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Indications and Results of Lower Gastrointestinal Endoscopy in a Regional Hospital Center in Senegal

Open Journal of Gastroenterology 2023年第1期13卷 43-48页

作者： Marième Polèle Fall Marie Louise Basséne Salamata Diallo Mamadou Ngoné Gueye Cheikh Ahamadou Bamba Cissé Madoky Magatte Diop Daouda Dia mouhamadou mbengue Department of Gastroenterology and Hepatology Aristide Le Dantec Hospital Dakar Senegal Department of Gastroenterology and Hepatology General Hospital Idrrisa Pouye Dakar Senegal Department of Internal Medecine Regional Hospital Center of Thiès Thiès Senegal

Introduction: Gastrointestinal endoscopy plays a crucial role in the management of gastrointestinal diseases. The aim of this study was to report the indications and results of lower digestive endoscopy in a hospital center in Senegal. Patients and Methods: We conducted a descriptive retrospective study from September 1st, 2017, to September 30, 2018 at the gastrointestinal endoscopy unit of the regional hospital center of Thiès. All patients received for lower gastrointestinal endoscopy and whose reports were usable, were included. In the reports, we collected and analyzed sociodemographic data, indication and results of the endoscopic examination. Results: We included 250 patients. There were 140 men (sex ratio 1.27). The average age was 42 years [range 1 - 92 years]. There were 37 colonoscopies (14.8%), 51 rectosigmoidoscopies (20.4%) and 162 anorectoscopies (64.8%). The patients were from the region of Thiès in 82% of cases. In most cases, they were most often referred by general practitioners (22.8%) and surgeons (20.8%). The main indications were rectal bleeding (36.8%), hemorrhoidal disease (23.2%) and proctalgia (11.6%). Hemorrhoidal disease (63.6%), anal fistula (14%) and tumors (8.8%) were the most common pathologies. Conclusion: Admitted patients at the gastrointestinal endoscopy unit of the regional hospital center of Thiès have many indications as well as pathologies. Anal pathology is dominated by hemorrhoidal disease.

关键词： Lower Gastrointestinal Endoscopy Rectal Bleeding Hemorrhoidal Disease

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Benign Stenosis of Oesophagus: About 101 Cases in the Digestive Endoscopy Department of the General Idrissa Pouye Hospital (Dakar, Senegal)

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Open Journal of Gastroenterology 2022年第1期12卷 19-26页

作者： Mamadou Ngoné Guèye Mame Anta Camara Gnagna Diouf Salamata Diallo Cheikh Ahmadou Bamba Cissé Marème Polèle Fall Mame Aïssé Thioubou Marie Louise Bassène Daouda Dial mouhamadou mbengue Hepato-Gastroenterology Department The Idrissa Pouye General Hospital Dakar Senegal Hepato-Gastroenterology Department The Aristide Ledantec Hospital Dakar Senegal Hepato-Gastroenterology Department The Ziguinchor Peace Hospital Dakar Senegal

Introduction: Benign oesophageal strictures are defined as narrowing of the oesophageal lumen not related to neoplastic pathology. They are frequently encountered during endoscopic practice and are often responsible for a reduction in the quality of life of patients due to the appearance of dysphagia. In sub-Saharan Africa, little data are available on these benign esophageal strictures. The objective of our study was to determine the sociodemographic, diagnostic and therapeutic aspects of benign oesophageal strictures in a digestive endoscopy centre in Senegal. Patients and Methods: This was a retrospective, descriptive study analysing reports of upper GI endoscopies performed between January 2015 and December 2017 in a hospital in Senegal. Reports that concluded to have non-neoplastic oesophageal stenosis were collated. Sociodemographic data, indications for and results of endoscopy, and therapeutic modalities were collected. These data were analysed using the Sphinx version 5 software. Results: We collected 101 cases of benign oesophageal stenosis, representing a prevalence of 2.1% in the endoscopy centre. The mean age of the patients was 34 years (range 2 and 83 years) with a median of 37.9 years. There was a female predominance with a sex ratio of 0.38 (73 females). Dysphagia, the main symptom, was present in 87 patients (86

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Plummer-Vinson Syndrome and Esophageal Cancer in an Endoscopy Center of Dakar

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Open Journal of Gastroenterology 2017年第8期7卷 217-222页

