Capture Center is the primary carbon-capture research facility for the US Department of Energy(DOE).Through its role as a neutral test site,the centre is advancing technologies to reduce greenhouse-gas(GHG)emis-sions from fossil-fueled power plants,while also supporting the development of technology solutions for carbon-dioxide(CO_(2))utilization and direct air capture(DAC).

关键词： solutions dioxide neutral

Mitochondrial bioenergetics and neurodegeneration:a paso doble

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Neural Regeneration Research 2021年第4期16卷 686-687页

作者： alice Rossi Paola Pizzo Department of Biomedical Sciences University of PaduaPaduaItaly Department of Neuroscience Max-Delbruck Centrum fur Molekulare MedizinBerlinGermany

Mitochondria and neuronal activity:The brain is one of the highest energy demanding organs,consuming~20%of the total ATP produced by the whole ***,neurons mainly rely on ATP synthesized by mitochondrial bioenergetics and neuronal activity is strictly dependent on specific mitochondrial localization at synapses,sites consuming a high amount of energy requested for both pre-and post-synaptic ***,mitochondria produce ATP and buffer Ca^2+rises,two essential processes for neurotransmission and generation of membrane potential along the axon(Magistretti and Allaman,2015).

关键词： organs consuming energetics

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Flow-induced vegetation uprooting in a meandering bend:Experimental investigation

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International Journal of Sediment Research 2022年第3期37卷 399-410页

作者： Donatella Termini alice Di Leonardo Department of Engineering University of Palermo

Vegetation uprooting is a complex process which depends on many interrelated factors. In this paper,attention is focused on the flow-induced uprooting in river bends, where the flow characteristics vary as effected by the channel's curvature and its continuous changing in the downstream direction. Results are presented by an experimental work done in a high-amplitude meandering flume with mature herbaceous vegetation on the bed. In the first part of the paper, the variation along the bend of the geometrical(length, thickness, and radical architecture) and the mechanical(resistance force) characteristics of the roots are analyzed. In the second part of the paper, the transition from the condition of vegetation distributed on the bed to the condition of vegetation uprooted by the flow is experimentally *** results show that the flow-induced uprooting varies along the bend depending on the roots' geometrical and mechanical characteristics which are, in turn, influenced by the variation of the water surface elevation along the bend itself. It has been found that lower values of the resistance force occur at the apex section where the roots are characterized by higher values of length and lower values of thickness and have radical apparatuses characterized by limited encumbrance, a high number of roots,and low bushyness. The flow-induced uprooting especially develops close to the outer bank along the channel reach between the bend entrance and the apex section, where the root resistance force and the water surface slope tend to decrease in value.

关键词： Physical experiment River bend Resistance Flow disturbance Vegetation Uprooting

Squirrel Search Optimization with Deep Convolutional Neural Network for Human Pose Estimation

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Computers, Materials & Continua 2023年第3期74卷 6081-6099页

作者： K.Ishwarya A.alice Nithya Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203TamilnaduIndia

Human pose estimation(HPE)is a procedure for determining the structure of the body pose and it is considered a challenging issue in the computer vision(CV)*** finds its applications in several fields namely activity recognition and human-computer *** the benefits of HPE,it is still a challenging process due to the variations in visual appearances,lighting,occlusions,dimensionality,*** resolve these issues,this paper presents a squirrel search optimization with a deep convolutional neural network for HPE(SSDCNN-HPE)*** major intention of the SSDCNN-HPE technique is to identify the human pose accurately and ***,the video frame conversion process is performed and pre-processing takes place via bilateral filtering-based noise removal ***,the EfficientNet model is applied to identify the body points of a person with no problem ***,the hyperparameter tuning of the EfficientNet model takes place by the use of the squirrel search algorithm(SSA).In the final stage,the multiclass support vector machine(M-SVM)technique was utilized for the identification and classification of human *** design of bilateral filtering followed by SSA based EfficientNetmodel for HPE depicts the novelty of the *** demonstrate the enhanced outcomes of the SSDCNN-HPE approach,a series of simulations are *** experimental results reported the betterment of the SSDCNN-HPE system over the recent existing techniques in terms of different measures.

