检索结果-南通市图书馆

Affective Behavior Dysregulation Was Induced by Chronic Administration of Copper in Wistar Rats

Neuroscience & Medicine 2019年第2期10卷 134-149页

作者： mouloud lamtai Sihame Ouakki Oussama Zghari Abdelhalem Mesfioui Aboubaker El Hessni Ali Ouichou Unit of Nervous and Endocrine Physiology Laboratory of Genetics Neuroendocrinology and Biotechnology Faculty of Science University Ibn Tofail Kenitra Morocco

As both deficiency and excess of copper (Cu) can be harmful, dysregulation in its homeostasis has been connected with various neurological disorders. The present study was undertaken to examine whether Cu chronic administration can induce alterations of affective behavior especially anxiety and depression levels in male and female rats. Twenty-four rats, for each gender, divided in control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or CuCl2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. Results demonstrated that Cu administered chronically, exerts an anxiogenic effect in rats. In the OFT, Cu decreases the TCA and NRC parameters without modifying the locomotor activity represented by the NTS parameter. With regard to EPM, Cu decreases TOA and EOA parameters without modifying the TAE parameter. A significant increase in depression-like symptoms was also exhibited by Cu treated rats (p 2 showed maximum anxiety-like and depression-like symptoms as compared to controls as well as from the other two doses indicating dose-dependent effects of chronic Cu administration. Overall, these results suggest that intoxication with Cu has potentially deleterious effects on brain as reflected in behavioral dysfunctions such as depression and anxiety.

关键词： Copper Depression-Like Anxiety-Like Rat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Chronic Aluminum Administration on Affective and Cognitive Behavior in Male and Female Rats

引用

Journal of Behavioral and Brain Science 2018年第4期8卷 179-196页

作者： Oussama Zghari Ayoub Rezqaoui Sihame Ouakki mouloud lamtai Jihane Chaibat Abdelhalem Mesfioui Aboubaker El Hessni El-Housseine Rifi Azzouz Essamri Ali Ouichou Unit of Nervous and Endocrine Physiology Laboratory of Genetics Neuroendocrinology and Biotechnology University Ibn Tofail Kenitra Morocco Laboratory of Synthesis Organic and Extraction Processes Department of Chemistry Faculty of Science University Ibn Tofail Kenitra Morocco Laboratory of Agro-Resources and Process Engineering Faculty of Science University Ibn Tofail Kenitra Morocco

In this study, we investigated the effect of chronic exposure of low doses of Aluminum on affective and cognitive disorders in male and female rats. Twenty-five rats for each gender are used and the treatment carried out for 8 weeks. Animals received distilled water for control or an intraperitoneal injection of different doses of Aluminum: 0.125, 0.25, 0.5 and 1 mg/kg. Behavioral performance is measured in various tests mainly the Open Field, Elevated Plus Maze, Force Swimming Test, Morris Water Maze, Y-maze and Object Recognition Test. Al exerts anxiogenic properties and depressive effect. The effect begins at 0.25 mg/kg to reach a maximum at 1 mg/kg. In addition, chronic exposure to Aluminum causes cognitive disorders characterized by affection of memory and influence spatial learning performance. The effect of Aluminum on working memory is effective just at 1 mg/kg, while the effect on spatial learning performance begins at 0.25 mg/kg to reach a maximum at 1 mg/kg. In conclusion, Aluminum enhances anxiety and depression parameters and cognitive disorders characterized by the affection of memory and spatial learning performance.