作者： Marie Louise Bassene Salamata Diallo Mame Aisse Thioubou Mamadou Ngone Gueye Marieme Polele Fall Daouda Dia mouhamadou mbengue Mamadou Lamine Diouf The Department of Hepato-Gastroenterology Aristide le Dantec HospitalDakarSenegal The Department of Hepato-Gastroenterology General Hospital of Grand YoffDakarSenegal

Introduction: Plummer Vinson Syndrome (PVS) is a rare pathology combining dysphagia, an iron deficiency anemia and a cervical esophageal web. It is one of the risk factors of the esophageal cancer. Objectives: To report the epidemiological, clinical, paraclinical and histological characteristics of patients with Plummer-Vinson syndrome associated with esophageal cancer. Patients and Methods: This was a retrospective study carried out at the digestive endoscopy center of Aristide le Dantec hospital in Dakar from January 2008 to December 2015. We included all patients with Plummer-Vinson syndrome associated with esophageal cancer. Results: We included 7 patients. The mean age was 36 years (24 - 65 years). There were 5 women and 2 men. The mean diagnostic period was 9 months (6 months - 15 years). The main clinical manifestations were dysphagia (100%), weight loss (100%) and clinical anemia (71.4%). The biology showed a mean hemoglobin level of 8.8 g/dl (6 - 11 g/dl), serum iron at 30.8 μg/dl (11 - 52 μg/dl) and ferritinemia at 6.2 ng/dl (1.5 - 25 ng/dl). The upper digestive endoscopy revealed a stenosis web of the cervical esophagus in all patients. An endoscopic dilatation was performed in all cases. After dilation, the endoscopy showed a tumor of the middle third of the esophagus in 4 cases and of the lower third in 3 cases. It was about of a squamous cell carcinoma in the tumors of middle third and of an adenocarcinoma in those of the lower third. Conclusion: At Aristide le Dantec hospital of Dakar, PVS is sometimes associated with an epidermoid carcinoma or an adenocarcinoma of the esophagus. The improvement of the prognosis depends on the early realization of an upper gastrointestinal endoscopy (UGI) in case of any dysphagia and the monitoring of the patients.

关键词： Plummer-Vinson Syndrome Esophageal Cancer Dysphagia Senegal

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Ulcerative Colitis in Sub-Saharan Africa: Analysis of 24 Cases in Dakar (Senegal)

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Open Journal of Gastroenterology 2020年第6期10卷 128-136页

作者： Mamadou Ngoné Gueye Sokhna Niang Diop Salamata Diallo Gnagna Diouf Cheikh Ahmadou Bamba Cissé Marème Polèle Fall Mame Aissé Thioubou Marie Louise Bassène Daouda Dia mouhamadou mbengue Department of Gastroenterology Idrissa Pouye General Hospital (Former Grand Yoff General Hospital) Dakar Senegal Cheikh Anta Diop University Dakar Senegal Department of Gastroenterology Aristide Le Dantec Hospital Dakar Senegal Department of Gastroenterology Peace Hospital Ziguinchor Senegal

Introduction: The aim of our study was to determine the socio-demographic, diagnostic and therapeutic aspects of ulcerative colitis (UC) in one of the largest gastroenterology departments in Senegal. Patients and Method: This was a retrospective and descriptive study based on the analysis of the records of patients hospitalized in the Hepato-Gastroenterology Department of the Grand Yoff General Hospital (Dakar, Senegal) between January 2013 and December 2019. All cases of UC were collected. Clinical, biological, endoscopic and histological data were collected, as well as treatment options. Results: We observed 24 cases, representing a prevalence of 0.87% of inpatients. The mean age of patients was 36 (ranged 18 to 73) and sex ratio 0.9 (13 females). The mean diagnostic delay was 1.6 years (ranged 4 months to 5 years). The clinical symptomatology was dominated by diarrhea with blood and mucus (18 cases). The Litchiger score on admission averaged 8 and 5 patients (20.8%) had severe acute colitis. Colonoscopy showed pancolonic involvement (Montreal E3) in 11 cases (45.8%) and severe endoscopic lesions (stage 3 of the Mayo endosc

