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DEAD-box RNA helicases with special reference to p68:Unwinding their biology,versatility,and therapeutic opportunity in cancer

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Genes & Diseases 2023年第4期10卷 1220-1241页

作者： Shaheda Tabassum mrinal K.ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusSalt LakeKolkata 700091India

In the era of advancement,the entire world continues to remain baffled by the increased rate of progression of *** has been an unending search for novel thera-peutic targets and prognostic markers to curb the oncogenic *** DEAD-box RNA he-licases are a large family of proteins characterized by their evolutionary conserved D-E-A-D(Asp-Glu-Ala-Asp)domain and merit consideration in the oncogenic *** perform multidimensional functions in RNA metabolism and also in the pathology of *** bio-logical role ranges from ribosome biogenesis,RNA unwinding,splicing,modification of second-ary and tertiary RNA structures to acting as transcriptional coactivators/repressors of various important oncogenic *** also play a crucial role in accelerating oncogenesis by pro-moting cell proliferation and ***5(p68)is one of the archetypal members of this family of proteins and has gained a lot of attention due to its oncogenic *** is found to be overexpressed in major cancer types such as colon,brain,breast,and prostate *** exhibits its multifaceted nature by not only coactivating genes implicated in cancers but also mediating crosstalk across major signaling pathways in ***,in this review,we aim to illustrate a comprehensive overview of DEAD-box RNA helicases especially p68 by focusing on their multifaceted roles in different cancers and the various signaling pathways affected by ***,we have also briefly discoursed the therapeutic interventional approaches with the DEAD-box RNA helicases as the pharmacological targets for designing in-hibitors to pave way for cancer therapy.

关键词： Cancer DDX5 DEAD-box RNA helicases Gene expression Oncogene Signaling Therapy Transcription factor

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Preparation of reduced sensitivity co-crystals of cyclic nitramines using spray flash evaporation

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Defence Technology（防务技术） 2020年第1期16卷 188-200页

作者： mrinal ghosh AKSikder Shaibal Banerjee MBTalawar NSikder High Energy Materials Research Laboratory Pune 411021India Defence Institute of Advanced Technology Pune 411025India

The present day weapon technology demands novel energetic materials that exhibit simultaneous high explosive yield and reduced *** article demonstrates application of spray evaporation to prepare reduced sensitive co-crystals of high performance nitramine explosives like HMX and CL-20 with a relatively less insensitive explosive 1,1-diamino-2,2-dinitroethylene or *** intermolecurar hydrogen bonding in FOX-7 is responsible for limited solubility in nost of o rganic *** solubility differences of FOX-7 with HMX and CL-20 restricts ifs co-crystallization through classical methods that yields thermodynamically favorable *** flash evaporation,a kinetic crystallization method,has been therefore adopted and could successfully produce CL-20/FOX-7(2:1) and HMX/FQX-7(4:1) *** fine powdered materials obtained were characterized by SEM,powder XRD,Raman spectro scopy,DSC-TGA *** Raman spectra showed consistent occurrence of spectral features indicating stoichiometric co-existence of ingredients in the crystal *** analysis showed absence of all thermally assisted solidsolid phase transformation in the co-crystals as they were observed in pristine *** thermal stability calculated in terms of activation barrier fordecomposition,revealed the CL-20/FOX-7 co-crystal to be interlediately stable on comparison to their constituents while,the HMX/FOX-7 co-crystal is more *** to pure HMX and CL-20,both the co-crystals have shown higher insensitivity to impact force,suggesting them to be suitable for future generation insensitive munitions.

关键词： Cyclic nitramine Solubility Spray evaporation Co-crystal Reduced sensitivity

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COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

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Genes & Diseases 2023年第4期10卷 1402-1428页

作者： Sunny Kumar Malini Basu Pratyasha ghosh Uttam Pal mrinal K.ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatWest Bengal 743372India Department of Economics Bethune CollegeUniversity of CalcuttaKolkata 700006India

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease *** are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only ***,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical *** in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early *** last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.

关键词： Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2

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Chaperone-assisted E3 ligase CHIP:A double agent in cancer

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Genes & Diseases 2022年第6期9卷 1521-1555页

作者： Sunny Kumar Malini Basu mrinal K.ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatSouth 24 ParaganasWest Bengal 743372India

The carboxy-terminus of Hsp70-interacting protein(CHIP)is a ubiquitin ligase and co-chaperone belonging to Ubox family that plays a crucial role in the maintenance of cellular homeostasis by switching the equilibrium of the folding-refolding mechanism towards the proteasomal or lysosomal degradation *** links molecular chaperones ***70,HSP70 and HSP90 with ubiquitin proteasome system(UPS),acting as a quality control *** contains charged domain in between N-terminal tetratricopeptide repeat(TPR)and C-terminal Ubox *** domain interacts with the aberrant client proteins via chaperones while Ubox domain facilitates the ubiquitin transfer to the client proteins for ***,CHIP is a classic molecule that executes ubiquitination for degradation of client ***,CHIP has been found to be indulged in cellular differentiation,proliferation,metastasis and ***,CHIP can play its dual role as a tumor suppressor as well as an oncogene in numerous malignancies,thus acting as a double ***,in this review,we have reported almost all substrates of CHIP established till date and classified them according to the hallmarks of *** addition,we discussed about its architectural alignment,tissue specific expression,sub-cellular localization,folding-refolding mechanisms of client proteins,E4 ligase activity,normal physiological roles,as well as involvement in various diseases and tumor ***,we aim to discuss its importance in HSP90 inhibitors mediated cancer ***,this report concludes that CHIP may be a promising and worthy drug target towards pharmaceutical industry for drug development.

