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Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings

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World Journal of Gastroenterology 2014年第35期20卷 12673-12677页

作者： Yugo Kai motohiko kato Yoshito Hayashi Tomofumi Akasaka Shinichiro Shinzaki Tsutomu Nishida Masahiko Tsujii Eiichi Morii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine Department of Diagnostic Pathology Osaka University Hospital

Basaloid squamous carcinoma (BSC) is a rare variant of esophageal cancer. There are very few reports of “early” BSC. Here we report a case of early BSC with unusual findings by narrowband imaging magnified endoscopy (NBI-ME). A 70-year-old man with a middle thoracic esophageal tumor was referred to our hospital. White-light endoscopy revealed a reddish depressed lesion 5 mm in diameter having a subepithelial tumor-like prominence with a gentle rising slope. NBI-ME revealed irregular loop-shaped microvessels coexistent with thick irregularly branched non-looped vessels. Iodine staining revealed a pale brown lesion. We performed endoscopic submucosal dissection for diagnostic treatment. Histologic examination showed the proliferation of basal cell-like hyperchromatic tumor cells in the lamina propria and with slight invasion into the submucosa at a depth of 320 μm. The tumor cells formed solid nests and microcystic structures, containing an Alcian blue-positive mucoid matrix. The surface was covered with squamous epithelium without cellular atypia. Thin vessels were observed in the intra-epithelial papilla and thick vessels were observed around the solid nests beneath the epithelium. Based on these findings together, we diagnosed the lesion as BSC. In this case, the NBI-ME findings differed from those of typical squamous cell carcinoma in that both non-invasive cancer-like irregular loop-shaped microvessels coexisted with massively invasive cancer-like thick non-looped vessels. We speculate that the looped and non-looped vessels observed by NBI-ME histologically corresponded to thin vessels in the intra-epithelial papilla and thick vessels around the tumor nests, respectively. These NBI-ME findings might be a feature of early esophageal BSC.

关键词： Basaloid squamous carcinoma Narrowband imaging Esophagus Endoscopic submucosal dissection

Endoscopic surveillance strategy after endoscopic resection for early gastric cancer

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World Journal of Gastrointestinal Pathophysiology 2014年第2期5卷 100-106页

作者： Tsutomu Nishida Masahiko Tsujii motohiko kato Yoshito Hayashi Tomofumi Akasaka Hideki Iijima Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine

Early detection of early gastric cancer(EGC)is important to improve the prognosis of patients with gastric *** advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and high-frequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection,a therapeutic option for gastric intraepithelial ***,short-term outcomes of endoscopic resection(ER)for EGC have ***,surveillance with endoscopy after ER for EGC is becoming more important,but how to perform endoscopic surveillance after ER has not been established,even though the follow-up strategy for more advanced gastric cancer has been ***,a surveillance strategy for patients with EGC after ER is needed.

关键词： Early gastric cancer Endoscopic resection Synchronous gastric cancer Metachronous gastric cancer Surveillance

Endoscopic submucosal dissection in early gastric cancer in elderly patients and comorbid conditions

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World Journal of Gastrointestinal Endoscopy 2015年第5期7卷 524-531页

作者： Tsutomu Nishida motohiko kato Toshiyuki Yoshio Tomofumi Akasaka Teppei Yoshioka Tomoki Michida Masashi Yamamoto Shiro Hayashi Yoshito Hayashi Masahiko Tsujii Tetsuo Takehara Department of Gastroenterology Toyonaka Municipal Hospital Department of Gastroenterology National Hospital Organization Tokyo Medical Center Division of Gastroenterology Cancer Institute HospitalTokyo Department of Gastrointestinal Oncology Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Gastroenterology and Hepatology Osaka University of Graduate School of Medicine Department of Gastroenterology Teikyo University Medical Center

The prognosis of early gastric cancer(EGC) is good if there is no concomitant lymph node metastasis. Therefore, the early detection of EGC is important to improve the prognosis of patients with gastric cancer. In Japan, 40% to 50% of all gastric cancers are EGC, and endoscopic submucosal dissection(ESD) is widely accepted as a local treatment for these lesions, particularly for large lesions that at one time were an indication for gastrectomy because of the difficulty of en-bloc resection. Consequently, this procedure can preserve the entire stomach and the patient's postoperative quality of life. ESD has become a general technique with improved procedures and devices, and has become the preferred treatment for EGC rather than gastrectomy. Therefore, ESD may demonstrate many advantages in patients who have several comorbidities, particularly elderly population, patients taking antithrombotic agents, or patients with chronic kidney disease, or liver cirrhosis. However, it is not yet clear whether patients with both EGC and comorbidities are feasible candidates for ESD and whether they would consequently be able to achieve a survival benefit after ESD. In this review, we discuss the clinical problems of ESD in patients with EGC and those comorbid conditions.