关键词： Ulcerative Colitis Sub-Saharan Africa Toxic Megacolon 5 ASA Azathioprine

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Upper Digestive Lesions Not Linked to Portal Hypertension during Cirrhosis: About 82 Cases in the Hepato-Gastroenterology Department of Aristide Le Dantec Hospital

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Open Journal of Gastroenterology 2020年第4期10卷 53-60页

作者： Mamadou Ngoné Gueye Marie Louise Bassè ne Salamata Diallo Marè me Polele Fall Cheikh Ahmadou Bamba Cissé Mame Aè ssé Thioubou Gnagna Diouf Daouda Dia mouhamadou mbengue Mamadou Lamine Diouf Hôpital Général Idrissa Pouye (HOGIP) Dakar Sénégal Hôpital Aristide Le Dantec (HALD) Dakar Sénégal Hôpital de la Paix Ziguinchor Sénégal

Introduction: The aim of this study was to determine the frequency of digestive lesions unrelated to portal hypertension during cirrhosis and to look for a possible correlation between these lesions and the severity of chronic liver disease. Material and method: Over a period of 15 months (April 1, 2014 to June 30, 2015), all the records of cirrhotic patients who followed up on an outpatient or inpatient basis in the hepato-gastroenterology department of the Aristide Le Dantec Hospital were collected. The data collected were as follows: age, sex, Child-Pugh severity score, etiology of cirrhosis, indication for endoscopy and endoscopic lesions observed. Results: Data were analyzed from 82 patient records with a mean age of 43 years (range 16 and 79 years) and a sex ratio of 1.4 (54 males). Cirrhosis was classified as Child-Pugh B in 47% of cases and Child-Pugh C in 35% of cases. The etiology was viral B in 75 patients (91.5%), B-D co-infection in 2 cases, and alcoholic in 1 case. The indication for oeso-gastroduodenal endoscopy was a systematic search for signs of portal hypertension in 66 cases (80.4%), upper gastrointestinal haemorrhage in 11 cases (13.4%) and epigastralgia in 6.2% of cases. Endoscopic lesions unrelated to portal hypertension were observed in 61 patients (74.4%). Peptic ulcer was present in 26 patients (31.7%), and congestive gastrobulbitis was observed in 38 patients (46.3%) and erosive gastrobulbitis in 32 patients (39%). Of the 43 upper GI endoscopies with biopsies, Helicobacter pylori was found at histology in 17 cases (39.5%). Eighteen patients (21.9%) had esophageal candidiasis. In multivariate analysis, there was no association between no portal hypertension lesions and the severity of cirrhosis. Conclusion:Upper gastro intestinal lesions unrelated to hypertension were present in 3/4 of cirrhotic patients. Peptic ulcer disease and congestive and erosive gastrobulbitis were the most frequently observed lesions. There was no significant association between non-PTH-related lesions and the se

关键词： Cirrhosis Peptic Ulcer Congestive Gastrobulbite Erosive Gastrobulbite

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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry traces the geographical source of Biomphalaria pfeifferi and Bulinus forskali,involved in schistosomiasis transmission

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Infectious Diseases of Poverty 2024年第1期13卷 98-99页

作者： Papa mouhamadou Gaye EI Hadj Ibrahima Ndiaye Souleymane Doucoure Doudou Sow Mapenda Gaye Ndiaw Goumballa Carole Cassagne Coralie L'Ollivier Oleg Medianikov Cheikh Sokhna Stephane Ranque Aix-Marseille University IRD AP-HM SSA VITROME Marseille France VITROME International IRD-UCAD Campus Dakar Senegal Hospital-University Institut (IHU) Mediterranée Infection Marseille France Departement of Animal Biology Faculty of Sciences and Techniques UCAD Dakar Senegal Department of Parasitology-Mycology UFR Sciences de la Santé Université Gaston Berger Saint-Louis Senegal

