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无对比增强VI-RADS的临床有效性:高梯度磁场3.0 T MRI的前瞻性研究

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国际医学放射学杂志 2023年第1期46卷 116-116页

作者： M.Watanabe S.Taguchi H.machida M.Tambo Y.Takeshita T.Kariyasu 陈晴晴

摘要目的旨在开发一项改良性无动态对比增强成像(DCEI)的膀胱影像报告和数据系统(VI-RADS),即“无对比增强VI-RADS(NCE-VI-RADS)”,并评估去噪深度学习重建

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快离子导体的机械化学合成

无机化学学报 2006年第5期22卷 779-784页

作者：彭会芬范志新梁艳峰町田信也重松利彦河北工业大学材料学院天津300130 河北工业大学理学院天津300130 甲南大学理工学部

快离子导体是二次高能电池及其他全固体电化学器件研制与开发的重要材料,常规方法由于存在原材料选择受限以及原料对容器侵蚀等技术问题,致使一些高性能快离子导体的制备受到很大限制。为此,人们将目标转移到不需加热、在室温条件下即... 详细信息

快离子导体是二次高能电池及其他全固体电化学器件研制与开发的重要材料,常规方法由于存在原材料选择受限以及原料对容器侵蚀等技术问题,致使一些高性能快离子导体的制备受到很大限制。为此,人们将目标转移到不需加热、在室温条件下即可实现这一材料制备的机械化学合成法。本文总结了近年来利用这种方法在制备快离子导体方面取得的一些最新研究成果。

关键词：快离子导体固体电解质机械化学合成高能球磨技术

Host Factors Alter Effects of Angiopoietin-Like Protein 8 on Glucose Homeostasis in Diabetic Mice

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Journal of Diabetes Mellitus 2016年第4期6卷 277-290页

作者： Sichen Liu Emily M. Smith Timothy H. King Lindsey Glenn Michelle Trevino So Hyun Park Yui machida Ciriaco Villaflor Wojciech Grzesik Margaret A. Morris Yumi Imai Jerry L. Nadler Eastern Virginia Medical School Department of Internal Medicine Strelitz Diabetes Center Norfolk VA USA Department of Internal Medicine Fraternal Order of Eagles Diabetes Research Center The University of Iowa Carver College of Medicine Iowa City IA USA

Recovery of functional beta cell mass offers a biological cure for type 1 diabetes. However, beta cell mass is difficult to regain once lost since the proliferation rate of beta cells after youth is very low. Angiopoietin like-protein 8 (ANGPTL8), a peptide that has a role in the regulation of lipoprotein lipase activity, was reported to increase beta cell proliferation in mice in 2013. Subsequent studies of human ANGPTL8 for short term (3 to 8 days) in non-diabetic mice showed little or no increase in beta cell proliferation. Here, we examined the effect of ANGPTL8 on glucose homeostasis in models that have not been examined previously. We expressed mouse ANGPTL8 using adenovirus in 2 mouse models of diabetes (streptozotocin and Non-Obese Diabetic (NOD) mice) over 2 weeks. Also, we tested ANGPTL8 in NOD mice deficient in leukocyte 12-lipoxygenase (12LO), an enzyme that contributes to insulitis and loss of beta cell function in NOD, in an effort to determine whether 12LO deficiency alters the response to ANGPTL8. Adenovirus-mediated expression of ANGPTL8 lowered blood glucose levels in streptozotocin treated mice without an increase in beta cell proliferation or serum insulin concentration. While ANGPTL8 did not reverse hyperglycemia in overtly hyperglycemic NOD mice or alter glucose homeostasis of non-diabetic NOD mice, ANGPTL8 reduced blood glucose levels in 12LOKO NOD mice. However, the lower glucose levels in 12LOKO NOD were not associated with higher serum insulin levels or beta cell proliferation. In summary, while mouse ANGPTL8 does not increase beta cell proliferation in NOD mice or streptozotocin treated mice in agreement with studies in non-diabetic mice, it lowers blood glucose levels in multiple low-dose streptozotocin induced diabetes and 12LO deficiency indicating that host factors influence the impact of ANGPTL8 on glucose homeostasis.

