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Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 557-562页

作者： Toshiaki Tsurui Yuya hirasawa Yutaro Kubota Kiyoshi Yoshimura Takuya Tsunoda Department of Medical Oncology Showa UniversityTokyo 1428555Japan Department of Clinical Immuno Oncology Clinical Research Institute of Clinical Pharmacology and TherapeuticsShowa UniversityTokyo 1578577Japan

BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,owing to the liver’s diffuse metastatic ***,an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently *** SUMMARY The patient,a man in his 50s,presented with progressive fatigue and severe *** tomography revealed multiple hepatic masses with thick-ened walls in the sigmoid colon,which was pathologically confirmed as a well-differentiated *** RAS or BRAF mutations were *** Eastern Cooperative Oncology Group(ECOG)performance status(PS)score was *** drainage was impossible due to the absence of a dilated bile duct,and panitumumab monotherapy was promptly ***,the bilirubin level decreased and then normalized,and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse *** Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.

关键词： Colorectal neoplasms Panitumumab Chemotherapy Hyperbilirubinemia Jaundice Case report

KIF3马达分子运送N-cadherin并对发育中的神经上皮的结构起组织作用

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KIF3马达分子运送N-cadherin并对发育中的神经上皮的结构起组织作...

Heterogeneous tunable Ⅲ-Ⅴ-on-silicon-nitride mode-locked laser emitting wide optical spectra

中国细胞生物学学会2005年学术大会、青年学术研讨会

作者：滕俊琳 Tatemitsu Rai Yosuke Tanaka Yosuke Takei Takao Nakata motoyuki hirasawa Ashok B．Kulkarni Nobutaka Hirokawa 北京大学生命科学学院 Department of Cell Biology and Anatomy Graduate School of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Department of Cell Biology and Anatomy Graduate School of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Department of Cell Biology and Anatomy Graduate School of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Functional Genomics Section Craniofacial Developmental Biology and Regeneration Branch National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda MD 20892-4326 USA Functional Genomics Section Craniofacial Developmental Biology and Regeneration Branch National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda MD 20892-4326 USA Functional Genomics Section Craniofacial Developmental Biology and Regeneration Branch National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda MD 20892-4326 USA Department of Cell Biology and Anatomy Graduate School of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan

KIFs(kinesin superfamily proteins)是依赖于微管的马达分子,在细胞内承担膜性细胞器或生物大分子复合物的运输作用。KIF3是由KIF3A／KIF3B／KAP3构成的向微管正极运输膜泡的马达分子。 KAP3(kinsein superfamily-associated prctein 3)为KIF3复合体的非马达亚基,负责调节KIF3马达蛋白与其货物间的相互连接。我们利用Cre／loxP介导的条件性基因靶技术(Cre／loxP-mediated conditional gene targeting strategy),建立了KAP3条件性基因剔除小鼠(conditional knockout mouse)。发现在神经系统的发育过程中,KAP3与维持神经前体细胞分裂和细胞间粘连的平衡相关。KIF3与N-cadherin和β-catenin结合,行使post-Golgi运输N-cadherin的功能。在KAP3缺失的细胞中,N-cadherin的亚细胞定位紊乱。在条件性基因剔除小鼠的脑中,由于N-cadherin不能正常定位而导致神经上皮组织的发育异常,并形成成室管膜瘤样结构。上述结果提示KIF3／KAP3具有抑制肿瘤形成的功能,为成室管膜瘤的研究提供了动物模型。

关键词：神经上皮 N-cadherin

来源： cnki会议评论

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Photonics Research 2024年第3期12卷 I0021-I0027页

作者： MAXIMILIEN BILLET STIJN CUYVERS STIJN POELMAN ARTUR HERMANS SANDEEP SEEMA SASEENDRA TASUKU NAKAMURA SHINYA OKAMOTO YASUHISA INADA KAZUYA HISADA TAKU hirasawa JOAN RAMIREZ DELPHINE NÉEL NICOLAS VAISSIÈRE JEAN DECOBERT PHILIPPE SOUSSAN XAVIER ROTTENBERG GUNTHER ROELKENS JONØ.KJELLMAN BART KUYKEN Photonics Research Group Department of Information TechnologyGhent University-imec9052 GhentBelgium imec 3001 LeuvenBelgium Technology Division Panasonic Holdings CorporationMoriguchi-CityOsakaJapan Ⅲ-Ⅴ Lab F91767 PalaiseauFrance