关键词： Aluminum Anxiety Depression Memory Behavioral Tests Wistar Rat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Chronic Administration of Cadmium on Anxiety-Like, Depression-Like and Memory Deficits in Male and Female Rats: Possible Involvement of Oxidative Stress Mechanism

引用

Journal of Behavioral and Brain Science 2018年第5期8卷 240-268页

作者： mouloud lamtai Jihane Chaibat Sihame Ouakki Inssaf Berkiks El-Housseine Rifi Aboubaker El Hessni Abdelhalem Mesfioui Ali Tadlaoui Hbibi Hassna Ahyayauch Azzouz Essamri Ali Ouichou Unit of Nervous and Endocrine Physiology Laboratory of Genetics Neuroendocrinology and Biotechnology Faculty of Science University Ibn Tofail Kenitra Morocco Laboratory of Synthesis Organic and Extraction Processes Department of Chemistry Faculty of Science University Ibn Tofail Kenitra Morocco Institut Supé rieur des Professions Infirmiè res et Techniques de Santé (ISPISTS) route Casablanca Rabat Morocco Laboratory of Agro-Resources and Process Engineering Faculty of Science University Ibn Tofail Kenitra Morocco

The main objective of this work is to study the effect of chronic administration of cadmium (Cd) on the level of depression-like, anxiety-like, memory state and oxidative stress in male and female Wistar rats. For this purpose, this study was conducted with 24 rats for each gender. Four groups were constituted: (Group 1: Control): received saline solution NaCl (0.9%), (Group 2: Cd-0.25;Group 3: Cd-0.5;Group 4: Cd-1): received daily 0.25 mg/kg, 0.5 mg/kg and 1 mg/kg of Cd respectively during 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. The Y maze was used to evaluate the working memory and the Morris Water Maze, to evaluate space learning and spatial memory. The results revealed that in males, all doses of Cd provoke depression-like, while in females only the group treated with 1 mg/kg Cd shows elevated depression-like behavior. In regard to anxiety-like behavior, Cd induces an anxiogenic effect in both genders tests. In the Y-Maze test, both males and females expressed a low percentage of alternations, suggesting that working memory was affected by Cd at 1 mg/kg. In the Morris Water Maze test, the space learning and spatial memory were significantly impaired in the group Cd-1. Neurochemical analysis showed that levels of nitric oxide and lipid peroxidation in the hippocampus were significantly increased after Cd treatments. Overall analysis of our data revealed that Cd caused significant alterations in the examined parameters that were sex-dependent and dose-dependent.

关键词： Cadmium Depression-Like Anxiety-Like Memory Oxidative Stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of the Association of a High Fructose Diet and Chronic Mild Stress on Metabolic and Affective Disorders in Male Rat

引用

Journal of Behavioral and Brain Science 2018年第4期8卷 157-170页

作者： Y. Chahirou M. lamtai A. Mesfioui A. Ouichou M. Coulibaly R. Boussekkour A. El Hessni Unit of Nervous and Endocrine Physiology Department of Biology Faculty of Science Kénitra Morocco

An early unbalanced nutritional diet can induce affective disorders in adulthood. As well as stress in adolescence can accentuate these disorders. Both human and rat structural changes have been demonstrated in the hippocampus, likewise, oxidative stress may be involved in these disturbances. The objective of this study is to see the impact of a high-fructose diet (PN21) associated with chronic mild stress (CMS) at the end of adolescence (PN55) on metabolic and affective disorders in rats Wistar. This study was performed on four groups of male rats: control group, CMS for five weeks (PN55), fructose for ten weeks (PN21) and fructose for ten weeks (PN21) associated with CMS for five weeks (PN55). These animals underwent behavioral tests to evaluate their affective states (open field test, Sucrose preference test). After sacrifice, the dosage of glucose, triglycerides and total cholesterol was performed at the prefrontal cortex (CPF) and also at the hippocampus;the dosage of nitric oxide (NO) was performed, too. The bulk of our results show that fructose induces metabolic disturbances;the CMS induces a state of depression-like, while the association potentiated metabolic disturbances, depression-like state and also inducing anxiety. This study has shown that fructose and CMS can disrupt the various functions of the body and their association can potentiate these disturbances.

关键词： Fructose CMS Metabolic Disorders Oxidative Stress Anxiety Depression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：