关键词： Angiopoietin-Like Protein 8 Type 1 Diabetes NOD 12-Lipoxygenase Beta Cells Glucose Homeostasis

高速公路长途运输卡车专用重型柴油机的燃油耗改善研究

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汽车与新动力 2016年第3期48卷 9-16页

作者： M.Ishii K.Shimokawa K.machida H.Nakajima 孙丹红

对高效率柴油机、混合动力系统、废热回收系统、后处理系统,以及先进传动系统等能够改善高速公路长途运输重型卡车燃油耗的可能途径进行了研究。介绍了改善柴油机本身燃油耗性能所用策略及实际发动机的试验评价结果。独立发动机的试验... 详细信息

对高效率柴油机、混合动力系统、废热回收系统、后处理系统,以及先进传动系统等能够改善高速公路长途运输重型卡车燃油耗的可能途径进行了研究。介绍了改善柴油机本身燃油耗性能所用策略及实际发动机的试验评价结果。独立发动机的试验评价结果表明,当卡车在高速公路上行驶时,采用高制动平均有效压力、两级涡轮增压系统、双循环废气再循环(高压循环和低压循环)系统、新型燃烧室和新型喷嘴喷油系统的小型化柴油机,可大幅降低发动机常用工况的燃油耗。

关键词：燃油耗柴油机重型卡车长途运输

烧结工艺使用气体燃料喷入技术减少CO2排放

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世界钢铁 2013年第1期13卷 16-22页

作者： Nobuyuki Oyama Yuji Iwami Satoshi machida Takahide Higuchi Tetsuya Yamamoto Yushinori Watanabe Michitaka Sato Kanji Takeda Masakata Shimizu Koki Nishioka 何海良 JFE钢铁公司日本九州大学

JFE钢铁公司开发了在烧结矿表面喷入含氢的气体燃料技术,可不增加焦粉配比,提高烧结矿质量。使用该技术,含氢气体可部分替代焦粉,使1200～1400℃的燃烧层变宽成为可能。通过X射线对多孔状的烧结饼进行CT检查与烧结锅试验,从理论到实践... 详细信息

JFE钢铁公司开发了在烧结矿表面喷入含氢的气体燃料技术,可不增加焦粉配比,提高烧结矿质量。使用该技术,含氢气体可部分替代焦粉,使1200～1400℃的燃烧层变宽成为可能。通过X射线对多孔状的烧结饼进行CT检查与烧结锅试验,从理论到实践都证明了喷入燃料气体技术的使用效果。保持1200～1400℃的温度带,为生产高强度、高还原性的烧结矿至关重要,它能使合适的温度带变宽、液相率增加、提高1～5mm孔隙间的熔合并提升烧结矿强度。大于5mm的孔隙的烧结矿数量增多提高了料层的透气性,低温烧结工艺也抑制了铁矿石的自身熔化。而在未熔化的铁矿石中,小于1μm的微孔隙的存在也使烧结矿的还原性提高,从而改善烧结饼的孔隙结构,提高烧结矿质量。2009年1月,京浜1号烧结机应用了该技术,到目前为止工况稳定。结果,烧结工序的能源利用率大幅提升,减排CO2约6万t/a。

关键词：气体燃料 CO2排放烧结工艺

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能谱CT提高腹部增强效果的可行性

中国医学影像技术 2016年第12期32卷 1914-1918页

作者：孙记航福井利佳町田治彦田中功沈云上野惠子彭芸首都医科大学附属北京儿童医院影像中心北京100045 东京女子医科大学东医疗中心影像科

目的探讨能谱CT(GSI)提高腹部增强效果的可行性。方法收集因病情需要先后接受腹部双期增强CT扫描的27例患者,于第1次均采用传统120kV单电压CT进行扫描(对照组),复查时采用GSI扫描(试验组),两次检查对比剂总量均为600mgI/kg体质量。于增... 详细信息