We demonstrate a Ⅲ-Ⅴ-on-silicon-nitride mode-locked laser through the heterogeneous integration of a semiconductor optical amplifier on a passive silicon-nitride cavity using the technique of micro-transfer printing. In the initial phase of our study, we focus on optimizing the lasing wavelength to be centered at 1550 nm. This optimization is achieved by conducting experiments with 27 mode-locked lasers, each incorporating optical amplifiers featuring distinct multiple-quantum-well photoluminescence values. Subsequently we present a comprehensive study investigating the behavior of the mode-locking regime when the electrical driving parameters are varied. Specifically, we explore the impact of the gain voltage and saturable absorber current on the locking stability of a tunable mode-locked laser. By manipulating these parameters, we demonstrate the precise control of the optical spectrum across a wide range of wavelengths spanning from 1530 to 1580 nm. Furthermore, we implement an optimization approach based on a Monte Carlo analysis aimed at enhancing the mode overlap within the gain region. This adjustment enables the achievement of a laser emitting a 23-nm-wide spectrum while maintaining a defined 10 dB bandwidth for a pulse repetition rate of 3 GHz.

关键词： tunable amplifier mode

Multispectral Phenotyping and Genetic Analyses of Spring Appearance in Greening Plant, Phedimus spp.

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Plant Phenomics 2023年第2期5卷 353-367页

作者： Taeko Koji Hiroyoshi Iwata motoyuki Ishimori Hideki Takanashi Yuji Yamasaki Hisashi Tsujimoto The United Graduate School of Agricultural Sciences Tottori University4-101 Koyamacho minamiTottori-shiTottori 680-8553Japan Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Yayoi-chouBunkyoTokyo 113-8657Japan Arid Land Research Center Tottori University1390 HamasakaTottori-shiTottori 680-0001Japan

The change in appearance during the seasonal transitions in ornamental greening plants is an important *** particular,the early onset of green leaf color is a desirable trait for a *** this study,we established a method for phenotyping leaf color change by multispectral imaging and performed genetic analysis based on the phenotypes to clarify the potential of the approach in breeding greening *** performed multispectral phenotyping and quantitative trait locus(QTL)analysis of an F1 population derived from 2 parental lines of Phedimus takesimensis,known to be a drought and heat-tolerant rooftop plant *** imaging was conducted in April of 2019 and 2020 when dormancy breakage occurs and growth extension *** component analysis of 9 different wavelength values showed a high contribution from the first principal component(PC1),which captured variation in the visible light *** high interannual correlation in PC1 and in the intensity of visible light indicated that the multispectral phenotyping captured genetic variation in the color of *** also performed restriction site-associated DNA sequencing and obtained the first genetic linkage map of Phedimus *** analysis revealed 2 QTLs related to early dormancy *** on the genotypes of the markers underlying these 2 QTLs,the F1 phenotypes with early(late)dormancy break,green(red or brown)leaves,and a high(low)degree of vegetative growth were *** results suggest the potential of multispectral phenotyping in the genetic dissection of seasonal leaf color changes in greening plants.

关键词： breeding cultivar visible

Near Range Radar and Its Application to Near Surface Geophysics and Disaster Mitigation

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Journal of Earth Science 2015年第6期26卷 858-863页

作者： motoyuki Sato Center for Northeast Asian Studies Tohoku University

In this paper, we discuss about the near range radar applied to various environmental applications and disaster mitigation issues. Synthetic aperture radar（SAR） processing or migration is the key technology in near range radar imaging, which can be used in ground penetrating radar（GPR） and ground-based synthetic aperture radar（GB-SAR）. We demonstrate some applications which include GPR for humanitarian demining, GPR for archaeological survey, GB-SAR for landslide monitoring and nondestructive inspection of wooden buildings. We also demonstrate a new array GPR system “Yakumo”, which was used for archaeological survey for demonstration of advanced multi-static radar signal processing for better radar imaging.

