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A novel clinical artificial intelligence model for disease detection via retinal imaging

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The Innovation 2024年第2期5卷 11-12页

作者： Yidian Fu Liang ma Sheng Wan Shengfang Ge Zhi Yang Department of Ophthalmology Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China PCA Lab Key Lab of Intelligent Perception and Systems for High-Dimensional Information of Ministry of EducationNanjing 210000China Jiangsu Key Lab of Image and Video Understanding for Social Security School of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing 210000China

Artificial intelligence(AI)is an emerging field in which computerized systems are used to carry out complex tasks in place of *** AI algorithms have been developed for disease diagnosis and prediction and treatment recommendation across various clinical data types,e.g.,chest X-rays,electrocardiograms,and other radiological images.1 In ophthalmology,particularly,great progress has been made in AI systems over the past *** fundus photography(CFP)and optical coherence tomography(OCT),which are readily available in routine clinical practice,are both mainstream and useful retinal imaging modalities in *** September 2023,the 2023 Lasker-Debakey Clinical Medical Research Award was awarded to three scientists for their work on OCT for accurate retinal disease detection.

关键词： clinical routine diagnosis

CLASSIFICATIONS OF DUPIN HYPeRSURFACeS IN LIe SPHeRe GeOMeTRY

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Acta mathematica Scientia 2024年第1期44卷 1-36页

作者： Thomas e.CeCIL Department of mathematics and Computer Science College of the Holy CrossWorcesterMA01610USA

This is a survey of local and global classification results concerning Dupin hypersurfaces in S^(n)(or R^(n))that have been obtained in the context of Lie sphere *** emphasis is on results that relate Dupin hypersurfaces to isoparametric hypersurfaces in *** with these classification results,many important concepts from Lie sphere geometry,such as curvature spheres,Lie curvatures,and Legendre lifts of submanifolds of S^(n)(or R^(n)),are described in *** paper also contains several important constructions of Dupin hypersurfaces with certain special properties.

关键词： Dupin hypersurfaces isoparametric hypersurfaces Lie sphere geometry Lie sphere transformations Lie curvatures

efficient removal of Cr(VI) by polydopamine-modified lignin from aqueous solution: Batch and XAFS studies

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Water Science and engineering 2024年第1期17卷 51-61页

作者： Xiao-jie Guo Wei-kang Fu Jing-yuan ma Bo-jun Xi Chen Wang Meng-yao Guan College of materials and environmental engineering Hangzhou Dianzi UniversityHangzhou 310018China College of Textile and Garment Shaoxing UniversityShaoxing 312000China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Lignocellulose has the potential to become a bio-based adsorbent due to its biodegradability and *** this study,a novel polydopamine functionalized-lignin(lignin@PDA),prepared via self-polymerization of dopamine(PDA)on lignin,was used as a bio-based adsorbent for rapid scavenging of hexavalent chromium(Cr(VI)).The morphology,functional groups,crystalline structure,and chemical composition of lignin@PDA were characterized with a scanning electron microscope-energy dispersive spectrometer,Fourier transform infrared spectroscopy,X-ray diffraction,and X-ray photoelectron *** Cr(VI)adsorption process of lignin@PDA was studied using batch experiments as a function of pH,ionic strength,adsorbent dose,and contact time at room *** adsorption rate of lignin@PDA was five times greater than that of the unmodified lignin,with a maximum adsorption capacity of 102.6 mg/g in an acidic *** adsorption of Cr(VI)on lignin@PDA fit the pseudo-secondorder equation and the Freundlich model,indicating that the adsorption process was mainly dominated by chemisorption and surface *** thermodynamic parameters showed that adsorption of Cr(VI)on lignin@PDA was an endothermic and spontaneous *** X-ray absorption fine structure results showed that sorption and reduction of Cr(VI)into Cr(II)occurred simultaneously on ***,PDA coating not only improved the reactivity of lignin but also promoted the complete reduction of Cr(VI)by *** to these results,polydopamine functionalized-lignin is a promising bio-based adsorbent for immobilization of Cr(VI)from wastewater.

关键词： Lignin Polydopamine Hexavalent chromium eXAFS Adsorption mechanism

Development of a Front end Array for Broadband Phased Array Receiver

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Research in Astronomy and Astrophysics 2024年第4期24卷 60-70页

作者： Kai Wang Liang Cao Jun ma Xue-Feng Duan Hao Yan mao-Zheng Chen Yun-Wei Ning Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 8300lChina University of the Chinese Academy of Sciences Beijing 100049China Xinjiang Key Laboratory of Microwave Technology Urumqi 830011China