关键词： Chaperones(HSC70/HSP70&HSP90) CHIP Oncogene Therapy Tumor suppressor Ubiquitin proteasome system(UPS)

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Targeting PD-1/PD-L1 in cancer immunotherapy:An effective strategy for treatment of triple-negative breast cancer(TNBC)patients

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Genes & Diseases 2023年第4期10卷 1318-1350页

作者： Sunny Kumar Mouli Chatterjee Pratyasha ghosh Kirat K.Ganguly Malini Basu mrinal K.ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata 700091JadavpurKolkataPIN 700032India Department of Economics Bethune CollegeUniversity of CalcuttaKolkataPIN 700006India Department of Microbiology Michael Madhusudan Memorial CollegeDurgapurPIN 713216India Department of Microbiology Dhruba Chand Halder CollegeUniversity of CalcuttaKolkataPIN 743372India

Maintaining the balance between eliciting immune responses against foreign pro-teins and tolerating self-proteins is crucial for maintenance of *** functions of programmed death protein 1(PD-1)and its ligand programmed death ligand 1(PD-L1)are to inhibit immune responses so that over-reacting immune cells does not cause any damage to its own body ***,cancer cells hijack this mechanism to attenuate immune cells functions and create an immunosuppressive environment that fuel their continuous growth and *** the past few years’rapid development in cancer immunotherapy has opened a new avenue in cancer *** of PD-1 and PD-L1 has become a potential strategy that rescue the functions of immune cells to fight against cancer with high ***,immune checkpoint monotherapies were not very successful,making breast cancer less ***,recent reports support the presence of tumor infiltrating lympho-cytes(TILs)in breast cancer that make it favorable for PD-1/PD-L1 mediated immunotherapy,which is effective in PD-L1 positive ***,anti-PD-1(pembrolizumab)and anti-PD-L1(atezolizumab)gets FDA approval for breast cancer treatment and make PD-1/PD-L1 immunotherapy is meaningful for further ***,this article gathered understand-ing of PD-1 and PD-L1 in recent years,their signaling networks,interaction with other mole-cules,regulations of their expressions and functions in both normal and tumor tissue microenvironments are crucial to find and design therapeutic agents that block this pathway and improve the treatment ***,authors collected and highlighted most of the important clinical trial reports on monotherapy and combination therapy.

关键词： Breast cancer Cancer Clinical trial Immunotherapy PD-1/PD-L1 TNBC

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The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports

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Signal Transduction and Targeted Therapy 2019年第1期4卷 298-310页

作者： mrinal K.ghosh Dipankar Chakraborty Sibani Sarkar Arijit Bhowmik Malini Basu Signal Transduction in Cancer and Stem Cells Laboratory Division of Cancer Biology and Inflammatory DisorderCouncil of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)4 Raja S.C.Mullick RoadKolkata 700032 and CN-06Sector-VSalt LakeKolkata 700091India Department of Cancer Chemoprevention Chittaranjan National Cancer Institute37 S.P.Mukherjee RoadKolkata 700026India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatSouth 24Paraganas 743372India

Glioma and cerebral ischemic stroke are two major events that lead to patient death *** these conditions have different physiological incidences,~10%of ischemic stroke patients develop cerebral cancer,especially glioma,in the postischemic ***,the high proliferation,venous thrombosis and hypercoagulability of the glioma mass increase the significant risk of thromboembolism,including ischemic ***,these events share several common pathways,***,cerebral inflammation,angiogenesis,etc.,but the proper mechanism behind this co-occurrence has yet to be *** hypercoagulability and presence of the D-dimer level in stroke are different in cancer patients than in the noncancerous *** factors such as atherosclerosis and coagulopathy involved in the pathogenesis of stroke are partially responsible for cancer,and the reverse is also partially *** on clinical and neurosurgical experience,the neuronal structures and functions in the brain and spine are observed to change after a progressive attack of ischemia that leads to hypoxia and *** major population of cancer cells cannot survive in an adverse ischemic environment that excludes cancer stem cells(CSCs).Cancer cells in stroke patients have already metastasized,but early-stage cancer patients also suffer stroke for multiple ***,stroke is an early manifestation of *** and cancer share many factors that result in an increased risk of stroke in cancer patients,and *** intricate mechanisms for stroke with and without cancer are *** review summarizes the current clinical reports,pathophysiology,probable causes of co-occurrence,prognoses,and treatment possibilities.