关键词： near range radar GPR GB-SAR disaster mitigation SAR processing migration,multi-static radar.

Relationship between arterial stiffness and cognitive function in outpatients with dementia and mild cognitive impairment compared with community residents without dementia

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Journal of Geriatric Cardiology 2022年第8期19卷 594-602页

作者： Ai hirasawa Kumiko Nagai Taiki Miyazawa Hitomi Koshiba Mami Tamada Shigeki Shibata Koichi Kozaki Department of Health and Welfare Faculty of Health SciencesKyorin UniversityTokyoJapan Department of Geriatric Medicine Faculty of MedicineKyorin UniversityTokyoJapan Department of Health and Sports Science Faculty of WellnessShigakkan UniversityAichiJapan

BACKGROUND It is unclear whether the dementia patients with Alzheimer’s disease(AD)and vascular dementia(VaD)and mixed dementia(MIX,including AD and VaD)would have more developed arterial stiffness as compared with local residents without *** aim of this study was to assess arterial stiffness and cognitive function in different types of dementia pa-tients[AD,VaD,MIX and mild cognitive impairment(MCI)]and community residents without *** This was a single-center,cross-sectional observational *** studied a cohort of 600 elderly outpatients with a complaint of memory loss,who were divided into four groups(AD,VaD,MIX and MCI).In addition,they were compared with 55 age-matched local residents without dementia(Controls).We assessed arterial stiffness by brachial-ankle pulse wave velocity(baPWV)and the global cognitive function by the Mini-Mental State Examination(MMSE).RESULTS The baPWV was higher in AD,VaD and MIX than in MCI and in Controls(P<0.05).The baPWV was higher in MCI than in Controls(P=0.021),while MMSE were compatible between them(P=0.119).The higher baPWV predicted the presence of AD,VaD,MIX and MCI with the odds ratio of 6.46,8.74,6.16 and 6.19,*** contrast,there were no difference in baPWV among three different types of dementia(P=0.191).The linear relationship between baPWV and MMSE was observed in the elderly with MMSE≥23(R=0.452,P=0.033),while it was not in dementia patients(MMSE<23).CONCLUSIONS The findings suggest that MCI and dementia patients have stiffer arteries as compared with age-matched local residents,although global cognitive function may be comparable between MCI and the local residents.

关键词： arterial impairment stiffness

Oxidation of antimony (Ⅲ) in soil by manganese (Ⅳ) oxide using X-ray absorption fine structure

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Journal of Environmental Sciences 2018年第11期30卷 31-37页

作者： Lei Fu Katsumi Shozugawa motoyuki Matsuo Graduate School of Arts and Sciences The University of Tokyo 3-8-1 Komaba Meguro-ku Tokyo 153-8902 Japan

The oxidation of antimony （Ⅲ） in soils was studied using X-ray absorption fine structure （XAFS） spectra. An andosol soft sample and artificial soil samples （SiO2 blended with iron （Ⅲ） hydroxide and manganese （Ⅳ） oxide） were used herein. After adding antimony （Ⅲ） oxide to all soil samples, the oxidation process was observed by recording the XAFS spectra of Sb K-edge, Fe Kedge, and Mn K-edge. The results indicated that manganese （Ⅳ） oxide played an important role in the oxidation of Sb（Ⅲ）; however iron （Ⅲ） hydroxide was not directly related to the reaction. During a 2-hr continuous Sb K-edge X-ray absorption near edge structure （XANES） measurement with an interval of I rain of one of the artificial soil samples （SiO2 ＋ MnO2 ＋ Sb2O3）, a pseudo-first-order reaction was determined with an average estimated rate of 0.52 ±0.04 hr-1. Compared to the lower oxidation rate of andosol, it is suggested that because of the low concentration of Mn（Ⅳ） in natural soils, the oxidation process of Sb（Ⅲ） might be relatively slow and require more time to convert Sb（Ⅲ） to Sb（V）.

