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Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis

World Journal of Gastroenterology 2009年第5期15卷 615-621页

作者： motoko sasaki Ichiro Araki Toshiaki Yasui Masaru Kinoshita Keita Itatsu Takayuki Nojima Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine Kanazawa 920-8640 Japan Department of Internal Medicine Asanogawa General Hospital Kanazawa 920-8621 Japan Department of Surgery Asanogawa General Hospital Kanazawa 920-8621 Japan Hanazono Medical Office Kanazawa 920-0293 Japan Department of Pathology Kanazawa Medical University Ishikawa 920-0293 Japan

We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type.

关键词： Malignant mesothelioma Pulmonaryasbestosis Liver Immunohistochemistry

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Metachronous intracystic and intraductal papillary neoplasms of the biliary tree

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World Journal of Gastroenterology 2013年第36期19卷 6125-6126页

作者： Hirohide Sato Yasunori Sato Kenichi Harada motoko sasaki Katsuyasu Hirano Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine Department of Surgery Wajima Hospital

A 77-year-old woman complained of epigastralgia,and a tumor(5 cm in diameter)of the gallbladder neck was detected by image *** cholecystectomy,the tumor was pathologically diagnosed as intraductal papillary neoplasm(IPN),gastric type,with associated invasive *** 10 mo later,intraluminal multiple masses(3 foci,up to 1.8 cm)were noted in the extrahepatic bile duct,and the resected specimen showed that all tumors had similar gross and microscopic features as seen in gallbladder IPN without invasion,and they were synchronous multiple *** case showed a papillary tumor of the gallbladder of gastric phenotype,and confirmed that the gallbladder is a target of IPN in addition to the bile ducts.

关键词： Intraductal papillary neoplasm Intracystic papillary neoplasm Gastric type Metachronous occurrence Synchronous occurrence

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Participation of peribiliary glands in biliary tract pathophysiologies

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World Journal of Hepatology 2013年第8期5卷 425-432页

作者： Saya Igarashi Yasunori Sato Xiang Shan Ren Kenichi Harada motoko sasaki Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine

AIM:To investigate the roles of peribiliary glands around the bile ducts in the pathophysiology of the biliary ***:The expression of fetal pancreatic markers,pancreatic duodenal homeobox factor 1(PDX1)and hairy and enhancer of split 1(HES1)and endodermal stem/progenitor(S/P)cell markers[CD44s,chemokine receptor type 4(CXCR4),SOX9 and epithelial cell adhesion molecule(EpCAM)]were examined immunohistochemically in 32 normal adult livers(autopsy livers)and 22 hepatolithiatic livers(surgically resected livers).The latter was characterized by the proliferation of the peribiliary *** was performed using formalin-fixed,paraffin-embedded tissue sections after *** PDX1and HES1 were expressed in both the nucleus and cytoplasm of epithelial cells,only nuclear staining was ***9 was expressed in the nucleus,while CD44s,CXCR4 and EpCAM were expressed in the cell *** frequency and extent of the expression of these molecules in the lining epithelia and peribiliary glands were evaluated semi-quantitatively based on the percentage of positive cells:0,1+(focal),2+(moderate)and 3+(extensive).RESULTS:In normal livers,PDX1 was infrequently expressed in the lining epithelia,but was frequently expressed in the peribiliary *** contrast,HES1was frequently expressed in the lining epithelia,but its expression in the peribiliary glands was focal,suggesting that the peribiliary glands retain the potential of differentiation toward the pancreas and the lining epithelia exhibit properties to inhibit such *** unique combination was also seen in hepatolithiatic *** expression of endodermal S/P cell markers varied in the peribiliary glands in normal livers:SOX9 and EpCAM were frequently expressed,CD44s infrequently,and CXCR4 almost not at *** expression of these markers,particularly CD44s and CXCR4,increased in the peribiliary glands and lining epithelia in hepatolithiatic *** increa

关键词： Biliary tree Peribiliary glands Pancreatic duodenal homeobox factor 1 Stem cells Differentiation Pancreas

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Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

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World Journal of Gastroenterology 2014年第13期20卷 3597-3608页

作者： Mio Kobayashi Yuko Kakuda Kenichi Harada Yasunori Sato motoko sasaki Hiroko Ikeda Mitsuhiro Terada Munenori Mukai Shuichi Kaneko Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 920-8640Japan Division of Pathology Kanazawa University HospitalKanazawa 920-8641Japan Department of Gastroenterology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Pathology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Gastroenterology Kanazawa University Graduate School of MedicineKanazawa 920-8640 Japan

AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH ***:Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were *** activity of periportal and lobular inflammation was scored0(none or minimal activity)to 4(severe),and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored *** infiltration of mononuclear cells positive for CD20,CD38,CD3,CD4,and CD8 and positive for immunoglobulins(IgG,IgM,and IgA)at the periportal areas(interface hepatitis)and in the hepatic lobules(lobular hepatitis)were semiquantitatively scored in immunostained liver sections(score 0-6).Serum aspartate aminotransferase(AST),immunoglobulins,and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual ***:Lobular hepatitis,hepatitic rosette formation,and emperipolesis were more extensive and frequent in AIH than in ***3+,CD4+,and CD8+cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in *** degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC,but to a lesser degree in ***20+cells were mainly found in the portal tracts and,occasionally,at the interface in both *** AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration,specifically CD38+cells in *** correlation existed between autoantibodies and inflammatory cell infiltration in PBC or *** most AIH cases were IgG-predominant at the interface,PBC cases were divided into IgM-predominant,IgM/IgGequal,and IgG-predominant types,with the latter sharing several features with ***:These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with inte

关键词： Primary biliary cirrhosis Autoimmune hepa-titis Interface hepatitis Lobular hepatitis Plasma cell subclass

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Drug-induced sarcoidosis-like reaction three months after BNT162b2 mRNA COVID-19 vaccination:A case report and review of literature

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World Journal of Clinical Cases 2023年第1期11卷 177-186页

作者： Soo Ryang Kim Soo Ki Kim Takako Fujii Hisato Kobayashi Toyokazu Okuda Takanobu Hayakumo Atsushi Nakai Yumi Fujii Ryuji Suzuki Noriko Sasase Aya Otani Yu-ichiro Koma motoko sasaki Tsutomu Kumabe Osamu Nakashima Department of Gastroenterology Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Radiology Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Clinical Laboratory Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Pharmacy Kobe Asahi HospitalKobe 6530801HyogoJapan Division of Pathology Department of PathologyKobe University Graduate School of MedicineKobe 6530801HyogoJapan Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 9208640IshikawaJapan Department of Gastroenterology Kumabe ClinicKumamoto 8611331KumamotoJapan Laboratory Services Center St.Mary's HospitalKurume 830-8543FukuokaJapan

BACKGROUND A 70-year-old man with hepatitis C virus-related recurrent hepatocellular carcinoma was admitted for further diagnosis of a 1 cm iso-hyperechoic nodule in segment(S)*** SUMMARY Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging(EOB-MRI)revealed the nodule in S5 with a defect at the hepatobiliary phase,hyperintensity on diffusion weighted imaging(DWI)and hypointensity on apparent diffusion coefficient(ADC)***-enhanced computed tomography revealed hypervascularity at the early phase,and delayed contrast-enhancement was observed at the late ***-enhanced ultrasound(US)revealed incomplete defect at the late vascular *** liver tumor,lymphoproliferative disease,intrahepatic cholangiocarcinoma(small duct type)and bile duct adenoma were suspected through the imaging *** guided biopsy,however,showed a noncaseating hepatic sarcoid-like epithelioid granuloma(HSEG),and histopathological analysis disclosed spindle shaped epithelioid cells harboring Langhans-type multinucleated giant *** month after admission,EOB-MRI signaled the disappearance of the defect at the hepatobiliary phase,of hyperintensity on DWI,of hypointensity on ADC map,and no stain at the early *** That the patient had received BNT162b2 messenger RNA(mRNA)coronavirus disease 2019 vaccination 3 mo before the occurrence of HSEG,and that its disappearance was confirmed 4 mo after mRNA vaccination suggested that the drug-induced sarcoidosis-like reaction(DISR)might be induced by the mRNA ***,rechallenge of drug-induced DISR with the third mRNA vaccination was not confirmed.

关键词： Drug-induced sarcoidosis-like reaction BNT162b2 mRNA COVID-19 vaccine Noncaseating granuloma Ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging Th1/Th2 profile Case report

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Rapidly enlarged inflammatory hepatocellular adenoma: A case report

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Open Journal of Gastroenterology 2013年第4期3卷 227-230页

作者： Kenji Koneri Hidetaka Kurebayashi Katsuji Sawai Yasuo Hirono Mitsuhiro Morikawa Makoto Murakami Takanori Goi Atsushi Iida Kanji Katayama Hiroshi Itoh motoko sasaki Yasuni Nakanuma Akio Yamaguchi Department of Gastroenterological Surgery University of Fukui Fukui Japan Department of Human Pathology Kanazawa University Graduate School of Medicine Kanazawa Japan Department of Tumor Pathology University of Fukui Fukui Japan

We present a rare case of rapidly enlarging inflamematory hepatocellular adenoma (IHCA) in a 60-year-old Japanese man. Screening abdominal computed tomography (CT) for the fatty liver patient revealed a 1.7-cm liver mass in the anterior segment of the liver. After 19 months, the lesion had rapidly enlarged to 6 cm in diameter and the patient was referred to our hospital. On perflubutane microbubble contrast-enhanced ultrasonography, the tumor showed a characteristic centripetal filling pattern in the vascular phase. We performed hepatic anterior segment resection because we could not rule out malignant tumor. Histopathological examination showed hyperplasia of mildly atypical hepatocytes and sinusoidal dilatation with marked inflammatory cell infiltration. Immunohistological staining revealed positive staining for serum amyloid A and C-reactive protein;therefore, we diagnosed this tumor as IHCA. The patient remains alive 42 months after operation without evidence of recurrence.