关键词： Parameter tuning human pose estimation deep learning squirrel search algorithm activity recognition

Hard to fly the nest： A study of body condition and plumage quality in house sparrow fledglings

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Current Zoology 2014年第4期60卷 449-459页

作者： Charlene LELOUTRE alice GOUZERH Frederic ANGELIER Centre d'Etudes Biologiques de Chiz6 CNRS F-79360 Villiers en Bois France

Contrary to the nestling phase, the post-fledging phase has been less studied probably because it is challenging to follow the chicks after they fledge. However, this phase is crucial to consider when focusing on the life cycle of individuals because it is associated with new demands： After leaving the nest, individuals have to find their own food and cope with a new set of previously unknown stressors. In this study, we aimed at better understanding how energetically demanding the post-ftedging period is in house sparrows Passer domesticus by measuring several indices of a fledgling＇s state （body condition, fat and muscle scores and plumage quality）. If the energetic demands of the post-fledging period are greater than those of the adult life, we predicted that fledglings should be in lower condition and should have a plumage of lower quality relative to adults. Supporting this prediction, the condition and the plumage of fledglings differed dramatically from those of adults. Interestingly, this difference disappeared in autumn. Overall, our results suggest that the post-fledging period is probably one of the most energetically demanding of the life cycle in this species. Supporting this idea, the resighting probability of fledglings was lower relative to adults. However, resighting probability depends on many factors （mortality, dispersal, habitat use and behaviours） and future studies are necessary to tease apart their relative importance in determining resighting probability [Current Zoology 60 （4）： 449-459, 2014].

关键词： Body condition Fault bar Fat score Muscle score Passer domesticus

Microglia-oligodendrocyte intercellular communication: role of extracellular vesicle lipids in functional signalling

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Neural Regeneration Research 2021年第6期16卷 1194-1195页

作者： alice Gualerzi Marta Lombardi Claudia Verderio IRCCS Fondazione Don Carlo Gnocchi MilanItaly CNR Institute of Neuroscience MilanItaly

The term microglia refers to the group of resident brain immune-cells that are responsible,mainly,for the immune response and the homeostasis of the *** monocyte-derived macrophages that infiltrate the brain,microglia are longlived cells which arise exclusively from the embryonic yolk sac(Stratoulias et al.,2019).Impairment in microglia functions is at the basis for the development of multiple brain diseases,including multiple sclerosis and neurodegenerative *** the last decade,the number of research articles and reviews dealing with the role of microglia in the pathogenesis of brain disorders has exponentially increased.

关键词： al. homeostasis diseases

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Novel Contiguous Cross Propagation Neural Network Built CAD for Lung Cancer

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Computer Systems Science & Engineering 2023年第2期44卷 1467-1484页

作者： A.alice Blessie P.Ramesh Department of Electronics&Communication Engineering Government College of EngineeringTirunelveli627007TamilnaduIndia Department of Electrical&Electronics Engineering University College of EngineeringRamanathapuram623513TamilnaduIndia

The present progress of visual-based detection of the diseased area of a malady plays an essential part in the medicalﬁ*** that case,the image proces-sing is performed to improve the image data,wherein it inhibits unintended dis-tortion of image features or it enhances further processing in various applications andﬁ*** helps to show better results especially for diagnosing *** late the early prediction of cancer is necessary to prevent disease-causing *** work is proposed to identify lung cancer using lung computed tomo-graphy(CT)scan *** helps to identify cancer cells’affected *** the present work,the original input image from Lung Image Database Consortium(LIDC)typically suffers from noise *** overcome this,the Gaborﬁlter used for image processing is highly *** the next stage,the Spherical Iterative Reﬁnement Clustering(SIRC)algorithm identiﬁes cancer-suspected areas on the CT scan *** approach can help radiologists and medical experts recognize cancer diseases and syndromes so that serious progress can be avoided in the early *** new methods help to remove unwanted por-tions of the CT image and better utilization the *** subspace extraction of features approach is beneﬁcial for evaluating lung *** paper introduces a novel approach called Contiguous Cross Propagation Neural Network that tends to locate regions afﬂicted by lung cancer using CT scan pictures(CCPNN).By using the feature values from the fourth step of the procedure,the proposed CCPNN tends to categorize the lesion in the lung nodular *** efﬁciency of the suggested CCPNN approach is evaluated using classiﬁcation metrics such as recall(%),precision(%),F-measure(percent),and accuracy(%).Finally,the incorrect classiﬁcation ratios are determined to compare the trained networks’effectiveness,through these parameters of CCPNN,it obtains the outstanding per-formance of 98.06%and it has provided the lowest false ratio of

关键词： Contiguous cross propagation neural network(CCPNN) Gaborﬁlter