目的探讨能谱CT(GSI)提高腹部增强效果的可行性。方法收集因病情需要先后接受腹部双期增强CT扫描的27例患者,于第1次均采用传统120kV单电压CT进行扫描(对照组),复查时采用GSI扫描(试验组),两次检查对比剂总量均为600mgI/kg体质量。于增强图像上腹主动脉、肝脏、胰腺、肾脏、下腔静脉、门静脉主干选取ROI进行分析,记录GSI图像上各器官相对于120kV单电压扫描的等价CT值时的平均单能量值(等价亚组),以及CT值提高50%(150%亚组)、100%(200%亚组)时的MEI,并记录所对应的噪声值,比较各亚组间单能量值、CT值与噪声值的差异,评估2名医师对MEI各亚组图像质量的主观评分一致性。结果等价亚组能量值(71.92±3.54)keV,图像噪声为(23.07±3.99)HU,与对照组比较,各器官CT值的差异均无统计学意义(P均>0.05);150%亚组能量值(57.39±2.77)keV,图像噪声为(35.30±7.56)HU,较等价亚组增高了53.01%;200%亚组能量值(49.94±2.72)keV,图像噪声为(44.01±8.59)HU,较等价亚组增高了90.77%。与对照组比较,150%亚组、200%亚组间单能量值、CT值与噪声值差异均有统计学意义(P均<0.01)。2名医师对试验组3个亚组的主观评分一致性均很好(P均<0.01)。结论采用GSI的单能量技术于72keV时可以达到常规120kV的腹部增强CT效果,57keV、50keV时增强效果可分别提高50%、100%。

关键词：体层摄影术,X线计算机腹部对比剂宝石能谱成像

Contrasting Historical and Recent Breakup Styles on the Meade River of Arctic Alaska in the Context of a Warming Climate

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American Journal of Climate Change 2013年第2期2卷 165-172页

作者： Richard A. Beck Kenneth M. Hinkel Wendy R. Eisner Douglas Whiteman Christopher D. Arp Richard machida Chris Cuomo Hongxing Liu Changjoo Kim Andrew J. Rettig Chantal Ivenso Bo Yang Qiusheng Wu Haibin Su Shujie Wang Karen Frey John D. Lenters Brittany L. Potter Atmospheric Radiation Measurement Program Atqasuk USA Department of Geography Clark University Worcester USA Department of Geography University of Cincinnati Cincinnati USA Department of GeogSchool of Natural Resources University of Nebraska at Lincoln Lincoln USA raphy Clark University Worcester USA Department of Philosophy University of Georgia Athens USA Department of Physics and Geosciences Texas A&M University-Kingsville Kingsville USA Information Technology University of Alaska at Fairbanks Fairbanks USA School of Natural Resources University of Nebraska at Lincoln Lincoln USA Water and Environmental Research Center University of Alaska Fairbanks USA

Although data for temporal spring river ice breakup are available for a number of Arctic rivers, there is a paucity of information related to the type of breakup. The Arctic Climate Impact Assessment (ACIA) of 2005 predicted a transition from mechanical to thermal spring breakup of ice cover on arctic rivers, with this shift being greatest in exclusively Arctic watersheds where observed warming is most pronounced. We describe a rare instance of an entirely Arctic river with limited but well documented historical and recent data regarding the type of breakup. Time-series ground imagery of spring breakup from 1966, 1975, 1978, 2009, 2010 and 2012, incombination with interviews of local inhabitants, documents a shift from predominantly mechanical to predominantly thermal breakup after spring 1978 and by spring 2009 within the context of a locally and regionally warming Arctic. The resultant shift from predominantly mechanical to predominantly thermal breakup is predicted to result in significant changes to water, sediment, nutrient and organic carbon fluxes, as well as riparian ecology and human activities.

关键词： Arctic Alaska Climate Change Meade River Thermal Breakup Mechanical Breakup Ice Snow

Tumor characteristics of ductal carcinoma in situ of breast visualized on [F-18] fluorodeoxyglucose-positron emission tomography/computed tomography: Results from a retrospective study

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World Journal of Radiology 2016年第8期8卷 743-749页

作者： Tomoyuki Fujioka Kazunori Kubota Akira Toriihara Youichi machida Kaori Okazawa Tsuyoshi Nakagawa Yukihisa Saida Ukihide Tateishi Department of Diagnostic Radiology Tokyo Medical and Dental University Department of Radiology Kameda Kyobashi Clinic Department of Breast Surgery Tokyo Medical and Dental University