关键词： Soil Antimony Oxidation Manganese (Ⅳ) oxide X-ray absorption fine structure (XAFS)

Influence of corneal power on circumpapillary retinal nerve fiber layer and optic nerve head measurements by spectral-domain optical coherence tomography

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1385-1391页

作者： Kazunori hirasawa Nobuyuki Shoji Department of Orthoptics and Visual Science School of Allied Health SciencesKitasato UniversitySagamiharaKanagawa 252-0373Japan Department of Ophthalmology School of medicineKitasato UniversitySagamiharaKanagawa 252-0373Japan

AIM：To evaluate the influence of corneal power on circumpapillary retinal nerve fiber layer（cp RNFL）and optic nerve head（ONH）measurements by spectral-domain optical coherence tomography（SD-OCT）.METHODS：Twenty-five eyes of 25 healthy participants（mean age 23.6±3.6y）were imaged by SD-OCT using horizontal raster *** soft contact lenses of different powers（from-11 to＋5 diopters including 0diopter）were worn to induce 2-diopter changes in corneal *** in the cp RNFL and ONH measurements per diopter of change in corneal power were ***：As corneal power increased by 1 diopter,total and quadrant cp RNFL thicknesses,except for the nasal sector,decreased by-0.19 to-0.32μm（P〈0.01）.Furthermore,the disc,cup,and rim areas decreased by-0.017,-0.007,and-0.015 mm2,respectively（P〈0.001）;the cup and rim volumes decreased by-0.0013 and-0.006 mm3,respectively（P〈0.01）;and the vertical and horizontal disc diameters decreased by-0.006 and-0.007 mm,respectively（P〈0.001）.CONCLUSION：For more precise OCT imaging,the ocular magnification should be corrected by considering both the axial length and corneal ***,the effect of corneal power changes on cp RNFL thickness and ONH topography are small when compare with those of the axial length.

关键词： optical coherence tomography ocularmagnification corneal power circumpapillary retinal nervefiber layer optic nerve head

Blood glucose control in patients with severe sepsis and septic shock

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World Journal of Gastroenterology 2009年第33期15卷 4132-4136页

作者： Hiroyuki hirasawa Shigeto Oda Masataka Nakamura Department of Emergency and Critical Care Medicine Chiba University Graduate School of Medicine

The main pathophysiological feature of sepsis is the uncontrollable activation of both pro-and anti-inflammatory responses arising from the overwhelming pro-duction of mediators such as pro-and anti-inflammatory cytokines. Such an uncontrollable inflammatory response would cause many kinds of metabolic derangements. One such metabolic derangement is hyperglycemia. Accordingly, control of hyperglycemia in sepsis is considered to be a very effective therapeutic approach. However, despite the initial enthusiasm, recent studies reported that tight glycemic control with intensive insulin therapy failed to show a beneficial effect on mortality of patients with severe sepsis and septic shock. One of the main reasons for this disappointing result is the incidence of harmful hypoglycemia during intensive insulin therapy. Therefore, avoidance of hypoglycemia during intensive insulin therapy may be a key issue in effective tight glycemic control. It is generally accepted that glycemic control aimed at a blood glucose level of 80-100 mg/dL, as initially proposed by van den Berghe, seems to be too tight and that such a level of tight glycemic control puts septic patients at increased risk of hypoglycemia. Therefore, now many researchers suggest less strict glycemic control with a target blood glucose level of 140-180 mg/dL. Also specific targeting of glycemic control in diabetic patients should be considered. Since there is a significantcorrelation between success rate of glycemic control and the degree of hypercytokinemia in septic patients, some countermeasures to hypercytokinemia may be an important aspect of successful glycemic control. Thus, in future, use of an artificial pancreas to avoid hypoglycemia during insulin therapy, special consideration of septic diabetic patients, and control of hypercytokinemia should be considered for more effective glycemic control in patients with severe sepsis and septic shock.

关键词：感染性休克脓毒症控制血糖患者