Background Freshwater snails of the genera Bulinus spp.,Biomphalaria spp.,and Oncomelania spp.are the main intermediate hosts of human and animal schistosomiasis.Identification of these snails has long been based on mor-phological and/or genomic criteria,which have their limitations.These limitations include a lack of precision for the morphological tool and cost and time for the DNA-based approach.Recently,Matrix-Assisted Laser Desorp-tion/lonization Time-Of-Flight(MALDI-TOF)mass spectrometry,a new tool used which is routinely in clinical microbi-ology,has emerged in the field of malacology for the identification of freshwater snails.This study aimed to evaluate the ability of MALDI-TOF MS to identify Biomphalaria pfeifferi and Bulinus forskali snail populations according to their geographicalorigin.Methods This study was conducted on 101 Bi.pfeifferi and 81 Bu.forskali snails collected in three distinct geo-graphical areas of Senegal(the North-East,South-East and central part of the country),and supplemented with wild and laboratory strains.Specimens which had previously been morphologically described were identified by MALDl-TOF MS[identification log score values(LSV)≥1.7],after an initial blind test using the pre-existing database.After DNA-based identification,new reference spectra of Bi.pfeiferi(n=10)and Bu.forskali(n=5)from the geographical areas were added to the MALDI-TOF spectral database.The final blind test against this updated database was per-formed to assess identification at the geographic source level.Results MALDI-TOF MS correctly identified 92.1%of 101 Bi.pfeifferi snails and 98.8%of 81 Bu.forskali snails.At the final blind test,88%of 166 specimens were correctly identified according to both their species and sampling site,with LSVs ranging from 1.74 to 2.70.The geographical source was adequately identified in 90.1%of 91 Bi.pfeifferi and 85.3%of 75 Bu.forskalii samples.Conclusions Our findings demonstrate that MALDI-TOF MS can identify and differentiate snail populations according to geographic

关键词： Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Snail Intermediate host Biomphalaria pfeifferi Bulinus forskali Schistosomiasis Senegal

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An Approach to Detect Structural Development Defects in Object-Oriented Programs

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Open Journal of Applied Sciences 2024年第2期14卷 494-510页

作者： Maxime Seraphin Gnagne mouhamadou Dosso Mamadou Diarra Souleymane Oumtanaga Department of Mathematics and Computer Science University Félix HOUPHOU&#203T-BOIGNY Abidjan C&#244te d’Ivoire Research and Innovation Unit in Mathematics and Digital Sciences National Polytechnic Institute Félix HOUPHOU&#203T-BOIGNY Yamoussoukro C&#244te d’Ivoire

Structural development defects essentially refer to code structure that violates object-oriented design principles. They make program maintenance challenging and deteriorate software quality over time. Various detection approaches, ranging from traditional heuristic algorithms to machine learning methods, are used to identify these defects. Ensemble learning methods have strengthened the detection of these defects. However, existing approaches do not simultaneously exploit the capabilities of extracting relevant features from pre-trained models and the performance of neural networks for the classification task. Therefore, our goal has been to design a model that combines a pre-trained model to extract relevant features from code excerpts through transfer learning and a bagging method with a base estimator, a dense neural network, for defect classification. To achieve this, we composed multiple samples of the same size with replacements from the imbalanced dataset MLCQ1. For all the samples, we used the CodeT5-small variant to extract features and trained a bagging method with the neural network Roberta Classification Head to classify defects based on these features. We then compared this model to RandomForest, one of the ensemble methods that yields good results. Our experiments showed that the number of base estimators to use for bagging depends on the defect to be detected. Next, we observed that it was not necessary to use a data balancing technique with our model when the imbalance rate was 23%. Finally, for blob detection, RandomForest had a median MCC value of 0.36 compared to 0.12 for our method. However, our method was predominant in Long Method detection with a median MCC value of 0.53 compared to 0.42 for RandomForest. These results suggest that the performance of ensemble methods in detecting structural development defects is dependent on specific defects.

关键词： Object-Oriented Programming Structural Development Defect Detection Software Maintenance Pre-Trained Models Features Extraction Bagging Neural Network

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Gastritis: Sociodemographic, Clinical, Endoscopic and Histological Aspects, about 593 Cases at the Digestive Endoscopy Unit of the General Hospital Idrissa Pouye

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Open Journal of Gastroenterology 2021年第10期11卷 184-193页

作者： Cissé Cheikh Ahmadou Bamba Gueye Mamadou Ngone Diallo Salamata Fall Marème Polèle Thioubou Mame Aïssé Diouf Gnagna Bassène Marie Louise Dia Daouda mbengue mouhamadou Department of Gastroenterology and Hepatology General Hospital Idrrisa Pouye Dakar Senegal Department of Gastroenterology and Hepatology Aristide Le Dantec Hospital Dakar Senegal Department of Gastroenterology and Hepatology Ziguinchor Peace Hospital Ziguinchor Senegal