AIM To clarify clinicopathological features of ductal carcinoma in situ(DCIS) visualized on [F-18] fluorodeoxyglucosepositron emission tomography/computed tomography(FDG-PET/CT).METHODS This study retrospectively reviewed 52 consecutive tumors in 50 patients with pathologically proven pure DCIS who underwent [F-18] FDG-PET/CT before surgery. [F-18] FDG-PET/CT was performed after biopsy in all patients. The mean interval from biopsy to [F-18] FDGPET/CT was 29.2 d. [F-18] FDG uptake by visual analysis and maximum standardized uptake value(SUVmax) was compared with clinicopathological ***[F-18] FDG uptake was visualized in 28 lesions(53.8%) and the mean and standard deviation of SUVmax was 1.63 and 0.90. On univariate analysis, visual analysis and the SUVmax were associated with symptomatic presentation(P = 0.012 and 0.002, respectively), palpability(P = 0.030 and 0.024, respectively), use of core-needle biopsy(CNB)(P = 0.023 and 0.012, respectively), ultrasound-guided biopsy(P = 0.040 and 0.006, respectively), enhancing lesion ≥ 20 mm on magnetic resonance imaging(MRI)(P = 0.001 and 0.010, respectively), tumor size ≥ 20 mm on histopathology(P = 0.002 and 0.008, respectively). However, [F-18] FDG uptake parameters were not significantly associated with age, presence of calcification on mammography, mass formation on MRI, presence of comedo necrosis, hormone status(estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2), and nuclear grade. The factors significantly associated with visual analysis and SUVmax were symptomatic presentation(P = 0.019 and 0.001, respectively), use of CNB(P = 0.001 and 0.031, respectively), and enhancing lesion ≥ 20 mm on MRI(P = 0.001 and 0.049, respectively) on multivariate *** Although DCIS of breast is generally non-avid tumor, symptomatic and large tumors(≥ 20 mm) tend to be visualized on [F-18] FDG-PET/CT.

关键词： Ductal carcinoma in situ Positron emission tomography Breast cancer [F-18] fluorodeoxyglucosepositron emission tomography/computed tomography

腹部CT能谱扫描与常规扫描射线剂量和图像噪声的对比研究

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中华放射学杂志 2013年第2期47卷 116-120页

作者：林晓珠田中功福井利佳徐学勤町田治彦上野惠子陈克敏严福华上海交通大学医学院附属瑞金医院放射科 200025 东京女子医科大学东医疗中心放射线科

目的探讨腹部CT单源瞬时kVp切换模式与常规CT120kVp扫描的射线剂量和图像噪声的关系。方法采用质量评价标准体模，对其中的水模部分分别进行能谱成像和常规螺旋扫描，获得常规扫描模式与能谱扫描模式mAs的回归方程，并计算出不同能谱成... 详细信息

目的探讨腹部CT单源瞬时kVp切换模式与常规CT120kVp扫描的射线剂量和图像噪声的关系。方法采用质量评价标准体模，对其中的水模部分分别进行能谱成像和常规螺旋扫描，获得常规扫描模式与能谱扫描模式mAs的回归方程，并计算出不同能谱成像（GSI）扫描参数所对应的常规120kVp扫描mAs。回顾性分析22例全腹部CT增强扫描患者资料。根据平扫常规扫描所使用的mAs选择相应的能谱模式进行增强门静脉期扫描，分别测量常规和能谱CT扫描在肝实质、膀胱区的图像噪声。采用配对t检验比较常规扫描与能谱扫描的射线剂量和图像噪声。结果22例患者CT能谱成像和常规螺旋扫描的CT剂量指数分别为（13．8±4．8）和（14．0±7．0）mGy，剂量长度乘积分别为（691．1±274．2）和（678．8±385．0）mGy·cm，差异均无统计学意义（t值分别为0．177和-0．260，P值均〉0．05）。在肝脏，65keV单能量图像的噪声为（7．6±1．4）HU，低于常规扫描滤波反投影（FBP）图像和20％自适应统计迭代重建（ASIR）图像[分别为（10．4±1．0）和（9．1±0．9）HU]，与40％ASIR图像相当[（7．8±0．7）HU]，高于60％ASIR图像噪声[（6．7±0．7）HU]；在膀胱，65keV单能量图像的噪声[（9．1±1．3）HU]低于常规扫描FBP图像[（10．5±1．3）HU]，与20％ASIR图像相当[（9．2±1．2）HU]，高于40％和60％ASIR图像的噪声[分别为（8．0±1．1）和（6．8±0．9）HU]。结论通过选择合适的参数，腹部CT能谱扫描与常规扫描的射线剂量相当；65keV单能量图像的噪声低于常规扫描的FBP重建图像、与20％～40％ASIR图像噪声相当，可在临床中常规应用。

关键词：体层摄影术,X线计算机辐射剂量对比研究