关键词： Endoscopic submucosal dissection Gastriccancer Elderly person Antithrombotic agents Livercirrhosis Chronic kidney disease

Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

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World Journal of Gastrointestinal Pathophysiology 2011年第6期2卷 93-99页

作者： Tsutomu Nishida Shusaku Tsutsui motohiko kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan

Treatment strategies,whether as follow-up or"total incisional biopsy"for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic *** on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive ***,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during *** advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade *** studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness.

关键词： Gastric intraepithelial neoplasia Adenoma Dysplasia Endoscopic submucosal dissection Endoscopic mucosal resection Endoscopic resection Adenocarcinoma

Percutaneous endoscopic gastrostomy under steadypressure automatically controlled endoscopy:First clinicalseries

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World Journal of Gastrointestinal Endoscopy 2016年第3期8卷 186-191页

作者： Hiroyuki Imaeda Kiyokazu Nakajima Naoki Hosoe Masanori Nakahara Shinichiro Zushi motohiko kato Kazuhiro Kashiwagi Yasushi Matsumoto Kayoko Kimura Rieko Nakamura Norihito Wada Masahiko Tsujii Naohisa Yahagi Toshifumi Hibi Takanori Kanai Tetsuo Takehara Haruhiko Ogata Department of General Internal Medicine Saitama Medical UniversitySaitama 350-0495Japan Division of Next Generation Endoscopic Intervention Osaka UniversityOsaka 565-0871Japan Center for Diagnostic and Therapeutic Endoscopy School of MedicineKeio UniversityTokyo 160-8582Japan Department of Gastroenterology Ikeda City HospitalOsaka 563-8510Japan Department of Gastroenterology and Hepatology Graduate School of MedicineOsaka UniversityOsaka 565-0871Japan Department of Surgery School of MedicineKeio UniversityTokyo 160-8582Japan Division of Research and Development for Minimally Invasive Treatment Cancer CenterSchool of MedicineKeio UniversityTokyo 160-8582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of MedicineKeio UniversityTokyo 160-8582Japan

AIM: To elucidate the safety of percutaneous endoscopic gastrostomy(PEG) under steady pressure automatically controlled endoscopy(SPACE) using carbon dioxide(CO_2).METHODS: Nine patients underwent PEG with a modified introducer method under conscious sedation. A T-tube was attached to the channel of an endoscope connected to an automatic surgical insufflator. The stomach was inflated under the SPACE system. The intragastric pressure was kept between 4-8 mmH g with a flow of CO_2 at 35 L/min. Median procedure time, intragastric pressure, median systolic blood pressure, partial pressure of CO_2, abdominal girth before and immediately after PEG, and free gas and small intestinal gas on abdominal X-ray before and after PEG were recorded. RESULTS: PEG was completed under stable pneumostomach in all patients, with a median procedural time of 22 min. Median intragastric pressure was 6.9 mmH g and median arterial CO_2 pressure before and after PEG was 42.1 and 45.5 Torr(NS). The median abdominal girth before and after PEG was 68.1 and 69.6 cm(NS). A mild free gas image after PEG was observed in two patients, and faint abdominal gas in the downstream bowel was documented in two ***: SPACE might enable standardized pneumostomach and modified introducer procedure of PEG.

关键词： Percutaneous endoscopic gastrostomy Steadypressure automatically controlled endoscopy Carbondioxide

Endoscopic removal of foreign bodies:A retrospective study in Japan

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World Journal of Gastrointestinal Endoscopy 2020年第1期12卷 33-41页

作者： Kenji JL Limpias Kamiya Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Xi Sun Ryoichi Miyanaga Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Atsushi Nakayama motohiko kato Tadateru Maehata Rieko Nakamura Koichi Ueno Junichi Sasaki Yuko Kitagawa Naohisa Yahagi Haruhiko Ogata Takanori Kanai Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School of MedicineTokyo 160-8582Japan Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China Division of Research and Development for Minimally Invasive Treatment Cancer CenterKeio University School of MedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Emergency and Critical Care Medicine Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND The ingestion of foreign bodies(FBs)and food bolus impaction(FBI)in the digestive tract are commonly encountered clinical *** to handle such problems continue to evolve offering advantages,such as the avoidance of surgery,reduced cost,improved visualization,reduced morbidity,and high removal success ***,to date,no studies have evaluated the endoscopic management of FBs in *** To elucidate level of safety and efficacy in the endoscopic management of FBs and *** A total of 215 procedures were performed at Keio University Hospital between November 2007 and August *** were collected from medical charts,and endoscopic details were collected from an endoscopic reporting *** performed with a flexible gastrointestinal endoscope were only taken into *** who underwent a technique involving FB or FBI from the digestive tract were only *** on patient sex,patient age,outpatient,inpatient,FB type,FB location,procedure time,procedure type,removal device type,success,and technical complications were reviewed and analyzed *** Among the 215 procedures,136(63.3%)were performed in old adults(≥60 years),180(83.7%)procedures were performed in *** most common type of FBs were press-through-pack(PTP)medications[72(33.5%)cases],FBI[47(21.9%)],Anisakis parasite(AP)[41(19.1%)cases].Most FBs were located in the esophagus[130(60.5%)cases]followed by the stomach[68(31.6%)cases].AP was commonly found in the stomach[39(57.4%)cases],and it was removed using biopsy forceps in 97.5%of the *** most common FBs according to anatomical location were PTP medications(40%)and dental prostheses(DP)(40%)in the laryngopharynx,PTP(48.5%)in the esophagus,AP(57.4%)in the stomach,DP(37.5%)in the small intestine and video capsule endoscopy device(75%)in the colon.A transparent cap with grasping forceps was the most commonly used device[82(38.1%)cases].The success rate of the procedure was