The receiver is a signal receiving device placed at the focus of the *** order to improve the observation efficiency,the concept of phased array receiver has been proposed in recent years,which places a small phased array at the focal plane of the reflector,and flexible pattern and beam scanning functions can be achieved through a beamforming *** combined with the element multiplexing,all beams within the entire field of view can be observed simultaneously to achieve continuous sky *** article focuses on the front-end array of phased array receiver at 0.7-1.8 GHz for QiTai Telescope,and designs a Vivaldi antenna array of PCB structure with dual line *** polarization antenna is designed to arrange in a rectangle manner by 11×*** on the simulation results of the focal field,32,18,and eight elements were selected to form one beam at 0.7,1.25,and1.8 *** analog beamforming network was constructed,and the measured gains of axial beam under uniform weighting were 19.32,13.72,and 15.22 *** the beam scanning method of reflector antenna,the pattern test of different position element sets required for PAF beam scanning was carried out under independent *** pattern optimization at 1.25 GHz was carried out by weighting method of conjugate field *** with uniform weighting,the gain,sidelobe level,and main beam direction under conjugate field matching have been *** the above test and simulation results are slightly different,which is related to the passive array and laboratory testing condition,the relevant work has accumulated experience in the development of the front-end array for the phased array receiver,and has good guiding significance for future performance verification after the array is installed on the telescope.

关键词： telescopes instrumentation:detectors techniques:radar astronomy

Large-Area Gravure-Printed AgNWs electrode on Water/Oxygen Barrier Substrate for Long-Term Stable Large-Area Flexible Organic Solar Cells

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Chinese Journal of Chemistry 2024年第5期42卷 478-484页

作者： Hao Wang Yaqin Pan Yunfei Han Zhuo Chen Tianyu Liu Lianping Zhang Qun Luo Chang-Qi ma Printable electronics Research Center & i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences (CAS)SuzhouJiangsu215123 China Nano Science and Technology Institute University of Science and Technology of China166 Ren Ai RoadSEID SIPSuzhouJiangsu215123 China

Large-area AgNWs electrodes(25 cm×10 cm)were fabricated through roll-to-roll printing on the polyvinyl alcohol(PVA)modified water and oxygen barrier *** modification of the barrier film with PVA improved the wettability of silver nanowires on the barrier films and led to the formation of homogenous large-area AgNWs *** mechanical flexibility,especially the adhesion force between the silver electrode and the barrier film substrate was dramatically improved through PVA *** efficiency of 13.51%for the flexible OSCs with an area of 0.64 cm2 was achieved based on the PeT/barrier film/PVA/AgNWs *** long-term stability showed the flexible OSCs based on the PeT/barrier film/PVA/AgNWs electrode have a significantly improved stability relative to the device on PeT/AgNWs electrode,and comparable air stability as the rigid device with glass/ITO *** unencapsulated devices maintained nearly 50%of the original efficiency after storage for 600 h in *** a simple top encapsulation,the flexible devices remained at 60%of the initial efficiency after 2000 h in the ***,the flexible AgNWs electrode based on the barrier film would have the potential to improve the air storage stability of organic flexible solar cells.

关键词： Flexible organic solar cell AgNWs electrode Air storage stability Barrier films substrate energy conversion Flexible electronics Interface

Variable frequency deep brain stimulation of subthalamic nucleus to improve freezing of gait in Parkinson's disease

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National Science Review 2024年第6期11卷 102-104页

作者： Fumin Jia Aparna Wagle Shukla Wei Hu Yu ma Jianguo Zhang Leonardo Almeida Chris Kao Yi Guo Shizhong Zhang Yingqun Tao Zhipei Ling Xin Xu Zhiquan Yang Fan-gang Meng Xinhua Wan Hesheng Liu Peter e.Konard Luming Li National engineering Laboratory for Neuromodulation Tsinghua University University of Florida Center for Movement Disorders and Neurorestoration Tsinghua University Yuquan Hospital Beijing Tiantan Hospital Capital Medical University School of Medicine Vanderbilt University Peking Union Medical College Hospital ZhuJiang Hospital of Southern Medical University The General Hospital of Shenyang Military Chinese PLA General Hospital Xiangya Hospital Central South University Beijing Neurosurgical Institute Capital Medical University Athinoula A. martinos Center for Biomedical Imaging Harvard Medical School Precision Medicine & Healthcare Research Center Tsinghua-Berkeley Shenzhen Institute man-machine-environment engineering Institute School of Aerospace EngineeringTsinghua University Center of epilepsy Beijing Institute for Brain Disorders

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a welle-stablished therapy for patients with Parkinson’s disease (PD) presenting with medication refractory tremors, motor fluctuations and dyskinesias induced by dopaminergic medications [1]. However,traditional high-frequency stimulation(HFS) does not effectively control axial symptoms such as gait dysfunction,postural instability and freezing of gait(FOG)[2,3].