关键词： cerebral glioma sized

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Emerging insights into HAUSP (USP7) in physiology, cancerand other diseases

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Signal Transduction and Targeted Therapy 2018年第1期3卷 162-173页

作者： Seemana Bhattacharya Dipankar Chakraborty Malini Basu mrinal K ghosh Signal Transduction in Cancer and Stem Cells Laboratory Division of Cancer Biology and Inflammatory DisorderCouncil of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)4 Raja S.C.Mullick RoadKolkata-700032 and CN-06Sector-VSalt LakeKolkata 700091India Department of Microbiology Barrackpore Rastraguru Surendranath College6 Riverside Road and 85 Middle RoadBarrackporeKolkata 700120India

Herpesvirus-associated ubiquitin-specific protease(HAUSP)is a USP family *** is a protein of immense biological importance as it is involved in several cellular processes,including host-virus interactions,oncogenesis and tumor suppression,DNA damage and repair processes,DNA dynamics and epigenetic modulations,regulation of gene expression and protein function,spatio-temporal distribution,and immune *** its discovery in the late 1990s as a protein interacting with a herpes virus regulatory protein,extensive studies have assessed its complex roles in p53-MDM2-related networks,identified numerous additional interacting partners,and elucidated the different roles of HAUSP in the context of cancer,development,and metabolic and neurological *** analyses have provided new insights into its biochemical and functional *** this review,we provide a comprehensive account of our current knowledge about emerging insights into HAUSP in physiology and diseases,which shed light on fundamental biological questions and promise to provide a potential target for therapeutic intervention.

关键词： diseases HAUSP insight

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An analytical approach for the fractional-order Hepatitis B model using new operator

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International Journal of Biomathematics 2024年第1期17卷 177-198页

作者： Surath ghosh Division of Mathematics School of Advanced Sciences Vellore Institute of TechnologyChennaiIndia

In this work,the main goal is to implement Homotopy perturbation transform method(HPTM)involving Katugampola fractional *** an example,a fractional order Hepatitis model is considered to analyze the *** first,the integer order model is converted to fractional order model in Caputo ***,the new operator Katugampola fractional derivative is used to present the *** new such kind of operator is illustrated in Caputo *** is described to get the solution of the proposed model using the new kind of ***,there are some analyses about the new kind of operator to prove the efficiency of the operator.

关键词： Caputo derivative Katugampola fractional derivative homotopy perturbation transform method Hepatitis B model

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Finite-time tracking control of heterogeneous multi-AUV systems with partial measurements and intermittent communication

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Science China(Information Sciences) 2024年第5期67卷 165-182页

作者： Bo CHEN Jiangping HU Bijoy Kumar ghosh School of Automation Engineering University of Electronic Science and Technology of China Key Laboratory of Intelligent Analysis and Decision on Complex Systems Chongqing University of Posts and Telecommunications Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Department of Mathematics and Statistics Texas Tech University

The development of a distributed trajectory-tracking control strategy that is independent of velocity measurements is critical to achieving finite-time tracking control of autonomous underwater vehicle(AUV) systems. In this study, a group of heterogeneous AUV systems with intermittent communication links is considered and a finite-time trajectory-tracking control strategy is developed. The strategy includes two observers and one controller proposed for each follower-AUV. The first observer, a hybrid finite-time observer,estimates the state of the leader, whereas the second observer, which relies only on the position measurement,is proposed to estimate the states of the follower-AUV itself. In addition, a distributed trajectory-tracking controller is designed using the states estimated by the intermittent communication network even without velocity measurements. A homogeneous technique is utilized to prove that all followers can track the leader in a finite time. Finally, the effectiveness of the developed finite-time tracking control strategy is illustrated by numerical simulations.

关键词： distributed observer finite-time tracking homogeneous technique intermittent communication multiple heterogeneous AUVs

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A NEWTON-TYPE GLOBALLY CONVERGENT INTERIOR-POINT METHOD TO SOLVE MULTI-OBJECTIVE OPTIMIZATION PROBLEMS

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Journal of Computational Mathematics 2024年第1期42卷 24-48页

作者： Jauny Prajapati Debdas ghosh Ashutosh Upadhayay Departmant of Mathematical Sciences Indian Institute of Technology(BHU)VaranasiUttar Pradesh 221005India

This paper proposes an interior-point technique for detecting the nondominated points of multi-objective optimization problems using the direction-based cone *** method decomposes the multi-objective optimization problems into a set of single-objective optimization *** this set of problems,parametric perturbed KKT conditions are ***,an interior point technique is developed to solve the parametric perturbed KKT conditions.A differentiable merit function is also proposed whose stationary point satisfies the KKT *** some mild assumptions,the proposed algorithm is shown to be globally *** results of unconstrained and constrained multi-objective optimization test problems are ***,three performance metrics(modified generational distance,hypervolume,inverted generational distance)are used on some test problems to investigate the efficiency of the proposed *** also compare the results of the proposed algorithm with the results of some other existing popular methods.

关键词： Cone method Interior point method Merit function Newton method Global convergence

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