关键词： Inflammatory Hepatocellular Adenoma Perflubutane Microbubble Contrast-Enhanced Ultrasonography Surgery Rapid Enlargement

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Effects of hydraulic oil and lubricant additives on dynamic friction properties under various reciprocating sliding conditions

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Friction 2020年第2期8卷 471-480页

作者： Shinji KATO Shinya sasaki Engineering Headquarters Automotive ComponentsKYB Corporation2548DolaKani-shiGifu 509-0298Japan Department of Mechanical Engineering Faculty of Engineering Division ITokyo University of Science6-3-1NiijukuKatsushika-kuTokyo 125-8585Japan

The friction characteristics of a shock absorber are very complex because the reciprocating motion is not always *** this study,a device was developed and used to analyze the dynamic friction characteristics under various reciprocating sliding conditions to determine the sliding materials and hydraulic oils that improve the shock absorber *** study describes the influence of hydraulic oil additive on the fine reciprocating friction characteristics of steel and copper *** oils were prepared by blending a paraffinic mineral oil with zinc dithiophosphate(ZnDTP)and polyhydric alcohol ester as *** results show that the dynamic frictional characteristics vary mainly depending on the additive concentration.A specific additive formulation induces a unique amplitude-dependent friction *** addition,the influence of different additives on the lubrication mechanism is investigated based on the instrumental analysis of the friction surface.

关键词： shock absorber dynamic friction reciprocating friction additive zinc dithiophosphate(ZnDTP)

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HYPERGAMES AND BAYESIAN GAMES:A THEORETICAL COMPARISON OF THE MODELS OF GAMES WITH INCOMPLETE INFORMATION

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Journal of Systems Science & Complexity 2012年第4期25卷 720-735页

作者： Yasuo sasaki Kyoichi KIJIMA Graduate School of Decision Science and Technology Tokyo Institute of Technology

The present study discusses the relationships between two independently developed models of games with incomplete information, hypergames （Bennett, 1977） and Bayesian games （Harsanyi, 1967）. The authors first show that any hypergame can naturally be reformulated in terms of Bayesian games in an unified way. The transformation procedure is called Bayesian representation of hypergame. The authors then prove that some equilibrium concepts defined for hypergames are in a sense equivalent to those for Bayesian games. Furthermore, the authors discuss carefully based on the proposed analysis how each model should be used according to the analyzer＇s purpose.

关键词： Bayesian game Bayesian representations of hypergame hypergame incomplete information."

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Hierarchical Hypergames and Bayesian Games:A Generalization of the Theoretical Comparison of Hypergames and Bayesian Games Considering Hierarchy of Perceptions

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Journal of Systems Science & Complexity 2016年第1期29卷 187-201页

作者： sasaki Yasuo KIJIMA Kyoichi School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1AsahidaiNomiIshikawaJapan Department of Value and Decision Science Tokyo Institute of Technology 2-12-1OokayamaMeguro-kuTokyoJapan

This paper discusses the relationship of two independently developed models of games with incomplete information,hierarchical hypergames and Bayesian *** can be considered as a generalization of the previous study on the theoretical comparison of simple hypergames and Bayesian games(sasaki and Kijima,2012) by taking into account hierarchy of perceptions,i.e.,an agent's perception about the other agents' perceptions,and so *** authors first introduce the general way of transformation of any hierarchical hypergames into corresponding Bayesian games,which was called as the Bayesian representation of hierarchical *** authors then show that some equilibrium concepts for hierarchical hypergames can be associated with those for Bayesian games and discuss implications of the results.

关键词： Bayesian games game theory hierarchy of perceptions hypergames incomplete information

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Candida-associated gastric ulcer relapsing in a different position with a different appearance

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World Journal of Gastroenterology 2012年第32期18卷 4450-4453页

作者： Kenji sasaki Department of Internal Medicine Tome Municipal Hospital of ToyosatoTomeMiyagi 987-0364Japan

An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the *** showed Candida tropicalis but not Helicobacter pylori(***).She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs(NSAIDs),diagnosed with Candida-associated gastric *** cured of the lesion,she developed another ulcer in a different position,in which Candida was demonstrated but *** was *** is the first case of recurrent Candida-associated gastric ulcer in the *** in both the original and recurrent lesions in an ***-negative patient with no antecedent ulcers who had not taken NSAIDs,Candida is considered,contrary to the prevailing opinion,to play an etiologic role in ulcer formation.

关键词： Candida-associated gastric ulcer Gastric candidiasis Helicobacter pylori-negative gastric ulcer Non-steroidal anti-inflammatory drugs-induced gastric ulcer Recurrent gastric ulcer

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