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evolution of chemistry and selection technology for DNA-encoded library

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Acta Pharmaceutica Sinica B 2024年第2期14卷 492-516页

作者： Peixiang ma Shuning Zhang Qianping Huang Yuang Gu Zhi Zhou Wei Hou Wei Yi Hongtao Xu Shanghai Key Laboratory of Orthopedic Implants Department of OrthopedicsShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech UniversityShanghai 201210China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology The NMPA and State Key Laboratory of Respiratory DiseaseGuangzhou Medical UniversityGuangzhou 511436China College of Pharmaceutical Science and Institute of Drug Development&Chemical Biology Zhejiang University of TechnologyHangzhou 310014China

DNA-encoded chemical library(DeL)links the power of amplifiable genetics and the nonself-replicating chemical phenotypes,generating a diverse chemical *** analogy with the biological world,the DeL world can evolve by using a chemical central dogma,wherein DNA replicates using the PCR reactions to amplify the genetic codes,DNA sequencing transcripts the genetic information,and DNA-compatible synthesis translates into chemical ***,DNA-compatible synthesis is the key to expanding the DeL chemical ***,the evolution-driven selection system pushes the chemicals to evolve under the selective pressure,i.e.,desired selection *** this perspective,we summarized recent advances in expanding DeL synthetic toolbox and panning strategies,which will shed light on the drug discovery harnessing in vitro evolution of chemicals via DeL.

关键词： DNA-encoded library Drug discovery High-throughput selection DNA-compatible synthesis In vitro evolution Chemical central dogma

SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo

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International Journal of Ophthalmology(english edition) 2024年第7期17卷 1205-1216页

作者： Hui Cui Di Sun Sheng Meng Tian-Ju ma Zi Ye Zhao-Hui Li Medical School of Chinese PLA Beijing 100089China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To explore the effect of silent information regulator factor 2-related enzyme 1(SIRT1)on modulating apoptosis of human lens epithelial cells(HLeCs)and alleviating lens opacification of rats through suppressing endoplasmic reticulum(eR)***:HLeCs(SRA01/04)were treated with varying concentrations of tunicamycin(TM)for 24h,and the expression of SIRT1 and C/eBP homologous protein(CHOP)was assessed using real-time quantitative polymerase chain reaction(RT-PCR),Western blotting,and *** morphology and proliferation was evaluated using an inverted microscope and cell counting kit-8(CCK-8)assay,*** the SRA01/04 cell apoptosis model,which underwent siRNA transfection for SIRT1 knockdown and SRT1720 treatment for its activation,the expression levels of SIRT1,CHOP,glucose regulated protein 78(GRP78),and activating transcription factor 4(ATF4)were *** potential reversal of SIRT1 knockdown effects by 4-phenyl butyric acid(4-PBA;an eR stress inhibitor)was *** vivo,age-related cataract(ARC)rat models were induced by sodium selenite injection,and the protective role of SIRT1,activated by SRT1720 intraperitoneal injections,was evaluated through morphology observation,hematoxylin and eosin(H&e)staining,Western blotting,and ***:SIRT1 expression was downregulated in TMinduced SRA01/04 ***,in SRA01/04 cells,both cell apoptosis and CHOP expression increased with the rising doses of *** stress was stimulated by TM,as evidenced by the increased GRP78 and ATF4 in the SRA01/04 cell apoptosis *** of SIRT1 by siRNA knockdown increased eR stress activation,whereas SRT1720 treatment had opposite results.4-PBA partly reverse the adverse effect of SIRT1 knockdown on *** vivo,SRT1720 attenuated the lens opacification and weakened the eR stress activation in ARC rat ***:SIRT1 plays a protective role against TM-induced apoptosis in HLeCs and slows the progression of cataract in

关键词： silent information regulator factor 2-related enzyme 1 endoplasmic reticulum stress apoptosis human lens epithelial cells cataract

Connection-Free Transmission for Critical MTC

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China Communications 2024年第8期21卷 162-171页

作者： Li Zhigang Yuan Zhifeng ma Yihua Liang Chulong ZTe Corporation Shenzhen 518057China State Key Laboratory of Mobile Network and Mobile Multimedia Technology Shenzhen 518055China

In this paper,a contention-based connection-free transmission scheme is proposed to meet the stringent requirements of ultra-reliability and low-latency for critical machine-type communication(cMTC).To improve reliability,we design multiple independent sparse orthogonal pilots(MISOP)to significantly reduce the probability of pilot collision to the order of 10^(−5).Besides,the advancements of massive MIMO(mMIMO)are exploited to further enhance the *** achieve low latency,connection-free slot-based one-shot transmission without retransmissions is *** the receiver side,single round of multi-user detection(MUD)without interference cancellation(IC)can reduce the processing *** imprecise synchronization between cMTC device and the gNB in connection-free transmission,e.g.,time and frequency offsets,are also *** simulation results shows that the proposed scheme can well satisfy the ambitious requirements of cMTC,and has the potential applications in supporting massive cMTC devices in 6G.

关键词： connection-free critical MTC pilot collision sparse orthogonal pilot