Introduction: Gastritis is a very common and widely distributed condition worldwide. It represents one of the most common pathological entities in gastroenterology and digestive endoscopy. Our objective was to determine the sociodemographic, clinical, endoscopic, and histological aspects of gastritis in the digestive endoscopy unit of the General Hospital Idrissa Pouye (GHIP). Materials and Method: This was a retrospective study over a period of 4 years (from 1 January 2014 to 31 December 2017) at the digestive endoscopy unit of GHIP. We had collated oesogastroduodenal endoscopy (EGDE) reports with gastritis appearance with gastric biopsies and reports with normal stomach appearance with gastric biopsies and their histological reports. We collected and analyzed data on age, gender, indications for endoscopy, endoscopic findings and histological results. Results: The reports of 593 patients were analyzed. The mean age was 45 years old (range 8 - 88 years old) and the sex ratio was 0.63 (230 men). The indications for endoscopy were epigastralgia in (91%) of cases, dyspepsia in (22%) of cases, pyrosis in (12%) of cases. The endoscopic appearance was normal in 229 patients (39%). The endoscopic location of the gastritis was antral in 76%, fundic in 22% and pangastric in 2%. The gastritis was erythematous in 327 patients (90%), erosive in 126 patients (35%), congestive in 53 patients (15%), pseudonodular in 14 patients (4%) and atrophic in 10 patients (3%). Histology was normal in 8 patients (1.3%) and showed gastritis in 585 patients (98.7%). Gastritis was chronic in 575 patients (98.2%), acute in 10 patients (1.7%). Gastritis activity was moder

关键词： Gastritis H. pylori Digestive Endoscopy

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Impact of Beekeeping on the Wild Bee Diversity in Northern Ivory Coast(West Africa)

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Research in Ecology 2024年第1期6卷 6-13页

作者： Drissa Coulibaly mouhamadou Koné Yalamoussa Tuo Kolo Soro Kouakou Hervé Koua Department of Animal Biology Biological Sciences UnityUniversity Peleforo Gon CoulibalyBP 1328KorhogoIvory Coast Biosciences Unity Department of ZoologyAnimal Biology and EcologyUniversity Felix Houphouët-Boigny22 BP 1611 Abidjan 22Ivory Coast

In Ivory Coast,beekeeping takes an important place among the major economic activities.It contributes to improv-ing the population’s livelihoods thanks to its derived products which are honey,propolis,wax and royal jelly.How-ever,the installation of honey bee hives could put pressure on wild bee species,which often live solitary.However,these wild bees are excellent pollinators of cultivated and wild plants.The study aimed to assess the effect of honey bee hives on the diversity of wild bees.The methodology approach consisted of capturing bees in three different plots inside the forest fragment of the botanical garden located at the University Peleforo Gon Coulibaly.The first plot was chosen approximately from 10 m to an apiary containing ten hives.The two other plots were chosen to be 200 m and 400 m from the apiary,respectively.Bees were captured once a month for three months using pan traps(UV—blue,yellow and white).A total of 17 bee species belonging to three families(Apidae,Megachilidae and Halictidae)were identified.The furthest plot from the apiary was the most diverse(H’=2.49)and that near the apiary was the least diverse(H’=0.11).Only,two wild bee species,Hypotrigona sp.and Thrinchostoma petersi,persisted inside the plot nearby the apiary where honey bees were most abundant.The furthest plots from the apiary seem to have the highest diversity of wild bees.These findings are very relevant because they can be used for the policies of conservation of wild bees and the management of beekeeping activities.

关键词： Honey bee Apiary Hive Conservation Korhogo

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Treatment of Prostatorectal Fistula by Transanorectal Route: About an Observation

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Open Journal of Urology 2024年第4期14卷 262-266页

作者： Mohamed Mahmoud Beya Ahmed Salem Terouzi Y. Tfeil Diagana mouhamadou Urology Department Cheikh Zayed Hospital Nouakchott Mauritania

This is a 54-year-old patient admitted for the management of urinary leakage through the anus that had been occurring for a month, in whom the diagnosis of a prostatorectal fistula was made. The fistula was successful... 详细信息

关键词： Fistula Prostate Rectum York Masson

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