关键词： Anisakis parasite Endoscopic removal Food bolus impaction Foreign body Grasping forceps

In-Situ Observation of SiC Bulk Single Crystal Growth by XRD System

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Journal of Rare Earths 2006年第z1期24卷 49-53页

作者： Tomohisa kato Natl Inst Adv Ind Sci & Technol AIST Tsukuba Ibaraki 3058568 Japan

In-situ analysis for SiC bulk single crystal growth was reported using vertical X-ray diffractometer system. A furnace for SiC sublimation growth combined with the XRD system which possessed three kinds of functions including topography, rocking curve measurement and crystal growth rate monitoring was developed. These functions could contribute as a powerful tool finding the optimum growth condition by dynamic observation in the crucible. In this study, the in-situ X-ray topographs succeeded to capture dynamic elongation of defects and dislocation generated in the SiC growing crystals. The in-situ rocking curve measurement reviled appearance of mosaic structure in the SiC crystal grown with high growth rate. The in-situ growth rate monitoring also succeeded very precisely using the direct X-ray beam absorption. On the base of findings and facts obtained by the in-situ observations, the importance for the SiC growth was discussed.

关键词： defects X-ray diffraction X-ray topography growth from vapor single crystal growth semiconducting materials

Effects of hydraulic oil and lubricant additives on dynamic friction properties under various reciprocating sliding conditions

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Friction 2020年第2期8卷 471-480页

作者： Shinji kato Shinya SASAKI Engineering Headquarters Automotive ComponentsKYB Corporation2548DolaKani-shiGifu 509-0298Japan Department of Mechanical Engineering Faculty of Engineering Division ITokyo University of Science6-3-1NiijukuKatsushika-kuTokyo 125-8585Japan

The friction characteristics of a shock absorber are very complex because the reciprocating motion is not always *** this study,a device was developed and used to analyze the dynamic friction characteristics under various reciprocating sliding conditions to determine the sliding materials and hydraulic oils that improve the shock absorber *** study describes the influence of hydraulic oil additive on the fine reciprocating friction characteristics of steel and copper *** oils were prepared by blending a paraffinic mineral oil with zinc dithiophosphate(ZnDTP)and polyhydric alcohol ester as *** results show that the dynamic frictional characteristics vary mainly depending on the additive concentration.A specific additive formulation induces a unique amplitude-dependent friction *** addition,the influence of different additives on the lubrication mechanism is investigated based on the instrumental analysis of the friction surface.

关键词： shock absorber dynamic friction reciprocating friction additive zinc dithiophosphate(ZnDTP)

GPS monitoring of temporal deformation of the Xianshuihe fault

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Science China Earth Sciences 2008年第9期51卷 1259-1266页

作者： TERUYUKI kato Earthquake Research Institute University of TokyoTokyo Japan

Highly precise (σ ~1 mm) temporal deformation measurements are taken across the Xianshuihe fault from two pairs of continuous GPS stations straddling the fault. Baseline vector changes of the two pairs of stations show clearly the difference in deformation behavior between the Qianning and Daofu segments of the fault: the former deforms steadily, and the latter deforms with a strong transient component. The transient deformation across the Daofu segment is possibly related to its irregular geometry, where the fault splits into two branches, that is, the east and west branches. An attempt is made to interpret the baseline vector changes using a kinematic fault model composed of a brittle layer in the upper crust, a ductile layer in the lower crust, and a transition zone in between. The slip in the transition zone of the south segment of the Xianshuihe fault is steady. The slips in the transition zones of the north and Daofu segments of the Xianshuihe fault, however, are not steady, and the average slip rates there are higher than that of the south segment. The difference in deformation behavior is probably associated with the rheological properties of the fault interface, suggesting that the overall fault strength of the south segment is greater than those of the north and Daofu segments, corresponding to longer earthquake recurrence time.

关键词： Xianshuihe fault GPS deformation field temporal change brittle-ductile transition zone