Ulcerative Colitis in Sub-Saharan Africa: Analysis of 24 Cases in Dakar (Senegal)

作     者：Mamadou Ngoné Gueye Sokhna Niang Diop Salamata Diallo Gnagna Diouf Cheikh Ahmadou Bamba Cissé Marème Polèle Fall Mame Aissé Thioubou Marie Louise Bassène Daouda Dia Mouhamadou Mbengue Mamadou Ngoné Gueye;Sokhna Niang Diop;Salamata Diallo;Gnagna Diouf;Cheikh Ahmadou Bamba Cissé;Marème Polèle Fall;Mame Aissé Thioubou;Marie Louise Bassène;Daouda Dia;Mouhamadou Mbengue

作者机构：Department of Gastroenterology Idrissa Pouye General Hospital (Former Grand Yoff General Hospital) Dakar Senegal Cheikh Anta Diop University Dakar Senegal Department of Gastroenterology Aristide Le Dantec Hospital Dakar Senegal Department of Gastroenterology Peace Hospital Ziguinchor Senegal 

出 版 物：《Open Journal of Gastroenterology》 (肠胃病学期刊（英文）)

年 卷 期：2020年第10卷第6期

页      面：128-136页

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Ulcerative Colitis Sub-Saharan Africa Toxic Megacolon 5 ASA Azathioprine 

摘      要：Introduction: The aim of our study was to determine the socio-demographic, diagnostic and therapeutic aspects of ulcerative colitis (UC) in one of the largest gastroenterology departments in Senegal. Patients and Method: This was a retrospective and descriptive study based on the analysis of the records of patients hospitalized in the Hepato-Gastroenterology Department of the Grand Yoff General Hospital (Dakar, Senegal) between January 2013 and December 2019. All cases of UC were collected. Clinical, biological, endoscopic and histological data were collected, as well as treatment options. Results: We observed 24 cases, representing a prevalence of 0.87% of inpatients. The mean age of patients was 36 (ranged 18 to 73) and sex ratio 0.9 (13 females). The mean diagnostic delay was 1.6 years (ranged 4 months to 5 years). The clinical symptomatology was dominated by diarrhea with blood and mucus (18 cases). The Litchiger score on admission averaged 8 and 5 patients (20.8%) had severe acute colitis. Colonoscopy showed pancolonic involvement (Montreal E3) in 11 cases (45.8%) and severe endoscopic lesions (stage 3 of the Mayo endoscopic subscore) in 10 cases (41.6%). Therapeutically, 17 patients (70.8%) were initially treated with corticosteroids. Background therapy was 5-ASA in 17 patients (70.8%) and azathioprine in 7 patients (29.2%).Two cases of death (8.3%) were observed following colectasia with colonic perforations before emergency surgery could be performed. Conclusion: UC in our study was primarily among young adults with a slight female predominance. Diagnosis is often late. The lack of biotherapy requires close collaboration with surgeons for the management of severe forms.